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Mouse Leukemia

MedGen UID:
154558
•Concept ID:
C0596978
•
Neoplastic Process

Professional guidelines

PubMed

INA03: A Potent Transferrin-Competitive Antibody-Drug Conjugate against CD71 for Safer Acute Leukemia Treatment.
Bratti M, Stubbs E, Kolodych S, Souchet H, Kelly L, Merlin J, Marchal M, Castellano R, Josselin E, Pasquer H, Benajiba L, Puissant A, Koniev O, Collette Y, Belanger C, Hermine O, Monteiro RC, Launay P
Mol Cancer Ther 2024 Aug 1;23(8):1159-1175. doi: 10.1158/1535-7163.MCT-23-0548. PMID: 38641421
hiPSC-derived bone marrow milieu identifies a clinically actionable driver of niche-mediated treatment resistance in leukemia.
Pal D, Blair H, Parker J, Hockney S, Beckett M, Singh M, Tirtakusuma R, Nelson R, McNeill H, Angel SH, Wilson A, Nizami S, Nakjang S, Zhou P, Schwab C, Sinclair P, Russell LJ, Coxhead J, Halsey C, Allan JM, Harrison CJ, Moorman AV, Heidenreich O, Vormoor J
Cell Rep Med 2022 Aug 16;3(8):100717. doi: 10.1016/j.xcrm.2022.100717. PMID: 35977468Free PMC Article
Homoharringtonine synergy with oridonin in treatment of t(8; 21) acute myeloid leukemia.
Zhang W, Lu Y, Zhen T, Chen X, Zhang M, Liu P, Weng X, Chen B, Wang Y
Front Med 2019 Jun;13(3):388-397. Epub 2019 Jun 11 doi: 10.1007/s11684-018-0624-1. PMID: 30206768

Recent clinical studies

Etiology

Ozone alleviates MSU-induced acute gout pain via upregulating AMPK/GAS6/MerTK/SOCS3 signaling pathway.
Fan W, Liu C, Chen D, Xu C, Qi X, Zhang A, Zhu X, Liu Y, Wang L, Hao L, Liu WT, Hu L
J Transl Med 2023 Dec 8;21(1):890. doi: 10.1186/s12967-023-04769-1. PMID: 38066599Free PMC Article
Muramyl dipeptide CD10 monoclonal antibody immunoconjugates inhibited acute leukemia in nude mice.
Wang Y, Jin X, Sun Y, Zhao Y, Qu Z, Wang L, Sun L
Biosci Rep 2023 Apr 26;43(4) doi: 10.1042/BSR20222668. PMID: 37039042Free PMC Article
High expression of FLT3 is a risk factor in leukemia.
Cheng J, Qu L, Wang J, Cheng L, Wang Y
Mol Med Rep 2018 Feb;17(2):2885-2892. Epub 2017 Dec 8 doi: 10.3892/mmr.2017.8232. PMID: 29257272Free PMC Article
Tumor suppressors BTG1 and IKZF1 cooperate during mouse leukemia development and increase relapse risk in B-cell precursor acute lymphoblastic leukemia patients.
Scheijen B, Boer JM, Marke R, Tijchon E, van Ingen Schenau D, Waanders E, van Emst L, van der Meer LT, Pieters R, Escherich G, Horstmann MA, Sonneveld E, Venn N, Sutton R, Dalla-Pozza L, Kuiper RP, Hoogerbrugge PM, den Boer ML, van Leeuwen FN
Haematologica 2017 Mar;102(3):541-551. Epub 2016 Dec 15 doi: 10.3324/haematol.2016.153023. PMID: 27979924Free PMC Article
Hypoxia inducible factor (HIF)-2α accelerates disease progression in mouse models of leukemia and lymphoma but is not a poor prognosis factor in human AML.
Forristal CE, Brown AL, Helwani FM, Winkler IG, Nowlan B, Barbier V, Powell RJ, Engler GA, Diakiw SM, Zannettino AC, Martin S, Pattabiraman D, D'Andrea RJ, Lewis ID, Levesque JP
Leukemia 2015 Oct;29(10):2075-85. Epub 2015 Apr 29 doi: 10.1038/leu.2015.102. PMID: 25921247

Diagnosis

Dnmt3a loss and Idh2 neomorphic mutations mutually potentiate malignant hematopoiesis.
Zhang X, Wang X, Wang XQD, Su J, Putluri N, Zhou T, Qu Y, Jeong M, Guzman A, Rosas C, Huang Y, Sreekumar A, Li W, Goodell MA
Blood 2020 Mar 12;135(11):845-856. doi: 10.1182/blood.2019003330. PMID: 31932841Free PMC Article
Immunomodulatory Drugs Exert Anti-Leukemia Effects in Acute Myeloid Leukemia by Direct and Immunostimulatory Activities.
Le Roy A, Prébet T, Castellano R, Goubard A, Riccardi F, Fauriat C, Granjeaud S, Benyamine A, Castanier C, Orlanducci F, Ben Amara A, Pont F, Fournié JJ, Collette Y, Mege JL, Vey N, Olive D
Front Immunol 2018;9:977. Epub 2018 May 4 doi: 10.3389/fimmu.2018.00977. PMID: 29780393Free PMC Article
High expression of FLT3 is a risk factor in leukemia.
Cheng J, Qu L, Wang J, Cheng L, Wang Y
Mol Med Rep 2018 Feb;17(2):2885-2892. Epub 2017 Dec 8 doi: 10.3892/mmr.2017.8232. PMID: 29257272Free PMC Article
Establishment of mouse leukemia cell lines expressing human CD4/CCR5 using lentiviral vectors.
Li YJ, ZhuGe FY, Zeng CC, He JY, Tan N, Liang J
Virus Genes 2017 Apr;53(2):197-204. Epub 2016 Dec 28 doi: 10.1007/s11262-016-1423-x. PMID: 28028680
Potent and specific inhibitors of mammalian phosphoribosylpyrophosphate (PRPP) synthetase.
Willis RC, Nord LD, Fujitaki JM, Robins RK
Adv Enzyme Regul 1989;28:167-82. doi: 10.1016/0065-2571(89)90070-8. PMID: 2560324

Therapy

Ozone alleviates MSU-induced acute gout pain via upregulating AMPK/GAS6/MerTK/SOCS3 signaling pathway.
Fan W, Liu C, Chen D, Xu C, Qi X, Zhang A, Zhu X, Liu Y, Wang L, Hao L, Liu WT, Hu L
J Transl Med 2023 Dec 8;21(1):890. doi: 10.1186/s12967-023-04769-1. PMID: 38066599Free PMC Article
Combinational treatment of 5-fluorouracil and casticin induces apoptosis in mouse leukemia WEHI-3 cells in vitro.
Cheng ZY, Chueh FS, Peng SF, Lin CH, Kuo CL, Huang WW, Chen PY, Way TD, Chung JG
Environ Toxicol 2020 Sep;35(9):911-921. Epub 2020 Apr 9 doi: 10.1002/tox.22927. PMID: 32270916
Immunomodulatory Drugs Exert Anti-Leukemia Effects in Acute Myeloid Leukemia by Direct and Immunostimulatory Activities.
Le Roy A, Prébet T, Castellano R, Goubard A, Riccardi F, Fauriat C, Granjeaud S, Benyamine A, Castanier C, Orlanducci F, Ben Amara A, Pont F, Fournié JJ, Collette Y, Mege JL, Vey N, Olive D
Front Immunol 2018;9:977. Epub 2018 May 4 doi: 10.3389/fimmu.2018.00977. PMID: 29780393Free PMC Article
Antitumor and antiangiogenic active dendrimer/5-fluorouracil conjugates.
Lee SM, Bala YS, Lee WK, Jo NJ, Chung I
J Biomed Mater Res A 2013 Aug;101(8):2306-12. Epub 2013 Jan 27 doi: 10.1002/jbm.a.34529. PMID: 23355500
Tumor models for efficacy determination.
Teicher BA
Mol Cancer Ther 2006 Oct;5(10):2435-43. doi: 10.1158/1535-7163.MCT-06-0391. PMID: 17041086

Prognosis

Molecular pathogenesis of disease progression in MLL-rearranged AML.
Kotani S, Yoda A, Kon A, Kataoka K, Ochi Y, Shiozawa Y, Hirsch C, Takeda J, Ueno H, Yoshizato T, Yoshida K, Nakagawa MM, Nannya Y, Kakiuchi N, Yamauchi T, Aoki K, Shiraishi Y, Miyano S, Maeda T, Maciejewski JP, Takaori-Kondo A, Ogawa S, Makishima H
Leukemia 2019 Mar;33(3):612-624. Epub 2018 Sep 12 doi: 10.1038/s41375-018-0253-3. PMID: 30209403Free PMC Article
High expression of FLT3 is a risk factor in leukemia.
Cheng J, Qu L, Wang J, Cheng L, Wang Y
Mol Med Rep 2018 Feb;17(2):2885-2892. Epub 2017 Dec 8 doi: 10.3892/mmr.2017.8232. PMID: 29257272Free PMC Article
Tumor suppressors BTG1 and IKZF1 cooperate during mouse leukemia development and increase relapse risk in B-cell precursor acute lymphoblastic leukemia patients.
Scheijen B, Boer JM, Marke R, Tijchon E, van Ingen Schenau D, Waanders E, van Emst L, van der Meer LT, Pieters R, Escherich G, Horstmann MA, Sonneveld E, Venn N, Sutton R, Dalla-Pozza L, Kuiper RP, Hoogerbrugge PM, den Boer ML, van Leeuwen FN
Haematologica 2017 Mar;102(3):541-551. Epub 2016 Dec 15 doi: 10.3324/haematol.2016.153023. PMID: 27979924Free PMC Article
Functional interdependence of BRD4 and DOT1L in MLL leukemia.
Gilan O, Lam EY, Becher I, Lugo D, Cannizzaro E, Joberty G, Ward A, Wiese M, Fong CY, Ftouni S, Tyler D, Stanley K, MacPherson L, Weng CF, Chan YC, Ghisi M, Smil D, Carpenter C, Brown P, Garton N, Blewitt ME, Bannister AJ, Kouzarides T, Huntly BJ, Johnstone RW, Drewes G, Dawson SJ, Arrowsmith CH, Grandi P, Prinjha RK, Dawson MA
Nat Struct Mol Biol 2016 Jul;23(7):673-81. Epub 2016 Jun 13 doi: 10.1038/nsmb.3249. PMID: 27294782
Hypoxia inducible factor (HIF)-2α accelerates disease progression in mouse models of leukemia and lymphoma but is not a poor prognosis factor in human AML.
Forristal CE, Brown AL, Helwani FM, Winkler IG, Nowlan B, Barbier V, Powell RJ, Engler GA, Diakiw SM, Zannettino AC, Martin S, Pattabiraman D, D'Andrea RJ, Lewis ID, Levesque JP
Leukemia 2015 Oct;29(10):2075-85. Epub 2015 Apr 29 doi: 10.1038/leu.2015.102. PMID: 25921247

Clinical prediction guides

Inhibiting PRMT1 protects against CoNV by regulating macrophages through the FGF2/PI3K/Akt pathway.
Gao Y, Mao J, Zhang R, Deng Q, Wang Y, Pan Y, Liudi S, Wang Y, Fan X, Yang Y, Wan S
Eur J Pharmacol 2024 Aug 15;977:176673. Epub 2024 May 28 doi: 10.1016/j.ejphar.2024.176673. PMID: 38815785
Establishment of Transgenic Mouse Leukemia Cell Lines Expressing Human CD4/CCR5/CyclinT1 Infected with HIV-1.
Li YJ, Liang J, Cheng XY, Zhao LM, Zeng CC
Discov Med 2023 Apr 1;35(175):116-123. doi: 10.24976/Discov.Med.202335175.12. PMID: 37105922
Embryonic β-Catenin Is Required for Priming of the Uterus to Implantation.
Takezawa Y, Iwai M, Fujiki Y, Yokomizo R, Kishigami H, Miyado M, Kawano N, Yamada M, Shindo M, Suzuki M, Sato B, Katano D, Kamijo S, Hamatani T, Tanaka M, Umezawa A, Kang W, Miyado K
Lab Invest 2023 Mar;103(3):100026. Epub 2023 Jan 10 doi: 10.1016/j.labinv.2022.100026. PMID: 36925206
Dnmt3a loss and Idh2 neomorphic mutations mutually potentiate malignant hematopoiesis.
Zhang X, Wang X, Wang XQD, Su J, Putluri N, Zhou T, Qu Y, Jeong M, Guzman A, Rosas C, Huang Y, Sreekumar A, Li W, Goodell MA
Blood 2020 Mar 12;135(11):845-856. doi: 10.1182/blood.2019003330. PMID: 31932841Free PMC Article
Immunomodulatory Drugs Exert Anti-Leukemia Effects in Acute Myeloid Leukemia by Direct and Immunostimulatory Activities.
Le Roy A, Prébet T, Castellano R, Goubard A, Riccardi F, Fauriat C, Granjeaud S, Benyamine A, Castanier C, Orlanducci F, Ben Amara A, Pont F, Fournié JJ, Collette Y, Mege JL, Vey N, Olive D
Front Immunol 2018;9:977. Epub 2018 May 4 doi: 10.3389/fimmu.2018.00977. PMID: 29780393Free PMC Article

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