U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Increased level of N-acetylneuraminic acid in urine

MedGen UID:
1639053
•Concept ID:
C4703650
•
Finding
Synonyms: Increased level of NANA in urine; Increased level of Neu5Ac in urine; Increased urinary sialic acid
 
HPO: HP:0410156

Definition

An increase in the level of N-acetylneuraminic acid in the urine. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased level of N-acetylneuraminic acid in urine

Conditions with this feature

Sialuria
MedGen UID:
137980
•Concept ID:
C0342853
•
Disease or Syndrome
Sialuria is a rare inborn error of metabolism in which excessive free sialic acid is synthesized. Clinical features include hepatosplenomegaly, coarse facial features, and varying degrees of developmental delay (summary by Enns et al., 2001).
See: Condition Record
Sialuria

Recent clinical studies

Etiology

Free urinary sialic acid levels may be elevated in patients with pneumococcal sepsis.
Donoghue SE, Heath O, Pitt J, Hong KM, Fuller M, Smith J
Clin Chem Lab Med 2022 Oct 26;60(11):1855-1858. Epub 2022 Aug 25 doi: 10.1515/cclm-2022-0473. PMID: 36000484
Urinary Metabolites Diagnostic and Prognostic of Intrahepatic Cholangiocarcinoma.
Haznadar M, Diehl CM, Parker AL, Krausz KW, Bowman ED, Rabibhadana S, Forgues M, Bhudhisawasdi V, Gonzalez FJ, Mahidol C, Budhu A, Wang XW, Ruchirawat M, Harris CC
Cancer Epidemiol Biomarkers Prev 2019 Oct;28(10):1704-1711. Epub 2019 Jul 29 doi: 10.1158/1055-9965.EPI-19-0453. PMID: 31358519Free PMC Article
Urinary Metabolite Risk Biomarkers of Lung Cancer: A Prospective Cohort Study.
Haznadar M, Cai Q, Krausz KW, Bowman ED, Margono E, Noro R, Thompson MD, Mathé EA, Munro HM, Steinwandel MD, Gonzalez FJ, Blot WJ, Harris CC
Cancer Epidemiol Biomarkers Prev 2016 Jun;25(6):978-86. Epub 2016 Mar 24 doi: 10.1158/1055-9965.EPI-15-1191. PMID: 27013655Free PMC Article
Relationship between sialic acid and metabolic variables in Indian type 2 diabetic patients.
Nayak SB, Bhaktha G
Lipids Health Dis 2005 Aug 10;4:15. doi: 10.1186/1476-511X-4-15. PMID: 16092968Free PMC Article
Elevated serum and urine sialic acid levels in renal diseases.
Ozben T
Ann Clin Biochem 1991 Jan;28 ( Pt 1):44-8. doi: 10.1177/000456329102800107. PMID: 2024933

Diagnosis

Free urinary sialic acid levels may be elevated in patients with pneumococcal sepsis.
Donoghue SE, Heath O, Pitt J, Hong KM, Fuller M, Smith J
Clin Chem Lab Med 2022 Oct 26;60(11):1855-1858. Epub 2022 Aug 25 doi: 10.1515/cclm-2022-0473. PMID: 36000484
Urinary Metabolites Diagnostic and Prognostic of Intrahepatic Cholangiocarcinoma.
Haznadar M, Diehl CM, Parker AL, Krausz KW, Bowman ED, Rabibhadana S, Forgues M, Bhudhisawasdi V, Gonzalez FJ, Mahidol C, Budhu A, Wang XW, Ruchirawat M, Harris CC
Cancer Epidemiol Biomarkers Prev 2019 Oct;28(10):1704-1711. Epub 2019 Jul 29 doi: 10.1158/1055-9965.EPI-19-0453. PMID: 31358519Free PMC Article
Urinary Metabolite Risk Biomarkers of Lung Cancer: A Prospective Cohort Study.
Haznadar M, Cai Q, Krausz KW, Bowman ED, Margono E, Noro R, Thompson MD, Mathé EA, Munro HM, Steinwandel MD, Gonzalez FJ, Blot WJ, Harris CC
Cancer Epidemiol Biomarkers Prev 2016 Jun;25(6):978-86. Epub 2016 Mar 24 doi: 10.1158/1055-9965.EPI-15-1191. PMID: 27013655Free PMC Article
Characterization of sialic acid index of plasma apolipoprotein J and phosphatidylethanol during alcohol detoxification--a pilot study.
Wurst FM, Thon N, Weinmann W, Tippetts S, Marques P, Hahn JA, Alling C, Aradottir S, Hartmann S, Lakshman R
Alcohol Clin Exp Res 2012 Feb;36(2):251-7. Epub 2011 Sep 20 doi: 10.1111/j.1530-0277.2011.01618.x. PMID: 21933198
The urinary concentration of sialic acid is increased in non-insulin-dependent diabetic patients with microangiopathy: a possible useful marker for diabetic microangiopathy.
Suzuki K, Ishida H, Sugimoto C, Taguchi Y, Matsuda H, Nosaka K, Someya Y, Kadowaki S, Seino Y
Diabet Med 1995 Dec;12(12):1092-6. doi: 10.1111/j.1464-5491.1995.tb00426.x. PMID: 8750219

Therapy

Urinary excretion of sialic acid in patients with bladder tumors.
Konukoğlu D, Akçay T, Celik C, Erözenci A
Cancer Lett 1995 Jul 20;94(1):97-100. doi: 10.1016/0304-3835(95)03830-p. PMID: 7621452

Prognosis

Urinary Metabolites Diagnostic and Prognostic of Intrahepatic Cholangiocarcinoma.
Haznadar M, Diehl CM, Parker AL, Krausz KW, Bowman ED, Rabibhadana S, Forgues M, Bhudhisawasdi V, Gonzalez FJ, Mahidol C, Budhu A, Wang XW, Ruchirawat M, Harris CC
Cancer Epidemiol Biomarkers Prev 2019 Oct;28(10):1704-1711. Epub 2019 Jul 29 doi: 10.1158/1055-9965.EPI-19-0453. PMID: 31358519Free PMC Article
Relationship between sialic acid and metabolic variables in Indian type 2 diabetic patients.
Nayak SB, Bhaktha G
Lipids Health Dis 2005 Aug 10;4:15. doi: 10.1186/1476-511X-4-15. PMID: 16092968Free PMC Article
Serum sialic acid and the long-term complications of insulin-dependent diabetes mellitus.
Powrie JK, Watts GF, Crook MA, Ingham JN, Taub NA, Shaw KM
Diabet Med 1996 Mar;13(3):238-42. doi: 10.1002/(SICI)1096-9136(199603)13:3<238::AID-DIA29>3.0.CO;2-W. PMID: 8689844
Urinary excretion of sialic acid in patients with bladder tumors.
Konukoğlu D, Akçay T, Celik C, Erözenci A
Cancer Lett 1995 Jul 20;94(1):97-100. doi: 10.1016/0304-3835(95)03830-p. PMID: 7621452
Serum sialic acid, a risk factor for cardiovascular disease, is increased in IDDM patients with microalbuminuria and clinical proteinuria.
Crook MA, Earle K, Morocutti A, Yip J, Viberti G, Pickup JC
Diabetes Care 1994 Apr;17(4):305-10. doi: 10.2337/diacare.17.4.305. PMID: 8026286

Clinical prediction guides

Free urinary sialic acid levels may be elevated in patients with pneumococcal sepsis.
Donoghue SE, Heath O, Pitt J, Hong KM, Fuller M, Smith J
Clin Chem Lab Med 2022 Oct 26;60(11):1855-1858. Epub 2022 Aug 25 doi: 10.1515/cclm-2022-0473. PMID: 36000484
Urinary Metabolites Diagnostic and Prognostic of Intrahepatic Cholangiocarcinoma.
Haznadar M, Diehl CM, Parker AL, Krausz KW, Bowman ED, Rabibhadana S, Forgues M, Bhudhisawasdi V, Gonzalez FJ, Mahidol C, Budhu A, Wang XW, Ruchirawat M, Harris CC
Cancer Epidemiol Biomarkers Prev 2019 Oct;28(10):1704-1711. Epub 2019 Jul 29 doi: 10.1158/1055-9965.EPI-19-0453. PMID: 31358519Free PMC Article
Relationship between sialic acid and metabolic variables in Indian type 2 diabetic patients.
Nayak SB, Bhaktha G
Lipids Health Dis 2005 Aug 10;4:15. doi: 10.1186/1476-511X-4-15. PMID: 16092968Free PMC Article
Serum sialic acid and the long-term complications of insulin-dependent diabetes mellitus.
Powrie JK, Watts GF, Crook MA, Ingham JN, Taub NA, Shaw KM
Diabet Med 1996 Mar;13(3):238-42. doi: 10.1002/(SICI)1096-9136(199603)13:3<238::AID-DIA29>3.0.CO;2-W. PMID: 8689844
Serum sialic acid, a risk factor for cardiovascular disease, is increased in IDDM patients with microalbuminuria and clinical proteinuria.
Crook MA, Earle K, Morocutti A, Yip J, Viberti G, Pickup JC
Diabetes Care 1994 Apr;17(4):305-10. doi: 10.2337/diacare.17.4.305. PMID: 8026286

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...