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Whey Protein Isolate

MedGen UID:
408107
Concept ID:
C1883555
Amino Acid, Peptide, or Protein; Pharmacologic Substance
Synonyms: Milk Serum Protein Isolate; Undenatured Bioactive Whey Protein Derivative
 

Definition

A biologically active, cystine-rich, whey-based protein isolate. Whey protein isolate is broken down in the body into cystine and glutamylcystine, which travel safely in the blood stream, upon cell entry, deliver a sustained amount of free cysteine to the cells. The available cysteine allows cells to synthesize glutathione (GSH), a tripeptide containing amino acids glycine, glutamate and cysteine, thereby maintaining and increasing intracellular GSH concentrations. GSH plays a major role as an antioxidant, thereby protecting cells from oxidative damage due to harmful substances such as free radicals and reactive oxygen compounds. [from NCI]

Recent clinical studies

Etiology

Zhang XY, Huang HS, Yang J, Yu YY, Zhang DX, Chang CQ
Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2017 Dec 20;39(6):792-799. doi: 10.3881/j.issn.1000-503X.2017.06.010. PMID: 29338824
Borack MS, Reidy PT, Husaini SH, Markofski MM, Deer RR, Richison AB, Lambert BS, Cope MB, Mukherjea R, Jennings K, Volpi E, Rasmussen BB
J Nutr 2016 Dec;146(12):2468-2475. Epub 2016 Oct 26 doi: 10.3945/jn.116.231159. PMID: 27798330Free PMC Article
Forbes SC, McCargar L, Jelen P, Bell GJ
Int J Sport Nutr Exerc Metab 2014 Apr;24(2):188-95. Epub 2013 Nov 13 doi: 10.1123/ijsnem.2013-0136. PMID: 24225595
Pal S, Ellis V
Br J Nutr 2011 May;105(10):1512-9. Epub 2011 Jan 28 doi: 10.1017/S0007114510005313. PMID: 21272399
Chitapanarux T, Tienboon P, Pojchamarnwiputh S, Leelarungrayub D
J Gastroenterol Hepatol 2009 Jun;24(6):1045-50. doi: 10.1111/j.1440-1746.2009.05865.x. PMID: 19638084

Diagnosis

Ezhilarasi PN, Indrani D, Jena BS, Anandharamakrishnan C
J Sci Food Agric 2014 Apr;94(6):1116-23. Epub 2013 Oct 2 doi: 10.1002/jsfa.6378. PMID: 23996701
Shertzer HG, Woods SE, Krishan M, Genter MB, Pearson KJ
J Nutr 2011 Apr 1;141(4):582-7. Epub 2011 Feb 10 doi: 10.3945/jn.110.133736. PMID: 21310864Free PMC Article
Grey V, Mohammed SR, Smountas AA, Bahlool R, Lands LC
J Cyst Fibros 2003 Dec;2(4):195-8. doi: 10.1016/S1569-1993(03)00097-3. PMID: 15463873

Therapy

Jain A, Sharma G, Ghoshal G, Kesharwani P, Singh B, Shivhare US, Katare OP
Int J Pharm 2018 Jul 30;546(1-2):97-105. Epub 2018 Apr 30 doi: 10.1016/j.ijpharm.2018.04.061. PMID: 29715533
Zhang XY, Huang HS, Yang J, Yu YY, Zhang DX, Chang CQ
Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2017 Dec 20;39(6):792-799. doi: 10.3881/j.issn.1000-503X.2017.06.010. PMID: 29338824
Song W, Tavitian A, Cressatti M, Galindez C, Liberman A, Schipper HM
Free Radic Biol Med 2017 Sep;110:162-175. Epub 2017 Jun 8 doi: 10.1016/j.freeradbiomed.2017.05.025. PMID: 28603087
Dhillon VS, Zabaras D, Almond T, Cavuoto P, James-Martin G, Fenech M
Mol Nutr Food Res 2017 May;61(5) Epub 2017 Feb 9 doi: 10.1002/mnfr.201600915. PMID: 27981743
Forbes SC, McCargar L, Jelen P, Bell GJ
Int J Sport Nutr Exerc Metab 2014 Apr;24(2):188-95. Epub 2013 Nov 13 doi: 10.1123/ijsnem.2013-0136. PMID: 24225595

Prognosis

Li Y, Damodaran S
Food Chem 2017 Apr 15;221:1151-1157. Epub 2016 Nov 9 doi: 10.1016/j.foodchem.2016.11.044. PMID: 27979073
McCormack WG, Cooke JP, O'Connor WT, Jakeman PM
Amino Acids 2017 Jan;49(1):151-159. Epub 2016 Oct 4 doi: 10.1007/s00726-016-2343-8. PMID: 27704291
Tosukhowong P, Boonla C, Dissayabutra T, Kaewwilai L, Muensri S, Chotipanich C, Joutsa J, Rinne J, Bhidayasiri R
J Neurol Sci 2016 Aug 15;367:162-70. Epub 2016 May 31 doi: 10.1016/j.jns.2016.05.056. PMID: 27423583
Pabari RM, Togashi D, Cama-Moncunill R, El Arnaout T, Rifai H, Cruise P, Cullen PJ, Sullivan C
Int J Food Sci Nutr 2015;66(5):526-32. Epub 2015 Jul 15 doi: 10.3109/09637486.2015.1064867. PMID: 26176650
Betts JA, Toone RJ, Stokes KA, Thompson D
Appl Physiol Nutr Metab 2009 Aug;34(4):773-84. doi: 10.1139/H09-070. PMID: 19767814

Clinical prediction guides

Zhang XY, Huang HS, Yang J, Yu YY, Zhang DX, Chang CQ
Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2017 Dec 20;39(6):792-799. doi: 10.3881/j.issn.1000-503X.2017.06.010. PMID: 29338824
Song W, Tavitian A, Cressatti M, Galindez C, Liberman A, Schipper HM
Free Radic Biol Med 2017 Sep;110:162-175. Epub 2017 Jun 8 doi: 10.1016/j.freeradbiomed.2017.05.025. PMID: 28603087
Eratte D, Dowling K, Barrow CJ, Adhikari BP
Food Chem 2017 Jul 15;227:129-136. Epub 2017 Jan 17 doi: 10.1016/j.foodchem.2017.01.080. PMID: 28274412
Forbes SC, McCargar L, Jelen P, Bell GJ
Int J Sport Nutr Exerc Metab 2014 Apr;24(2):188-95. Epub 2013 Nov 13 doi: 10.1123/ijsnem.2013-0136. PMID: 24225595
Chitapanarux T, Tienboon P, Pojchamarnwiputh S, Leelarungrayub D
J Gastroenterol Hepatol 2009 Jun;24(6):1045-50. doi: 10.1111/j.1440-1746.2009.05865.x. PMID: 19638084

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