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Mechanotransduction, Cellular

MedGen UID:
215106
Concept ID:
C1138568
Molecular Function
Synonyms: Cellular Mechanotransduction; Mechanical Signal Transduction; Mechanosensory Transduction; Signal Transduction, Mechanical; Transduction, Mechanosensory

Definition

The process by which cells convert mechanical stimuli into a chemical response. It can occur in both cells specialized for sensing mechanical cues such as MECHANORECEPTORS, and in parenchymal cells whose primary function is not mechanosensory. [from MeSH]

Professional guidelines

PubMed

Ji Q, Wang P, He C
Prog Biophys Mol Biol 2016 Sep;121(3):255-65. Epub 2016 Jul 14 doi: 10.1016/j.pbiomolbio.2016.07.001. PMID: 27423987

Recent clinical studies

Etiology

Zhu W, Guo S, Homilius M, Nsubuga C, Wright SH, Quan D, Kc A, Eddy SS, Victorio RA, Beerens M, Flaumenhaft R, Deo RC, MacRae CA
Sci Transl Med 2022 Jan 5;14(626):eabk1707. doi: 10.1126/scitranslmed.abk1707. PMID: 34985971
Logerstedt DS, Ebert JR, MacLeod TD, Heiderscheit BC, Gabbett TJ, Eckenrode BJ
Sports Med 2022 Feb;52(2):201-235. Epub 2021 Oct 20 doi: 10.1007/s40279-021-01579-7. PMID: 34669175
Samarelli AV, Masciale V, Aramini B, Coló GP, Tonelli R, Marchioni A, Bruzzi G, Gozzi F, Andrisani D, Castaniere I, Manicardi L, Moretti A, Tabbì L, Guaitoli G, Cerri S, Dominici M, Clini E
Int J Mol Sci 2021 Nov 10;22(22) doi: 10.3390/ijms222212179. PMID: 34830058Free PMC Article
Ma S, Dubin AE, Zhang Y, Mousavi SAR, Wang Y, Coombs AM, Loud M, Andolfo I, Patapoutian A
Cell 2021 Feb 18;184(4):969-982.e13. Epub 2021 Feb 10 doi: 10.1016/j.cell.2021.01.024. PMID: 33571427Free PMC Article
Friedrich O, Reid MB, Van den Berghe G, Vanhorebeek I, Hermans G, Rich MM, Larsson L
Physiol Rev 2015 Jul;95(3):1025-109. doi: 10.1152/physrev.00028.2014. PMID: 26133937Free PMC Article

Diagnosis

Chakrabarti S, Klich JD, Khallaf MA, Hulme AJ, Sánchez-Carranza O, Baran ZM, Rossi A, Huang AT, Pohl T, Fleischer R, Fürst C, Hammes A, Bégay V, Hörnberg H, Finol-Urdaneta RK, Poole K, Dottori M, Lewin GR
Science 2024 Mar;383(6686):992-998. Epub 2024 Feb 29 doi: 10.1126/science.adl0495. PMID: 38422143
Davis MJ, Earley S, Li YS, Chien S
Physiol Rev 2023 Apr 1;103(2):1247-1421. Epub 2023 Jan 5 doi: 10.1152/physrev.00053.2021. PMID: 36603156Free PMC Article
Beech DJ, Kalli AC
Arterioscler Thromb Vasc Biol 2019 Nov;39(11):2228-2239. Epub 2019 Sep 19 doi: 10.1161/ATVBAHA.119.313348. PMID: 31533470Free PMC Article
Syeda R, Xu J, Dubin AE, Coste B, Mathur J, Huynh T, Matzen J, Lao J, Tully DC, Engels IH, Petrassi HM, Schumacher AM, Montal M, Bandell M, Patapoutian A
Elife 2015 May 22;4 doi: 10.7554/eLife.07369. PMID: 26001275Free PMC Article
Lolignier S, Eijkelkamp N, Wood JN
Pflugers Arch 2015 Jan;467(1):133-9. Epub 2014 May 22 doi: 10.1007/s00424-014-1532-0. PMID: 24846747Free PMC Article

Therapy

Atcha H, Jairaman A, Holt JR, Meli VS, Nagalla RR, Veerasubramanian PK, Brumm KT, Lim HE, Othy S, Cahalan MD, Pathak MM, Liu WF
Nat Commun 2021 May 31;12(1):3256. doi: 10.1038/s41467-021-23482-5. PMID: 34059671Free PMC Article
Frangogiannis NG
Cardiovasc Res 2021 May 25;117(6):1450-1488. doi: 10.1093/cvr/cvaa324. PMID: 33135058Free PMC Article
Ding Z, Pothineni NVK, Goel A, Lüscher TF, Mehta JL
Cardiovasc Res 2020 Apr 1;116(5):908-915. doi: 10.1093/cvr/cvz313. PMID: 31746997
Liu F, Lagares D, Choi KM, Stopfer L, Marinković A, Vrbanac V, Probst CK, Hiemer SE, Sisson TH, Horowitz JC, Rosas IO, Fredenburgh LE, Feghali-Bostwick C, Varelas X, Tager AM, Tschumperlin DJ
Am J Physiol Lung Cell Mol Physiol 2015 Feb 15;308(4):L344-57. Epub 2014 Dec 12 doi: 10.1152/ajplung.00300.2014. PMID: 25502501Free PMC Article
Khan KM, Scott A
Br J Sports Med 2009 Apr;43(4):247-52. Epub 2009 Feb 24 doi: 10.1136/bjsm.2008.054239. PMID: 19244270Free PMC Article

Prognosis

Liu X, Ye Y, Zhu L, Xiao X, Zhou B, Gu Y, Si H, Liang H, Liu M, Li J, Jiang Q, Li J, Yu S, Ma R, Su S, Liao JY, Zhao Q
Nat Commun 2023 Jan 16;14(1):238. doi: 10.1038/s41467-023-35856-y. PMID: 36646707Free PMC Article
Zhu W, Guo S, Homilius M, Nsubuga C, Wright SH, Quan D, Kc A, Eddy SS, Victorio RA, Beerens M, Flaumenhaft R, Deo RC, MacRae CA
Sci Transl Med 2022 Jan 5;14(626):eabk1707. doi: 10.1126/scitranslmed.abk1707. PMID: 34985971
Long Y, Niu Y, Liang K, Du Y
Trends Cell Biol 2022 Jan;32(1):70-90. Epub 2021 Nov 19 doi: 10.1016/j.tcb.2021.10.002. PMID: 34810063
Xu Z, Rui YN, Hagan JP, Kim DH
Neuromolecular Med 2019 Dec;21(4):325-343. Epub 2019 May 4 doi: 10.1007/s12017-019-08537-7. PMID: 31055715Free PMC Article
Friedrich O, Reid MB, Van den Berghe G, Vanhorebeek I, Hermans G, Rich MM, Larsson L
Physiol Rev 2015 Jul;95(3):1025-109. doi: 10.1152/physrev.00028.2014. PMID: 26133937Free PMC Article

Clinical prediction guides

Leask A, Naik A, Stratton RJ
Nat Rev Rheumatol 2023 Nov;19(11):713-723. Epub 2023 Oct 3 doi: 10.1038/s41584-023-01032-1. PMID: 37789119
Long Y, Niu Y, Liang K, Du Y
Trends Cell Biol 2022 Jan;32(1):70-90. Epub 2021 Nov 19 doi: 10.1016/j.tcb.2021.10.002. PMID: 34810063
Friedrich O, Reid MB, Van den Berghe G, Vanhorebeek I, Hermans G, Rich MM, Larsson L
Physiol Rev 2015 Jul;95(3):1025-109. doi: 10.1152/physrev.00028.2014. PMID: 26133937Free PMC Article
Angelini TE, Dunn AC, Urueña JM, Dickrell DJ 3rd, Burris DL, Sawyer WG
Faraday Discuss 2012;156:31-9; discussion 87-103. doi: 10.1039/c2fd00130f. PMID: 23285620
Bae C, Sachs F, Gottlieb PA
Biochemistry 2011 Jul 26;50(29):6295-300. Epub 2011 Jun 29 doi: 10.1021/bi200770q. PMID: 21696149Free PMC Article

Recent systematic reviews

Oliveira S, Andrade R, Silva FS, Espregueira-Mendes J, Hinckel BB, Leal A, Carvalho Ó
Osteoarthritis Cartilage 2023 Mar;31(3):317-339. Epub 2022 Dec 5 doi: 10.1016/j.joca.2022.07.014. PMID: 36481451
Shah JS, Sabouni R, Cayton Vaught KC, Owen CM, Albertini DF, Segars JH
J Assist Reprod Genet 2018 Jul;35(7):1135-1148. Epub 2018 Apr 24 doi: 10.1007/s10815-018-1180-y. PMID: 29691711Free PMC Article
Dobbenga S, Fratila-Apachitei LE, Zadpoor AA
Acta Biomater 2016 Dec;46:3-14. Epub 2016 Sep 22 doi: 10.1016/j.actbio.2016.09.031. PMID: 27667018
Lascurain-Aguirrebeña I, Newham D, Critchley DJ
Spine (Phila Pa 1976) 2016 Jan;41(2):159-72. doi: 10.1097/BRS.0000000000001151. PMID: 26751060
Neidlinger-Wilke C, Galbusera F, Pratsinis H, Mavrogonatou E, Mietsch A, Kletsas D, Wilke HJ
Eur Spine J 2014 Jun;23 Suppl 3:S333-43. Epub 2013 Jun 21 doi: 10.1007/s00586-013-2855-9. PMID: 23793454

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