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Abnormal lip morphology

MedGen UID:
389175
•Concept ID:
C2183966
•
Anatomical Abnormality
Synonym: Abnormality of the lip
 
HPO: HP:0000159

Definition

An abnormality of the lip. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal lip morphology

Conditions with this feature

Phlebectasia of lips
MedGen UID:
356962
•Concept ID:
C1868391
•
Disease or Syndrome
See: Condition Record
Phlebectasia of lips

Professional guidelines

PubMed

Management of the protuberant premaxilla: where does it fit in?
Morris L
Curr Opin Otolaryngol Head Neck Surg 2019 Aug;27(4):302-309. doi: 10.1097/MOO.0000000000000558. PMID: 31219831
Excessive gingival display--etiology, diagnosis, and treatment modalities.
Silberberg N, Goldstein M, Smidt A
Quintessence Int 2009 Nov-Dec;40(10):809-18. PMID: 19898712
Prenatal diagnosis.
Paek B, Goldberg JD, Albanese CT
World J Surg 2003 Jan;27(1):27-37. doi: 10.1007/s00268-002-6734-5. PMID: 12557035

Recent clinical studies

Etiology

The unilateral cleft lip repair.
Grewal JS, Yanik SC, Strohl-Bryan AM, Tatum SA
Am J Otolaryngol 2021 May-Jun;42(3):102908. Epub 2021 Jan 13 doi: 10.1016/j.amjoto.2021.102908. PMID: 33508593
Diagnosis of fetal non-chromosomal abnormalities on routine ultrasound examination at 11-13 weeks' gestation.
Syngelaki A, Hammami A, Bower S, Zidere V, Akolekar R, Nicolaides KH
Ultrasound Obstet Gynecol 2019 Oct;54(4):468-476. doi: 10.1002/uog.20844. PMID: 31408229
Cervical vertebrae anomalies and cleft lip and palate: a systematic review and meta-analysis.
Berrocal C, Terrero-Pérez Á, Peralta-Mamani M, Fischer Rubira-Bullen IR, Honório HM, de Carvalho IMM, Alvares Capelozza AL
Dentomaxillofac Radiol 2019 Dec;48(8):20190085. Epub 2019 Jul 23 doi: 10.1259/dmfr.20190085. PMID: 31271540Free PMC Article
Toward an orofacial gene regulatory network.
Kousa YA, Schutte BC
Dev Dyn 2016 Mar;245(3):220-32. Epub 2015 Sep 17 doi: 10.1002/dvdy.24341. PMID: 26332872Free PMC Article
Acro-cardio-facial syndrome.
Digilio MC, Dallapiccola B
Orphanet J Rare Dis 2010 Sep 29;5:25. doi: 10.1186/1750-1172-5-25. PMID: 20920258Free PMC Article

Diagnosis

A Rorschach Test.
Caluseriu O
Am J Med Genet C Semin Med Genet 2024 Nov;196(2-3):e32116. Epub 2024 Oct 9 doi: 10.1002/ajmg.c.32116. PMID: 39381977
Diagnosis of fetal non-chromosomal abnormalities on routine ultrasound examination at 11-13 weeks' gestation.
Syngelaki A, Hammami A, Bower S, Zidere V, Akolekar R, Nicolaides KH
Ultrasound Obstet Gynecol 2019 Oct;54(4):468-476. doi: 10.1002/uog.20844. PMID: 31408229
Acro-cardio-facial syndrome.
Digilio MC, Dallapiccola B
Orphanet J Rare Dis 2010 Sep 29;5:25. doi: 10.1186/1750-1172-5-25. PMID: 20920258Free PMC Article
Postaxial polydactyly.
Aggarwal AN, Goyal MK, Rishi Gupta N
JNMA J Nepal Med Assoc 2009 Apr-Jun;48(174):153-4. PMID: 20387358
Excessive gingival display--etiology, diagnosis, and treatment modalities.
Silberberg N, Goldstein M, Smidt A
Quintessence Int 2009 Nov-Dec;40(10):809-18. PMID: 19898712

Therapy

An overview of cleft lip and palate.
Alois CI, Ruotolo RA
JAAPA 2020 Dec;33(12):17-20. doi: 10.1097/01.JAA.0000721644.06681.06. PMID: 33234889
Ankyloglossia and Other Oral Ties.
Walsh J, McKenna Benoit M
Otolaryngol Clin North Am 2019 Oct;52(5):795-811. Epub 2019 Jul 25 doi: 10.1016/j.otc.2019.06.008. PMID: 31353141
Biomaterials for Cleft Lip and Palate Regeneration.
Martín-Del-Campo M, Rosales-Ibañez R, Rojo L
Int J Mol Sci 2019 May 2;20(9) doi: 10.3390/ijms20092176. PMID: 31052503Free PMC Article
Orthognathic Surgery for Patients with Cleft Lip and Palate.
Roy AA, Rtshiladze MA, Stevens K, Phillips J
Clin Plast Surg 2019 Apr;46(2):157-171. Epub 2019 Feb 6 doi: 10.1016/j.cps.2018.11.002. PMID: 30851748
Will This Patient Be Difficult to Intubate?: The Rational Clinical Examination Systematic Review.
Detsky ME, Jivraj N, Adhikari NK, Friedrich JO, Pinto R, Simel DL, Wijeysundera DN, Scales DC
JAMA 2019 Feb 5;321(5):493-503. doi: 10.1001/jama.2018.21413. PMID: 30721300

Prognosis

Congenital Upper Lip Sinus.
Zhang J, Li Z, Pang P
J Craniofac Surg 2024 Jul-Aug 01;35(5):e438-e441. Epub 2024 May 2 doi: 10.1097/SCS.0000000000010138. PMID: 38688013
"Pitted" lesions in dermatology.
Adya KA, Inamadar AC, Palit A
Int J Dermatol 2017 Jan;56(1):3-17. Epub 2016 Sep 9 doi: 10.1111/ijd.13358. PMID: 27613605
Acro-cardio-facial syndrome.
Digilio MC, Dallapiccola B
Orphanet J Rare Dis 2010 Sep 29;5:25. doi: 10.1186/1750-1172-5-25. PMID: 20920258Free PMC Article
Excessive gingival display--etiology, diagnosis, and treatment modalities.
Silberberg N, Goldstein M, Smidt A
Quintessence Int 2009 Nov-Dec;40(10):809-18. PMID: 19898712
Prenatal diagnosis.
Paek B, Goldberg JD, Albanese CT
World J Surg 2003 Jan;27(1):27-37. doi: 10.1007/s00268-002-6734-5. PMID: 12557035

Clinical prediction guides

Ocular Phenotype of Peters-Plus Syndrome.
Shah PR, Chauhan B, Chu CT, Kofler J, Nischal KK
Cornea 2022 Feb 1;41(2):219-223. doi: 10.1097/ICO.0000000000002889. PMID: 34629439
The unilateral cleft lip repair.
Grewal JS, Yanik SC, Strohl-Bryan AM, Tatum SA
Am J Otolaryngol 2021 May-Jun;42(3):102908. Epub 2021 Jan 13 doi: 10.1016/j.amjoto.2021.102908. PMID: 33508593
Evaluation of Facial Appearance in Patients With Cleft Lip and Palate by Laypeople and Professionals: A Systematic Literature Review.
Zhu S, Jayaraman J, Khambay B
Cleft Palate Craniofac J 2016 Mar;53(2):187-96. Epub 2015 Feb 4 doi: 10.1597/14-177. PMID: 25650654
Excessive gingival display--etiology, diagnosis, and treatment modalities.
Silberberg N, Goldstein M, Smidt A
Quintessence Int 2009 Nov-Dec;40(10):809-18. PMID: 19898712
The effect of hypoxia in development.
Webster WS, Abela D
Birth Defects Res C Embryo Today 2007 Sep;81(3):215-28. doi: 10.1002/bdrc.20102. PMID: 17963271

Recent systematic reviews

Phenotypic spectrum of FGF10-related disorders: a systematic review.
Bzdega K, Karolak JA
PeerJ 2022;10:e14003. Epub 2022 Sep 14 doi: 10.7717/peerj.14003. PMID: 36124135Free PMC Article
Effectiveness of pre-surgical orthopedics on patients with cleft lip and palate: A systematic review and meta-analysis.
Dallaserra M, Pantoja T, Salazar J, Araya I, Yanine N, Villanueva J
J Stomatol Oral Maxillofac Surg 2022 Oct;123(5):e506-e520. Epub 2022 Feb 10 doi: 10.1016/j.jormas.2022.02.004. PMID: 35151895
Cervical vertebrae anomalies and cleft lip and palate: a systematic review and meta-analysis.
Berrocal C, Terrero-Pérez Á, Peralta-Mamani M, Fischer Rubira-Bullen IR, Honório HM, de Carvalho IMM, Alvares Capelozza AL
Dentomaxillofac Radiol 2019 Dec;48(8):20190085. Epub 2019 Jul 23 doi: 10.1259/dmfr.20190085. PMID: 31271540Free PMC Article
Will This Patient Be Difficult to Intubate?: The Rational Clinical Examination Systematic Review.
Detsky ME, Jivraj N, Adhikari NK, Friedrich JO, Pinto R, Simel DL, Wijeysundera DN, Scales DC
JAMA 2019 Feb 5;321(5):493-503. doi: 10.1001/jama.2018.21413. PMID: 30721300
Dental implants in cleft lip, alveolus, and palate patients: a systematic review.
Wermker K, Jung S, Joos U, Kleinheinz J
Int J Oral Maxillofac Implants 2014 Mar-Apr;29(2):384-90. doi: 10.11607/jomi.3303. PMID: 24683564

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