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Pneumocystis infectious disease

MedGen UID:
163415
•Concept ID:
C0851886
•
Disease or Syndrome
Synonyms: Infection, Pneumocystis; Pneumocystis carinii Infections; Pneumocystis Infection; Pneumocystis Infections
 
Monarch Initiative: MONDO:0005923

Definition

Infections with species in the genus pneumocystis, a fungus causing interstitial plasma cell pneumonia (pneumonia, pneumocystis) and other infections in humans and other mammals. Immunocompromised patients, especially those with aids, are particularly susceptible to these infections. Extrapulmonary sites are rare but seen occasionally. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPneumocystis infectious disease

Professional guidelines

PubMed

HIV Infection in Adults: Initial Management.
Goldschmidt R, Chu C
Am Fam Physician 2021 Apr 1;103(7):407-416. PMID: 33788514
Management of HIV-infected patients in the intensive care unit.
Barbier F, Mer M, Szychowiak P, Miller RF, Mariotte É, Galicier L, Bouadma L, Tattevin P, Azoulay É
Intensive Care Med 2020 Feb;46(2):329-342. Epub 2020 Feb 3 doi: 10.1007/s00134-020-05945-3. PMID: 32016535Free PMC Article
The results of direct and indirect treatment comparisons in meta-analysis of randomized controlled trials.
Bucher HC, Guyatt GH, Griffith LE, Walter SD
J Clin Epidemiol 1997 Jun;50(6):683-91. doi: 10.1016/s0895-4356(97)00049-8. PMID: 9250266

Recent clinical studies

Etiology

Pneumocystis jirovecii pneumonia in people living with HIV: a review.
McDonald EG, Afshar A, Assiri B, Boyles T, Hsu JM, Khuong N, Prosty C, So M, Sohani ZN, Butler-Laporte G, Lee TC
Clin Microbiol Rev 2024 Mar 14;37(1):e0010122. Epub 2024 Jan 18 doi: 10.1128/cmr.00101-22. PMID: 38235979Free PMC Article
Risk Factors and Prevention of Pneumocystis jirovecii Pneumonia in Patients With Autoimmune and Inflammatory Diseases.
Ghembaza A, Vautier M, Cacoub P, Pourcher V, Saadoun D
Chest 2020 Dec;158(6):2323-2332. Epub 2020 Jun 2 doi: 10.1016/j.chest.2020.05.558. PMID: 32502592
Pneumocystis jiroveci.
Fishman JA
Semin Respir Crit Care Med 2020 Feb;41(1):141-157. Epub 2020 Jan 30 doi: 10.1055/s-0039-3399559. PMID: 32000290
Pneumocystis pneumonia in the twenty-first century: HIV-infected versus HIV-uninfected patients.
Cillóniz C, Dominedò C, Álvarez-Martínez MJ, Moreno A, García F, Torres A, Miro JM
Expert Rev Anti Infect Ther 2019 Oct;17(10):787-801. Epub 2019 Oct 4 doi: 10.1080/14787210.2019.1671823. PMID: 31550942
Clinical, Diagnostic, and Treatment Disparities between HIV-Infected and Non-HIV-Infected Immunocompromised Patients with Pneumocystis jirovecii Pneumonia.
Salzer HJF, Schäfer G, Hoenigl M, Günther G, Hoffmann C, Kalsdorf B, Alanio A, Lange C
Respiration 2018;96(1):52-65. Epub 2018 Apr 10 doi: 10.1159/000487713. PMID: 29635251

Diagnosis

Non-invasive diagnosis of Pneumocystis jirovecii pneumonia: a systematic review and meta-analysis.
Senécal J, Smyth E, Del Corpo O, Hsu JM, Amar-Zifkin A, Bergeron A, Cheng MP, Butler-Laporte G, McDonald EG, Lee TC
Clin Microbiol Infect 2022 Jan;28(1):23-30. Epub 2021 Aug 28 doi: 10.1016/j.cmi.2021.08.017. PMID: 34464734
Pneumocystis jiroveci.
Fishman JA
Semin Respir Crit Care Med 2020 Feb;41(1):141-157. Epub 2020 Jan 30 doi: 10.1055/s-0039-3399559. PMID: 32000290
Pneumocystis pneumonia in the twenty-first century: HIV-infected versus HIV-uninfected patients.
Cillóniz C, Dominedò C, Álvarez-Martínez MJ, Moreno A, García F, Torres A, Miro JM
Expert Rev Anti Infect Ther 2019 Oct;17(10):787-801. Epub 2019 Oct 4 doi: 10.1080/14787210.2019.1671823. PMID: 31550942
Molecular diagnosis of Pneumocystis pneumonia in immunocompromised patients.
Guegan H, Robert-Gangneux F
Curr Opin Infect Dis 2019 Aug;32(4):314-321. doi: 10.1097/QCO.0000000000000559. PMID: 31107250
Pneumocystis jirovecii Pneumonia.
Catherinot E, Lanternier F, Bougnoux ME, Lecuit M, Couderc LJ, Lortholary O
Infect Dis Clin North Am 2010 Mar;24(1):107-38. doi: 10.1016/j.idc.2009.10.010. PMID: 20171548

Therapy

Pneumocystis jirovecii pneumonia in people living with HIV: a review.
McDonald EG, Afshar A, Assiri B, Boyles T, Hsu JM, Khuong N, Prosty C, So M, Sohani ZN, Butler-Laporte G, Lee TC
Clin Microbiol Rev 2024 Mar 14;37(1):e0010122. Epub 2024 Jan 18 doi: 10.1128/cmr.00101-22. PMID: 38235979Free PMC Article
Risk Factors and Prevention of Pneumocystis jirovecii Pneumonia in Patients With Autoimmune and Inflammatory Diseases.
Ghembaza A, Vautier M, Cacoub P, Pourcher V, Saadoun D
Chest 2020 Dec;158(6):2323-2332. Epub 2020 Jun 2 doi: 10.1016/j.chest.2020.05.558. PMID: 32502592
Pneumocystis jiroveci.
Fishman JA
Semin Respir Crit Care Med 2020 Feb;41(1):141-157. Epub 2020 Jan 30 doi: 10.1055/s-0039-3399559. PMID: 32000290
Pneumocystis pneumonia in the twenty-first century: HIV-infected versus HIV-uninfected patients.
Cillóniz C, Dominedò C, Álvarez-Martínez MJ, Moreno A, García F, Torres A, Miro JM
Expert Rev Anti Infect Ther 2019 Oct;17(10):787-801. Epub 2019 Oct 4 doi: 10.1080/14787210.2019.1671823. PMID: 31550942
Clinical, Diagnostic, and Treatment Disparities between HIV-Infected and Non-HIV-Infected Immunocompromised Patients with Pneumocystis jirovecii Pneumonia.
Salzer HJF, Schäfer G, Hoenigl M, Günther G, Hoffmann C, Kalsdorf B, Alanio A, Lange C
Respiration 2018;96(1):52-65. Epub 2018 Apr 10 doi: 10.1159/000487713. PMID: 29635251

Prognosis

Risk Factors and Prevention of Pneumocystis jirovecii Pneumonia in Patients With Autoimmune and Inflammatory Diseases.
Ghembaza A, Vautier M, Cacoub P, Pourcher V, Saadoun D
Chest 2020 Dec;158(6):2323-2332. Epub 2020 Jun 2 doi: 10.1016/j.chest.2020.05.558. PMID: 32502592
Pneumocystis jiroveci.
Fishman JA
Semin Respir Crit Care Med 2020 Feb;41(1):141-157. Epub 2020 Jan 30 doi: 10.1055/s-0039-3399559. PMID: 32000290
Pneumocystis pneumonia in the twenty-first century: HIV-infected versus HIV-uninfected patients.
Cillóniz C, Dominedò C, Álvarez-Martínez MJ, Moreno A, García F, Torres A, Miro JM
Expert Rev Anti Infect Ther 2019 Oct;17(10):787-801. Epub 2019 Oct 4 doi: 10.1080/14787210.2019.1671823. PMID: 31550942
Molecular diagnosis of Pneumocystis pneumonia in immunocompromised patients.
Guegan H, Robert-Gangneux F
Curr Opin Infect Dis 2019 Aug;32(4):314-321. doi: 10.1097/QCO.0000000000000559. PMID: 31107250
Clinical, Diagnostic, and Treatment Disparities between HIV-Infected and Non-HIV-Infected Immunocompromised Patients with Pneumocystis jirovecii Pneumonia.
Salzer HJF, Schäfer G, Hoenigl M, Günther G, Hoffmann C, Kalsdorf B, Alanio A, Lange C
Respiration 2018;96(1):52-65. Epub 2018 Apr 10 doi: 10.1159/000487713. PMID: 29635251

Clinical prediction guides

Pneumocystis jirovecii pneumonia in people living with HIV: a review.
McDonald EG, Afshar A, Assiri B, Boyles T, Hsu JM, Khuong N, Prosty C, So M, Sohani ZN, Butler-Laporte G, Lee TC
Clin Microbiol Rev 2024 Mar 14;37(1):e0010122. Epub 2024 Jan 18 doi: 10.1128/cmr.00101-22. PMID: 38235979Free PMC Article
How to diagnose and treat a patient without human immunodeficiency virus infection having Pneumocystis jirovecii pneumonia?
Hänsel L, Schumacher J, Denis B, Hamane S, Cornely OA, Koehler P
Clin Microbiol Infect 2023 Aug;29(8):1015-1023. Epub 2023 Apr 20 doi: 10.1016/j.cmi.2023.04.015. PMID: 37086781
Risk Factors and Prevention of Pneumocystis jirovecii Pneumonia in Patients With Autoimmune and Inflammatory Diseases.
Ghembaza A, Vautier M, Cacoub P, Pourcher V, Saadoun D
Chest 2020 Dec;158(6):2323-2332. Epub 2020 Jun 2 doi: 10.1016/j.chest.2020.05.558. PMID: 32502592
Pneumocystis pneumonia in the twenty-first century: HIV-infected versus HIV-uninfected patients.
Cillóniz C, Dominedò C, Álvarez-Martínez MJ, Moreno A, García F, Torres A, Miro JM
Expert Rev Anti Infect Ther 2019 Oct;17(10):787-801. Epub 2019 Oct 4 doi: 10.1080/14787210.2019.1671823. PMID: 31550942
Molecular diagnosis of Pneumocystis pneumonia in immunocompromised patients.
Guegan H, Robert-Gangneux F
Curr Opin Infect Dis 2019 Aug;32(4):314-321. doi: 10.1097/QCO.0000000000000559. PMID: 31107250

Recent systematic reviews

Systematic literature review informing the 2022 EULAR recommendations for screening and prophylaxis of chronic and opportunistic infections in adults with autoimmune inflammatory rheumatic diseases.
Fragoulis GE, Dey M, Zhao S, Schoones J, Courvoisier D, Galloway J, Hyrich KL, Nikiphorou E
RMD Open 2022 Nov;8(2) doi: 10.1136/rmdopen-2022-002726. PMID: 36323488Free PMC Article
Non-invasive diagnosis of Pneumocystis jirovecii pneumonia: a systematic review and meta-analysis.
Senécal J, Smyth E, Del Corpo O, Hsu JM, Amar-Zifkin A, Bergeron A, Cheng MP, Butler-Laporte G, McDonald EG, Lee TC
Clin Microbiol Infect 2022 Jan;28(1):23-30. Epub 2021 Aug 28 doi: 10.1016/j.cmi.2021.08.017. PMID: 34464734
Ruxolitinib-associated infections: A systematic review and meta-analysis.
Lussana F, Cattaneo M, Rambaldi A, Squizzato A
Am J Hematol 2018 Mar;93(3):339-347. Epub 2017 Dec 4 doi: 10.1002/ajh.24976. PMID: 29150886
Burden of pneumocystis pneumonia in HIV-infected adults in sub-Saharan Africa: a systematic review and meta-analysis.
Wasserman S, Engel ME, Griesel R, Mendelson M
BMC Infect Dis 2016 Sep 9;16(1):482. doi: 10.1186/s12879-016-1809-3. PMID: 27612639Free PMC Article
Outbreaks and clustering of Pneumocystis pneumonia in kidney transplant recipients: a systematic review.
de Boer MG, de Fijter JW, Kroon FP
Med Mycol 2011 Oct;49(7):673-80. Epub 2011 Apr 1 doi: 10.3109/13693786.2011.571294. PMID: 21453224

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