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Tumorigenesis

MedGen UID:
3302
•Concept ID:
C0007621
•
Neoplastic Process
Synonyms: Cell Neoplastic Transformation; Cell Neoplastic Transformations; Cell Transformation, Neoplastic; Cell Transformations, Neoplastic; Neoplastic Cell Transformation; Neoplastic Cell Transformations; Neoplastic Transformation, Cell; Neoplastic Transformations, Cell; Transformation, Cell Neoplastic; Transformation, Neoplastic Cell; Transformation, Tumorigenic; Transformations, Cell Neoplastic; Transformations, Neoplastic Cell; Transformations, Tumorigenic; Tumorigenic Transformation; Tumorigenic Transformations

Definition

A pathologic process that involves the transformation of normal cells to a neoplastic state and resulting in polyclonal or monoclonal neoplastic cell proliferation. [from NCI]

Professional guidelines

PubMed

Biomarkers for the diagnosis and management of heart failure.
Castiglione V, Aimo A, Vergaro G, Saccaro L, Passino C, Emdin M
Heart Fail Rev 2022 Mar;27(2):625-643. Epub 2021 Apr 14 doi: 10.1007/s10741-021-10105-w. PMID: 33852110Free PMC Article
Role of oncogenic KRAS in the prognosis, diagnosis and treatment of colorectal cancer.
Zhu G, Pei L, Xia H, Tang Q, Bi F
Mol Cancer 2021 Nov 6;20(1):143. doi: 10.1186/s12943-021-01441-4. PMID: 34742312Free PMC Article
Ketogenic diet in the treatment of cancer - Where do we stand?
Weber DD, Aminzadeh-Gohari S, Tulipan J, Catalano L, Feichtinger RG, Kofler B
Mol Metab 2020 Mar;33:102-121. Epub 2019 Jul 27 doi: 10.1016/j.molmet.2019.06.026. PMID: 31399389Free PMC Article

Recent clinical studies

Etiology

Single-cell transcriptomic profiling uncovers cellular complexity and microenvironment in gastric tumorigenesis associated with Helicobacter pylori.
Li N, Chen S, Xu X, Wang H, Zheng P, Fei X, Ke H, Lei Y, Zhou Y, Yang X, Ouyang Y, Xie C, He C, Hu Y, Cao Y, Li Z, Xie Y, Ge Z, Shu X, Lu N, Liu J, Zhu Y
J Adv Res 2025 Aug;74:471-491. Epub 2024 Oct 15 doi: 10.1016/j.jare.2024.10.012. PMID: 39414226Free PMC Article
Tumor initiation and early tumorigenesis: molecular mechanisms and interventional targets.
Zhang S, Xiao X, Yi Y, Wang X, Zhu L, Shen Y, Lin D, Wu C
Signal Transduct Target Ther 2024 Jun 19;9(1):149. doi: 10.1038/s41392-024-01848-7. PMID: 38890350Free PMC Article
p53 suppresses lipid droplet-fueled tumorigenesis through phosphatidylcholine.
Xu X, Wang J, Xu L, Li P, Jiang P
J Clin Invest 2024 Jan 9;134(4) doi: 10.1172/JCI171788. PMID: 38194288Free PMC Article
HMGB1 in the interplay between autophagy and apoptosis in cancer.
Chen R, Zou J, Zhong X, Li J, Kang R, Tang D
Cancer Lett 2024 Jan 28;581:216494. Epub 2023 Nov 24 doi: 10.1016/j.canlet.2023.216494. PMID: 38007142
High-Fat Diet Promotes Colorectal Tumorigenesis Through Modulating Gut Microbiota and Metabolites.
Yang J, Wei H, Zhou Y, Szeto CH, Li C, Lin Y, Coker OO, Lau HCH, Chan AWH, Sung JJY, Yu J
Gastroenterology 2022 Jan;162(1):135-149.e2. Epub 2021 Aug 27 doi: 10.1053/j.gastro.2021.08.041. PMID: 34461052

Diagnosis

TRPML1 triggers ferroptosis defense and is a potential therapeutic target in AKT-hyperactivated cancer.
Zhang HL, Hu BX, Ye ZP, Li ZL, Liu S, Zhong WQ, Du T, Yang D, Mai J, Li LC, Chen YH, Zhu XY, Li X, Feng GK, Zhu XF, Deng R
Sci Transl Med 2024 Jun 26;16(753):eadk0330. doi: 10.1126/scitranslmed.adk0330. PMID: 38924427
p53 suppresses lipid droplet-fueled tumorigenesis through phosphatidylcholine.
Xu X, Wang J, Xu L, Li P, Jiang P
J Clin Invest 2024 Jan 9;134(4) doi: 10.1172/JCI171788. PMID: 38194288Free PMC Article
SIX1 amplification modulates stemness and tumorigenesis in breast cancer.
Guo L, Li F, Liu H, Kong D, Chen C, Sun S
J Transl Med 2023 Nov 29;21(1):866. doi: 10.1186/s12967-023-04679-2. PMID: 38031089Free PMC Article
The exercise IL-6 enigma in cancer.
Orange ST, Leslie J, Ross M, Mann DA, Wackerhage H
Trends Endocrinol Metab 2023 Nov;34(11):749-763. Epub 2023 Aug 24 doi: 10.1016/j.tem.2023.08.001. PMID: 37633799
Interplay between Circadian Clock and Cancer: New Frontiers for Cancer Treatment.
Sulli G, Lam MTY, Panda S
Trends Cancer 2019 Aug;5(8):475-494. Epub 2019 Aug 3 doi: 10.1016/j.trecan.2019.07.002. PMID: 31421905Free PMC Article

Therapy

CDK4 and CDK6 kinases: From basic science to cancer therapy.
Fassl A, Geng Y, Sicinski P
Science 2022 Jan 14;375(6577):eabc1495. doi: 10.1126/science.abc1495. PMID: 35025636Free PMC Article
Current Understanding of Neurofibromatosis Type 1, 2, and Schwannomatosis.
Tamura R
Int J Mol Sci 2021 May 29;22(11) doi: 10.3390/ijms22115850. PMID: 34072574Free PMC Article
Enhancing the Efficacy of Glutamine Metabolism Inhibitors in Cancer Therapy.
Yang WH, Qiu Y, Stamatatos O, Janowitz T, Lukey MJ
Trends Cancer 2021 Aug;7(8):790-804. Epub 2021 May 18 doi: 10.1016/j.trecan.2021.04.003. PMID: 34020912Free PMC Article
Immune cells within the tumor microenvironment: Biological functions and roles in cancer immunotherapy.
Lei X, Lei Y, Li JK, Du WX, Li RG, Yang J, Li J, Li F, Tan HB
Cancer Lett 2020 Feb 1;470:126-133. Epub 2019 Nov 12 doi: 10.1016/j.canlet.2019.11.009. PMID: 31730903
Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy.
Cannarile MA, Weisser M, Jacob W, Jegg AM, Ries CH, Rüttinger D
J Immunother Cancer 2017 Jul 18;5(1):53. doi: 10.1186/s40425-017-0257-y. PMID: 28716061Free PMC Article

Prognosis

Activated Hippo Pathway is Associated with a Worse Response to Trastuzumab and Worse Survival in HER2-Positive Breast Cancer.
Oshi M, Ghasemi F, Yamada A, Yan L, Zhang J, Abrams SI, Endo I, Takabe K
Ann Surg Oncol 2025 Oct;32(10):7959-7969. Epub 2025 Jun 21 doi: 10.1245/s10434-025-17657-3. PMID: 40544210Free PMC Article
Global epidemiology of NAFLD-related HCC: trends, predictions, risk factors and prevention.
Huang DQ, El-Serag HB, Loomba R
Nat Rev Gastroenterol Hepatol 2021 Apr;18(4):223-238. Epub 2020 Dec 21 doi: 10.1038/s41575-020-00381-6. PMID: 33349658Free PMC Article
Silent corticotroph adenomas.
Ben-Shlomo A, Cooper O
Pituitary 2018 Apr;21(2):183-193. doi: 10.1007/s11102-018-0864-8. PMID: 29344907
Endocrine therapy in ovarian cancer: where do we stand?
Paleari L, DeCensi A
Curr Opin Obstet Gynecol 2018 Feb;30(1):17-22. doi: 10.1097/GCO.0000000000000423. PMID: 29176513
Genetic testing for pheochromocytoma.
Karasek D, Frysak Z, Pacak K
Curr Hypertens Rep 2010 Dec;12(6):456-64. doi: 10.1007/s11906-010-0151-1. PMID: 20938758Free PMC Article

Clinical prediction guides

Detection of esophageal varices and prediction of hepatic decompensation in unresectable hepatocellular carcinoma using AI.
Rabasco Meneghetti A, Campani C, Roux C, I Carrero Z, Popica DA, Amaddeo G, Lequoy M, Hollande C, Mouri S, Wagner M, Plaforet V, Sidali S, Ronot M, Rudler M, Luciani A, Sutter O, Spitzer E, Regnault H, El Mouhadi S, Ozenne V, Ganne-Carrié N, Bouattour M, Nault JC, Thabut D, Kather JN, Allaire M
J Hepatol 2026 Jun;84(6):1149-1163. Epub 2026 Feb 10 doi: 10.1016/j.jhep.2026.01.021. PMID: 41679555
Comprehensive assessment of cellular senescence in the tumor microenvironment.
Wang X, Ma L, Pei X, Wang H, Tang X, Pei JF, Ding YN, Qu S, Wei ZY, Wang HY, Wang X, Wei GH, Liu DP, Chen HZ
Brief Bioinform 2022 May 13;23(3) doi: 10.1093/bib/bbac118. PMID: 35419596Free PMC Article
Spermidine as a target for cancer therapy.
Fan J, Feng Z, Chen N
Pharmacol Res 2020 Sep;159:104943. Epub 2020 May 24 doi: 10.1016/j.phrs.2020.104943. PMID: 32461185
Genetics of Familial and Sporadic Pancreatic Cancer.
Wood LD, Yurgelun MB, Goggins MG
Gastroenterology 2019 May;156(7):2041-2055. Epub 2019 Jan 18 doi: 10.1053/j.gastro.2018.12.039. PMID: 30660730
Epigenetic biomarkers in skin cancer.
Greenberg ES, Chong KK, Huynh KT, Tanaka R, Hoon DS
Cancer Lett 2014 Jan 28;342(2):170-7. Epub 2012 Jan 27 doi: 10.1016/j.canlet.2012.01.020. PMID: 22289720Free PMC Article

Recent systematic reviews

Early diagnosis of ovarian cancer based on methylation profiles in peripheral blood cell-free DNA: a systematic review.
Terp SK, Stoico MP, Dybkær K, Pedersen IS
Clin Epigenetics 2023 Feb 14;15(1):24. doi: 10.1186/s13148-023-01440-w. PMID: 36788585Free PMC Article
Alternative splicing and cancer: a systematic review.
Zhang Y, Qian J, Gu C, Yang Y
Signal Transduct Target Ther 2021 Feb 24;6(1):78. doi: 10.1038/s41392-021-00486-7. PMID: 33623018Free PMC Article
Selective autophagy of intracellular organelles: recent research advances.
Li W, He P, Huang Y, Li YF, Lu J, Li M, Kurihara H, Luo Z, Meng T, Onishi M, Ma C, Jiang L, Hu Y, Gong Q, Zhu D, Xu Y, Liu R, Liu L, Yi C, Zhu Y, Ma N, Okamoto K, Xie Z, Liu J, He RR, Feng D
Theranostics 2021;11(1):222-256. Epub 2021 Jan 1 doi: 10.7150/thno.49860. PMID: 33391472Free PMC Article
NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis.
Braidy N, Liu Y
Exp Gerontol 2020 Apr;132:110831. Epub 2020 Jan 7 doi: 10.1016/j.exger.2020.110831. PMID: 31917996
Epigenetics in non-small cell lung carcinomas.
Peralta-Arrieta I, Armas-López L, Zúñiga J, Ávila-Moreno F
Salud Publica Mex 2019 May-Jun;61(3):318-328. doi: 10.21149/10089. PMID: 31276346

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