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Disorder of bone

MedGen UID:
14182
Concept ID:
C0005940
Disease or Syndrome
Synonyms: Bone Disease; Bone Diseases; Disease, Bone; Diseases, Bone
SNOMED CT: Bone disease (76069003); Osteopathia (76069003); Disorder of bone (76069003)
 

Definition

Your bones help you move, give you shape and support your body. They are living tissues that rebuild constantly throughout your life. During childhood and your teens, your body adds new bone faster than it removes old bone. After about age 20, you can lose bone faster than you make bone. To have strong bones when you are young, and to prevent bone loss when you are older, you need to get enough calcium, vitamin D and exercise. . There are many kinds of bone problems:. - Low bone density and osteoporosis, which make your bones weak and more likely to break . - Osteogenesis imperfecta makes your bones brittle . - Paget's disease of bone makes them weak . - Bone disease can make bones easy to break . - Bones can also develop cancer and infections. - Other bone diseases are caused by poor nutrition, genetic factors or problems with the rate of bone growth or rebuilding. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases.  [from MedlinePlus]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDisorder of bone

Recent clinical studies

Etiology

Weinerman S, Usera GL
Oral Maxillofac Surg Clin North Am 2015 Nov;27(4):567-71. Epub 2015 Sep 9 doi: 10.1016/j.coms.2015.06.009. PMID: 26363939
Wang Y, Sun G, Lu M, Hu Q
Br J Oral Maxillofac Surg 2015 Apr;53(4):336-41. Epub 2015 Feb 4 doi: 10.1016/j.bjoms.2015.01.004. PMID: 25660597
Kashii M, Yamazaki R, Yamashita T, Okuda S, Fujimori T, Nagamoto Y, Tamura Y, Oda T, Ohwada T, Iwasaki M, Yoshikawa H
J Bone Miner Metab 2015 Jul;33(4):422-31. Epub 2014 Jul 6 doi: 10.1007/s00774-014-0604-8. PMID: 24997524
Babayev R, Nickolas TL
Curr Opin Nephrol Hypertens 2014 Jul;23(4):431-7. doi: 10.1097/01.mnh.0000447014.36475.58. PMID: 24867672Free PMC Article
Glick R, Khaldi L, Ptaszynski K, Steiner GC
Hum Pathol 2007 Aug;38(8):1265-72. Epub 2007 May 8 doi: 10.1016/j.humpath.2007.01.017. PMID: 17490719

Diagnosis

White KK, Bompadre V, Goldberg MJ, Bober MB, Campbell JW, Cho TJ, Hoover-Fong J, Mackenzie W, Parnell SE, Raggio C, Rapoport DM, Spencer SA, Savarirayan R
Am J Med Genet A 2016 Jan;170A(1):42-51. Epub 2015 Sep 23 doi: 10.1002/ajmg.a.37394. PMID: 26394886
Mattei TA, Rehman AA, Issawi A, Fassett DR
Eur Spine J 2015 Dec;24(12):2746-53. Epub 2015 Jul 22 doi: 10.1007/s00586-015-4092-x. PMID: 26198704
Horny HP
Am J Clin Pathol 2009 Sep;132(3):438-47. doi: 10.1309/AJCPPXHMN5CJOXHZ. PMID: 19687320
Glick R, Khaldi L, Ptaszynski K, Steiner GC
Hum Pathol 2007 Aug;38(8):1265-72. Epub 2007 May 8 doi: 10.1016/j.humpath.2007.01.017. PMID: 17490719
Cole DE, Fraser FC, Glorieux FH, Jequier S, Marie PJ, Reade TM, Scriver CR
Am J Med Genet 1983 Apr;14(4):725-35. doi: 10.1002/ajmg.1320140414. PMID: 6846403

Therapy

Weinerman S, Usera GL
Oral Maxillofac Surg Clin North Am 2015 Nov;27(4):567-71. Epub 2015 Sep 9 doi: 10.1016/j.coms.2015.06.009. PMID: 26363939
Kosnik-Infinger L, Gendron C, Gordon CB, Pan BS, van Aalst JA, Vogel TW
Neurosurg Focus 2015 May;38(5):E10. doi: 10.3171/2015.2.FOCUS14847. PMID: 25929963
Ferraz-de-Souza B, Correa PH
Arq Bras Endocrinol Metabol 2013 Nov;57(8):577-82. PMID: 24343625
Bolland MJ, Cundy T
J Clin Pathol 2013 Nov;66(11):924-7. Epub 2013 Sep 16 doi: 10.1136/jclinpath-2013-201688. PMID: 24043712
Drug Ther Bull 2012 Jan;50(1):6-8. doi: 10.1136/dtb.2011.02.0080. PMID: 22241889

Prognosis

White KK, Bompadre V, Goldberg MJ, Bober MB, Campbell JW, Cho TJ, Hoover-Fong J, Mackenzie W, Parnell SE, Raggio C, Rapoport DM, Spencer SA, Savarirayan R
Am J Med Genet A 2016 Jan;170A(1):42-51. Epub 2015 Sep 23 doi: 10.1002/ajmg.a.37394. PMID: 26394886
Weinerman S, Usera GL
Oral Maxillofac Surg Clin North Am 2015 Nov;27(4):567-71. Epub 2015 Sep 9 doi: 10.1016/j.coms.2015.06.009. PMID: 26363939
Kosnik-Infinger L, Gendron C, Gordon CB, Pan BS, van Aalst JA, Vogel TW
Neurosurg Focus 2015 May;38(5):E10. doi: 10.3171/2015.2.FOCUS14847. PMID: 25929963
Wang Y, Sun G, Lu M, Hu Q
Br J Oral Maxillofac Surg 2015 Apr;53(4):336-41. Epub 2015 Feb 4 doi: 10.1016/j.bjoms.2015.01.004. PMID: 25660597
Kashii M, Yamazaki R, Yamashita T, Okuda S, Fujimori T, Nagamoto Y, Tamura Y, Oda T, Ohwada T, Iwasaki M, Yoshikawa H
J Bone Miner Metab 2015 Jul;33(4):422-31. Epub 2014 Jul 6 doi: 10.1007/s00774-014-0604-8. PMID: 24997524

Clinical prediction guides

Kashii M, Yamazaki R, Yamashita T, Okuda S, Fujimori T, Nagamoto Y, Tamura Y, Oda T, Ohwada T, Iwasaki M, Yoshikawa H
J Bone Miner Metab 2015 Jul;33(4):422-31. Epub 2014 Jul 6 doi: 10.1007/s00774-014-0604-8. PMID: 24997524
Hofmann C, Girschick H, Mornet E, Schneider D, Jakob F, Mentrup B
Eur J Hum Genet 2014 Oct;22(10):1160-4. Epub 2014 Feb 26 doi: 10.1038/ejhg.2014.10. PMID: 24569605Free PMC Article
Taketani T, Onigata K, Kobayashi H, Mushimoto Y, Fukuda S, Yamaguchi S
Arch Dis Child 2014 Mar;99(3):211-5. Epub 2013 Nov 25 doi: 10.1136/archdischild-2013-305037. PMID: 24276437
Friedrich RE, Giese M, Stelljes C, Froeder C, Scheuer HA
Anticancer Res 2012 May;32(5):2207-14. PMID: 22593511
Calabrò T, Mavrogenis AF, Ruggieri P
Musculoskelet Surg 2011 Apr;95(1):37-40. Epub 2011 Mar 16 doi: 10.1007/s12306-011-0100-4. PMID: 21409504

Recent systematic reviews

White KK, Bompadre V, Goldberg MJ, Bober MB, Campbell JW, Cho TJ, Hoover-Fong J, Mackenzie W, Parnell SE, Raggio C, Rapoport DM, Spencer SA, Savarirayan R
Am J Med Genet A 2016 Jan;170A(1):42-51. Epub 2015 Sep 23 doi: 10.1002/ajmg.a.37394. PMID: 26394886
Brenckmann C, Papaioannou A
Cochrane Database Syst Rev 2001;(4):CD002010. doi: 10.1002/14651858.CD002010. PMID: 11687132

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