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AKT Signaling Pathway

MedGen UID:
271894
•Concept ID:
C1515844
•
Molecular Function

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAKT Signaling Pathway

Professional guidelines

PubMed

Activation of PI3K/AKT Pathway Is a Potential Mechanism of Treatment Resistance in Small Cell Lung Cancer.
Jin Y, Chen Y, Tang H, Hu X, Hubert SM, Li Q, Su D, Xu H, Fan Y, Yu X, Chen Q, Liu J, Hong W, Xu Y, Deng H, Zhu D, Li P, Gong Y, Xia X, Gay CM, Zhang J, Chen M
Clin Cancer Res 2022 Feb 1;28(3):526-539. Epub 2021 Dec 17 doi: 10.1158/1078-0432.CCR-21-1943. PMID: 34921019
Network Pharmacology-Based and Molecular Docking-Based Analysis of Suanzaoren Decoction for the Treatment of Parkinson's Disease with Sleep Disorder.
Liu YY, Yu LH, Zhang J, Xie DJ, Zhang XX, Yu JM
Biomed Res Int 2021;2021:1752570. Epub 2021 Oct 8 doi: 10.1155/2021/1752570. PMID: 34660782Free PMC Article
In Vitro Follicular Activation and Stem Cell Therapy as a Novel Treatment Strategies in Diminished Ovarian Reserve and Primary Ovarian Insufficiency.
Fàbregues F, Ferreri J, Méndez M, Calafell JM, Otero J, Farré R
Front Endocrinol (Lausanne) 2020;11:617704. Epub 2021 Feb 24 doi: 10.3389/fendo.2020.617704. PMID: 33716954Free PMC Article

Recent clinical studies

Etiology

The PI3K/Akt Pathway in Meta-Inflammation.
Acosta-Martinez M, Cabail MZ
Int J Mol Sci 2022 Dec 5;23(23) doi: 10.3390/ijms232315330. PMID: 36499659Free PMC Article
Melatonin treatment improves human umbilical cord mesenchymal stem cell therapy in a mouse model of type II diabetes mellitus via the PI3K/AKT signaling pathway.
Aierken A, Li B, Liu P, Cheng X, Kou Z, Tan N, Zhang M, Yu S, Shen Q, Du X, Enkhbaatar BB, Zhang J, Zhang R, Wu X, Wang R, He X, Li N, Peng S, Jia W, Wang C, Hua J
Stem Cell Res Ther 2022 Apr 12;13(1):164. doi: 10.1186/s13287-022-02832-0. PMID: 35414044Free PMC Article
Prognostic and therapeutic significance of a novel ferroptosis related signature in colorectal cancer patients.
Du S, Zeng F, Sun H, Liu Y, Han P, Zhang B, Xue W, Deng G, Yin M, Cui B
Bioengineered 2022 Feb;13(2):2498-2512. doi: 10.1080/21655979.2021.2017627. PMID: 35067161Free PMC Article
Anti-inflammatory and immunomodulatory effects of the extracellular vesicles derived from human umbilical cord mesenchymal stem cells on osteoarthritis via M2 macrophages.
Li K, Yan G, Huang H, Zheng M, Ma K, Cui X, Lu D, Zheng L, Zhu B, Cheng J, Zhao J
J Nanobiotechnology 2022 Jan 20;20(1):38. doi: 10.1186/s12951-021-01236-1. PMID: 35057811Free PMC Article
Growth hormone activates PI3K/Akt signaling and inhibits ROS accumulation and apoptosis in granulosa cells of patients with polycystic ovary syndrome.
Gong Y, Luo S, Fan P, Zhu H, Li Y, Huang W
Reprod Biol Endocrinol 2020 Dec 7;18(1):121. doi: 10.1186/s12958-020-00677-x. PMID: 33287836Free PMC Article

Diagnosis

Targeting PI3K/AKT signaling pathway in obesity.
Savova MS, Mihaylova LV, Tews D, Wabitsch M, Georgiev MI
Biomed Pharmacother 2023 Mar;159:114244. Epub 2023 Jan 11 doi: 10.1016/j.biopha.2023.114244. PMID: 36638594
RRP9 promotes gemcitabine resistance in pancreatic cancer via activating AKT signaling pathway.
Zhang Z, Yu H, Yao W, Zhu N, Miao R, Liu Z, Song X, Xue C, Cai C, Cheng M, Lin K, Qi D
Cell Commun Signal 2022 Nov 24;20(1):188. doi: 10.1186/s12964-022-00974-5. PMID: 36434608Free PMC Article
Prognostic and therapeutic significance of a novel ferroptosis related signature in colorectal cancer patients.
Du S, Zeng F, Sun H, Liu Y, Han P, Zhang B, Xue W, Deng G, Yin M, Cui B
Bioengineered 2022 Feb;13(2):2498-2512. doi: 10.1080/21655979.2021.2017627. PMID: 35067161Free PMC Article
Erdheim-Chester disease.
Brychtová M, Vlachová M, Gregorová J, Krejčí M, Adam Z, Ševčíková S
Klin Onkol 2021 Fall;34(6):434-439. doi: 10.48095/ccko2021434. PMID: 34911328
PI3k/AKT signaling pathway: Erythropoiesis and beyond.
Jafari M, Ghadami E, Dadkhah T, Akhavan-Niaki H
J Cell Physiol 2019 Mar;234(3):2373-2385. Epub 2018 Sep 7 doi: 10.1002/jcp.27262. PMID: 30192008

Therapy

A network pharmacology approach and experimental validation to investigate the anticancer mechanism and potential active targets of ethanol extract of Wei-Tong-Xin against colorectal cancer through induction of apoptosis via PI3K/AKT signaling pathway.
Lin F, Zhang G, Yang X, Wang M, Wang R, Wan M, Wang J, Wu B, Yan T, Jia Y
J Ethnopharmacol 2023 Mar 1;303:115933. Epub 2022 Nov 18 doi: 10.1016/j.jep.2022.115933. PMID: 36403742
Toripalimab Plus Chemotherapy for Patients With Treatment-Naive Advanced Non-Small-Cell Lung Cancer: A Multicenter Randomized Phase III Trial (CHOICE-01).
Wang Z, Wu L, Li B, Cheng Y, Li X, Wang X, Han L, Wu X, Fan Y, Yu Y, Lv D, Shi J, Huang J, Zhou S, Han B, Sun G, Guo Q, Ji Y, Zhu X, Hu S, Zhang W, Wang Q, Jia Y, Wang Z, Song Y, Wu J, Shi M, Li X, Han Z, Liu Y, Yu Z, Liu AW, Wang X, Zhou C, Zhong D, Miao L, Zhang Z, Zhao H, Yang J, Wang D, Wang Y, Li Q, Zhang X, Ji M, Yang Z, Cui J, Gao B, Wang B, Liu H, Nie L, He M, Jin S, Gu W, Shu Y, Zhou T, Feng J, Yang X, Huang C, Zhu B, Yao Y, Tang X, Yu J, Maher E, Feng H, Yao S, Keegan P, Wang J
J Clin Oncol 2023 Jan 20;41(3):651-663. Epub 2022 Oct 7 doi: 10.1200/JCO.22.00727. PMID: 36206498Free PMC Article
The PI3K/AKT signalling pathway in inflammation, cell death and glial scar formation after traumatic spinal cord injury: Mechanisms and therapeutic opportunities.
He X, Li Y, Deng B, Lin A, Zhang G, Ma M, Wang Y, Yang Y, Kang X
Cell Prolif 2022 Sep;55(9):e13275. Epub 2022 Jun 26 doi: 10.1111/cpr.13275. PMID: 35754255Free PMC Article
Melatonin treatment improves human umbilical cord mesenchymal stem cell therapy in a mouse model of type II diabetes mellitus via the PI3K/AKT signaling pathway.
Aierken A, Li B, Liu P, Cheng X, Kou Z, Tan N, Zhang M, Yu S, Shen Q, Du X, Enkhbaatar BB, Zhang J, Zhang R, Wu X, Wang R, He X, Li N, Peng S, Jia W, Wang C, Hua J
Stem Cell Res Ther 2022 Apr 12;13(1):164. doi: 10.1186/s13287-022-02832-0. PMID: 35414044Free PMC Article
Growth hormone activates PI3K/Akt signaling and inhibits ROS accumulation and apoptosis in granulosa cells of patients with polycystic ovary syndrome.
Gong Y, Luo S, Fan P, Zhu H, Li Y, Huang W
Reprod Biol Endocrinol 2020 Dec 7;18(1):121. doi: 10.1186/s12958-020-00677-x. PMID: 33287836Free PMC Article

Prognosis

A network pharmacology approach and experimental validation to investigate the anticancer mechanism and potential active targets of ethanol extract of Wei-Tong-Xin against colorectal cancer through induction of apoptosis via PI3K/AKT signaling pathway.
Lin F, Zhang G, Yang X, Wang M, Wang R, Wan M, Wang J, Wu B, Yan T, Jia Y
J Ethnopharmacol 2023 Mar 1;303:115933. Epub 2022 Nov 18 doi: 10.1016/j.jep.2022.115933. PMID: 36403742
RRP9 promotes gemcitabine resistance in pancreatic cancer via activating AKT signaling pathway.
Zhang Z, Yu H, Yao W, Zhu N, Miao R, Liu Z, Song X, Xue C, Cai C, Cheng M, Lin K, Qi D
Cell Commun Signal 2022 Nov 24;20(1):188. doi: 10.1186/s12964-022-00974-5. PMID: 36434608Free PMC Article
Integrating Network Pharmacology and Experimental Verification to Explore the Pharmacological Mechanisms of Aloin Against Gastric Cancer.
Gao J, Yang S, Xie G, Pan J, Zhu F
Drug Des Devel Ther 2022;16:1947-1961. Epub 2022 Jun 20 doi: 10.2147/DDDT.S360790. PMID: 35757520Free PMC Article
Prognostic and therapeutic significance of a novel ferroptosis related signature in colorectal cancer patients.
Du S, Zeng F, Sun H, Liu Y, Han P, Zhang B, Xue W, Deng G, Yin M, Cui B
Bioengineered 2022 Feb;13(2):2498-2512. doi: 10.1080/21655979.2021.2017627. PMID: 35067161Free PMC Article
Erianin, the main active ingredient of Dendrobium chrysotoxum Lindl, inhibits precancerous lesions of gastric cancer (PLGC) through suppression of the HRAS-PI3K-AKT signaling pathway as revealed by network pharmacology and in vitro experimental verification.
Wang Y, Chu F, Lin J, Li Y, Johnson N, Zhang J, Gai C, Su Z, Cheng H, Wang L, Ding X
J Ethnopharmacol 2021 Oct 28;279:114399. Epub 2021 Jul 8 doi: 10.1016/j.jep.2021.114399. PMID: 34246740

Clinical prediction guides

A network pharmacology approach and experimental validation to investigate the anticancer mechanism and potential active targets of ethanol extract of Wei-Tong-Xin against colorectal cancer through induction of apoptosis via PI3K/AKT signaling pathway.
Lin F, Zhang G, Yang X, Wang M, Wang R, Wan M, Wang J, Wu B, Yan T, Jia Y
J Ethnopharmacol 2023 Mar 1;303:115933. Epub 2022 Nov 18 doi: 10.1016/j.jep.2022.115933. PMID: 36403742
RRP9 promotes gemcitabine resistance in pancreatic cancer via activating AKT signaling pathway.
Zhang Z, Yu H, Yao W, Zhu N, Miao R, Liu Z, Song X, Xue C, Cai C, Cheng M, Lin K, Qi D
Cell Commun Signal 2022 Nov 24;20(1):188. doi: 10.1186/s12964-022-00974-5. PMID: 36434608Free PMC Article
TEAD4 functions as a prognostic biomarker and triggers EMT via PI3K/AKT pathway in bladder cancer.
Chi M, Liu J, Mei C, Shi Y, Liu N, Jiang X, Liu C, Xue N, Hong H, Xie J, Sun X, Yin B, Meng X, Wang B
J Exp Clin Cancer Res 2022 May 17;41(1):175. doi: 10.1186/s13046-022-02377-3. PMID: 35581606Free PMC Article
Single-Cell Transcriptome Analysis Reveals Inter-Tumor Heterogeneity in Bilateral Papillary Thyroid Carcinoma.
Wang T, Shi J, Li L, Zhou X, Zhang H, Zhang X, Wang Y, Liu L, Sheng L
Front Immunol 2022;13:840811. Epub 2022 Apr 20 doi: 10.3389/fimmu.2022.840811. PMID: 35515000Free PMC Article
PI3K/Akt and HIF‑1 signaling pathway in hypoxia‑ischemia (Review).
Zhang Z, Yao L, Yang J, Wang Z, Du G
Mol Med Rep 2018 Oct;18(4):3547-3554. Epub 2018 Aug 9 doi: 10.3892/mmr.2018.9375. PMID: 30106145Free PMC Article

Recent systematic reviews

Charting the proteome landscape in major psychiatric disorders: From biomarkers to biological pathways towards drug discovery.
Fernandes BS, Dai Y, Jia P, Zhao Z
Eur Neuropsychopharmacol 2022 Aug;61:43-59. Epub 2022 Jun 25 doi: 10.1016/j.euroneuro.2022.06.001. PMID: 35763977Free PMC Article
Pharmacological PTEN inhibition: potential clinical applications and effects in tissue regeneration.
Borges GA, Webber LP, M Marques AE, Guerra EN, Castilho RM, Squarize CH
Regen Med 2020 Feb;15(2):1329-1344. Epub 2020 Mar 30 doi: 10.2217/rme-2019-0065. PMID: 32223643Free PMC Article
Identification of microRNA-181 as a promising biomarker for predicting the poor survival in colorectal cancer.
Peng Q, Yao W, Yu C, Zou L, Shen Y, Zhu Y, Cheng M, Feng Z, Xu B
Cancer Med 2019 Oct;8(13):5995-6009. Epub 2019 Aug 25 doi: 10.1002/cam4.2520. PMID: 31448575Free PMC Article
Circulating microRNA expression and their target genes in deep vein thrombosis: A systematic review and bioinformatics analysis.
Jiang Z, Ma J, Wang Q, Wu F, Ping J, Ming L
Medicine (Baltimore) 2017 Dec;96(50):e9330. doi: 10.1097/MD.0000000000009330. PMID: 29390402Free PMC Article
Identified molecular mechanism of interaction between environmental risk factors and differential expression genes in cartilage of Kashin-Beck disease.
Yu FF, Zhang YX, Zhang LH, Li WR, Guo X, Lammi MJ
Medicine (Baltimore) 2016 Dec;95(52):e5669. doi: 10.1097/MD.0000000000005669. PMID: 28033256Free PMC Article

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