U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Decreased VLDL cholesterol concentration

MedGen UID:
1625610
•Concept ID:
C4531249
•
Finding
Synonym: Decreased circulating very-low-density lipoprotein levels
 
HPO: HP:0031243

Definition

A reduction in the amount of very-low-density lipoprotein cholesterol in the blood. [from HPO]

Professional guidelines

PubMed

Contribution of ApoCIII to Diabetic Dyslipidemia and Treatment With Volanesorsen.
Zhang J, Rocha NA, McCullough PA
Rev Cardiovasc Med 2018 Mar 30;19(1):13-19. doi: 10.31083/j.rcm.2018.01.890. PMID: 31032598
The clinical relevance of omega-3 fatty acids in the management of hypertriglyceridemia.
Backes J, Anzalone D, Hilleman D, Catini J
Lipids Health Dis 2016 Jul 22;15(1):118. doi: 10.1186/s12944-016-0286-4. PMID: 27444154Free PMC Article
Treatment of diabetic dyslipidemia.
Garg A
Am J Cardiol 1998 Feb 26;81(4A):47B-51B. doi: 10.1016/s0002-9149(98)00038-1. PMID: 9526814

Recent clinical studies

Etiology

Icosapent ethyl therapy for very high triglyceride levels: a 12-week, multi-center, placebo-controlled, randomized, double-blinded, phase III clinical trial in China.
Wang Z, Zhang X, Qu Y, Zhang S, Chen Y, Chen X, Qi X, Liu P, Liu S, Jiang S, Man R, He L, Wu L, Li Z, Shang Y, Qiu Z, Liu F, Xu C, Lai C, Ge J
Lipids Health Dis 2023 Jun 10;22(1):71. doi: 10.1186/s12944-023-01838-8. PMID: 37301827Free PMC Article
The clinical relevance of omega-3 fatty acids in the management of hypertriglyceridemia.
Backes J, Anzalone D, Hilleman D, Catini J
Lipids Health Dis 2016 Jul 22;15(1):118. doi: 10.1186/s12944-016-0286-4. PMID: 27444154Free PMC Article
The composition and metabolism of large and small LDL.
Diffenderfer MR, Schaefer EJ
Curr Opin Lipidol 2014 Jun;25(3):221-6. doi: 10.1097/MOL.0000000000000067. PMID: 24811298
Treatment of diabetic dyslipidemia.
Garg A
Am J Cardiol 1998 Feb 26;81(4A):47B-51B. doi: 10.1016/s0002-9149(98)00038-1. PMID: 9526814
Lipoproteins and atherosclerosis.
Babiak J, Rudel LL
Baillieres Clin Endocrinol Metab 1987 Aug;1(3):515-50. doi: 10.1016/s0950-351x(87)80022-8. PMID: 3330421

Diagnosis

Effect of PCSK9 inhibition with evolocumab on lipoprotein subfractions in familial dysbetalipoproteinemia (type III hyperlipidemia).
Waldmann E, Wu L, Busygina K, Altenhofer J, Henze K, Folwaczny A, Parhofer KG
PLoS One 2022;17(3):e0265838. Epub 2022 Mar 23 doi: 10.1371/journal.pone.0265838. PMID: 35320320Free PMC Article
Quantifying the contribution of lipoprotein(a) to all apoB containing particles.
Chilazi M, Zheng W, Park J, Marvel FA, Khoury S, Jones SR, Martin SS
J Clin Lipidol 2022 Mar-Apr;16(2):220-226. Epub 2022 Feb 12 doi: 10.1016/j.jacl.2022.02.004. PMID: 35241398
Contribution of ApoCIII to Diabetic Dyslipidemia and Treatment With Volanesorsen.
Zhang J, Rocha NA, McCullough PA
Rev Cardiovasc Med 2018 Mar 30;19(1):13-19. doi: 10.31083/j.rcm.2018.01.890. PMID: 31032598
New dimension of statin action on ApoB atherogenicity.
Chapman MJ, Caslake M, Packard C, McTaggart F
Clin Cardiol 2003 Jan;26(1 Suppl 1):I7-10. doi: 10.1002/clc.4960261304. PMID: 12539816Free PMC Article
Dyslipidemia of the metabolic syndrome.
Ruotolo G, Howard BV
Curr Cardiol Rep 2002 Nov;4(6):494-500. doi: 10.1007/s11886-002-0113-6. PMID: 12379172

Therapy

Icosapent ethyl therapy for very high triglyceride levels: a 12-week, multi-center, placebo-controlled, randomized, double-blinded, phase III clinical trial in China.
Wang Z, Zhang X, Qu Y, Zhang S, Chen Y, Chen X, Qi X, Liu P, Liu S, Jiang S, Man R, He L, Wu L, Li Z, Shang Y, Qiu Z, Liu F, Xu C, Lai C, Ge J
Lipids Health Dis 2023 Jun 10;22(1):71. doi: 10.1186/s12944-023-01838-8. PMID: 37301827Free PMC Article
Effect of Evolocumab on Lipoprotein Particles.
Toth PP, Sattar N, Blom DJ, Martin SS, Jones SR, Monsalvo ML, Elliott M, Davis M, Somaratne R, Preiss D
Am J Cardiol 2018 Feb 1;121(3):308-314. Epub 2017 Nov 8 doi: 10.1016/j.amjcard.2017.10.028. PMID: 29221604
Recent explanatory trials of the mode of action of drug therapies on lipoprotein metabolism.
Chan DC, Barrett PH, Watts GF
Curr Opin Lipidol 2016 Dec;27(6):550-556. doi: 10.1097/MOL.0000000000000348. PMID: 27749370
Mechanism of action of niacin.
Kamanna VS, Kashyap ML
Am J Cardiol 2008 Apr 17;101(8A):20B-26B. doi: 10.1016/j.amjcard.2008.02.029. PMID: 18375237
Treatment of diabetic dyslipidemia.
Garg A
Am J Cardiol 1998 Feb 26;81(4A):47B-51B. doi: 10.1016/s0002-9149(98)00038-1. PMID: 9526814

Prognosis

Evolocumab Effects on Lipoproteins, Measured by High-Performance Liquid Chromatography.
Masuda D, Kiyosue A, Hirayama A, Shimauchi J, López JAG, Miyawaki K, Yamashita S
J Atheroscler Thromb 2020 Nov 1;27(11):1183-1207. Epub 2020 May 20 doi: 10.5551/jat.54353. PMID: 32435010Free PMC Article
VLDL Triglyceride Kinetics in Lean, Overweight, and Obese Men and Women.
Mittendorfer B, Yoshino M, Patterson BW, Klein S
J Clin Endocrinol Metab 2016 Nov;101(11):4151-4160. Epub 2016 Sep 2 doi: 10.1210/jc.2016-1500. PMID: 27588438Free PMC Article
Cholesterol esterification and atherogenic index of plasma correlate with lipoprotein size and findings on coronary angiography.
Dobiásová M, Frohlich J, Sedová M, Cheung MC, Brown BG
J Lipid Res 2011 Mar;52(3):566-71. Epub 2011 Jan 11 doi: 10.1194/jlr.P011668. PMID: 21224290Free PMC Article
High-density lipoprotein cholesterol and triglycerides as therapeutic targets for preventing and treating coronary artery disease.
Gotto AM Jr
Am Heart J 2002 Dec;144(6 Suppl):S33-42. doi: 10.1067/mhj.2002.130301. PMID: 12486414
Serum cholesterol and lipoprotein concentrations in mothers during and after prolonged exclusive lactation.
Kallio MJ, Siimes MA, Perheentupa J, Salmenperä L, Miettinen TA
Metabolism 1992 Dec;41(12):1327-30. doi: 10.1016/0026-0495(92)90103-h. PMID: 1461138

Clinical prediction guides

Inverse association between apolipoprotein C-II and cardiovascular mortality: role of lipoprotein lipase activity modulation.
Silbernagel G, Chen YQ, Rief M, Kleber ME, Hoffmann MM, Stojakovic T, Stang A, Sarzynski MA, Bouchard C, März W, Qian YW, Scharnagl H, Konrad RJ
Eur Heart J 2023 Jul 1;44(25):2335-2345. doi: 10.1093/eurheartj/ehad261. PMID: 37155355
Attenuation of obesity-induced hyperlipidemia reduces tumor growth.
Hussain A, Lian J, Watts R, Gutiérrez T, Nelson R, Goping IS, Lehner R
Biochim Biophys Acta Mol Cell Biol Lipids 2022 Apr;1867(4):159124. Epub 2022 Feb 9 doi: 10.1016/j.bbalip.2022.159124. PMID: 35150894
Lipoprotein metabolism and CKD: overview.
Barter P
Clin Exp Nephrol 2014 Apr;18(2):243-6. Epub 2013 Sep 20 doi: 10.1007/s10157-013-0866-9. PMID: 24052157
Phospholipid transfer protein.
van Tol A
Curr Opin Lipidol 2002 Apr;13(2):135-9. doi: 10.1097/00041433-200204000-00004. PMID: 11891415
Familial defective apolipoprotein B-100.
Hansen PS
Dan Med Bull 1998 Sep;45(4):370-82. PMID: 9777289

Recent systematic reviews

The effects of chromium supplementation on lipidprofile in humans: A systematic review and meta-analysis ofrandomized controlled trials.
Tarrahi MJ, Tarrahi MA, Rafiee M, Mansourian M
Pharmacol Res 2021 Feb;164:105308. Epub 2020 Nov 14 doi: 10.1016/j.phrs.2020.105308. PMID: 33197598
Effects of α-linolenic acid intake on blood lipid profiles：a systematic review and meta-analysis of randomized controlled trials.
Yue H, Qiu B, Jia M, Liu W, Guo XF, Li N, Xu ZX, Du FL, Xu T, Li D
Crit Rev Food Sci Nutr 2021;61(17):2894-2910. Epub 2020 Jul 9 doi: 10.1080/10408398.2020.1790496. PMID: 32643951
The Effects of L-Carnitine Supplementation on Serum Lipids: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Fathizadeh H, Milajerdi A, Reiner Ž, Kolahdooz F, Chamani M, Amirani E, Asemi Z
Curr Pharm Des 2019;25(30):3266-3281. doi: 10.2174/1381612825666190830154336. PMID: 31470778
Rice Bran Oil Decreases Total and LDL Cholesterol in Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials.
Jolfaie NR, Rouhani MH, Surkan PJ, Siassi F, Azadbakht L
Horm Metab Res 2016 Jul;48(7):417-26. Epub 2016 Jun 16 doi: 10.1055/s-0042-105748. PMID: 27311126
Effect of alpha linolenic acid on cardiovascular risk markers: a systematic review.
Wendland E, Farmer A, Glasziou P, Neil A
Heart 2006 Feb;92(2):166-9. Epub 2005 May 12 doi: 10.1136/hrt.2004.053538. PMID: 15890766Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...