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Increased Bone Density

MedGen UID:
215128
•Concept ID:
C1141880
•
Finding
Synonym: Increased bone density

Definition

A finding indicating an increased density of minerals in the bones. Causes include osteopetrosis and Paget disease. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased Bone Density

Professional guidelines

PubMed

The Efficacy and Safety of Medical and Surgical Therapy in Patients With Primary Hyperparathyroidism: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Ye Z, Silverberg SJ, Sreekanta A, Tong K, Wang Y, Chang Y, Zhang M, Guyatt G, Tangamornsuksun W, Zhang Y, Manja V, Bakaa L, Couban RJ, Brandi ML, Clarke B, Khan AA, Mannstadt M, Bilezikian JP
J Bone Miner Res 2022 Nov;37(11):2351-2372. Epub 2022 Oct 17 doi: 10.1002/jbmr.4685. PMID: 36053960
Male hypogonadism : an update on diagnosis and treatment.
Darby E, Anawalt BD
Treat Endocrinol 2005;4(5):293-309. doi: 10.2165/00024677-200504050-00003. PMID: 16185098
Primary hyperparathyroidism: diagnosis and management in the older individual.
Boonen S, Vanderschueren D, Pelemans W, Bouillon R
Eur J Endocrinol 2004 Sep;151(3):297-304. doi: 10.1530/eje.0.1510297. PMID: 15362957

Recent clinical studies

Etiology

Molecular Mechanisms of Craniofacial and Dental Abnormalities in Osteopetrosis.
Ma Y, Xu Y, Zhang Y, Duan X
Int J Mol Sci 2023 Jun 20;24(12) doi: 10.3390/ijms241210412. PMID: 37373559Free PMC Article
Spectrum of Skeletal Imaging Features in Osteopetrosis: Inheritance Pattern and Radiological Associations.
Spinnato P, Pedrini E, Petrera MR, Zarantonello P, Trisolino G, Sangiorgi L, Carpenzano M, Crombé A, Tetta C
Genes (Basel) 2022 Oct 28;13(11) doi: 10.3390/genes13111965. PMID: 36360203Free PMC Article
Bone disease in hypoparathyroidism.
Clarke BL
Arq Bras Endocrinol Metabol 2014 Jul;58(5):545-52. doi: 10.1590/0004-2730000003399. PMID: 25166046
Skeletal dysplasias with increased bone density: evolution of molecular pathogenesis in the last century.
Aggarwal S
Gene 2013 Oct 1;528(1):41-5. Epub 2013 May 5 doi: 10.1016/j.gene.2013.04.069. PMID: 23657117
Osteopetrosis.
Stark Z, Savarirayan R
Orphanet J Rare Dis 2009 Feb 20;4:5. doi: 10.1186/1750-1172-4-5. PMID: 19232111Free PMC Article

Diagnosis

Molecular Mechanisms of Craniofacial and Dental Abnormalities in Osteopetrosis.
Ma Y, Xu Y, Zhang Y, Duan X
Int J Mol Sci 2023 Jun 20;24(12) doi: 10.3390/ijms241210412. PMID: 37373559Free PMC Article
Paget's disease of bone: 1877-2023. Etiology, and management of a disease on epidemiologic transition.
Corral Gudino L
Med Clin (Barc) 2023 Sep 8;161(5):207-216. Epub 2023 May 30 doi: 10.1016/j.medcli.2023.05.005. PMID: 37263846
HBP/O-GlcNAcylation Metabolic Axis Regulates Bone Resorption Outcome.
Taira TM, Ramos-Junior ES, Melo PH, Costa-Silva CC, Alteen MG, Vocadlo DJ, Dias WB, Cunha FQ, Alves-Filho JC, Søe K, Fukada SY
J Dent Res 2023 Apr;102(4):440-449. Epub 2023 Feb 7 doi: 10.1177/00220345221141043. PMID: 36749069
Osteopetrosis.
Khan MN, Datta PK, Hasan MI, Hossain MA, Patwary KH, Ferdous J
Mymensingh Med J 2011 Oct;20(4):715-8. PMID: 22081195
Osteopetrosis.
Stark Z, Savarirayan R
Orphanet J Rare Dis 2009 Feb 20;4:5. doi: 10.1186/1750-1172-4-5. PMID: 19232111Free PMC Article

Therapy

The Efficacy and Safety of Medical and Surgical Therapy in Patients With Primary Hyperparathyroidism: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Ye Z, Silverberg SJ, Sreekanta A, Tong K, Wang Y, Chang Y, Zhang M, Guyatt G, Tangamornsuksun W, Zhang Y, Manja V, Bakaa L, Couban RJ, Brandi ML, Clarke B, Khan AA, Mannstadt M, Bilezikian JP
J Bone Miner Res 2022 Nov;37(11):2351-2372. Epub 2022 Oct 17 doi: 10.1002/jbmr.4685. PMID: 36053960
V-ATPases and osteoclasts: ambiguous future of V-ATPases inhibitors in osteoporosis.
Duan X, Yang S, Zhang L, Yang T
Theranostics 2018;8(19):5379-5399. Epub 2018 Oct 26 doi: 10.7150/thno.28391. PMID: 30555553Free PMC Article
Inhaled corticosteroids: Effects on growth and bone health.
Skoner DP
Ann Allergy Asthma Immunol 2016 Dec;117(6):595-600. doi: 10.1016/j.anai.2016.07.043. PMID: 27979015
Bone disease in hypoparathyroidism.
Clarke BL
Arq Bras Endocrinol Metabol 2014 Jul;58(5):545-52. doi: 10.1590/0004-2730000003399. PMID: 25166046
Radiation-induced changes in bone.
Mitchell MJ, Logan PM
Radiographics 1998 Sep-Oct;18(5):1125-36; quiz 1242-3. doi: 10.1148/radiographics.18.5.9747611. PMID: 9747611

Prognosis

Hypoparathyroidism: update of guidelines from the 2022 International Task Force.
Clarke BL
Arch Endocrinol Metab 2022 Nov 11;66(5):604-610. doi: 10.20945/2359-3997000000549. PMID: 36382749Free PMC Article
Spectrum of Skeletal Imaging Features in Osteopetrosis: Inheritance Pattern and Radiological Associations.
Spinnato P, Pedrini E, Petrera MR, Zarantonello P, Trisolino G, Sangiorgi L, Carpenzano M, Crombé A, Tetta C
Genes (Basel) 2022 Oct 28;13(11) doi: 10.3390/genes13111965. PMID: 36360203Free PMC Article
Denosumab treatment is associated with decreased cortical porosity and increased bone density and strength at the proximal humerus of ovariectomized cynomolgus monkeys.
Haider IT, Sawatsky A, Zhu Y, Page R, Kostenuik PJ, Boyd SK, Edwards WB
Bone 2022 Nov;164:116517. Epub 2022 Aug 10 doi: 10.1016/j.bone.2022.116517. PMID: 35961611
Endocrine manifestations of systemic mastocytosis in bone.
Greene LW, Asadipooya K, Corradi PF, Akin C
Rev Endocr Metab Disord 2016 Sep;17(3):419-431. doi: 10.1007/s11154-016-9362-3. PMID: 27239674
Primary hyperparathyroidism: diagnosis and management in the older individual.
Boonen S, Vanderschueren D, Pelemans W, Bouillon R
Eur J Endocrinol 2004 Sep;151(3):297-304. doi: 10.1530/eje.0.1510297. PMID: 15362957

Clinical prediction guides

Hypoparathyroidism: update of guidelines from the 2022 International Task Force.
Clarke BL
Arch Endocrinol Metab 2022 Nov 11;66(5):604-610. doi: 10.20945/2359-3997000000549. PMID: 36382749Free PMC Article
The Efficacy and Safety of Medical and Surgical Therapy in Patients With Primary Hyperparathyroidism: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Ye Z, Silverberg SJ, Sreekanta A, Tong K, Wang Y, Chang Y, Zhang M, Guyatt G, Tangamornsuksun W, Zhang Y, Manja V, Bakaa L, Couban RJ, Brandi ML, Clarke B, Khan AA, Mannstadt M, Bilezikian JP
J Bone Miner Res 2022 Nov;37(11):2351-2372. Epub 2022 Oct 17 doi: 10.1002/jbmr.4685. PMID: 36053960
Melorheostosis and Osteopoikilosis Clinical and Molecular Description of an Italian Case Series.
Gnoli M, Staals EL, Campanacci L, Bedeschi MF, Faletra F, Gallone S, Gaudio A, Mattina T, Gurrieri F, Percesepe A, Neri I, Virdi A, Tremosini M, Milanesi A, Brizola E, Pedrini E, Sangiorgi L
Calcif Tissue Int 2019 Aug;105(2):215-221. Epub 2019 May 25 doi: 10.1007/s00223-019-00565-6. PMID: 31129707
Pycnodysostosis: clinical, radiologic, and endocrine evaluation and linear growth after growth hormone therapy.
Soliman AT, Ramadan MA, Sherif A, Aziz Bedair ES, Rizk MM
Metabolism 2001 Aug;50(8):905-11. doi: 10.1053/meta.2001.24924. PMID: 11474477
Radiation-induced changes in bone.
Mitchell MJ, Logan PM
Radiographics 1998 Sep-Oct;18(5):1125-36; quiz 1242-3. doi: 10.1148/radiographics.18.5.9747611. PMID: 9747611

Recent systematic reviews

The Effect of Advanced Platelet-Rich Fibrin in Tissue Regeneration in Reconstructive and Graft Surgery: Systematic Review.
Santos Pereira VB, Barbirato DDS, Lago CAPD, Vasconcelos BCDE
J Craniofac Surg 2023 Jun 1;34(4):1217-1221. Epub 2023 May 5 doi: 10.1097/SCS.0000000000009328. PMID: 37143188
The Efficacy and Safety of Medical and Surgical Therapy in Patients With Primary Hyperparathyroidism: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Ye Z, Silverberg SJ, Sreekanta A, Tong K, Wang Y, Chang Y, Zhang M, Guyatt G, Tangamornsuksun W, Zhang Y, Manja V, Bakaa L, Couban RJ, Brandi ML, Clarke B, Khan AA, Mannstadt M, Bilezikian JP
J Bone Miner Res 2022 Nov;37(11):2351-2372. Epub 2022 Oct 17 doi: 10.1002/jbmr.4685. PMID: 36053960
Maxillary osteomyelitis associated with osteopetrosis: Systematic review.
Carvalho PHA, Moura LB, Real Gabrielli MF, Cabrini Gabrielli MA, Antonio Pereira Filho V
J Craniomaxillofac Surg 2018 Nov;46(11):1905-1910. Epub 2018 Sep 24 doi: 10.1016/j.jcms.2018.09.004. PMID: 30309794
Bone Health in Patients With Hematopoietic Disorders of Bone Marrow Origin: Systematic Review and Meta- Analysis.
Steer K, Stavnichuk M, Morris M, Komarova SV
J Bone Miner Res 2017 Apr;32(4):731-742. Epub 2016 Nov 30 doi: 10.1002/jbmr.3026. PMID: 27787922
Bone safety of long-term bisphosphonate treatment.
Rodan G, Reszka A, Golub E, Rizzoli R
Curr Med Res Opin 2004 Aug;20(8):1291-300. doi: 10.1185/030079904125004475. PMID: 15324532

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