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Anus leiomyosarcoma

MedGen UID:
231370
•Concept ID:
C1332267
•
Neoplastic Process
Synonyms: Anal Leiomyosarcoma; anal leiomyosarcoma; anus leiomyosarcoma; Leiomyosarcoma of Anus; leiomyosarcoma of anus; Leiomyosarcoma of the Anus; leiomyosarcoma of the anus
 
Monarch Initiative: MONDO:0003358

Definition

An aggressive malignant smooth muscle neoplasm, arising from the anus. It is characterized by a proliferation of neoplastic spindle cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnus leiomyosarcoma

Professional guidelines

PubMed

Effect of Double-Balloon Enteroscopy on Diagnosis and Treatment of Small-Bowel Diseases.
Tang L, Huang LY, Cui J, Wu CR
Chin Med J (Engl) 2018 Jun 5;131(11):1321-1326. doi: 10.4103/0366-6999.232802. PMID: 29786046Free PMC Article
Management of less common tumors of the colon, rectum, and anus.
Cuffy M, Abir F, Longo WE
Clin Colorectal Cancer 2006 Jan;5(5):327-37. doi: 10.3816/CCC.2006.n.002. PMID: 16512991
Malignant tumors of the anal canal: the spectrum of disease, treatment, and outcomes.
Klas JV, Rothenberger DA, Wong WD, Madoff RD
Cancer 1999 Apr 15;85(8):1686-93. doi: 10.1002/(sici)1097-0142(19990415)85:8<1686::aid-cncr7>3.0.co;2-7. PMID: 10223561

Recent clinical studies

Etiology

The growing problem of non-AIDS-defining malignancies in HIV.
Pantanowitz L, Schlecht HP, Dezube BJ
Curr Opin Oncol 2006 Sep;18(5):469-78. doi: 10.1097/01.cco.0000239886.13537.ed. PMID: 16894295
Non-AIDS-defining malignancies.
Trubowitz P, Gates A, Kaplan L
Cancer Treat Res 2001;104:303-28. doi: 10.1007/978-1-4615-1601-9_12. PMID: 11191132
The epidemiology of acquired immunodeficiency syndrome malignancies.
Goedert JJ
Semin Oncol 2000 Aug;27(4):390-401. PMID: 10950365
The epidemiology of AIDS--related neoplasms.
Biggar RJ, Rabkin CS
Hematol Oncol Clin North Am 1996 Oct;10(5):997-1010. doi: 10.1016/s0889-8588(05)70380-4. PMID: 8880192
Epidemiology of AIDS-related malignancies.
Rabkin CS
Curr Opin Oncol 1994 Sep;6(5):492-6. doi: 10.1097/00001622-199409000-00008. PMID: 7827152

Diagnosis

Ischiorectal fossa: benign and malignant neoplasms of this "ignored" radiological anatomical space.
Faria SC, Elsherif SB, Sagebiel T, Cox V, Rao B, Lall C, Bhosale PR
Abdom Radiol (NY) 2019 May;44(5):1644-1674. doi: 10.1007/s00261-019-01930-7. PMID: 30955068
Effect of Double-Balloon Enteroscopy on Diagnosis and Treatment of Small-Bowel Diseases.
Tang L, Huang LY, Cui J, Wu CR
Chin Med J (Engl) 2018 Jun 5;131(11):1321-1326. doi: 10.4103/0366-6999.232802. PMID: 29786046Free PMC Article
Management of less common tumors of the colon, rectum, and anus.
Cuffy M, Abir F, Longo WE
Clin Colorectal Cancer 2006 Jan;5(5):327-37. doi: 10.3816/CCC.2006.n.002. PMID: 16512991
Tumors of the rectum and anal canal.
Hatch KF, Blanchard DK, Hatch GF 3rd, Wertheimer-Hatch L, Davis GB, Foster RS Jr, Skandalakis JE
World J Surg 2000 Apr;24(4):437-43. doi: 10.1007/s002689910069. PMID: 10706916
Anorectal leiomyosarcomas.
Wang TK, Chung MT
J Gastroenterol 1998 Jun;33(3):402-7. doi: 10.1007/s005350050103. PMID: 9658321

Therapy

The growing problem of non-AIDS-defining malignancies in HIV.
Pantanowitz L, Schlecht HP, Dezube BJ
Curr Opin Oncol 2006 Sep;18(5):469-78. doi: 10.1097/01.cco.0000239886.13537.ed. PMID: 16894295
Histologic analysis of the irradiated anal sphincter.
Da Silva GM, Berho M, Wexner SD, Efron J, Weiss EG, Nogueras JJ, Vernava AM 3rd, Connor JT, Gervaz P
Dis Colon Rectum 2003 Nov;46(11):1492-7. doi: 10.1007/s10350-004-6800-1. PMID: 14605568
The epidemiology of acquired immunodeficiency syndrome malignancies.
Goedert JJ
Semin Oncol 2000 Aug;27(4):390-401. PMID: 10950365
Sphincter preservation of leiomyosarcoma of the rectum and anus with local excision and brachytherapy.
Grann A, Paty PB, Guillem JG, Cohen AM, Minsky BD
Dis Colon Rectum 1999 Oct;42(10):1296-9. doi: 10.1007/BF02234218. PMID: 10528767
Malignant tumors of the anal canal: the spectrum of disease, treatment, and outcomes.
Klas JV, Rothenberger DA, Wong WD, Madoff RD
Cancer 1999 Apr 15;85(8):1686-93. doi: 10.1002/(sici)1097-0142(19990415)85:8<1686::aid-cncr7>3.0.co;2-7. PMID: 10223561

Prognosis

The growing problem of non-AIDS-defining malignancies in HIV.
Pantanowitz L, Schlecht HP, Dezube BJ
Curr Opin Oncol 2006 Sep;18(5):469-78. doi: 10.1097/01.cco.0000239886.13537.ed. PMID: 16894295
Management of less common tumors of the colon, rectum, and anus.
Cuffy M, Abir F, Longo WE
Clin Colorectal Cancer 2006 Jan;5(5):327-37. doi: 10.3816/CCC.2006.n.002. PMID: 16512991
Sphincter preservation of leiomyosarcoma of the rectum and anus with local excision and brachytherapy.
Grann A, Paty PB, Guillem JG, Cohen AM, Minsky BD
Dis Colon Rectum 1999 Oct;42(10):1296-9. doi: 10.1007/BF02234218. PMID: 10528767
Malignant tumors of the anal canal: the spectrum of disease, treatment, and outcomes.
Klas JV, Rothenberger DA, Wong WD, Madoff RD
Cancer 1999 Apr 15;85(8):1686-93. doi: 10.1002/(sici)1097-0142(19990415)85:8<1686::aid-cncr7>3.0.co;2-7. PMID: 10223561
Anorectal leiomyosarcomas.
Wang TK, Chung MT
J Gastroenterol 1998 Jun;33(3):402-7. doi: 10.1007/s005350050103. PMID: 9658321

Clinical prediction guides

A novel approach for perirectal tumours: the perianal intersphincteric excision.
Pescatori M, Brusciano L, Binda GA, Serventi A
Int J Colorectal Dis 2005 Jan;20(1):72-5. Epub 2004 Aug 26 doi: 10.1007/s00384-004-0623-3. PMID: 15338167
Histologic analysis of the irradiated anal sphincter.
Da Silva GM, Berho M, Wexner SD, Efron J, Weiss EG, Nogueras JJ, Vernava AM 3rd, Connor JT, Gervaz P
Dis Colon Rectum 2003 Nov;46(11):1492-7. doi: 10.1007/s10350-004-6800-1. PMID: 14605568
Anorectal sarcomas.
Molnár L, Bezsnyák I, Daubner K, Horák E, Svastits E
Acta Chir Hung 1985;26(2):85-91. PMID: 4024821

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