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B-Symptoms

MedGen UID:
353402
Concept ID:
C1706867
Sign or Symptom

Definition

Features commonly associated with lymphoma, including fever above 38C, drenching night sweats, and weight loss of more than 10% of body mass in the previous 6 months. B symptoms are signs of a poor prognosis in patients with lymphoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVB-Symptoms

Professional guidelines

PubMed

Kittai AS, Marchetti M, Al-Sawaf O, Benjamini O, Danilov AV, Davids MS, Eichhorst B, Eyre TA, Frustaci AM, Hallek M, Hampel PJ, Herishanu Y, Hicks RJ, Kater AP, King RL, Martin-Subero JI, Owen C, Parry E, Ponzoni M, Rossi D, Siddiqi T, Stilgenbauer S, Tam CS, Hacken ET, Thompson PA, Wierda W, Gaidano G, Woyach JA, Ghia P
Blood 2025 Jul 17;146(3):291-303. doi: 10.1182/blood.2024028064. PMID: 40239121
Shadman M
JAMA 2023 Mar 21;329(11):918-932. doi: 10.1001/jama.2023.1946. PMID: 36943212
Rigaud C, Knörr F, Brugières L, Woessmann W
Best Pract Res Clin Haematol 2023 Mar;36(1):101444. Epub 2023 Feb 2 doi: 10.1016/j.beha.2023.101444. PMID: 36907641

Recent clinical studies

Etiology

Zanwar S, Kapoor P
J Natl Compr Canc Netw 2024 Sep;22(7) doi: 10.6004/jnccn.2024.7024. PMID: 39236757
Malpica L, Marques-Piubelli ML, Beltran BE, Chavez JC, Miranda RN, Castillo JJ
Am J Hematol 2024 Oct;99(10):2002-2015. Epub 2024 Jul 3 doi: 10.1002/ajh.27430. PMID: 38957951
Lo AC, Dieckmann K, Pelz T, Gallop-Evans E, Engenhart-Cabillic R, Vordermark D, Kelly KM, Schwartz CL, Constine LS, Roberts K, Hodgson D
Pediatr Blood Cancer 2021 May;68 Suppl 2:e28562. doi: 10.1002/pbc.28562. PMID: 33818890
Vitolo U, Ferreri AJ, Zucca E
Crit Rev Oncol Hematol 2008 Feb;65(2):183-9. Epub 2007 Oct 24 doi: 10.1016/j.critrevonc.2007.08.005. PMID: 17962036
Armitage JO, Greer JP, Levine AM, Weisenburger DD, Formenti SC, Bast M, Conley S, Pierson J, Linder J, Cousar JB
Cancer 1989 Jan 1;63(1):158-63. doi: 10.1002/1097-0142(19890101)63:1<158::aid-cncr2820630125>3.0.co;2-b. PMID: 2783376

Diagnosis

Zanwar S, Kapoor P
J Natl Compr Canc Netw 2024 Sep;22(7) doi: 10.6004/jnccn.2024.7024. PMID: 39236757
Malpica L, Marques-Piubelli ML, Beltran BE, Chavez JC, Miranda RN, Castillo JJ
Am J Hematol 2024 Oct;99(10):2002-2015. Epub 2024 Jul 3 doi: 10.1002/ajh.27430. PMID: 38957951
Rigaud C, Knörr F, Brugières L, Woessmann W
Best Pract Res Clin Haematol 2023 Mar;36(1):101444. Epub 2023 Feb 2 doi: 10.1016/j.beha.2023.101444. PMID: 36907641
Padhan RK, Das P, Shalimar
Trop Gastroenterol 2015 Jan-Mar;36(1):14-20. doi: 10.7869/tg.239. PMID: 26591949
Vitolo U, Ferreri AJ, Montoto S
Crit Rev Oncol Hematol 2008 Aug;67(2):172-85. Epub 2008 May 21 doi: 10.1016/j.critrevonc.2008.03.008. PMID: 18499469

Therapy

Kittai AS, Marchetti M, Al-Sawaf O, Benjamini O, Danilov AV, Davids MS, Eichhorst B, Eyre TA, Frustaci AM, Hallek M, Hampel PJ, Herishanu Y, Hicks RJ, Kater AP, King RL, Martin-Subero JI, Owen C, Parry E, Ponzoni M, Rossi D, Siddiqi T, Stilgenbauer S, Tam CS, Hacken ET, Thompson PA, Wierda W, Gaidano G, Woyach JA, Ghia P
Blood 2025 Jul 17;146(3):291-303. doi: 10.1182/blood.2024028064. PMID: 40239121
Borchmann P, Ferdinandus J, Schneider G, Moccia A, Greil R, Hertzberg M, Schaub V, Hüttmann A, Keil F, Dierlamm J, Hänel M, Novak U, Meissner J, Zimmermann A, Mathas S, Zijlstra JM, Fosså A, Viardot A, Hertenstein B, Martin S, Giri P, Scholl S, Topp MS, Jung W, Vucinic V, Beck HJ, Kerkhoff A, Unger B, Rank A, Schroers R, Zum Büschenfelde CM, de Wit M, Trautmann-Grill K, Kamper P, Molin D, Kreissl S, Kaul H, von Tresckow B, Borchmann S, Behringer K, Fuchs M, Rosenwald A, Klapper W, Eich HT, Baues C, Zomas A, Hallek M, Dietlein M, Kobe C, Diehl V; German Hodgkin Study Group; Swiss Group for Clinical Cancer Research; Arbeitsgemeinschaft Medikamentöse Tumortherapie; Nordic Lymphoma Group; Australasian Leukaemia and Lymphoma Group
Lancet 2024 Jul 27;404(10450):341-352. Epub 2024 Jul 3 doi: 10.1016/S0140-6736(24)01315-1. PMID: 38971175
Rigaud C, Knörr F, Brugières L, Woessmann W
Best Pract Res Clin Haematol 2023 Mar;36(1):101444. Epub 2023 Feb 2 doi: 10.1016/j.beha.2023.101444. PMID: 36907641
Harker-Murray P, Mauz-Körholz C, Leblanc T, Mascarin M, Michel G, Cooper S, Beishuizen A, Leger KJ, Amoroso L, Buffardi S, Rigaud C, Hoppe BS, Lisano J, Francis S, Sacchi M, Cole PD, Drachtman RA, Kelly KM, Daw S
Blood 2023 Apr 27;141(17):2075-2084. doi: 10.1182/blood.2022017118. PMID: 36564047Free PMC Article
Lo AC, Dieckmann K, Pelz T, Gallop-Evans E, Engenhart-Cabillic R, Vordermark D, Kelly KM, Schwartz CL, Constine LS, Roberts K, Hodgson D
Pediatr Blood Cancer 2021 May;68 Suppl 2:e28562. doi: 10.1002/pbc.28562. PMID: 33818890

Prognosis

Panjan M, Šetrajčič Dragoš V, Gašljević G, Novaković S, Jezeršek Novaković B
Int J Mol Sci 2025 May 26;26(11) doi: 10.3390/ijms26115087. PMID: 40507898Free PMC Article
Lim RMH, Tan JY, Tan YH, Heng ZEQ, Ng LCK, Lim FLWI, Goh YT, Lim ST, Chan JY
Ann Hematol 2024 Dec;103(12):5483-5493. Epub 2024 Nov 15 doi: 10.1007/s00277-024-06067-2. PMID: 39542909
Savage KJ, Ferreri AJ, Zinzani PL, Pileri SA
Crit Rev Oncol Hematol 2011 Sep;79(3):321-9. Epub 2010 Aug 10 doi: 10.1016/j.critrevonc.2010.07.007. PMID: 20702104
Morrison WH, Hoppe RT, Weiss LM, Picozzi VJ Jr, Horning SJ
J Clin Oncol 1989 May;7(5):598-606. doi: 10.1200/JCO.1989.7.5.598. PMID: 2651577
Gallagher CJ, Lister TA
Baillieres Clin Haematol 1987 Mar;1(1):141-55. doi: 10.1016/s0950-3536(87)80048-3. PMID: 3327551

Clinical prediction guides

Lim RMH, Tan JY, Tan YH, Heng ZEQ, Ng LCK, Lim FLWI, Goh YT, Lim ST, Chan JY
Ann Hematol 2024 Dec;103(12):5483-5493. Epub 2024 Nov 15 doi: 10.1007/s00277-024-06067-2. PMID: 39542909
Malpica L, Marques-Piubelli ML, Beltran BE, Chavez JC, Miranda RN, Castillo JJ
Am J Hematol 2024 Oct;99(10):2002-2015. Epub 2024 Jul 3 doi: 10.1002/ajh.27430. PMID: 38957951
Binkley MS, Flerlage JE, Savage KJ, Akhtar S, Steiner R, Zhang XY, Dickinson M, Prica A, Major A, Hendrickson PG, Hopkins D, Ng A, Casulo C, Baron J, Roberts KB, Al Kendi J, Balogh A, Ricardi U, Torka P, Specht L, De Silva R, Pickard K, Blazin LJ, Henry M, Smith CM, Halperin D, Brady J, Brennan B, Senchenko MA, Reeves M, Hoppe BS, Terezakis S, Talaulikar D, Picardi M, Kirova Y, Fergusson P, Hawkes EA, Lee D, Doo NW, Barraclough A, Cheah CY, Ku M, Hamad N, Mutsando H, Gilbertson M, Marconi T, Viiala N, Maurer MJ, Eichenauer DA, Hoppe RT; GLOW Consortium
J Clin Oncol 2024 Jul 1;42(19):2271-2280. Epub 2024 Mar 26 doi: 10.1200/JCO.23.01655. PMID: 38531001
Ye H, Desai A, Zeng D, Nomie K, Romaguera J, Ahmed M, Wang ML
J Exp Clin Cancer Res 2017 Dec 15;36(1):185. doi: 10.1186/s13046-017-0652-8. PMID: 29246179Free PMC Article
Vitolo U, Ferreri AJ, Montoto S
Crit Rev Oncol Hematol 2008 Aug;67(2):172-85. Epub 2008 May 21 doi: 10.1016/j.critrevonc.2008.03.008. PMID: 18499469

Recent systematic reviews

Saatci D, Zhu C, Harnden A, Hippisley-Cox J
BMC Cancer 2024 Jun 11;24(1):718. doi: 10.1186/s12885-024-12372-w. PMID: 38862882Free PMC Article
Gendreau JL, Patel N, Brown NJ, Lee SJ, Sahyouni R, Chan AK, Clifton WE, Chen S
Clin Spine Surg 2024 Aug 1;37(7):296-304. Epub 2023 Sep 5 doi: 10.1097/BSD.0000000000001522. PMID: 37684726
Di Santo D, Bramati C, Festa BM, Pace GM, Comini LV, Luparello P, Cascardi E, Galizia D, Galli A, De Virgilio A, Giordano L, Bondi S
Eur Arch Otorhinolaryngol 2023 Dec;280(12):5219-5227. Epub 2023 Aug 28 doi: 10.1007/s00405-023-08206-3. PMID: 37638999
Rodrigues-Fernandes CI, de Souza LL, Santos-Costa SFD, Silva AMB, Pontes HAR, Lopes MA, de Almeida OP, Brennan PA, Fonseca FP
J Oral Pathol Med 2018 Nov;47(10):915-922. Epub 2018 Jul 5 doi: 10.1111/jop.12753. PMID: 29917262
Rashidi A, Fisher SI
Ann Hematol 2013 Dec;92(12):1583-93. Epub 2013 Jun 15 doi: 10.1007/s00277-013-1812-3. PMID: 23771429

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