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Abnormal liver enzyme activity or concentration

MedGen UID:
1842083
•Concept ID:
C5826587
•
Finding
Synonym: Abnormal hepatic enzyme activity or concentration
 
HPO: HP:0034685

Definition

Concentration or activity of an enzyme is above or below the limits of normal in liver tissue. [from HPO]

Professional guidelines

PubMed

Continuous glucose monitoring and metrics for clinical trials: an international consensus statement.
Battelino T, Alexander CM, Amiel SA, Arreaza-Rubin G, Beck RW, Bergenstal RM, Buckingham BA, Carroll J, Ceriello A, Chow E, Choudhary P, Close K, Danne T, Dutta S, Gabbay R, Garg S, Heverly J, Hirsch IB, Kader T, Kenney J, Kovatchev B, Laffel L, Maahs D, Mathieu C, Mauricio D, Nimri R, Nishimura R, Scharf M, Del Prato S, Renard E, Rosenstock J, Saboo B, Ueki K, Umpierrez GE, Weinzimer SA, Phillip M
Lancet Diabetes Endocrinol 2023 Jan;11(1):42-57. Epub 2022 Dec 6 doi: 10.1016/S2213-8587(22)00319-9. PMID: 36493795
Lipoprotein(a) in atherosclerotic cardiovascular disease and aortic stenosis: a European Atherosclerosis Society consensus statement.
Kronenberg F, Mora S, Stroes ESG, Ference BA, Arsenault BJ, Berglund L, Dweck MR, Koschinsky M, Lambert G, Mach F, McNeal CJ, Moriarty PM, Natarajan P, Nordestgaard BG, Parhofer KG, Virani SS, von Eckardstein A, Watts GF, Stock JK, Ray KK, Tokgözoğlu LS, Catapano AL
Eur Heart J 2022 Oct 14;43(39):3925-3946. doi: 10.1093/eurheartj/ehac361. PMID: 36036785Free PMC Article
Clinical practice guideline on diagnosis and treatment of hyponatraemia.
Spasovski G, Vanholder R, Allolio B, Annane D, Ball S, Bichet D, Decaux G, Fenske W, Hoorn EJ, Ichai C, Joannidis M, Soupart A, Zietse R, Haller M, van der Veer S, Van Biesen W, Nagler E; Hyponatraemia Guideline Development Group
Eur J Endocrinol 2014 Mar;170(3):G1-47. Epub 2014 Feb 25 doi: 10.1530/EJE-13-1020. PMID: 24569125

Recent clinical studies

Etiology

International consensus guidelines for phosphoglucomutase 1 deficiency (PGM1-CDG): Diagnosis, follow-up, and management.
Altassan R, Radenkovic S, Edmondson AC, Barone R, Brasil S, Cechova A, Coman D, Donoghue S, Falkenstein K, Ferreira V, Ferreira C, Fiumara A, Francisco R, Freeze H, Grunewald S, Honzik T, Jaeken J, Krasnewich D, Lam C, Lee J, Lefeber D, Marques-da-Silva D, Pascoal C, Quelhas D, Raymond KM, Rymen D, Seroczynska M, Serrano M, Sykut-Cegielska J, Thiel C, Tort F, Vals MA, Videira P, Voermans N, Witters P, Morava E
J Inherit Metab Dis 2021 Jan;44(1):148-163. Epub 2020 Sep 15 doi: 10.1002/jimd.12286. PMID: 32681750Free PMC Article
The interplay between thyroid and liver: implications for clinical practice.
Piantanida E, Ippolito S, Gallo D, Masiello E, Premoli P, Cusini C, Rosetti S, Sabatino J, Segato S, Trimarchi F, Bartalena L, Tanda ML
J Endocrinol Invest 2020 Jul;43(7):885-899. Epub 2020 Mar 12 doi: 10.1007/s40618-020-01208-6. PMID: 32166702
A Practical Guide for Treatment of Rapidly Progressive ADPKD with Tolvaptan.
Chebib FT, Perrone RD, Chapman AB, Dahl NK, Harris PC, Mrug M, Mustafa RA, Rastogi A, Watnick T, Yu ASL, Torres VE
J Am Soc Nephrol 2018 Oct;29(10):2458-2470. Epub 2018 Sep 18 doi: 10.1681/ASN.2018060590. PMID: 30228150Free PMC Article
The interpretation and management of abnormal liver function tests.
Simpson MA, Freshwater DA
J R Nav Med Serv 2015;101(1):74-9. PMID: 26292397
Adverse effects of creatine supplementation: fact or fiction?
Poortmans JR, Francaux M
Sports Med 2000 Sep;30(3):155-70. doi: 10.2165/00007256-200030030-00002. PMID: 10999421

Diagnosis

International consensus guidelines for phosphoglucomutase 1 deficiency (PGM1-CDG): Diagnosis, follow-up, and management.
Altassan R, Radenkovic S, Edmondson AC, Barone R, Brasil S, Cechova A, Coman D, Donoghue S, Falkenstein K, Ferreira V, Ferreira C, Fiumara A, Francisco R, Freeze H, Grunewald S, Honzik T, Jaeken J, Krasnewich D, Lam C, Lee J, Lefeber D, Marques-da-Silva D, Pascoal C, Quelhas D, Raymond KM, Rymen D, Seroczynska M, Serrano M, Sykut-Cegielska J, Thiel C, Tort F, Vals MA, Videira P, Voermans N, Witters P, Morava E
J Inherit Metab Dis 2021 Jan;44(1):148-163. Epub 2020 Sep 15 doi: 10.1002/jimd.12286. PMID: 32681750Free PMC Article
A Practical Guide for Treatment of Rapidly Progressive ADPKD with Tolvaptan.
Chebib FT, Perrone RD, Chapman AB, Dahl NK, Harris PC, Mrug M, Mustafa RA, Rastogi A, Watnick T, Yu ASL, Torres VE
J Am Soc Nephrol 2018 Oct;29(10):2458-2470. Epub 2018 Sep 18 doi: 10.1681/ASN.2018060590. PMID: 30228150Free PMC Article
The interpretation and management of abnormal liver function tests.
Simpson MA, Freshwater DA
J R Nav Med Serv 2015;101(1):74-9. PMID: 26292397
Liver enzyme alteration: a guide for clinicians.
Giannini EG, Testa R, Savarino V
CMAJ 2005 Feb 1;172(3):367-79. doi: 10.1503/cmaj.1040752. PMID: 15684121Free PMC Article
Riboflavin metabolism.
Rivlin RS
N Engl J Med 1970 Aug 27;283(9):463-72. doi: 10.1056/NEJM197008272830906. PMID: 4915004

Therapy

A Practical Guide for Treatment of Rapidly Progressive ADPKD with Tolvaptan.
Chebib FT, Perrone RD, Chapman AB, Dahl NK, Harris PC, Mrug M, Mustafa RA, Rastogi A, Watnick T, Yu ASL, Torres VE
J Am Soc Nephrol 2018 Oct;29(10):2458-2470. Epub 2018 Sep 18 doi: 10.1681/ASN.2018060590. PMID: 30228150Free PMC Article
New drug development in childhood cancer.
Kearns P, Morland B
Curr Opin Pediatr 2014 Feb;26(1):37-42. doi: 10.1097/MOP.0000000000000054. PMID: 24362409
Liver dysfunction in Turner syndrome and its relationship to exogenous oestrogen.
Lee MC, Conway GS
Eur J Gastroenterol Hepatol 2013 Oct;25(10):1141-5. doi: 10.1097/MEG.0b013e3283614b75. PMID: 23603786
Adverse effects of creatine supplementation: fact or fiction?
Poortmans JR, Francaux M
Sports Med 2000 Sep;30(3):155-70. doi: 10.2165/00007256-200030030-00002. PMID: 10999421
Vitamin neurotoxicity.
Snodgrass SR
Mol Neurobiol 1992 Spring;6(1):41-73. doi: 10.1007/BF02935566. PMID: 1463588

Prognosis

Thyroid Storm: A Japanese Perspective.
Akamizu T
Thyroid 2018 Jan;28(1):32-40. Epub 2017 Oct 5 doi: 10.1089/thy.2017.0243. PMID: 28899229Free PMC Article
Disease manifestations and burden of illness in patients with acid sphingomyelinase deficiency (ASMD).
McGovern MM, Avetisyan R, Sanson BJ, Lidove O
Orphanet J Rare Dis 2017 Feb 23;12(1):41. doi: 10.1186/s13023-017-0572-x. PMID: 28228103Free PMC Article
Hemochromatosis.
Powell LW, Yapp TR
Clin Liver Dis 2000 Feb;4(1):211-28, viii. doi: 10.1016/s1089-3261(05)70104-5. PMID: 11232185
Vitamin neurotoxicity.
Snodgrass SR
Mol Neurobiol 1992 Spring;6(1):41-73. doi: 10.1007/BF02935566. PMID: 1463588
Long-term methotrexate therapy for rheumatoid arthritis.
Scully CJ, Anderson CJ, Cannon GW
Semin Arthritis Rheum 1991 Apr;20(5):317-31. doi: 10.1016/0049-0172(91)90032-u. PMID: 2068577

Clinical prediction guides

The interplay between thyroid and liver: implications for clinical practice.
Piantanida E, Ippolito S, Gallo D, Masiello E, Premoli P, Cusini C, Rosetti S, Sabatino J, Segato S, Trimarchi F, Bartalena L, Tanda ML
J Endocrinol Invest 2020 Jul;43(7):885-899. Epub 2020 Mar 12 doi: 10.1007/s40618-020-01208-6. PMID: 32166702
Gas chromatography-olfactometry.
Delahunty CM, Eyres G, Dufour JP
J Sep Sci 2006 Sep;29(14):2107-25. doi: 10.1002/jssc.200500509. PMID: 17069240
Inborn error of amino acid synthesis: human glutamine synthetase deficiency.
Häberle J, Görg B, Toutain A, Rutsch F, Benoist JF, Gelot A, Suc AL, Koch HG, Schliess F, Häussinger D
J Inherit Metab Dis 2006 Apr-Jun;29(2-3):352-8. doi: 10.1007/s10545-006-0256-5. PMID: 16763901
Measurement of observer agreement.
Kundel HL, Polansky M
Radiology 2003 Aug;228(2):303-8. Epub 2003 Jun 20 doi: 10.1148/radiol.2282011860. PMID: 12819342
Vitamin neurotoxicity.
Snodgrass SR
Mol Neurobiol 1992 Spring;6(1):41-73. doi: 10.1007/BF02935566. PMID: 1463588

Recent systematic reviews

Patients With Knee Osteoarthritis Who Receive Platelet-Rich Plasma or Bone Marrow Aspirate Concentrate Injections Have Better Outcomes Than Patients Who Receive Hyaluronic Acid: Systematic Review and Meta-analysis.
Belk JW, Lim JJ, Keeter C, McCulloch PC, Houck DA, McCarty EC, Frank RM, Kraeutler MJ
Arthroscopy 2023 Jul;39(7):1714-1734. Epub 2023 Mar 11 doi: 10.1016/j.arthro.2023.03.001. PMID: 36913992
Risk factors for postpartum depression: An evidence-based systematic review of systematic reviews and meta-analyses.
Zhao XH, Zhang ZH
Asian J Psychiatr 2020 Oct;53:102353. Epub 2020 Aug 30 doi: 10.1016/j.ajp.2020.102353. PMID: 32927309
Efficacy of chlorhexidine rinses after periodontal or implant surgery: a systematic review.
Solderer A, Kaufmann M, Hofer D, Wiedemeier D, Attin T, Schmidlin PR
Clin Oral Investig 2019 Jan;23(1):21-32. Epub 2018 Dec 7 doi: 10.1007/s00784-018-2761-y. PMID: 30535817
Radiological intervention of the hand and wrist.
Chopra A, Rowbotham EL, Grainger AJ
Br J Radiol 2016;89(1057):20150373. Epub 2015 Sep 23 doi: 10.1259/bjr.20150373. PMID: 26313500Free PMC Article
Lithium toxicity profile: a systematic review and meta-analysis.
McKnight RF, Adida M, Budge K, Stockton S, Goodwin GM, Geddes JR
Lancet 2012 Feb 25;379(9817):721-8. Epub 2012 Jan 20 doi: 10.1016/S0140-6736(11)61516-X. PMID: 22265699

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