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Opportunistic infection

MedGen UID:
18177
Concept ID:
C0029118
Disease or Syndrome
Synonyms: Infection, Opportunistic; Infections, Opportunistic; Opportunistic Infection; Opportunistic Infections
SNOMED CT: Opportunistic infectious disease (61274003)
 
HPO: HP:0031690

Definition

An infection that is caused by a pathogen that would generally not be able to cause an infection in a host with a normal immune system. Such pathogens take advantage of the opportunity, so to speak, that is provided by a weakened immune system. [from HPO]

Professional guidelines

PubMed

Cook LB, Fuji S, Hermine O, Bazarbachi A, Ramos JC, Ratner L, Horwitz S, Fields P, Tanase A, Bumbea H, Cwynarski K, Taylor G, Waldmann TA, Bittencourt A, Marcais A, Suarez F, Sibon D, Phillips A, Lunning M, Farid R, Imaizumi Y, Choi I, Ishida T, Ishitsuka K, Fukushima T, Uchimaru K, Takaori-Kondo A, Tokura Y, Utsunomiya A, Matsuoka M, Tsukasaki K, Watanabe T
J Clin Oncol 2019 Mar 10;37(8):677-687. Epub 2019 Jan 18 doi: 10.1200/JCO.18.00501. PMID: 30657736Free PMC Article
Kirchgesner J, Lemaitre M, Carrat F, Zureik M, Carbonnel F, Dray-Spira R
Gastroenterology 2018 Aug;155(2):337-346.e10. Epub 2018 Apr 12 doi: 10.1053/j.gastro.2018.04.012. PMID: 29655835
Bowen LN, Smith B, Reich D, Quezado M, Nath A
Nat Rev Neurol 2016 Oct 27;12(11):662-674. doi: 10.1038/nrneurol.2016.149. PMID: 27786246

Recent clinical studies

Etiology

Bingham A, Shrestha RK, Khurana N, Jacobson EU, Farnham PG
Sex Transm Dis 2021 Apr 1;48(4):299-304. doi: 10.1097/OLQ.0000000000001366. PMID: 33492100
Roberts MB, Fishman JA
Clin Infect Dis 2021 Oct 5;73(7):e1302-e1317. doi: 10.1093/cid/ciaa1189. PMID: 32803228Free PMC Article
Restrepo A, Clark NM; Infectious Diseases Community of Practice of the American Society of Transplantation
Clin Transplant 2019 Sep;33(9):e13509. Epub 2019 Mar 19 doi: 10.1111/ctr.13509. PMID: 30817024
Sedghizadeh PP, Mahabady S, Allen CM
Dent Clin North Am 2017 Apr;61(2):389-400. doi: 10.1016/j.cden.2016.12.007. PMID: 28317572Free PMC Article
Akpan A, Morgan R
Postgrad Med J 2002 Aug;78(922):455-9. doi: 10.1136/pmj.78.922.455. PMID: 12185216Free PMC Article

Diagnosis

Bingham A, Shrestha RK, Khurana N, Jacobson EU, Farnham PG
Sex Transm Dis 2021 Apr 1;48(4):299-304. doi: 10.1097/OLQ.0000000000001366. PMID: 33492100
Restrepo A, Clark NM; Infectious Diseases Community of Practice of the American Society of Transplantation
Clin Transplant 2019 Sep;33(9):e13509. Epub 2019 Mar 19 doi: 10.1111/ctr.13509. PMID: 30817024
Sedghizadeh PP, Mahabady S, Allen CM
Dent Clin North Am 2017 Apr;61(2):389-400. doi: 10.1016/j.cden.2016.12.007. PMID: 28317572Free PMC Article
Catherinot E, Lanternier F, Bougnoux ME, Lecuit M, Couderc LJ, Lortholary O
Infect Dis Clin North Am 2010 Mar;24(1):107-38. doi: 10.1016/j.idc.2009.10.010. PMID: 20171548
Akpan A, Morgan R
Postgrad Med J 2002 Aug;78(922):455-9. doi: 10.1136/pmj.78.922.455. PMID: 12185216Free PMC Article

Therapy

Boulware DR, Atukunda M, Kagimu E, Musubire AK, Akampurira A, Tugume L, Ssebambulidde K, Kasibante J, Nsangi L, Mugabi T, Gakuru J, Kimuda S, Kasozi D, Namombwe S, Turyasingura I, Rutakingirwa MK, Mpoza E, Kigozi E, Muzoora C, Ellis J, Skipper CP, Matkovits T, Williamson PR, Williams DA, Fieberg A, Hullsiek KH, Abassi M, Dai B, Meya DB
Clin Infect Dis 2023 Dec 15;77(12):1659-1667. doi: 10.1093/cid/ciad440. PMID: 37606364Free PMC Article
D'Haens G, Dubinsky M, Kobayashi T, Irving PM, Howaldt S, Pokrotnieks J, Krueger K, Laskowski J, Li X, Lissoos T, Milata J, Morris N, Arora V, Milch C, Sandborn W, Sands BE; LUCENT Study Group
N Engl J Med 2023 Jun 29;388(26):2444-2455. doi: 10.1056/NEJMoa2207940. PMID: 37379135
Roberts MB, Fishman JA
Clin Infect Dis 2021 Oct 5;73(7):e1302-e1317. doi: 10.1093/cid/ciaa1189. PMID: 32803228Free PMC Article
Restrepo A, Clark NM; Infectious Diseases Community of Practice of the American Society of Transplantation
Clin Transplant 2019 Sep;33(9):e13509. Epub 2019 Mar 19 doi: 10.1111/ctr.13509. PMID: 30817024
Akpan A, Morgan R
Postgrad Med J 2002 Aug;78(922):455-9. doi: 10.1136/pmj.78.922.455. PMID: 12185216Free PMC Article

Prognosis

Regueiro M, Siegmund B, Yarur AJ, Steinwurz F, Gecse KB, Goetsch M, Bhattacharjee A, Wu J, Green J, McDonnell A, Crosby C, Lazin K, Branquinho D, Modesto I, Abreu MT
J Crohns Colitis 2024 Oct 15;18(10):1596-1605. doi: 10.1093/ecco-jcc/jjae060. PMID: 38700040Free PMC Article
Saltiel G, Faure E, Assaf A, Chopin MC, Moreau F, Faure K, Goeminne C, Vuotto F
Clin Transplant 2024 May;38(5):e15327. doi: 10.1111/ctr.15327. PMID: 38686437
Makimoto K, Konno R, Kinoshita A, Kanzaki H, Suto S
JBI Evid Synth 2023 May 1;21(5):835-885. doi: 10.11124/JBIES-22-00048. PMID: 36630204
Fishman JA
Clin Microbiol Infect 2014 Sep;20 Suppl 7:4-9. doi: 10.1111/1469-0691.12593. PMID: 24528498
Kelly MN, Shellito JE
Future Microbiol 2010 Jan;5(1):43-65. doi: 10.2217/fmb.09.116. PMID: 20020829Free PMC Article

Clinical prediction guides

Hederman AP, Remmel CA, Sharma S, Natarajan H, Weiner JA, Wrapp D, Donner C, Delforge ML, d'Angelo P, Furione M, Fornara C, McLellan JS, Lilleri D, Marchant A, Ackerman ME
J Clin Invest 2024 Oct 15;134(20) doi: 10.1172/JCI180560. PMID: 39207860Free PMC Article
Torres LK, Pickkers P, van der Poll T
Annu Rev Physiol 2022 Feb 10;84:157-181. Epub 2021 Oct 27 doi: 10.1146/annurev-physiol-061121-040214. PMID: 34705481
Bryant PA, Baddley JW
Rheum Dis Clin North Am 2017 Feb;43(1):27-41. Epub 2016 Oct 22 doi: 10.1016/j.rdc.2016.09.005. PMID: 27890172
Rechenberg DK, Galicia JC, Peters OA
PLoS One 2016;11(11):e0167289. Epub 2016 Nov 29 doi: 10.1371/journal.pone.0167289. PMID: 27898727Free PMC Article
Patz EF Jr, Goodman PC
J Thorac Imaging 1992 Sep;7(4):51-5. doi: 10.1097/00005382-199209000-00008. PMID: 1404545

Recent systematic reviews

Prosty C, Katergi K, Sorin M, Rjeily MB, Butler-Laporte G, McDonald EG, Lee TC
Clin Microbiol Infect 2024 Jul;30(7):866-876. Epub 2024 Apr 6 doi: 10.1016/j.cmi.2024.03.037. PMID: 38583518
Senécal J, Smyth E, Del Corpo O, Hsu JM, Amar-Zifkin A, Bergeron A, Cheng MP, Butler-Laporte G, McDonald EG, Lee TC
Clin Microbiol Infect 2022 Jan;28(1):23-30. Epub 2021 Aug 28 doi: 10.1016/j.cmi.2021.08.017. PMID: 34464734
Margalit I, Lebeaux D, Tishler O, Goldberg E, Bishara J, Yahav D, Coussement J
Clin Microbiol Infect 2021 Apr;27(4):550-558. Epub 2021 Jan 5 doi: 10.1016/j.cmi.2020.12.019. PMID: 33418019
Del Corpo O, Butler-Laporte G, Sheppard DC, Cheng MP, McDonald EG, Lee TC
Clin Microbiol Infect 2020 Sep;26(9):1137-1143. Epub 2020 May 30 doi: 10.1016/j.cmi.2020.05.024. PMID: 32479781
Rechenberg DK, Galicia JC, Peters OA
PLoS One 2016;11(11):e0167289. Epub 2016 Nov 29 doi: 10.1371/journal.pone.0167289. PMID: 27898727Free PMC Article

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