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Mouse Skeletal System Neoplasms

MedGen UID:
269329
•Concept ID:
C1513679
•
Neoplastic Process

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMouse Skeletal System Neoplasms

Professional guidelines

PubMed

Lung Cancer Cachexia: Can Molecular Understanding Guide Clinical Management?
Sørensen J
Integr Cancer Ther 2018 Sep;17(3):1000-1008. Epub 2018 Jun 13 doi: 10.1177/1534735418781743. PMID: 29896984Free PMC Article
Combined treatment of carfilzomib and z-VAD-fmk inhibits skeletal proteolysis and apoptosis and ameliorates cancer cachexia.
Wang Q, Li C, Peng X, Kang Q, Deng D, Zhang L, Zheng Y, Wang C, Qiao Z, Guo D, You S, Tang H
Med Oncol 2015 Apr;32(4):100. Epub 2015 Mar 4 doi: 10.1007/s12032-015-0538-6. PMID: 25737433
Receptor activator of nuclear factor-kappaB ligand and osteoprotegerin: potential implications for the pathogenesis and treatment of malignant bone diseases.
Hofbauer LC, Neubauer A, Heufelder AE
Cancer 2001 Aug 1;92(3):460-70. doi: 10.1002/1097-0142(20010801)92:3<460::aid-cncr1344>3.0.co;2-d. PMID: 11505389

Recent clinical studies

Etiology

EXT418, a novel long-acting ghrelin, mitigates Lewis lung carcinoma induced cachexia in mice.
Kerr HL, Krumm K, Lee II, Anderson B, Christiani A, Strait L, Breckheimer BA, Irwin B, Jiang AS, Rybachok A, Chen A, Caeiro L, Dacek E, Hall DB, Kostyla CH, Hales LM, Soliman TM, Garcia JM
J Cachexia Sarcopenia Muscle 2023 Jun;14(3):1337-1348. Epub 2023 Mar 21 doi: 10.1002/jcsm.13211. PMID: 36942661Free PMC Article
PTEN, Insulin Resistance and Cancer.
Li A, Qiu M, Zhou H, Wang T, Guo W
Curr Pharm Des 2017;23(25):3667-3676. doi: 10.2174/1381612823666170704124611. PMID: 28677502
GPRC6A: Jack of all metabolism (or master of none).
Pi M, Nishimoto SK, Quarles LD
Mol Metab 2017 Feb;6(2):185-193. Epub 2016 Dec 21 doi: 10.1016/j.molmet.2016.12.006. PMID: 28180060Free PMC Article
Zebrafish models of rhabdomyosarcoma.
Chen EY, Langenau DM
Methods Cell Biol 2011;105:383-402. doi: 10.1016/B978-0-12-381320-6.00016-3. PMID: 21951539Free PMC Article
Do RANKL inhibitors (denosumab) affect inflammation and immunity?
Ferrari-Lacraz S, Ferrari S
Osteoporos Int 2011 Feb;22(2):435-46. Epub 2010 Jun 23 doi: 10.1007/s00198-010-1326-y. PMID: 20571772

Diagnosis

Lung Cancer Cachexia: Can Molecular Understanding Guide Clinical Management?
Sørensen J
Integr Cancer Ther 2018 Sep;17(3):1000-1008. Epub 2018 Jun 13 doi: 10.1177/1534735418781743. PMID: 29896984Free PMC Article
PTEN, Insulin Resistance and Cancer.
Li A, Qiu M, Zhou H, Wang T, Guo W
Curr Pharm Des 2017;23(25):3667-3676. doi: 10.2174/1381612823666170704124611. PMID: 28677502
GPRC6A: Jack of all metabolism (or master of none).
Pi M, Nishimoto SK, Quarles LD
Mol Metab 2017 Feb;6(2):185-193. Epub 2016 Dec 21 doi: 10.1016/j.molmet.2016.12.006. PMID: 28180060Free PMC Article
Insulin-like growth factor-II: its role in metabolic and endocrine disease.
Livingstone C, Borai A
Clin Endocrinol (Oxf) 2014 Jun;80(6):773-81. Epub 2014 Mar 24 doi: 10.1111/cen.12446. PMID: 24593700
Developmental abnormalities and cancer predisposition in neurofibromatosis type 1.
Larizza L, Gervasini C, Natacci F, Riva P
Curr Mol Med 2009 Jun;9(5):634-53. doi: 10.2174/156652409788488801. PMID: 19601812

Therapy

PTEN, Insulin Resistance and Cancer.
Li A, Qiu M, Zhou H, Wang T, Guo W
Curr Pharm Des 2017;23(25):3667-3676. doi: 10.2174/1381612823666170704124611. PMID: 28677502
The nonskeletal effects of vitamin D: an Endocrine Society scientific statement.
Rosen CJ, Adams JS, Bikle DD, Black DM, Demay MB, Manson JE, Murad MH, Kovacs CS
Endocr Rev 2012 Jun;33(3):456-92. Epub 2012 May 17 doi: 10.1210/er.2012-1000. PMID: 22596255Free PMC Article
Do RANKL inhibitors (denosumab) affect inflammation and immunity?
Ferrari-Lacraz S, Ferrari S
Osteoporos Int 2011 Feb;22(2):435-46. Epub 2010 Jun 23 doi: 10.1007/s00198-010-1326-y. PMID: 20571772
Statins, bone, and neurofibromatosis type 1.
Korf BR
BMC Med 2008 Jul 31;6:22. doi: 10.1186/1741-7015-6-22. PMID: 18671845Free PMC Article
Clinical research update: zoledronate.
Body JJ
Cancer 1997 Oct 15;80(8 Suppl):1699-701. doi: 10.1002/(sici)1097-0142(19971015)80:8+<1699::aid-cncr23>3.3.co;2-a. PMID: 9362440

Prognosis

Water-soluble dietary fiber alleviates cancer-induced muscle wasting through changes in gut microenvironment in mice.
Sakakida T, Ishikawa T, Doi T, Morita R, Endo Y, Matsumura S, Ota T, Yoshida J, Hirai Y, Mizushima K, Higashimura Y, Inoue K, Okayama T, Uchiyama K, Takagi T, Abe A, Inoue R, Itoh Y, Naito Y
Cancer Sci 2022 May;113(5):1789-1800. Epub 2022 Mar 17 doi: 10.1111/cas.15306. PMID: 35201655Free PMC Article
Functions of SMYD proteins in biological processes: What do we know? An updated review.
Rueda-Robles A, Audano M, Álvarez-Mercado AI, Rubio-Tomás T
Arch Biochem Biophys 2021 Nov 15;712:109040. Epub 2021 Sep 20 doi: 10.1016/j.abb.2021.109040. PMID: 34555372
Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway.
Gao X, Wang Y, Lu F, Chen X, Yang D, Cao Y, Zhang W, Chen J, Zheng L, Wang G, Fu M, Ma L, Song Y, Zhan Q
J Extracell Vesicles 2021 Mar;10(5):e12060. Epub 2021 Mar 10 doi: 10.1002/jev2.12060. PMID: 33732415Free PMC Article
GPRC6A: Jack of all metabolism (or master of none).
Pi M, Nishimoto SK, Quarles LD
Mol Metab 2017 Feb;6(2):185-193. Epub 2016 Dec 21 doi: 10.1016/j.molmet.2016.12.006. PMID: 28180060Free PMC Article
Zebrafish models of rhabdomyosarcoma.
Chen EY, Langenau DM
Methods Cell Biol 2011;105:383-402. doi: 10.1016/B978-0-12-381320-6.00016-3. PMID: 21951539Free PMC Article

Clinical prediction guides

Androgen receptor splice variants drive castration-resistant prostate cancer metastasis by activating distinct transcriptional programs.
Han D, Labaf M, Zhao Y, Owiredu J, Zhang S, Patel K, Venkataramani K, Steinfeld JS, Han W, Li M, Liu M, Wang Z, Besschetnova A, Patalano S, Mulhearn MJ, Macoska JA, Yuan X, Balk SP, Nelson PS, Plymate SR, Gao S, Siegfried KR, Liu R, Stangis MM, Foxa G, Czernik PJ, Williams BO, Zarringhalam K, Li X, Cai C
J Clin Invest 2024 Apr 30;134(11) doi: 10.1172/JCI168649. PMID: 38687617Free PMC Article
Hypothalamic-pituitary-adrenal axis activation and glucocorticoid-responsive gene expression in skeletal muscle and liver of Apc mice.
Martin A, Castells J, Allibert V, Emerit A, Zolotoff C, Cardot-Ruffino V, Gallot YS, Vernus B, Chauvet V, Bartholin L, Schaeffer L, Durieux AC, Hourdé C, Favier FB, Mazelin L, Freyssenet D
J Cachexia Sarcopenia Muscle 2022 Jun;13(3):1686-1703. Epub 2022 Mar 11 doi: 10.1002/jcsm.12939. PMID: 35277933Free PMC Article
Functions of SMYD proteins in biological processes: What do we know? An updated review.
Rueda-Robles A, Audano M, Álvarez-Mercado AI, Rubio-Tomás T
Arch Biochem Biophys 2021 Nov 15;712:109040. Epub 2021 Sep 20 doi: 10.1016/j.abb.2021.109040. PMID: 34555372
GPRC6A: Jack of all metabolism (or master of none).
Pi M, Nishimoto SK, Quarles LD
Mol Metab 2017 Feb;6(2):185-193. Epub 2016 Dec 21 doi: 10.1016/j.molmet.2016.12.006. PMID: 28180060Free PMC Article
Hey bHLH transcription factors.
Weber D, Wiese C, Gessler M
Curr Top Dev Biol 2014;110:285-315. doi: 10.1016/B978-0-12-405943-6.00008-7. PMID: 25248480

Recent systematic reviews

The nonskeletal effects of vitamin D: an Endocrine Society scientific statement.
Rosen CJ, Adams JS, Bikle DD, Black DM, Demay MB, Manson JE, Murad MH, Kovacs CS
Endocr Rev 2012 Jun;33(3):456-92. Epub 2012 May 17 doi: 10.1210/er.2012-1000. PMID: 22596255Free PMC Article

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