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AIDS related complex

MedGen UID:
1793
•Concept ID:
C0001857
•
Disease or Syndrome
Synonyms: AIDS Related Complex; AIDS-Related Complex; ARC; Complex, AIDS-Related; Lymphadenopathy Syndrome; Lymphadenopathy Syndromes; Syndrome, Lymphadenopathy; Syndromes, Lymphadenopathy
 
Monarch Initiative: MONDO:0005639

Definition

A prodromal phase of infection with the human immunodeficiency virus (HIV). Laboratory criteria separating aids-related complex (ARC) from aids include elevated or hyperactive B-cell humoral immune responses, compared to depressed or normal antibody reactivity in aids; follicular or mixed hyperplasia in arc lymph nodes, leading to lymphocyte degeneration and depletion more typical of aids; evolving succession of histopathological lesions such as localization of Kaposi's sarcoma, signaling the transition to the full-blown aids. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAIDS related complex

Professional guidelines

PubMed

Carotenoids in cancer, mastalgia, and AIDS: prevention and treatment--an overview.
Santamaria L, Bianchi-Santamaria A, dell'Orti M
J Environ Pathol Toxicol Oncol 1996;15(2-4):89-95. PMID: 9216791
Zidovudine toxicity. Clinical features and management.
Rachlis A, Fanning MM
Drug Saf 1993 Apr;8(4):312-20. doi: 10.2165/00002018-199308040-00005. PMID: 8481217
Thymostimulin treatment in AIDS-related complex.
Palmisano L, Chisesi T, Galli M, Gritti FM, Ielasi G, Lazzarin A, Mezzaroma I, Moroni M, Raise E, Vaglia A
Clin Immunol Immunopathol 1988 Jun;47(3):253-61. doi: 10.1016/s0090-1229(88)80003-5. PMID: 3259480

Recent clinical studies

Etiology

The changing face of HIV/AIDS in treated patients.
Llibre JM, Falco V, Tural C, Negredo E, Pineda JA, Muñoz J, Ortega E, Videla S, Sirera G, Martinez E, Miralles C, Iribarren J, Galindo MJ, Domingo P, d'Arminio-Monforte A, Miro JM, Clotet B
Curr HIV Res 2009 Jul;7(4):365-77. doi: 10.2174/157016209788680633. PMID: 19601771
AIDS and cerebrovascular disease.
Pinto AN
Stroke 1996 Mar;27(3):538-43. doi: 10.1161/01.str.27.3.538. PMID: 8610326
Pseudomonas infections in patients with AIDS and AIDS-related complex.
Franzetti F, Cernuschi M, Esposito R, Moroni M
J Intern Med 1992 Apr;231(4):437-43. doi: 10.1111/j.1365-2796.1992.tb00957.x. PMID: 1588272
AIDS Clinical Trials Group: phase I/II study of combination 2',3'-dideoxycytidine and zidovudine in patients with acquired immunodeficiency syndrome (AIDS) and advanced AIDS-related complex.
Meng TC, Fischl MA, Richman DD
Am J Med 1990 May 21;88(5B):27S-30S. doi: 10.1016/0002-9343(90)90419-e. PMID: 2159707
Fungal infections in patients with AIDS and AIDS-related complex.
Holmberg K, Meyer RD
Scand J Infect Dis 1986;18(3):179-92. doi: 10.3109/00365548609032326. PMID: 3526530

Diagnosis

Pregnancy and AIDS.
Henrion R
Hum Reprod 1988 Feb;3(2):257-62. doi: 10.1093/oxfordjournals.humrep.a136689. PMID: 3281969
AIDS.
Murphy RL, Phair JP
Compr Ther 1988 Jan;14(1):3-12. PMID: 3277764
AIDS-related lymphadenopathies.
Said JW
Semin Diagn Pathol 1988 Nov;5(4):365-75. PMID: 3064217
Generalized lymphadenopathy.
Libman H
J Gen Intern Med 1987 Jan-Feb;2(1):48-58. doi: 10.1007/BF02596251. PMID: 3543267
Fungal infections in patients with AIDS and AIDS-related complex.
Holmberg K, Meyer RD
Scand J Infect Dis 1986;18(3):179-92. doi: 10.3109/00365548609032326. PMID: 3526530

Therapy

Metabolism of Zidovudine.
Veal GJ, Back DJ
Gen Pharmacol 1995 Nov;26(7):1469-75. doi: 10.1016/0306-3623(95)00047-x. PMID: 8690233
Zidovudine (Retrovir) update.
Rachlis AR
CMAJ 1990 Dec 1;143(11):1177-85. PMID: 2224694Free PMC Article
Zidovudine intolerance.
Groopman JE
Rev Infect Dis 1990 Jul-Aug;12 Suppl 5:S500-6. doi: 10.1093/clinids/12.supplement_5.s500. PMID: 2201071
Zidovudine update: 1990.
Morse GD, Lechner JL, Santora JA, Rozek SL
DICP 1990 Jul-Aug;24(7-8):754-60. doi: 10.1177/106002809002400720. PMID: 2197818
Odynophagia/dysphagia in AIDS.
Raufman JP
Gastroenterol Clin North Am 1988 Sep;17(3):599-614. PMID: 3049365

Prognosis

HIV/AIDS-related hyponatremia: an old but still serious problem.
Shu Z, Tian Z, Chen J, Ma J, Abudureyimu A, Qian Q, Zhuo L
Ren Fail 2018 Nov;40(1):68-74. doi: 10.1080/0886022X.2017.1419975. PMID: 29299949Free PMC Article
AIDS.
Murphy RL, Phair JP
Compr Ther 1988 Jan;14(1):3-12. PMID: 3277764
AIDS-related lymphadenopathies.
Said JW
Semin Diagn Pathol 1988 Nov;5(4):365-75. PMID: 3064217
Immune pathogenesis of AIDS and related syndromes.
Fahey JL, Giorgi J, Martínez-Maza O, Detels R, Mitsuyasu R, Taylor J
Ann Inst Pasteur Immunol 1987 Mar-Apr;138(2):245-52. doi: 10.1016/s0769-2625(87)80075-2. PMID: 2955795
Acquired immune deficiency syndrome: review.
Scully C, Cawson RA, Porter SR
Br Dent J 1986 Jul 19;161(2):53-60. doi: 10.1038/sj.bdj.4805895. PMID: 3524629

Clinical prediction guides

Pathology of AIDS in children.
Joshi VV
Indian J Pediatr 1994 Sep-Oct;61(5):497-512. doi: 10.1007/BF02751710. PMID: 7744451
The effects of HIV on hematopoiesis.
Calenda V, Chermann JC
Eur J Haematol 1992 Apr;48(4):181-6. doi: 10.1111/j.1600-0609.1992.tb01582.x. PMID: 1592096
Pregnancy and AIDS.
Henrion R
Hum Reprod 1988 Feb;3(2):257-62. doi: 10.1093/oxfordjournals.humrep.a136689. PMID: 3281969
AIDS-related lymphadenopathies.
Said JW
Semin Diagn Pathol 1988 Nov;5(4):365-75. PMID: 3064217
Histopathology and immunohistology of HTLV-III/LAV related lymphadenopathy and AIDS.
Biberfeld P, Ost A, Porwit A, Sandstedt B, Pallesen G, Böttiger B, Morfelt-Månsson L, Biberfeld G
Acta Pathol Microbiol Immunol Scand A 1987 Jan;95(1):47-65. doi: 10.1111/j.1699-0463.1987.tb00009_95a.x. PMID: 2435107

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