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Alzheimer disease, type 8(AD8)

MedGen UID:
375956
Concept ID:
C1846735
Disease or Syndrome
Synonyms: AD8; ALZHEIMER DISEASE, FAMILIAL, 8
 
OMIM®: 607116

Professional guidelines

PubMed

Williams JW, Plassman BL, Burke J, Benjamin S
Evid Rep Technol Assess (Full Rep) 2010 Apr;(193):1-727. PMID: 21500874Free PMC Article
Hort J, O'Brien JT, Gainotti G, Pirttila T, Popescu BO, Rektorova I, Sorbi S, Scheltens P; EFNS Scientist Panel on Dementia.
Eur J Neurol 2010 Oct;17(10):1236-48. doi: 10.1111/j.1468-1331.2010.03040.x. PMID: 20831773

Recent clinical studies

Etiology

Xia C, Makaretz SJ, Caso C, McGinnis S, Gomperts SN, Sepulcre J, Gomez-Isla T, Hyman BT, Schultz A, Vasdev N, Johnson KA, Dickerson BC
JAMA Neurol 2017 Apr 1;74(4):427-436. doi: 10.1001/jamaneurol.2016.5755. PMID: 28241163Free PMC Article
Tosto G, Bird TD, Bennett DA, Boeve BF, Brickman AM, Cruchaga C, Faber K, Foroud TM, Farlow M, Goate AM, Graff-Radford NR, Lantigua R, Manly J, Ottman R, Rosenberg R, Schaid DJ, Schupf N, Stern Y, Sweet RA, Mayeux R; National Institute on Aging Late-Onset Alzheimer Disease/National Cell Repository for Alzheimer Disease (NIA-LOAD/NCRAD) Family Study Group.
JAMA Neurol 2016 Oct 1;73(10):1231-1237. doi: 10.1001/jamaneurol.2016.2539. PMID: 27533593Free PMC Article
Hashimoto Y, Toyama Y, Kusakari S, Nawa M, Matsuoka M
J Biol Chem 2016 Jun 3;291(23):12282-93. Epub 2016 Apr 11 doi: 10.1074/jbc.M115.698092. PMID: 27068745Free PMC Article
Aguirre-Acevedo DC, Lopera F, Henao E, Tirado V, Muñoz C, Giraldo M, Bangdiwala SI, Reiman EM, Tariot PN, Langbaum JB, Quiroz YT, Jaimes F
JAMA Neurol 2016 Apr;73(4):431-8. doi: 10.1001/jamaneurol.2015.4851. PMID: 26902171Free PMC Article
Sirin FB, Kumbul Doğuç D, Vural H, Eren I, Inanli I, Sütçü R, Delibaş N
Turk J Med Sci 2015;45(5):1073-7. PMID: 26738349

Diagnosis

Xia C, Makaretz SJ, Caso C, McGinnis S, Gomperts SN, Sepulcre J, Gomez-Isla T, Hyman BT, Schultz A, Vasdev N, Johnson KA, Dickerson BC
JAMA Neurol 2017 Apr 1;74(4):427-436. doi: 10.1001/jamaneurol.2016.5755. PMID: 28241163Free PMC Article
Aguirre-Acevedo DC, Lopera F, Henao E, Tirado V, Muñoz C, Giraldo M, Bangdiwala SI, Reiman EM, Tariot PN, Langbaum JB, Quiroz YT, Jaimes F
JAMA Neurol 2016 Apr;73(4):431-8. doi: 10.1001/jamaneurol.2015.4851. PMID: 26902171Free PMC Article
Sirin FB, Kumbul Doğuç D, Vural H, Eren I, Inanli I, Sütçü R, Delibaş N
Turk J Med Sci 2015;45(5):1073-7. PMID: 26738349
Fleisher AS, Chen K, Quiroz YT, Jakimovich LJ, Gutierrez Gomez M, Langois CM, Langbaum JB, Roontiva A, Thiyyagura P, Lee W, Ayutyanont N, Lopez L, Moreno S, Muñoz C, Tirado V, Acosta-Baena N, Fagan AM, Giraldo M, Garcia G, Huentelman MJ, Tariot PN, Lopera F, Reiman EM
JAMA Neurol 2015 Mar;72(3):316-24. doi: 10.1001/jamaneurol.2014.3314. PMID: 25580592Free PMC Article
Liljegren M, Naasan G, Temlett J, Perry DC, Rankin KP, Merrilees J, Grinberg LT, Seeley WW, Englund E, Miller BL
JAMA Neurol 2015 Mar;72(3):295-300. doi: 10.1001/jamaneurol.2014.3781. PMID: 25559744Free PMC Article

Therapy

Beauchet O, Launay CP, Montero-Odasso M, Annweiler C, Allali G
Curr Alzheimer Res 2015;12(8):761-71. PMID: 26159199
Ehret MJ, Chamberlin KW
Clin Ther 2015 Aug;37(8):1604-16. Epub 2015 Jun 27 doi: 10.1016/j.clinthera.2015.05.510. PMID: 26122885
Østergaard SD, Mukherjee S, Sharp SJ, Proitsi P, Lotta LA, Day F, Perry JR, Boehme KL, Walter S, Kauwe JS, Gibbons LE; Alzheimer’s Disease Genetics Consortium.; GERAD1 Consortium.; EPIC-InterAct Consortium., Larson EB, Powell JF, Langenberg C, Crane PK, Wareham NJ, Scott RA
PLoS Med 2015 Jun;12(6):e1001841; discussion e1001841. Epub 2015 Jun 16 doi: 10.1371/journal.pmed.1001841. PMID: 26079503Free PMC Article
Mayeux R, Stern Y
Cold Spring Harb Perspect Med 2012 Aug 1;2(8) doi: 10.1101/cshperspect.a006239. PMID: 22908189Free PMC Article
Lambracht-Washington D, Qu BX, Fu M, Eagar TN, Stüve O, Rosenberg RN
JAMA 2009 Oct 28;302(16):1796-802. doi: 10.1001/jama.2009.1547. PMID: 19861672Free PMC Article

Prognosis

Tang M, Ryman DC, McDade E, Jasielec MS, Buckles VD, Cairns NJ, Fagan AM, Goate A, Marcus DS, Xiong C, Allegri RF, Chhatwal JP, Danek A, Farlow MR, Fox NC, Ghetti B, Graff-Radford NR, Laske C, Martins RN, Masters CL, Mayeux RP, Ringman JM, Rossor MN, Salloway SP, Schofield PR, Morris JC, Bateman RJ; Dominantly Inherited Alzheimer Network (DIAN).
Lancet Neurol 2016 Dec;15(13):1317-1325. Epub 2016 Oct 21 doi: 10.1016/S1474-4422(16)30229-0. PMID: 27777020Free PMC Article
Østergaard SD, Mukherjee S, Sharp SJ, Proitsi P, Lotta LA, Day F, Perry JR, Boehme KL, Walter S, Kauwe JS, Gibbons LE; Alzheimer’s Disease Genetics Consortium.; GERAD1 Consortium.; EPIC-InterAct Consortium., Larson EB, Powell JF, Langenberg C, Crane PK, Wareham NJ, Scott RA
PLoS Med 2015 Jun;12(6):e1001841; discussion e1001841. Epub 2015 Jun 16 doi: 10.1371/journal.pmed.1001841. PMID: 26079503Free PMC Article
Fleisher AS, Chen K, Quiroz YT, Jakimovich LJ, Gutierrez Gomez M, Langois CM, Langbaum JB, Roontiva A, Thiyyagura P, Lee W, Ayutyanont N, Lopez L, Moreno S, Muñoz C, Tirado V, Acosta-Baena N, Fagan AM, Giraldo M, Garcia G, Huentelman MJ, Tariot PN, Lopera F, Reiman EM
JAMA Neurol 2015 Mar;72(3):316-24. doi: 10.1001/jamaneurol.2014.3314. PMID: 25580592Free PMC Article
Mayeux R, Stern Y
Cold Spring Harb Perspect Med 2012 Aug 1;2(8) doi: 10.1101/cshperspect.a006239. PMID: 22908189Free PMC Article
Roe CM, Mintun MA, D'Angelo G, Xiong C, Grant EA, Morris JC
Arch Neurol 2008 Nov;65(11):1467-71. doi: 10.1001/archneur.65.11.1467. PMID: 19001165Free PMC Article

Clinical prediction guides

Xia C, Makaretz SJ, Caso C, McGinnis S, Gomperts SN, Sepulcre J, Gomez-Isla T, Hyman BT, Schultz A, Vasdev N, Johnson KA, Dickerson BC
JAMA Neurol 2017 Apr 1;74(4):427-436. doi: 10.1001/jamaneurol.2016.5755. PMID: 28241163Free PMC Article
Tosto G, Bird TD, Bennett DA, Boeve BF, Brickman AM, Cruchaga C, Faber K, Foroud TM, Farlow M, Goate AM, Graff-Radford NR, Lantigua R, Manly J, Ottman R, Rosenberg R, Schaid DJ, Schupf N, Stern Y, Sweet RA, Mayeux R; National Institute on Aging Late-Onset Alzheimer Disease/National Cell Repository for Alzheimer Disease (NIA-LOAD/NCRAD) Family Study Group.
JAMA Neurol 2016 Oct 1;73(10):1231-1237. doi: 10.1001/jamaneurol.2016.2539. PMID: 27533593Free PMC Article
Aguirre-Acevedo DC, Lopera F, Henao E, Tirado V, Muñoz C, Giraldo M, Bangdiwala SI, Reiman EM, Tariot PN, Langbaum JB, Quiroz YT, Jaimes F
JAMA Neurol 2016 Apr;73(4):431-8. doi: 10.1001/jamaneurol.2015.4851. PMID: 26902171Free PMC Article
Sirin FB, Kumbul Doğuç D, Vural H, Eren I, Inanli I, Sütçü R, Delibaş N
Turk J Med Sci 2015;45(5):1073-7. PMID: 26738349
Kristofiková Z, Bocková M, Hegnerová K, Bartos A, Klaschka J, Rícný J, Rípová D, Homola J
Mol Biosyst 2009 Oct;5(10):1174-9. Epub 2009 Jul 6 doi: 10.1039/b904799a. PMID: 19756307

Recent systematic reviews

Wang M, Roussos P, McKenzie A, Zhou X, Kajiwara Y, Brennand KJ, De Luca GC, Crary JF, Casaccia P, Buxbaum JD, Ehrlich M, Gandy S, Goate A, Katsel P, Schadt E, Haroutunian V, Zhang B
Genome Med 2016 Nov 1;8(1):104. doi: 10.1186/s13073-016-0355-3. PMID: 27799057Free PMC Article
Tang M, Ryman DC, McDade E, Jasielec MS, Buckles VD, Cairns NJ, Fagan AM, Goate A, Marcus DS, Xiong C, Allegri RF, Chhatwal JP, Danek A, Farlow MR, Fox NC, Ghetti B, Graff-Radford NR, Laske C, Martins RN, Masters CL, Mayeux RP, Ringman JM, Rossor MN, Salloway SP, Schofield PR, Morris JC, Bateman RJ; Dominantly Inherited Alzheimer Network (DIAN).
Lancet Neurol 2016 Dec;15(13):1317-1325. Epub 2016 Oct 21 doi: 10.1016/S1474-4422(16)30229-0. PMID: 27777020Free PMC Article
Beauchet O, Launay CP, Montero-Odasso M, Annweiler C, Allali G
Curr Alzheimer Res 2015;12(8):761-71. PMID: 26159199
Ehret MJ, Chamberlin KW
Clin Ther 2015 Aug;37(8):1604-16. Epub 2015 Jun 27 doi: 10.1016/j.clinthera.2015.05.510. PMID: 26122885
Vagelatos NT, Eslick GD
Epidemiol Rev 2013;35:152-60. Epub 2013 Jan 11 doi: 10.1093/epirev/mxs012. PMID: 23314404

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