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Wasting Disease, Chronic

MedGen UID:
211688
Concept ID:
C1135993
Disease or Syndrome
Synonyms: Chronic Wasting Disease
 

Definition

A transmissible spongiform encephalopathy (prion disease) of DEER and elk characterized by chronic weight loss leading to death. It is thought to spread by direct contact between animals or through environmental contamination with the prion protein (PRIONS). [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVWasting Disease, Chronic

Recent clinical studies

Etiology

Kurt TD, Sigurdson CJ
Prion 2016;10(1):83-91. doi: 10.1080/19336896.2015.1118603. PMID: 26809254Free PMC Article
Kurt TD, Jiang L, Fernández-Borges N, Bett C, Liu J, Yang T, Spraker TR, Castilla J, Eisenberg D, Kong Q, Sigurdson CJ
J Clin Invest 2015 Apr;125(4):1485-96. Epub 2015 Feb 23 doi: 10.1172/JCI79408. PMID: 25705888Free PMC Article
Olszowy KM, Lavelle J, Rachfal K, Hempstead S, Drouin K, Darcy JM 2nd, Reiber C, Garruto RM
Public Health 2014 Sep;128(9):860-8. Epub 2014 Sep 13 doi: 10.1016/j.puhe.2014.06.012. PMID: 25225155
Magle SB, Samuel MD, Van Deelen TR, Robinson SJ, Mathews NE
PLoS One 2013;8(2):e56568. Epub 2013 Feb 20 doi: 10.1371/journal.pone.0056568. PMID: 23437171Free PMC Article
Wilson R, Plinston C, Hunter N, Casalone C, Corona C, Tagliavini F, Suardi S, Ruggerone M, Moda F, Graziano S, Sbriccoli M, Cardone F, Pocchiari M, Ingrosso L, Baron T, Richt J, Andreoletti O, Simmons M, Lockey R, Manson JC, Barron RM
J Gen Virol 2012 Jul;93(Pt 7):1624-9. Epub 2012 Apr 11 doi: 10.1099/vir.0.042507-0. PMID: 22495232

Diagnosis

Potapov A, Merrill E, Pybus M, Lewis MA
PLoS One 2015;10(10):e0140024. Epub 2015 Oct 9 doi: 10.1371/journal.pone.0140024. PMID: 26452231Free PMC Article
Daus ML, Beekes M
Prion 2012 Jan-Mar;6(1):17-22. doi: 10.4161/pri.6.1.17776. PMID: 22453172Free PMC Article
Gilch S, Chitoor N, Taguchi Y, Stuart M, Jewell JE, Schätzl HM
Top Curr Chem 2011;305:51-77. doi: 10.1007/128_2011_159. PMID: 21598099
Race B, Meade-White KD, Miller MW, Barbian KD, Rubenstein R, LaFauci G, Cervenakova L, Favara C, Gardner D, Long D, Parnell M, Striebel J, Priola SA, Ward A, Williams ES, Race R, Chesebro B
Emerg Infect Dis 2009 Sep;15(9):1366-76. doi: 10.3201/eid1509.090253. PMID: 19788803Free PMC Article
Prcina M, Bardon J, Kontseková E
Acta Virol 2008;52(4):209-18. PMID: 19143476

Therapy

Wisniewski T, Goñi F
Expert Rev Anti Infect Ther 2012 Mar;10(3):307-17. doi: 10.1586/eri.11.177. PMID: 22397565Free PMC Article
Li L, Napper S, Cashman NR
Immunotherapy 2010 Mar;2(2):269-82. doi: 10.2217/imt.10.3. PMID: 20635933
Angers RC, Browning SR, Seward TS, Sigurdson CJ, Miller MW, Hoover EA, Telling GC
Science 2006 Feb 24;311(5764):1117. Epub 2006 Jan 26 doi: 10.1126/science.1122864. PMID: 16439622
Belay ED, Schonberger LB
Annu Rev Public Health 2005;26:191-212. doi: 10.1146/annurev.publhealth.26.021304.144536. PMID: 15760286
Donnelly CA
N Engl J Med 2004 Feb 5;350(6):539-42. doi: 10.1056/NEJMp038005. PMID: 14762179

Prognosis

Olszowy KM, Lavelle J, Rachfal K, Hempstead S, Drouin K, Darcy JM 2nd, Reiber C, Garruto RM
Public Health 2014 Sep;128(9):860-8. Epub 2014 Sep 13 doi: 10.1016/j.puhe.2014.06.012. PMID: 25225155
Vaske JJ, Lyon KM
Risk Anal 2011 Mar;31(3):488-96. Epub 2010 Oct 6 doi: 10.1111/j.1539-6924.2010.01514.x. PMID: 21039704
Kong Q, Huang S, Zou W, Vanegas D, Wang M, Wu D, Yuan J, Zheng M, Bai H, Deng H, Chen K, Jenny AL, O'Rourke K, Belay ED, Schonberger LB, Petersen RB, Sy MS, Chen SG, Gambetti P
J Neurosci 2005 Aug 31;25(35):7944-9. doi: 10.1523/JNEUROSCI.2467-05.2005. PMID: 16135751
Hoey J
CMAJ 2003 Sep 2;169(5):443. PMID: 12952807Free PMC Article
JAMA 2003 Mar 19;289(11):1369-71. PMID: 12636441

Clinical prediction guides

Zimmer N, Boxall PC, Adamowicz WL
J Toxicol Environ Health A 2011;74(22-24):1621-35. doi: 10.1080/15287394.2011.618988. PMID: 22043918
Vaske JJ, Lyon KM
Risk Anal 2011 Mar;31(3):488-96. Epub 2010 Oct 6 doi: 10.1111/j.1539-6924.2010.01514.x. PMID: 21039704
Sandberg MK, Al-Doujaily H, Sigurdson CJ, Glatzel M, O'Malley C, Powell C, Asante EA, Linehan JM, Brandner S, Wadsworth JD, Collinge J
J Gen Virol 2010 Oct;91(Pt 10):2651-7. Epub 2010 Jul 7 doi: 10.1099/vir.0.024380-0. PMID: 20610667Free PMC Article
Miller MW, Williams ES
Curr Top Microbiol Immunol 2004;284:193-214. PMID: 15148993
Safar JG, Scott M, Monaghan J, Deering C, Didorenko S, Vergara J, Ball H, Legname G, Leclerc E, Solforosi L, Serban H, Groth D, Burton DR, Prusiner SB, Williamson RA
Nat Biotechnol 2002 Nov;20(11):1147-50. Epub 2002 Oct 21 doi: 10.1038/nbt748. PMID: 12389035

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