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Degenerative disorder

MedGen UID:: 224837
•Concept ID:: C1285162
•: Disease or Syndrome

Synonyms:	Degenerative Disease; Degenerative Disorder
SNOMED CT:	Degenerative disorder (362975008)

Definition

A disorder characterized by the progressive loss of function and/or structure of the affected tissues. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVDegenerative disorder

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Non-Neoplastic Disorder
      - Non-Neoplastic Disorder by Special Category
        Degenerative disorder
        Degenerative disease of the central nervous system
        Amyotrophic lateral sclerosis
        Amyotrophic Lateral Sclerosis 14, with or without Frontotemporal Dementia
        Amyotrophic lateral sclerosis 26 with or without frontotemporal dementia
        Amyotrophic lateral sclerosis type 1
        Amyotrophic lateral sclerosis type 3
        Amyotrophic lateral sclerosis type 4
        Amyotrophic lateral sclerosis type 6
        Amyotrophic lateral sclerosis type 7
        Amyotrophic lateral sclerosis type 8
        Amyotrophic lateral sclerosis type 9
        Amyotrophic lateral sclerosis type 10
        Amyotrophic lateral sclerosis type 11
        Amyotrophic lateral sclerosis type 15
        Amyotrophic lateral sclerosis type 16
        Amyotrophic lateral sclerosis type 18
        Amyotrophic lateral sclerosis type 19
        Amyotrophic lateral sclerosis type 20
        Amyotrophic lateral sclerosis type 21
        Amyotrophic lateral sclerosis type 23
        Juvenile amyotrophic lateral sclerosis
        Progressive muscular atrophy
        Brachial amyotrophic diplegia
        Cerebral palsy
        Ataxic cerebral palsy
        Athetoid cerebral palsy
        Hypotonic cerebral palsy
        Mixed cerebral palsy
        Spastic cerebral palsy
        Spastic diplegia
        Spastic hemiparesis
        Spastic quadriplegic cerebral palsy
        Spastic triplegia
        Dementia
        Alzheimer disease
        Creutzfeldt-Jakob disease
        Degenerations, Frontotemporal Lobar
        Dementia associated with AIDS
        Diffuse Neurofibrillary Tangles with Calcification
        Frontal lobe dementia
        Frontolimbic dementia
        Frontotemporal dementia
        Huntington disease
        Kluver-Bucy syndrome
        Lewy body dementia
        Presenile dementia
        Primary progressive aphasia
        Senile dementia
        Subcortical dementia
        Vascular dementia
        Demyelinating disease of central nervous system
        Demyelinating Encephalopathy
        Dentatorubral-pallidoluysian atrophy
        Extrapyramidal disease
        Parkinson disease
        Frontotemporal dementia and/or amyotrophic lateral sclerosis 2
        Frontotemporal dementia and/or amyotrophic lateral sclerosis 4
        Frontotemporal dementia and/or amyotrophic lateral sclerosis 7
        Frontotemporal dementia with motor neuron disease
        Hereditary Neurodegenerative Disorder
        Multiple system atrophy 1, susceptibility to
        Neurodegeneration with brain iron accumulation 4
        Neurodegeneration with brain iron accumulation 5
        Hereditary spastic paraplegia
        Cerebral palsy, spastic quadriplegic, 3
        Hereditary spastic paraplegia 4
        Hereditary spastic paraplegia 7
        Hereditary spastic paraplegia 11
        Hereditary spastic paraplegia 3A
        Hereditary spastic paraplegia 47
        Hereditary spastic paraplegia 52
        Hereditary spastic paraplegia 5A
        Spastic Paraplegia 76
        Pelizaeus-Merzbacher disease
        Null syndrome
        Pelizaeus-Merzbacher disease in female carriers
        Pelizaeus-Merzbacher disease, classic form
        Pelizaeus-Merzbacher disease, connatal form
        Pelizaeus-Merzbacher disease, transitional form
        Pick disease
        Progressive supranuclear palsy
        Atypical progressive supranuclear palsy syndrome
        Supranuclear palsy, progressive, 1
        Supranuclear palsy, progressive, 2
        Supranuclear palsy, progressive, 3
        Spinocerebellar atrophy
        Ataxia with oculomotor apraxia type 3
        Ataxia, early-onset, with oculomotor apraxia and hypoalbuminemia
        Ataxia-telangiectasia syndrome
        Autosomal dominant cerebellar ataxia
        Autosomal recessive cerebellar ataxia
        Azorean disease
        Familial isolated deficiency of vitamin E
        Spinocerebellar ataxia 7
        Spinocerebellar ataxia type 1
        Spinocerebellar ataxia type 2
        Spinocerebellar ataxia type 6
        Spinocerebellar ataxia type 12
        Spinocerebellar ataxia type 13
        Spinocerebellar ataxia type 14
        Spinocerebellar ataxia type 17
        Spinocerebellar Ataxia Type 19/22
        Spinocerebellar ataxia type 29
        Spinocerebellar ataxia type 31
        Spinocerebellar ataxia type 36
        Spinocerebellar ataxia type 42
        Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2
        Striatonigral degeneration
        Demyelinating disease
        Central pontine myelinolysis
        CNS demyelinating autoimmune disease
        Acute disseminated encephalomyelitis
        Multiple sclerosis
        Myelin oligodendrocyte glycoprotein antibody-associated disease
        Neuromyelitis optica
        Schilder disease
        Transverse myelitis
        Demyelinating peripheral neuropathy
        Acute demyelinating polyneuropathy
        Chronic inflammatory demyelinating polyradiculoneuropathy
        Demyelinating sensory neuropathy
        Hereditary Central Nervous System Demyelinating Diseases
        Adrenoleukodystrophy
        Alexander disease
        Galactosylceramide beta-galactosidase deficiency
        Metachromatic leukodystrophy
        Spongy degeneration of central nervous system
        Marchiafava-Bignami disease
        Polyradiculoneuropathy
        Cauda equina syndrome
        Guillain-Barre syndrome
        Polyradiculopathy
        Progressive multifocal leukoencephalopathy
        Recurrent painful ophthalmoplegic neuropathy
        Subacute combined degeneration of spinal cord
        Plexopathy
        Brachial plexus neuropathy
        Brachial plexus neuritis
        Neonatal Brachial Plexus Palsy
        Spinal Degenerative Disorder
        Intervertebral disk degeneration
        Cervical disk degenerative disorder
        Degeneration of lumbar intervertebral disc
        Thoracic disk degenerative disorder
        Spinal arthritis deformans

Professional guidelines

PubMed

Neurotrophic keratopathy: Update in diagnosis and management.

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Indian J Ophthalmol 2025 Apr 1;73(4):483-495. Epub 2025 Mar 27 doi: 10.4103/IJO.IJO_2963_24. PMID: 40146136 Free PMC Article

Patellar Tendinopathy: Diagnosis and Treatment.

Figueroa D, Figueroa F, Calvo R
J Am Acad Orthop Surg 2016 Dec;24(12):e184-e192. doi: 10.5435/JAAOS-D-15-00703. PMID: 27855131

Osteoarthritis: diagnosis and treatment.

Sinusas K
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Recent clinical studies

Etiology

Patellar Tendinopathy: Diagnosis and Treatment.

Figueroa D, Figueroa F, Calvo R
J Am Acad Orthop Surg 2016 Dec;24(12):e184-e192. doi: 10.5435/JAAOS-D-15-00703. PMID: 27855131

Inclusion body myositis.

Dimachkie MM, Barohn RJ
Semin Neurol 2012 Jul;32(3):237-45. Epub 2012 Nov 1 doi: 10.1055/s-0032-1329197. PMID: 23117948 Free PMC Article

Osteoarthritis: diagnosis and treatment.

Sinusas K
Am Fam Physician 2012 Jan 1;85(1):49-56. PMID: 22230308

Osteoarthritis.

Das SK, Farooqi A
Best Pract Res Clin Rheumatol 2008 Aug;22(4):657-75. doi: 10.1016/j.berh.2008.07.002. PMID: 18783743

Osteoarthritis.

Haq I, Murphy E, Dacre J
Postgrad Med J 2003 Jul;79(933):377-83. doi: 10.1136/pmj.79.933.377. PMID: 12897215 Free PMC Article

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Diagnosis

Leukodystrophies.

Waldman AT
Continuum (Minneap Minn) 2018 Feb;24(1, Child Neurology):130-149. doi: 10.1212/CON.0000000000000560. PMID: 29432240

Patellar Tendinopathy: Diagnosis and Treatment.

Figueroa D, Figueroa F, Calvo R
J Am Acad Orthop Surg 2016 Dec;24(12):e184-e192. doi: 10.5435/JAAOS-D-15-00703. PMID: 27855131

Lateral epicondylitis of the elbow.

Tosti R, Jennings J, Sewards JM
Am J Med 2013 Apr;126(4):357.e1-6. Epub 2013 Feb 8 doi: 10.1016/j.amjmed.2012.09.018. PMID: 23398951

Osteoarthritis: diagnosis and treatment.

Sinusas K
Am Fam Physician 2012 Jan 1;85(1):49-56. PMID: 22230308

Osteoarthritis.

Haq I, Murphy E, Dacre J
Postgrad Med J 2003 Jul;79(933):377-83. doi: 10.1136/pmj.79.933.377. PMID: 12897215 Free PMC Article

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Therapy

Effectiveness of therapeutic ultrasound on reducing pain intensity and functional disability in patients with plantar fasciitis: a systematic review of randomised controlled trials.

Alhakami AM, Babkair RA, Sahely A, Nuhmani S
PeerJ 2024;12:e17147. Epub 2024 Mar 22 doi: 10.7717/peerj.17147. PMID: 38529309 Free PMC Article

Retinal biomarkers of Cerebral Small Vessel Disease: A systematic review.

Biffi E, Turple Z, Chung J, Biffi A
PLoS One 2022;17(4):e0266974. Epub 2022 Apr 14 doi: 10.1371/journal.pone.0266974. PMID: 35421194 Free PMC Article

Osteoarthritis: diagnosis and treatment.

Sinusas K
Am Fam Physician 2012 Jan 1;85(1):49-56. PMID: 22230308

Osteoarthritis.

Mahajan A, Verma S, Tandon V
J Assoc Physicians India 2005 Jul;53:634-41. PMID: 16190135

Osteoarthritis.

Haq I, Murphy E, Dacre J
Postgrad Med J 2003 Jul;79(933):377-83. doi: 10.1136/pmj.79.933.377. PMID: 12897215 Free PMC Article

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Prognosis

Biomarkers Assessing Endothelial Dysfunction in Alzheimer's Disease.

Custodia A, Aramburu-Núñez M, Rodríguez-Arrizabalaga M, Pías-Peleteiro JM, Vázquez-Vázquez L, Camino-Castiñeiras J, Aldrey JM, Castillo J, Ouro A, Sobrino T, Romaus-Sanjurjo D
Cells 2023 Mar 22;12(6) doi: 10.3390/cells12060962. PMID: 36980302 Free PMC Article

The Chiari I malformation.

McClugage SG, Oakes WJ
J Neurosurg Pediatr 2019 Sep 1;24(3):217-226. doi: 10.3171/2019.5.PEDS18382. PMID: 31473667

Primary Progressive Aphasias and Apraxia of Speech.

Botha H, Josephs KA
Continuum (Minneap Minn) 2019 Feb;25(1):101-127. doi: 10.1212/CON.0000000000000699. PMID: 30707189 Free PMC Article

Inclusion body myositis.

Dimachkie MM, Barohn RJ
Semin Neurol 2012 Jul;32(3):237-45. Epub 2012 Nov 1 doi: 10.1055/s-0032-1329197. PMID: 23117948 Free PMC Article

Huntington's disease.

Craufurd D
Prenat Diagn 1996 Dec;16(13):1237-45. doi: 10.1002/(SICI)1097-0223(199612)16:13<1237::AID-PD98>3.0.CO;2-T. PMID: 9061754

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Clinical prediction guides

Microglia-drive IRF8 upregulates complement pathway in Parkinson's disease.

Yao H, Liu C, Jin L, Song Y
Biochim Biophys Acta Mol Basis Dis 2025 Oct;1871(7):167928. Epub 2025 May 31 doi: 10.1016/j.bbadis.2025.167928. PMID: 40456297

Effectiveness of therapeutic ultrasound on reducing pain intensity and functional disability in patients with plantar fasciitis: a systematic review of randomised controlled trials.

Alhakami AM, Babkair RA, Sahely A, Nuhmani S
PeerJ 2024;12:e17147. Epub 2024 Mar 22 doi: 10.7717/peerj.17147. PMID: 38529309 Free PMC Article

1-L Transcription in Parkinson's Disease.

Nahalka J
Front Biosci (Landmark Ed) 2023 Nov 23;28(11):292. doi: 10.31083/j.fbl2811292. PMID: 38062843

Neuropathology of Rett syndrome.

Armstrong DD
Ment Retard Dev Disabil Res Rev 2002;8(2):72-6. doi: 10.1002/mrdd.10027. PMID: 12112730

Huntington's disease.

Craufurd D
Prenat Diagn 1996 Dec;16(13):1237-45. doi: 10.1002/(SICI)1097-0223(199612)16:13<1237::AID-PD98>3.0.CO;2-T. PMID: 9061754

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Recent systematic reviews

The complex relationship between gut microbiota and Alzheimer's disease: A systematic review.

Zhou XP, Sun LB, Liu WH, Zhu WM, Li LC, Song XY, Xing JP, Gao SH
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Effectiveness of therapeutic ultrasound on reducing pain intensity and functional disability in patients with plantar fasciitis: a systematic review of randomised controlled trials.

Alhakami AM, Babkair RA, Sahely A, Nuhmani S
PeerJ 2024;12:e17147. Epub 2024 Mar 22 doi: 10.7717/peerj.17147. PMID: 38529309 Free PMC Article

Retinal biomarkers of Cerebral Small Vessel Disease: A systematic review.

Biffi E, Turple Z, Chung J, Biffi A
PLoS One 2022;17(4):e0266974. Epub 2022 Apr 14 doi: 10.1371/journal.pone.0266974. PMID: 35421194 Free PMC Article

Diabetes Mellitus and Amyotrophic Lateral Sclerosis: A Systematic Review.

Ferri L, Ajdinaj P, Rispoli MG, Carrarini C, Barbone F, D'Ardes D, Capasso M, Muzio AD, Cipollone F, Onofrj M, Bonanni L
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Genetic factors of cervical spondylotic myelopathy-a systemic review.

Wang G, Cao Y, Wu T, Duan C, Wu J, Hu J, Lu H
J Clin Neurosci 2017 Oct;44:89-94. Epub 2017 Jul 19 doi: 10.1016/j.jocn.2017.06.043. PMID: 28734792

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Degenerative disorder

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

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