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B-Symptoms

MedGen UID:
353402
Concept ID:
C1706867
Sign or Symptom

Definition

Features commonly associated with lymphoma, including fever above 38C, drenching night sweats, and weight loss of more than 10% of body mass in the previous 6 months. B symptoms are signs of a poor prognosis in patients with lymphoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVB-Symptoms

Professional guidelines

PubMed

Shadman M
JAMA 2023 Mar 21;329(11):918-932. doi: 10.1001/jama.2023.1946. PMID: 36943212
Rigaud C, Knörr F, Brugières L, Woessmann W
Best Pract Res Clin Haematol 2023 Mar;36(1):101444. Epub 2023 Feb 2 doi: 10.1016/j.beha.2023.101444. PMID: 36907641
Malpica L, Marques-Piubelli ML, Beltran BE, Chavez JC, Miranda RN, Castillo JJ
Am J Hematol 2022 Jul;97(7):951-965. Epub 2022 May 3 doi: 10.1002/ajh.26579. PMID: 35472248

Recent clinical studies

Etiology

Binkley MS, Advani RH
Clin Lymphoma Myeloma Leuk 2023 Jul;23(7):471-476. Epub 2023 Mar 31 doi: 10.1016/j.clml.2023.03.014. PMID: 37076366
Mahajan A, Bakhshi S, Singh M, Seth R, Verma N, Jain S, Radhakrishnan V, Mandal P, Arora RS, Dinand V, Kalra M, Kapoor G, Sajid M, Kumar R, Mallick S, Taluja A, Chandra J
Indian J Pediatr 2023 Aug;90(8):761-765. Epub 2022 Jun 23 doi: 10.1007/s12098-022-04180-6. PMID: 35737182
Lo AC, Dieckmann K, Pelz T, Gallop-Evans E, Engenhart-Cabillic R, Vordermark D, Kelly KM, Schwartz CL, Constine LS, Roberts K, Hodgson D
Pediatr Blood Cancer 2021 May;68 Suppl 2:e28562. doi: 10.1002/pbc.28562. PMID: 33818890
Eyre TA, Collins GP
Drugs Today (Barc) 2013 Oct;49(10):631-46. doi: 10.1358/dot.2013.49.10.2025391. PMID: 24191256
Athale UH, Nagel K, Khan AA, Chan AK
Thromb Res 2008;122(4):459-65. Epub 2008 Jan 30 doi: 10.1016/j.thromres.2007.12.006. PMID: 18237767

Diagnosis

Gjelberg HK, Helgeland L, Liseth K, Micci F, Sandnes M, Russnes HG, Reikvam H
Curr Oncol 2023 Nov 18;30(11):10007-10018. doi: 10.3390/curroncol30110727. PMID: 37999147Free PMC Article
Mattes M, Steele A, Chung J, Alvarez E
J Pediatr Hematol Oncol 2021 Apr 1;43(3):114-115. doi: 10.1097/MPH.0000000000001825. PMID: 32433447
Goel A, Fan W, Patel AA, Devabhaktuni M, Grossbard ML
Clin Lymphoma Myeloma Leuk 2014 Aug;14(4):261-70. Epub 2014 Feb 3 doi: 10.1016/j.clml.2014.01.006. PMID: 24650975
Eyre TA, Collins GP
Drugs Today (Barc) 2013 Oct;49(10):631-46. doi: 10.1358/dot.2013.49.10.2025391. PMID: 24191256
Thomas CR Jr, Share R
Med Pediatr Oncol 1991;19(1):48-60. doi: 10.1002/mpo.2950190109. PMID: 1990257

Therapy

Gjelberg HK, Helgeland L, Liseth K, Micci F, Sandnes M, Russnes HG, Reikvam H
Curr Oncol 2023 Nov 18;30(11):10007-10018. doi: 10.3390/curroncol30110727. PMID: 37999147Free PMC Article
Binkley MS, Advani RH
Clin Lymphoma Myeloma Leuk 2023 Jul;23(7):471-476. Epub 2023 Mar 31 doi: 10.1016/j.clml.2023.03.014. PMID: 37076366
Eyre TA, Collins GP
Drugs Today (Barc) 2013 Oct;49(10):631-46. doi: 10.1358/dot.2013.49.10.2025391. PMID: 24191256
Martis N, Mounier N
Curr Hematol Malig Rep 2012 Sep;7(3):228-34. doi: 10.1007/s11899-012-0125-2. PMID: 22547166
Thomas CR Jr, Share R
Med Pediatr Oncol 1991;19(1):48-60. doi: 10.1002/mpo.2950190109. PMID: 1990257

Prognosis

Liu WP, Wang XP, Zheng W, Xie Y, Tu MF, Lin NJ, Ping LY, Ying ZT, Zhang C, Deng LJ, Ding N, Wang XG, Song YQ, Zhu J
Ann Hematol 2018 Jan;97(1):133-139. Epub 2017 Oct 31 doi: 10.1007/s00277-017-3157-9. PMID: 29086010Free PMC Article
Cabanillas F, Rivera N, Pardo WI
Clin Lymphoma Myeloma Leuk 2016 Oct;16(10):550-557. Epub 2016 Aug 10 doi: 10.1016/j.clml.2016.08.011. PMID: 27618361
Sanfilippo KM, Wang TF, Gage BF, Luo S, Riedell P, Carson KR
Thromb Res 2016 Jul;143:86-90. Epub 2016 May 11 doi: 10.1016/j.thromres.2016.05.008. PMID: 27208462Free PMC Article
Jackson C, Sirohi B, Cunningham D, Horwich A, Thomas K, Wotherspoon A
Ann Oncol 2010 Oct;21(10):2061-2068. Epub 2010 Mar 23 doi: 10.1093/annonc/mdq063. PMID: 20332141
Gallagher CJ, Lister TA
Baillieres Clin Haematol 1987 Mar;1(1):141-55. doi: 10.1016/s0950-3536(87)80048-3. PMID: 3327551

Clinical prediction guides

Malpica L, Marques-Piubelli ML, Beltran BE, Chavez JC, Miranda RN, Castillo JJ
Am J Hematol 2022 Jul;97(7):951-965. Epub 2022 May 3 doi: 10.1002/ajh.26579. PMID: 35472248
Ren YM, Shang CY, Liang JH, Yin H, Xia Y, Wu JZ, Wang L, Jian-Yong L, Li Y, Xu W
Br J Haematol 2022 Mar;196(6):1353-1361. Epub 2021 Dec 28 doi: 10.1111/bjh.18000. PMID: 34961920
Durani U, Ansell SM
Leuk Lymphoma 2021 Dec;62(13):3078-3086. Epub 2021 Jul 21 doi: 10.1080/10428194.2021.1953010. PMID: 34284686
Bentolila G, Pavlovsky A
Leuk Lymphoma 2020 Jul;61(7):1548-1554. Epub 2020 Mar 9 doi: 10.1080/10428194.2020.1732959. PMID: 32148142
Yang J, Li W, He X, Zhang G, Yue L, Chai Y
Dis Markers 2015;2015:786790. Epub 2015 Feb 25 doi: 10.1155/2015/786790. PMID: 25810565Free PMC Article

Recent systematic reviews

Saatci D, Zhu C, Harnden A, Hippisley-Cox J
BMC Cancer 2024 Jun 11;24(1):718. doi: 10.1186/s12885-024-12372-w. PMID: 38862882Free PMC Article
Di Santo D, Bramati C, Festa BM, Pace GM, Comini LV, Luparello P, Cascardi E, Galizia D, Galli A, De Virgilio A, Giordano L, Bondi S
Eur Arch Otorhinolaryngol 2023 Dec;280(12):5219-5227. Epub 2023 Aug 28 doi: 10.1007/s00405-023-08206-3. PMID: 37638999
Lightner AL, Shannon E, Gibbons MM, Russell MM
J Gastrointest Surg 2016 Apr;20(4):827-39. Epub 2015 Dec 16 doi: 10.1007/s11605-015-3052-4. PMID: 26676930
Rashidi A, Fisher SI
Ann Hematol 2013 Dec;92(12):1583-93. Epub 2013 Jun 15 doi: 10.1007/s00277-013-1812-3. PMID: 23771429
Alekshun TJ, Tao J, Sokol L
Am J Hematol 2007 Jun;82(6):481-5. doi: 10.1002/ajh.20853. PMID: 17205534

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