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Embryo Loss

MedGen UID:
155754
•Concept ID:
C0752351
•
Pathologic Function

Definition

Early pregnancy loss during the EMBRYO, MAMMALIAN stage of development. In the human, this period comprises the second through eighth week after fertilization. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEmbryo Loss

Professional guidelines

PubMed

Preimplantation genetic testing for aneuploidy (PGT-A): The biology, the technology and the clinical outcomes.
Homer HA
Aust N Z J Obstet Gynaecol 2019 Apr;59(2):317-324. Epub 2019 Feb 27 doi: 10.1111/ajo.12960. PMID: 30811595
The impact of mitochondrial function/dysfunction on IVF and new treatment possibilities for infertility.
Schatten H, Sun QY, Prather R
Reprod Biol Endocrinol 2014 Nov 24;12:111. doi: 10.1186/1477-7827-12-111. PMID: 25421171Free PMC Article
Congenital urological anomalies diagnosed in adulthood - management considerations.
Halachmi S, Pillar G
J Pediatr Urol 2008 Feb;4(1):2-7. Epub 2007 Apr 27 doi: 10.1016/j.jpurol.2007.03.001. PMID: 18631884

Recent clinical studies

Etiology

Inheritance of paternal DNA damage by histone-mediated repair restriction.
Wang S, Meyer DH, Schumacher B
Nature 2023 Jan;613(7943):365-374. Epub 2022 Dec 21 doi: 10.1038/s41586-022-05544-w. PMID: 36544019Free PMC Article
A defective lysophosphatidic acid-autophagy axis increases miscarriage risk by restricting decidual macrophage residence.
Yang HL, Lai ZZ, Shi JW, Zhou WJ, Mei J, Ye JF, Zhang T, Wang J, Zhao JY, Li DJ, Li MQ
Autophagy 2022 Oct;18(10):2459-2480. Epub 2022 Feb 27 doi: 10.1080/15548627.2022.2039000. PMID: 35220880Free PMC Article
Testing, Monitoring, and Treatment of Thyroid Dysfunction in Pregnancy.
Lee SY, Pearce EN
J Clin Endocrinol Metab 2021 Mar 8;106(3):883-892. doi: 10.1210/clinem/dgaa945. PMID: 33349844Free PMC Article
Antiphospholipid syndrome.
Sammaritano LR
Best Pract Res Clin Rheumatol 2020 Feb;34(1):101463. Epub 2019 Dec 19 doi: 10.1016/j.berh.2019.101463. PMID: 31866276
Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair.
Ceccaldi R, Liu JC, Amunugama R, Hajdu I, Primack B, Petalcorin MI, O'Connor KW, Konstantinopoulos PA, Elledge SJ, Boulton SJ, Yusufzai T, D'Andrea AD
Nature 2015 Feb 12;518(7538):258-62. Epub 2015 Feb 2 doi: 10.1038/nature14184. PMID: 25642963Free PMC Article

Diagnosis

Should we stop screening for chronic endometritis?
Darici E, Blockeel C, Mackens S
Reprod Biomed Online 2023 Jan;46(1):3-5. Epub 2022 Jul 16 doi: 10.1016/j.rbmo.2022.07.008. PMID: 36075850
Testing, Monitoring, and Treatment of Thyroid Dysfunction in Pregnancy.
Lee SY, Pearce EN
J Clin Endocrinol Metab 2021 Mar 8;106(3):883-892. doi: 10.1210/clinem/dgaa945. PMID: 33349844Free PMC Article
Antiphospholipid syndrome.
Sammaritano LR
Best Pract Res Clin Rheumatol 2020 Feb;34(1):101463. Epub 2019 Dec 19 doi: 10.1016/j.berh.2019.101463. PMID: 31866276
Risk of miscarriage following amniocentesis or chorionic villus sampling: systematic review of literature and updated meta-analysis.
Salomon LJ, Sotiriadis A, Wulff CB, Odibo A, Akolekar R
Ultrasound Obstet Gynecol 2019 Oct;54(4):442-451. Epub 2019 Sep 6 doi: 10.1002/uog.20353. PMID: 31124209
Recurrent pregnancy loss: evaluation and treatment.
Shahine L, Lathi R
Obstet Gynecol Clin North Am 2015 Mar;42(1):117-34. doi: 10.1016/j.ogc.2014.10.002. PMID: 25681844

Therapy

Jiawei Shoutai Pill promotes decidualization by regulating the SGK1/ENaC pathway in recurrent spontaneous abortion.
Di X, Duan Z, Ma Y, Song X, Hao Y, Li G, Tan Z, Lou Y, Lin X
J Ethnopharmacol 2024 Jan 10;318(Pt A):116939. Epub 2023 Jul 20 doi: 10.1016/j.jep.2023.116939. PMID: 37479068
Hormonal Contraceptives and Post-fertilization Effects.
Calçada MMS, Alves AMR
Issues Law Med 2022 Spring;37(1):29-80. PMID: 36629790
Testing the endometrium: is there enough evidence to justify clinical use?
Rahmati M, Macklon N
Curr Opin Obstet Gynecol 2020 Jun;32(3):185-190. doi: 10.1097/GCO.0000000000000627. PMID: 32251094
Risk of miscarriage following amniocentesis or chorionic villus sampling: systematic review of literature and updated meta-analysis.
Salomon LJ, Sotiriadis A, Wulff CB, Odibo A, Akolekar R
Ultrasound Obstet Gynecol 2019 Oct;54(4):442-451. Epub 2019 Sep 6 doi: 10.1002/uog.20353. PMID: 31124209
Congenital Malformations Attributed to Prenatal Exposure to Cyclophosphamide.
Rengasamy P
Anticancer Agents Med Chem 2017;17(9):1211-1227. doi: 10.2174/1871520616666161206150421. PMID: 27924730

Prognosis

A metabolic signature for NADSYN1-dependent congenital NAD deficiency disorder.
Szot JO, Cuny H, Martin EM, Sheng DZ, Iyer K, Portelli S, Nguyen V, Gereis JM, Alankarage D, Chitayat D, Chong K, Wentzensen IM, Vincent-Delormé C, Lermine A, Burkitt-Wright E, Ji W, Jeffries L, Pais LS, Tan TY, Pitt J, Wise CA, Wright H, Andrews ID, Pruniski B, Grebe TA, Corsten-Janssen N, Bouman K, Poulton C, Prakash S, Keren B, Brown NJ, Hunter MF, Heath O, Lakhani SA, McDermott JH, Ascher DB, Chapman G, Bozon K, Dunwoodie SL
J Clin Invest 2024 Feb 15;134(4) doi: 10.1172/JCI174824. PMID: 38357931Free PMC Article
Detection of nonpregnant cows and potential embryo losses by color Doppler ultrasound and interferon-stimulated gene expression in grazing dairy cows.
Madoz LV, Lorenti SN, Rearte R, Quintero-Rodriguez L, Migliorisi AL, Jaureguiberry M, Gabler C, Drillich M, de la Sota RL
J Dairy Sci 2022 Aug;105(8):6973-6984. Epub 2022 Jul 2 doi: 10.3168/jds.2021-21171. PMID: 35787328
Diminished miR-374c-5p negatively regulates IL (interleukin)-6 in unexplained recurrent spontaneous abortion.
Zhao L, Han L, Hei G, Wei R, Zhang Z, Zhu X, Guo Q, Chu C, Fu X, Xu K, Li X
J Mol Med (Berl) 2022 Jul;100(7):1043-1056. Epub 2022 Jun 10 doi: 10.1007/s00109-022-02178-3. PMID: 35689099
Symposium review: Embryo survival-A genomic perspective of the other side of fertility.
Khatib H, Gross N
J Dairy Sci 2019 Apr;102(4):3744-3753. Epub 2018 Oct 4 doi: 10.3168/jds.2018-15252. PMID: 30293848
Recurrent pregnancy loss: evaluation and treatment.
Shahine L, Lathi R
Obstet Gynecol Clin North Am 2015 Mar;42(1):117-34. doi: 10.1016/j.ogc.2014.10.002. PMID: 25681844

Clinical prediction guides

A metabolic signature for NADSYN1-dependent congenital NAD deficiency disorder.
Szot JO, Cuny H, Martin EM, Sheng DZ, Iyer K, Portelli S, Nguyen V, Gereis JM, Alankarage D, Chitayat D, Chong K, Wentzensen IM, Vincent-Delormé C, Lermine A, Burkitt-Wright E, Ji W, Jeffries L, Pais LS, Tan TY, Pitt J, Wise CA, Wright H, Andrews ID, Pruniski B, Grebe TA, Corsten-Janssen N, Bouman K, Poulton C, Prakash S, Keren B, Brown NJ, Hunter MF, Heath O, Lakhani SA, McDermott JH, Ascher DB, Chapman G, Bozon K, Dunwoodie SL
J Clin Invest 2024 Feb 15;134(4) doi: 10.1172/JCI174824. PMID: 38357931Free PMC Article
Decidual macrophages derived NO downregulates PD-L1 in trophoblasts leading to decreased Treg cells in recurrent miscarriage.
Zhang Y, Wang H, Qiu P, Jiang J, Wu X, Mei J, Sun H
Front Immunol 2023;14:1180154. Epub 2023 Jul 14 doi: 10.3389/fimmu.2023.1180154. PMID: 37520550Free PMC Article
A defective lysophosphatidic acid-autophagy axis increases miscarriage risk by restricting decidual macrophage residence.
Yang HL, Lai ZZ, Shi JW, Zhou WJ, Mei J, Ye JF, Zhang T, Wang J, Zhao JY, Li DJ, Li MQ
Autophagy 2022 Oct;18(10):2459-2480. Epub 2022 Feb 27 doi: 10.1080/15548627.2022.2039000. PMID: 35220880Free PMC Article
Testing, Monitoring, and Treatment of Thyroid Dysfunction in Pregnancy.
Lee SY, Pearce EN
J Clin Endocrinol Metab 2021 Mar 8;106(3):883-892. doi: 10.1210/clinem/dgaa945. PMID: 33349844Free PMC Article
Rapamycin prevents spontaneous abortion by triggering decidual stromal cell autophagy-mediated NK cell residence.
Lu H, Yang HL, Zhou WJ, Lai ZZ, Qiu XM, Fu Q, Zhao JY, Wang J, Li DJ, Li MQ
Autophagy 2021 Sep;17(9):2511-2527. Epub 2020 Nov 1 doi: 10.1080/15548627.2020.1833515. PMID: 33030400Free PMC Article

Recent systematic reviews

Risk of miscarriage following amniocentesis or chorionic villus sampling: systematic review of literature and updated meta-analysis.
Salomon LJ, Sotiriadis A, Wulff CB, Odibo A, Akolekar R
Ultrasound Obstet Gynecol 2019 Oct;54(4):442-451. Epub 2019 Sep 6 doi: 10.1002/uog.20353. PMID: 31124209
Gap junction connexins in female reproductive organs: implications for women's reproductive health.
Winterhager E, Kidder GM
Hum Reprod Update 2015 May-Jun;21(3):340-52. Epub 2015 Feb 9 doi: 10.1093/humupd/dmv007. PMID: 25667189
Association between plasminogen activator inhibitor-1 gene polymorphisms and recurrent pregnancy loss: a systematic review and meta-analysis.
Chen H, Nie S, Lu M
Am J Reprod Immunol 2015 Apr;73(4):292-300. Epub 2014 Sep 24 doi: 10.1111/aji.12321. PMID: 25250948
Pregnancy loss after chorionic villus sampling and genetic amniocentesis in twin pregnancies: a systematic review.
Agarwal K, Alfirevic Z
Ultrasound Obstet Gynecol 2012 Aug;40(2):128-34. Epub 2012 Jul 13 doi: 10.1002/uog.10152. PMID: 22125091
Embryo cryopreservation: proposal for a new indicator of efficiency.
Prades M, Golmard JL, Schubert B, Poirot C
Fertil Steril 2011 Feb;95(2):577-82.e1-2. doi: 10.1016/j.fertnstert.2010.05.040. PMID: 20599194

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