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Whey Protein Isolate

MedGen UID:
408107
Concept ID:
C1883555
Amino Acid, Peptide, or Protein; Pharmacologic Substance
Synonyms: Milk Serum Protein Isolate; Undenatured Bioactive Whey Protein Derivative

Definition

A biologically active, cystine-rich, whey-based protein isolate. Whey protein isolate is broken down in the body into cystine and glutamylcystine, which travel safely in the blood stream, upon cell entry, deliver a sustained amount of free cysteine to the cells. The available cysteine allows cells to synthesize glutathione (GSH), a tripeptide containing amino acids glycine, glutamate and cysteine, thereby maintaining and increasing intracellular GSH concentrations. GSH plays a major role as an antioxidant, thereby protecting cells from oxidative damage due to harmful substances such as free radicals and reactive oxygen compounds. [from NCI]

Recent clinical studies

Etiology

Zhang X, Huang H, Yu Y, Yang J, Liang Z, Chang C
J Rehabil Med 2020 Mar 31;52(3):jrm00035. doi: 10.2340/16501977-2664. PMID: 32152642
Forbes SC, Bell GJ
J Sports Med Phys Fitness 2020 Jun;60(6):832-840. Epub 2020 Mar 4 doi: 10.23736/S0022-4707.20.10314-1. PMID: 32141277
Hoefle AS, Bangert AM, Rist MJ, Gedrich K, Lee YM, Skurk T, Danier J, Schwarzenbolz U, Daniel H
Eur J Nutr 2019 Aug;58(5):2067-2077. Epub 2018 Jul 12 doi: 10.1007/s00394-018-1763-5. PMID: 30003332
Zhang XY, Huang HS, Yang J, Yu YY, Zhang DX, Chang CQ
Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2017 Dec 20;39(6):792-799. doi: 10.3881/j.issn.1000-503X.2017.06.010. PMID: 29338824
Forbes SC, McCargar L, Jelen P, Bell GJ
Int J Sport Nutr Exerc Metab 2014 Apr;24(2):188-95. Epub 2013 Nov 13 doi: 10.1123/ijsnem.2013-0136. PMID: 24225595

Diagnosis

Xu L, Gong Y, Gern JE, Lucey JA
J Dairy Sci 2020 Feb;103(2):1141-1150. Epub 2019 Nov 27 doi: 10.3168/jds.2019-17187. PMID: 31785876
Cereda E, Turri A, Klersy C, Cappello S, Ferrari A, Filippi AR, Brugnatelli S, Caraccia M, Chiellino S, Borioli V, Monaco T, Stella GM, Arcaini L, Benazzo M, Grugnetti G, Pedrazzoli P, Caccialanza R
Cancer Med 2019 Nov;8(16):6923-6932. Epub 2019 Sep 30 doi: 10.1002/cam4.2517. PMID: 31568698Free PMC Article
Devries MC, McGlory C, Bolster DR, Kamil A, Rahn M, Harkness L, Baker SK, Phillips SM
J Nutr 2018 Jul 1;148(7):1088-1095. doi: 10.1093/jn/nxy091. PMID: 29901760
Xu L, Gong Y, Gern JE, Ikeda S, Lucey JA
J Dairy Sci 2018 Aug;101(8):6823-6834. Epub 2018 May 16 doi: 10.3168/jds.2017-14338. PMID: 29778476
Ezhilarasi PN, Indrani D, Jena BS, Anandharamakrishnan C
J Sci Food Agric 2014 Apr;94(6):1116-23. Epub 2013 Oct 2 doi: 10.1002/jsfa.6378. PMID: 23996701

Therapy

Zhang X, Huang H, Yu Y, Yang J, Liang Z, Chang C
J Rehabil Med 2020 Mar 31;52(3):jrm00035. doi: 10.2340/16501977-2664. PMID: 32152642
Jain A, Sharma G, Ghoshal G, Kesharwani P, Singh B, Shivhare US, Katare OP
Int J Pharm 2018 Jul 30;546(1-2):97-105. Epub 2018 Apr 30 doi: 10.1016/j.ijpharm.2018.04.061. PMID: 29715533
Zhang XY, Huang HS, Yang J, Yu YY, Zhang DX, Chang CQ
Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2017 Dec 20;39(6):792-799. doi: 10.3881/j.issn.1000-503X.2017.06.010. PMID: 29338824
Song W, Tavitian A, Cressatti M, Galindez C, Liberman A, Schipper HM
Free Radic Biol Med 2017 Sep;110:162-175. Epub 2017 Jun 8 doi: 10.1016/j.freeradbiomed.2017.05.025. PMID: 28603087
Dhillon VS, Zabaras D, Almond T, Cavuoto P, James-Martin G, Fenech M
Mol Nutr Food Res 2017 May;61(5) Epub 2017 Feb 9 doi: 10.1002/mnfr.201600915. PMID: 27981743

Prognosis

Wang X, Ye A, Lin Q, Han J, Singh H
J Dairy Sci 2018 Aug;101(8):6842-6852. Epub 2018 May 10 doi: 10.3168/jds.2017-14284. PMID: 29753488
Li Y, Damodaran S
Food Chem 2017 Apr 15;221:1151-1157. Epub 2016 Nov 9 doi: 10.1016/j.foodchem.2016.11.044. PMID: 27979073
McCormack WG, Cooke JP, O'Connor WT, Jakeman PM
Amino Acids 2017 Jan;49(1):151-159. Epub 2016 Oct 4 doi: 10.1007/s00726-016-2343-8. PMID: 27704291
Tosukhowong P, Boonla C, Dissayabutra T, Kaewwilai L, Muensri S, Chotipanich C, Joutsa J, Rinne J, Bhidayasiri R
J Neurol Sci 2016 Aug 15;367:162-70. Epub 2016 May 31 doi: 10.1016/j.jns.2016.05.056. PMID: 27423583
Betts JA, Toone RJ, Stokes KA, Thompson D
Appl Physiol Nutr Metab 2009 Aug;34(4):773-84. doi: 10.1139/H09-070. PMID: 19767814

Clinical prediction guides

Zhang X, Huang H, Yu Y, Yang J, Liang Z, Chang C
J Rehabil Med 2020 Mar 31;52(3):jrm00035. doi: 10.2340/16501977-2664. PMID: 32152642
Cubides YTP, Eklund PR, Foegeding EA
J Food Sci 2019 Dec;84(12):3399-3410. Epub 2019 Nov 21 doi: 10.1111/1750-3841.14933. PMID: 31750948
Zhang XY, Huang HS, Yang J, Yu YY, Zhang DX, Chang CQ
Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2017 Dec 20;39(6):792-799. doi: 10.3881/j.issn.1000-503X.2017.06.010. PMID: 29338824
Song W, Tavitian A, Cressatti M, Galindez C, Liberman A, Schipper HM
Free Radic Biol Med 2017 Sep;110:162-175. Epub 2017 Jun 8 doi: 10.1016/j.freeradbiomed.2017.05.025. PMID: 28603087
Forbes SC, McCargar L, Jelen P, Bell GJ
Int J Sport Nutr Exerc Metab 2014 Apr;24(2):188-95. Epub 2013 Nov 13 doi: 10.1123/ijsnem.2013-0136. PMID: 24225595

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