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Childhood Testicular Teratoma

MedGen UID:
234138
•Concept ID:
C1333011
•
Neoplastic Process
Synonyms: Childhood Teratoma of Testis; Childhood Teratoma of the Testis; Pediatric Testicular Teratoma

Definition

A teratoma that arises from the testis during childhood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood Testicular Teratoma

Professional guidelines

PubMed

Clinical characteristics and long-term management of prepubertal testicular teratomas: a retrospective, multicenter study.
Zhou G, Sun F, Yu X, Huang R, Liu X, Ouyang Y, Yang Z, Li S
Eur J Pediatr 2023 Apr;182(4):1823-1828. Epub 2023 Feb 16 doi: 10.1007/s00431-023-04859-8. PMID: 36795187Free PMC Article
Childhood ovarian nonseminomatous germ cell tumors: A highly curable disease with few long-term treatment-related toxicities-Results of the French TGM95 study.
Pavone R, Pacquement H, Pasquet M, Sudour-Bonnange H, Hameury F, Sarnacki S, Chastagner P, Faure-Conter C, Poirée M, Taque S, Patte C, Fresneau B
Int J Cancer 2021 Nov 1;149(9):1705-1712. Epub 2021 Jul 5 doi: 10.1002/ijc.33710. PMID: 34146403
Management of teratoma.
Herr HW, LaQuaglia MP
Urol Clin North Am 1993 Feb;20(1):145-52. PMID: 8434433

Recent clinical studies

Etiology

The fate of germ cells in cryptorchid testis.
Thorup J, Hildorf S, Hildorf AE, Baastrup JM, Mamsen LS, Andersen CY, Olsen TE, Cortes D
Front Endocrinol (Lausanne) 2023;14:1305428. Epub 2024 Jan 3 doi: 10.3389/fendo.2023.1305428. PMID: 38234428Free PMC Article
Intratubular germ cell neoplasia of the testis: a brief review.
Al-Hussain T, Bakshi N, Akhtar M
Adv Anat Pathol 2015 May;22(3):202-12. doi: 10.1097/PAP.0000000000000066. PMID: 25844678
Prepubertal testicular tumours and efficacy of testicular preserving surgery.
Bujons A, Sfulcini JC, Pascual M, Feu OA, Garat JM, Villavicencio H
BJU Int 2011 Jun;107(11):1812-6. Epub 2010 Oct 29 doi: 10.1111/j.1464-410X.2010.09796.x. PMID: 21040368
Germ cell tumors.
Rescorla FJ
Semin Pediatr Surg 1997 Feb;6(1):29-37. PMID: 9117272
Teratomas in childhood.
Bale PM, Painter DM, Cohen D
Pathology 1975 Jul;7(3):209-18. doi: 10.3109/00313027509094411. PMID: 1196679

Diagnosis

Clinical characteristics and long-term management of prepubertal testicular teratomas: a retrospective, multicenter study.
Zhou G, Sun F, Yu X, Huang R, Liu X, Ouyang Y, Yang Z, Li S
Eur J Pediatr 2023 Apr;182(4):1823-1828. Epub 2023 Feb 16 doi: 10.1007/s00431-023-04859-8. PMID: 36795187Free PMC Article
Pediatric cardiac tumors: clinical and imaging features.
Tao TY, Yahyavi-Firouz-Abadi N, Singh GK, Bhalla S
Radiographics 2014 Jul-Aug;34(4):1031-46. doi: 10.1148/rg.344135163. PMID: 25019440
Management of teratoma.
Herr HW, LaQuaglia MP
Urol Clin North Am 1993 Feb;20(1):145-52. PMID: 8434433
Solid malignancies in children and adolescents.
Lampkin BC, Wong KY, Kalinyak KA, Carter D, Heckel J, Zaboy KA, Compaan P
Surg Clin North Am 1985 Dec;65(6):1351-86. doi: 10.1016/s0039-6109(16)43779-5. PMID: 3000007
Germinal testicular tumors in childhood. Report of observations and literature review.
Weissbach L, Altwein JE, Stiens R
Eur Urol 1984;10(2):73-85. doi: 10.1159/000463762. PMID: 6368238

Therapy

The malignant potential of teratomas in infancy and childhood: the MAKEI experiences in non-testicular teratoma and implications for a new protocol.
Göbel U, Calaminus G, Schneider DT, Koch S, Teske C, Harms D
Klin Padiatr 2006 Nov-Dec;218(6):309-14. doi: 10.1055/s-2006-942275. PMID: 17080332
Teratomas in infancy and childhood.
Göbel U, Calaminus G, Engert J, Kaatsch P, Gadner H, Bökkerink JP, Hass RJ, Waag K, Blohm ME, Dippert S, Teske C, Harms D
Med Pediatr Oncol 1998 Jul;31(1):8-15. doi: 10.1002/(sici)1096-911x(199807)31:1<8::aid-mpo2>3.0.co;2-h. PMID: 9607423
Extracranial non-testicular teratoma in childhood and adolescence: introduction of a risk score for stratification of therapy.
Göbel U, Calaminus G, Blohm M, Booss D, Felberbauer F, Hofmann U, Holschneider AM, Willnow U, Harms D
Klin Padiatr 1997 Jul-Aug;209(4):228-34. doi: 10.1055/s-2008-1043955. PMID: 9293455
Primary testicular tumors in children.
Lin JN, Wang KL, Chuang JH
Int Surg 1988 Jul-Sep;73(3):190-2. PMID: 2466012
Solid malignancies in children and adolescents.
Lampkin BC, Wong KY, Kalinyak KA, Carter D, Heckel J, Zaboy KA, Compaan P
Surg Clin North Am 1985 Dec;65(6):1351-86. doi: 10.1016/s0039-6109(16)43779-5. PMID: 3000007

Prognosis

Prepubertal testicular tumours and efficacy of testicular preserving surgery.
Bujons A, Sfulcini JC, Pascual M, Feu OA, Garat JM, Villavicencio H
BJU Int 2011 Jun;107(11):1812-6. Epub 2010 Oct 29 doi: 10.1111/j.1464-410X.2010.09796.x. PMID: 21040368
Management of teratoma.
Herr HW, LaQuaglia MP
Urol Clin North Am 1993 Feb;20(1):145-52. PMID: 8434433
Germinal testicular tumors in childhood. Report of observations and literature review.
Weissbach L, Altwein JE, Stiens R
Eur Urol 1984;10(2):73-85. doi: 10.1159/000463762. PMID: 6368238
Gonadal and extragonadal germ cell neoplasia of childhood.
Dehner LP
Hum Pathol 1983 Jun;14(6):493-511. doi: 10.1016/s0046-8177(83)80004-5. PMID: 6343221
Teratomas in childhood.
Bale PM, Painter DM, Cohen D
Pathology 1975 Jul;7(3):209-18. doi: 10.3109/00313027509094411. PMID: 1196679

Clinical prediction guides

Associations between birth defects and childhood and adolescent germ cell tumors according to sex, histologic subtype, and site.
Schraw JM, Sok P, Desrosiers TA, Janitz AE, Langlois PH, Canfield MA, Frazier AL, Plon SE, Lupo PJ, Poynter JN
Cancer 2023 Oct 15;129(20):3300-3308. Epub 2023 Jun 27 doi: 10.1002/cncr.34906. PMID: 37366624Free PMC Article
Clinical characteristics and long-term management of prepubertal testicular teratomas: a retrospective, multicenter study.
Zhou G, Sun F, Yu X, Huang R, Liu X, Ouyang Y, Yang Z, Li S
Eur J Pediatr 2023 Apr;182(4):1823-1828. Epub 2023 Feb 16 doi: 10.1007/s00431-023-04859-8. PMID: 36795187Free PMC Article
Extracranial non-testicular teratoma in childhood and adolescence: introduction of a risk score for stratification of therapy.
Göbel U, Calaminus G, Blohm M, Booss D, Felberbauer F, Hofmann U, Holschneider AM, Willnow U, Harms D
Klin Padiatr 1997 Jul-Aug;209(4):228-34. doi: 10.1055/s-2008-1043955. PMID: 9293455
Germ cell tumors.
Rescorla FJ
Semin Pediatr Surg 1997 Feb;6(1):29-37. PMID: 9117272
Germinal testicular tumors in childhood. Report of observations and literature review.
Weissbach L, Altwein JE, Stiens R
Eur Urol 1984;10(2):73-85. doi: 10.1159/000463762. PMID: 6368238

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