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Abnormal Blood Chemistry and Hematology Test Result

MedGen UID:
233128
•Concept ID:
C1332129
•
Finding

Definition

A laboratory test result that indicates the presence of abnormal blood chemistry and/or hematology values. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal Blood Chemistry and Hematology Test Result

Professional guidelines

PubMed

Associations of peripheral blood lymphopenia to disease course, treatment and TNF-α in sarcoidosis.
Padhi A, Eklund A, Malmeström C, Erikson E, Hallén G, Smed-Sörensen A, Kullberg S
Respir Res 2025 Apr 9;26(1):130. doi: 10.1186/s12931-025-03212-x. PMID: 40205574Free PMC Article
Laboratory aspects of von Willebrand disease: test repertoire and options for activity assays and genetic analysis.
Castaman G, Hillarp A, Goodeve A
Haemophilia 2014 May;20 Suppl 4(0 4):65-70. doi: 10.1111/hae.12410. PMID: 24762278Free PMC Article
Systemic mastocytosis in adults: 2012 Update on diagnosis, risk stratification, and management.
Pardanani A
Am J Hematol 2012 Apr;87(4):401-11. doi: 10.1002/ajh.23134. PMID: 22410759

Recent clinical studies

Etiology

A score-based method of immune status evaluation for healthy individuals with complete blood cell counts.
Zhang M, Zhao C, Cheng Q, Xu J, Xu N, Yu L, Feng W
BMC Bioinformatics 2023 Dec 11;24(1):467. doi: 10.1186/s12859-023-05603-7. PMID: 38082403Free PMC Article
Major liver resection, systemic fibrinolytic activity, and the impact of tranexamic acid.
Karanicolas PJ, Lin Y, Tarshis J, Law CH, Coburn NG, Hallet J, Nascimento B, Pawliszyn J, McCluskey SA
HPB (Oxford) 2016 Dec;18(12):991-999. Epub 2016 Oct 18 doi: 10.1016/j.hpb.2016.09.005. PMID: 27765582Free PMC Article
Alpha and beta thalassemia.
Muncie HL Jr, Campbell J
Am Fam Physician 2009 Aug 15;80(4):339-44. PMID: 19678601
Cerebral oximetry during infant cardiac surgery: evaluation and relationship to early postoperative outcome.
Kussman BD, Wypij D, DiNardo JA, Newburger JW, Mayer JE Jr, del Nido PJ, Bacha EA, Pigula F, McGrath E, Laussen PC
Anesth Analg 2009 Apr;108(4):1122-31. doi: 10.1213/ane.0b013e318199dcd2. PMID: 19299774Free PMC Article
Review of 1027 patients with newly diagnosed multiple myeloma.
Kyle RA, Gertz MA, Witzig TE, Lust JA, Lacy MQ, Dispenzieri A, Fonseca R, Rajkumar SV, Offord JR, Larson DR, Plevak ME, Therneau TM, Greipp PR
Mayo Clin Proc 2003 Jan;78(1):21-33. doi: 10.4065/78.1.21. PMID: 12528874

Diagnosis

Laboratory abnormalities in children with mild and severe coronavirus disease 2019 (COVID-19): A pooled analysis and review.
Henry BM, Benoit SW, de Oliveira MHS, Hsieh WC, Benoit J, Ballout RA, Plebani M, Lippi G
Clin Biochem 2020 Jul;81:1-8. Epub 2020 May 27 doi: 10.1016/j.clinbiochem.2020.05.012. PMID: 32473151Free PMC Article
Use of biomarkers in inflammatory bowel disease.
Egea Valenzuela J, Antón Ródenas G, Sánchez Martínez A
Med Clin (Barc) 2019 Apr 18;152(8):310-316. Epub 2018 Nov 27 doi: 10.1016/j.medcli.2018.10.010. PMID: 30502302
Alpha and beta thalassemia.
Muncie HL Jr, Campbell J
Am Fam Physician 2009 Aug 15;80(4):339-44. PMID: 19678601
Review of 1027 patients with newly diagnosed multiple myeloma.
Kyle RA, Gertz MA, Witzig TE, Lust JA, Lacy MQ, Dispenzieri A, Fonseca R, Rajkumar SV, Offord JR, Larson DR, Plevak ME, Therneau TM, Greipp PR
Mayo Clin Proc 2003 Jan;78(1):21-33. doi: 10.4065/78.1.21. PMID: 12528874
BIOCHEMICAL INVESTIGATION OF HISTIDINAEMIA.
HOLTON JB, LEWIS FJ, MOORE GR
J Clin Pathol 1964 Nov;17(6):671-5. doi: 10.1136/jcp.17.6.671. PMID: 14227438Free PMC Article

Therapy

A score-based method of immune status evaluation for healthy individuals with complete blood cell counts.
Zhang M, Zhao C, Cheng Q, Xu J, Xu N, Yu L, Feng W
BMC Bioinformatics 2023 Dec 11;24(1):467. doi: 10.1186/s12859-023-05603-7. PMID: 38082403Free PMC Article
Haematological and fibrinolytic status of Nigerian women with post-partum haemorrhage.
Roberts I, Shakur H, Fawole B, Kuti M, Olayemi O, Bello A, Ogunbode O, Kotila T, Aimakhu CO, Olutogun T, Hunt BJ, Huque S
BMC Pregnancy Childbirth 2018 May 9;18(1):143. doi: 10.1186/s12884-018-1794-1. PMID: 29743045Free PMC Article
Major liver resection, systemic fibrinolytic activity, and the impact of tranexamic acid.
Karanicolas PJ, Lin Y, Tarshis J, Law CH, Coburn NG, Hallet J, Nascimento B, Pawliszyn J, McCluskey SA
HPB (Oxford) 2016 Dec;18(12):991-999. Epub 2016 Oct 18 doi: 10.1016/j.hpb.2016.09.005. PMID: 27765582Free PMC Article
Bleeding issues in neonates and infants - update 2015.
Nowak-Göttl U, Limperger V, Bauer A, Kowalski D, Kenet G
Thromb Res 2015 Feb;135 Suppl 1:S41-3. Epub 2015 Feb 9 doi: 10.1016/S0049-3848(15)50440-4. PMID: 25903533
Abnormality of CD4(+)CD25(+) regulatory T cells in idiopathic thrombocytopenic purpura.
Liu B, Zhao H, Poon MC, Han Z, Gu D, Xu M, Jia H, Yang R, Han ZC
Eur J Haematol 2007 Feb;78(2):139-43. doi: 10.1111/j.1600-0609.2006.00780.x. PMID: 17328716

Prognosis

Laboratory abnormalities in children with mild and severe coronavirus disease 2019 (COVID-19): A pooled analysis and review.
Henry BM, Benoit SW, de Oliveira MHS, Hsieh WC, Benoit J, Ballout RA, Plebani M, Lippi G
Clin Biochem 2020 Jul;81:1-8. Epub 2020 May 27 doi: 10.1016/j.clinbiochem.2020.05.012. PMID: 32473151Free PMC Article
Use of biomarkers in inflammatory bowel disease.
Egea Valenzuela J, Antón Ródenas G, Sánchez Martínez A
Med Clin (Barc) 2019 Apr 18;152(8):310-316. Epub 2018 Nov 27 doi: 10.1016/j.medcli.2018.10.010. PMID: 30502302
Major liver resection, systemic fibrinolytic activity, and the impact of tranexamic acid.
Karanicolas PJ, Lin Y, Tarshis J, Law CH, Coburn NG, Hallet J, Nascimento B, Pawliszyn J, McCluskey SA
HPB (Oxford) 2016 Dec;18(12):991-999. Epub 2016 Oct 18 doi: 10.1016/j.hpb.2016.09.005. PMID: 27765582Free PMC Article
Analysis of serum protein fractions from women with recurrent miscarriage.
Nowak-Łoś L, Odrowaz-Sypniewska G, Zegarska J, Zalewska-Zacharek M, Kłyszejko-Molska J, Grabiec M, Adamczak R
Ginekol Pol 2013 Oct;84(10):851-6. doi: 10.17772/gp/1651. PMID: 24273907
Review of 1027 patients with newly diagnosed multiple myeloma.
Kyle RA, Gertz MA, Witzig TE, Lust JA, Lacy MQ, Dispenzieri A, Fonseca R, Rajkumar SV, Offord JR, Larson DR, Plevak ME, Therneau TM, Greipp PR
Mayo Clin Proc 2003 Jan;78(1):21-33. doi: 10.4065/78.1.21. PMID: 12528874

Clinical prediction guides

A score-based method of immune status evaluation for healthy individuals with complete blood cell counts.
Zhang M, Zhao C, Cheng Q, Xu J, Xu N, Yu L, Feng W
BMC Bioinformatics 2023 Dec 11;24(1):467. doi: 10.1186/s12859-023-05603-7. PMID: 38082403Free PMC Article
Laboratory abnormalities in children with mild and severe coronavirus disease 2019 (COVID-19): A pooled analysis and review.
Henry BM, Benoit SW, de Oliveira MHS, Hsieh WC, Benoit J, Ballout RA, Plebani M, Lippi G
Clin Biochem 2020 Jul;81:1-8. Epub 2020 May 27 doi: 10.1016/j.clinbiochem.2020.05.012. PMID: 32473151Free PMC Article
Use of biomarkers in inflammatory bowel disease.
Egea Valenzuela J, Antón Ródenas G, Sánchez Martínez A
Med Clin (Barc) 2019 Apr 18;152(8):310-316. Epub 2018 Nov 27 doi: 10.1016/j.medcli.2018.10.010. PMID: 30502302
Discriminant score for celiac disease based on immunohistochemical analysis of duodenal biopsies.
Tosco A, Maglio M, Paparo F, Greco L, Troncone R, Auricchio R
J Pediatr Gastroenterol Nutr 2015 May;60(5):621-5. doi: 10.1097/MPG.0000000000000675. PMID: 25514620
Review of 1027 patients with newly diagnosed multiple myeloma.
Kyle RA, Gertz MA, Witzig TE, Lust JA, Lacy MQ, Dispenzieri A, Fonseca R, Rajkumar SV, Offord JR, Larson DR, Plevak ME, Therneau TM, Greipp PR
Mayo Clin Proc 2003 Jan;78(1):21-33. doi: 10.4065/78.1.21. PMID: 12528874

Recent systematic reviews

Routine preoperative testing: a systematic review of the evidence.
Munro J, Booth A, Nicholl J
Health Technol Assess 1997;1(12):i-iv; 1-62. PMID: 9483155

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