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Stevens-Johnson syndrome, susceptibility to

MedGen UID:
392859
•Concept ID:
C2608081
•
Finding
Synonym: STEVENS-JOHNSON SYNDROME, SUSCEPTIBILITY TO
 
OMIM®: 142830; 608579

Professional guidelines

PubMed

Clinical presentation and management of atypical and recalcitrant acute generalized exanthematous pustulosis.
Hadavand MA, Kaffenberger B, Cartron AM, Trinidad JCL
J Am Acad Dermatol 2022 Sep;87(3):632-639. Epub 2020 Sep 11 doi: 10.1016/j.jaad.2020.09.024. PMID: 32926975
Diagnosis and management of Stevens-Johnson syndrome/toxic epidermal necrolysis.
Noe MH, Micheletti RG
Clin Dermatol 2020 Nov-Dec;38(6):607-612. Epub 2020 Jun 30 doi: 10.1016/j.clindermatol.2020.06.016. PMID: 33341195
Stevens-Johnson syndrome and toxic epidermal necrolysis: clinical patterns, diagnostic considerations, etiology, and therapeutic management.
Mockenhaupt M
Semin Cutan Med Surg 2014 Mar;33(1):10-6. doi: 10.12788/j.sder.0058. PMID: 25037254

Recent clinical studies

Etiology

Lamotrigine and Stevens-Johnson Syndrome Prevention.
Edinoff AN, Nguyen LH, Fitz-Gerald MJ, Crane E, Lewis K, Pierre SS, Kaye AD, Kaye AM, Kaye JS, Kaye RJ, Gennuso SA, Varrassi G, Viswanath O, Urits I
Psychopharmacol Bull 2021 Mar 16;51(2):96-114. PMID: 34092825Free PMC Article
Diagnosis and management of Stevens-Johnson syndrome/toxic epidermal necrolysis.
Noe MH, Micheletti RG
Clin Dermatol 2020 Nov-Dec;38(6):607-612. Epub 2020 Jun 30 doi: 10.1016/j.clindermatol.2020.06.016. PMID: 33341195
Drug allergy.
Greenberger PA
Allergy Asthma Proc 2019 Nov 1;40(6):474-479. doi: 10.2500/aap.2019.40.4275. PMID: 31690398
Results of Detailed Investigations Into Stevens-Johnson Syndrome With Severe Ocular Complications.
Ueta M
Invest Ophthalmol Vis Sci 2018 Nov 1;59(14):DES183-DES191. doi: 10.1167/iovs.17-23537. PMID: 30481825
Toxic epidermal necrolysis and Stevens-Johnson syndrome.
Harr T, French LE
Orphanet J Rare Dis 2010 Dec 16;5:39. doi: 10.1186/1750-1172-5-39. PMID: 21162721Free PMC Article

Diagnosis

Diagnosis and management of Stevens-Johnson syndrome/toxic epidermal necrolysis.
Noe MH, Micheletti RG
Clin Dermatol 2020 Nov-Dec;38(6):607-612. Epub 2020 Jun 30 doi: 10.1016/j.clindermatol.2020.06.016. PMID: 33341195
Stevens-Johnson syndrome/toxic epidermal necrolysis with severe ocular complications.
Ueta M
Expert Rev Clin Immunol 2020 Mar;16(3):285-291. Epub 2020 Feb 28 doi: 10.1080/1744666X.2020.1729128. PMID: 32045311
Drug allergy.
Greenberger PA
Allergy Asthma Proc 2019 Nov 1;40(6):474-479. doi: 10.2500/aap.2019.40.4275. PMID: 31690398
Drug hypersensitivity in HIV infection.
Peter J, Choshi P, Lehloenya RJ
Curr Opin Allergy Clin Immunol 2019 Aug;19(4):272-282. doi: 10.1097/ACI.0000000000000545. PMID: 31145192Free PMC Article
Toxic epidermal necrolysis and Stevens-Johnson syndrome.
Harr T, French LE
Orphanet J Rare Dis 2010 Dec 16;5:39. doi: 10.1186/1750-1172-5-39. PMID: 21162721Free PMC Article

Therapy

Lamotrigine and Stevens-Johnson Syndrome Prevention.
Edinoff AN, Nguyen LH, Fitz-Gerald MJ, Crane E, Lewis K, Pierre SS, Kaye AD, Kaye AM, Kaye JS, Kaye RJ, Gennuso SA, Varrassi G, Viswanath O, Urits I
Psychopharmacol Bull 2021 Mar 16;51(2):96-114. PMID: 34092825Free PMC Article
Diagnosis and management of Stevens-Johnson syndrome/toxic epidermal necrolysis.
Noe MH, Micheletti RG
Clin Dermatol 2020 Nov-Dec;38(6):607-612. Epub 2020 Jun 30 doi: 10.1016/j.clindermatol.2020.06.016. PMID: 33341195
Drug hypersensitivity in HIV infection.
Peter J, Choshi P, Lehloenya RJ
Curr Opin Allergy Clin Immunol 2019 Aug;19(4):272-282. doi: 10.1097/ACI.0000000000000545. PMID: 31145192Free PMC Article
Toxic epidermal necrolysis and Stevens-Johnson syndrome.
Harr T, French LE
Orphanet J Rare Dis 2010 Dec 16;5:39. doi: 10.1186/1750-1172-5-39. PMID: 21162721Free PMC Article
Allopurinol in dermatology.
Tsai TF, Yeh TY
Am J Clin Dermatol 2010;11(4):225-32. doi: 10.2165/11533190-000000000-00000. PMID: 20509717

Prognosis

Drug hypersensitivity in HIV infection.
Peter J, Choshi P, Lehloenya RJ
Curr Opin Allergy Clin Immunol 2019 Aug;19(4):272-282. doi: 10.1097/ACI.0000000000000545. PMID: 31145192Free PMC Article
Results of Detailed Investigations Into Stevens-Johnson Syndrome With Severe Ocular Complications.
Ueta M
Invest Ophthalmol Vis Sci 2018 Nov 1;59(14):DES183-DES191. doi: 10.1167/iovs.17-23537. PMID: 30481825
Genetic Predisposition to Stevens-Johnson Syndrome With Severe Ocular Surface Complications.
Ueta M
Cornea 2015 Nov;34 Suppl 11:S158-65. doi: 10.1097/ICO.0000000000000605. PMID: 26448174
Adverse drug reactions in dermatology.
Ferner RE
Clin Exp Dermatol 2015 Mar;40(2):105-9; quiz 109-10. Epub 2015 Jan 27 doi: 10.1111/ced.12572. PMID: 25622648
Toxic epidermal necrolysis and Stevens-Johnson syndrome.
Harr T, French LE
Orphanet J Rare Dis 2010 Dec 16;5:39. doi: 10.1186/1750-1172-5-39. PMID: 21162721Free PMC Article

Clinical prediction guides

Whole genome-wide sequence analysis of long-lived families (Long-Life Family Study) identifies MTUS2 gene associated with late-onset Alzheimer's disease.
Xicota L, Cosentino S, Vardarajan B, Mayeux R, Perls TT, Andersen SL, Zmuda JM, Thyagarajan B, Yashin A, Wojczynski MK, Krinsky-McHale S, Handen BL, Christian BT, Head E, Mapstone ME, Schupf N, Lee JH, Barral S; Long‐Life Family Study (LLFS); Alzheimer's Disease Genetic Consortium (ADGC); Alzheimer's Biomarkers Consortium‐Down Syndrome (ABC‐DS)
Alzheimers Dement 2024 Apr;20(4):2670-2679. Epub 2024 Feb 21 doi: 10.1002/alz.13718. PMID: 38380866Free PMC Article
Chronic ocular sequelae in Stevens-Johnson syndrome: a genetic association study.
Sangwan SK, Sharma N, Agarwal T, Khanna N, Pandey RM, Sharma A, Vajpayee RB
Mol Vis 2022;28:526-535. Epub 2022 Dec 31 PMID: 37089698Free PMC Article
Drug hypersensitivity in HIV infection.
Peter J, Choshi P, Lehloenya RJ
Curr Opin Allergy Clin Immunol 2019 Aug;19(4):272-282. doi: 10.1097/ACI.0000000000000545. PMID: 31145192Free PMC Article
Results of Detailed Investigations Into Stevens-Johnson Syndrome With Severe Ocular Complications.
Ueta M
Invest Ophthalmol Vis Sci 2018 Nov 1;59(14):DES183-DES191. doi: 10.1167/iovs.17-23537. PMID: 30481825
Toxic epidermal necrolysis and Stevens-Johnson syndrome.
Harr T, French LE
Orphanet J Rare Dis 2010 Dec 16;5:39. doi: 10.1186/1750-1172-5-39. PMID: 21162721Free PMC Article

Recent systematic reviews

Unraveling the genetic link: an umbrella review on HLA-B*15:02 and antiepileptic drug-induced Stevens-Johnson syndrome/toxic epidermal necrolysis.
Tham KM, Yek JJL, Liu CWY
Pharmacogenet Genomics 2024 Jul 1;34(5):154-165. Epub 2024 Mar 22 doi: 10.1097/FPC.0000000000000531. PMID: 38527170
Photodistributed Stevens-Johnson syndrome and toxic epidermal necrolysis: a systematic review and proposal for a new diagnostic classification.
McKinley BJ, Allen ME, Michels N
Eur J Med Res 2023 Jun 12;28(1):188. doi: 10.1186/s40001-023-01142-2. PMID: 37303053Free PMC Article
Genetic predisposition for the development of lamotrigine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis: a systematic review and meta-analysis.
Das SK, Sampath A, Zaman SU, Pati AK, Atal S
Per Med 2023 Mar;20(2):201-213. Epub 2023 May 17 doi: 10.2217/pme-2022-0126. PMID: 37194923
Association between HLA-B*5901 and methazolamide-induced Stevens-Johnson syndrome/toxic epidermal necrolysis: a systematic review and meta-analysis.
Tangamornsuksan W, Lohitnavy M
Pharmacogenomics J 2019 Jun;19(3):286-294. Epub 2018 Sep 21 doi: 10.1038/s41397-018-0052-2. PMID: 30242287
HLA alleles and hypersensitivity to carbamazepine: an updated systematic review with meta-analysis.
Grover S, Kukreti R
Pharmacogenet Genomics 2014 Feb;24(2):94-112. doi: 10.1097/FPC.0000000000000021. PMID: 24336023

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