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Factor XI Inactivation

MedGen UID:
1378454
•Concept ID:
C4329971
•
Disease or Syndrome

Definition

Presence of inactivating antibodies to factor XI in the blood. [from NCI]

Professional guidelines

PubMed

Treatment of rare factor deficiencies in 2016.
Peyvandi F, Menegatti M
Hematology Am Soc Hematol Educ Program 2016 Dec 2;2016(1):663-669. doi: 10.1182/asheducation-2016.1.663. PMID: 27913544Free PMC Article
Factor XI deficiency and its management.
Bolton-Maggs PH
Haemophilia 2000 Jul;6 Suppl 1:100-9. doi: 10.1046/j.1365-2516.2000.00053.x. PMID: 10982275
The management of factor XI deficiency.
Bolton-Maggs PH
Haemophilia 1998 Jul;4(4):683-8. doi: 10.1046/j.1365-2516.1998.440683.x. PMID: 9873814

Recent clinical studies

Etiology

Treatment of rare factor deficiencies in 2016.
Peyvandi F, Menegatti M
Hematology Am Soc Hematol Educ Program 2016 Dec 2;2016(1):663-669. doi: 10.1182/asheducation-2016.1.663. PMID: 27913544Free PMC Article
Gene methylation in gastric cancer.
Qu Y, Dang S, Hou P
Clin Chim Acta 2013 Sep 23;424:53-65. Epub 2013 May 10 doi: 10.1016/j.cca.2013.05.002. PMID: 23669186
Factor V Leiden and inflammatory bowel disease: a systematic review and meta-analysis.
Liang J, Wu S, Feng B, Lei S, Luo G, Wang J, Li K, Li X, Xie H, Zhang D, Wang X, Wu K, Miao D, Fan D
J Gastroenterol 2011 Oct;46(10):1158-66. Epub 2011 Jul 30 doi: 10.1007/s00535-011-0441-7. PMID: 21805067
Factor XI deficiency and its management.
Bolton-Maggs PH
Haemophilia 2000 Jul;6 Suppl 1:100-9. doi: 10.1046/j.1365-2516.2000.00053.x. PMID: 10982275
The management of factor XI deficiency.
Bolton-Maggs PH
Haemophilia 1998 Jul;4(4):683-8. doi: 10.1046/j.1365-2516.1998.440683.x. PMID: 9873814

Diagnosis

CRL4-DCAF8L1 Regulates BRCA1 and BARD1 Protein Stability.
Liu F, Han Q, Zhang T, Chang F, Deng J, Huang X, Wang W, Xu Y, Li Q, Xu L, Zhang B, Li W, Li L, Su Y, Li Y, Shao G
Int J Biol Sci 2022;18(4):1434-1450. Epub 2022 Jan 24 doi: 10.7150/ijbs.57178. PMID: 35280675Free PMC Article
Treatment of rare factor deficiencies in 2016.
Peyvandi F, Menegatti M
Hematology Am Soc Hematol Educ Program 2016 Dec 2;2016(1):663-669. doi: 10.1182/asheducation-2016.1.663. PMID: 27913544Free PMC Article
Gene methylation in gastric cancer.
Qu Y, Dang S, Hou P
Clin Chim Acta 2013 Sep 23;424:53-65. Epub 2013 May 10 doi: 10.1016/j.cca.2013.05.002. PMID: 23669186
Role of ATRX in chromatin structure and function: implications for chromosome instability and human disease.
De La Fuente R, Baumann C, Viveiros MM
Reproduction 2011 Aug;142(2):221-34. Epub 2011 Jun 8 doi: 10.1530/REP-10-0380. PMID: 21653732Free PMC Article
Coagulation procofactor activation by factor XIa.
Whelihan MF, Orfeo T, Gissel MT, Mann KG
J Thromb Haemost 2010 Jul;8(7):1532-9. Epub 2010 May 4 doi: 10.1111/j.1538-7836.2010.03899.x. PMID: 20456758Free PMC Article

Therapy

Caveolin-1 scaffolding domain peptide prevents corpus cavernosum fibrosis and erectile dysfunction in bilateral cavernous nerve injury-induced rats.
Xi Y, Ge Y, Hu D, Xia T, Chen J, Zhang C, Cui Y, Xiao H
J Sex Med 2023 Oct 31;20(11):1274-1284. doi: 10.1093/jsxmed/qdad108. PMID: 37724695
Corilagin alleviates acetaminophen-induced hepatotoxicity via enhancing the AMPK/GSK3β-Nrf2 signaling pathway.
Lv H, Hong L, Tian Y, Yin C, Zhu C, Feng H
Cell Commun Signal 2019 Jan 10;17(1):2. doi: 10.1186/s12964-018-0314-2. PMID: 30630510Free PMC Article
Treatment of rare factor deficiencies in 2016.
Peyvandi F, Menegatti M
Hematology Am Soc Hematol Educ Program 2016 Dec 2;2016(1):663-669. doi: 10.1182/asheducation-2016.1.663. PMID: 27913544Free PMC Article
Factor XI deficiency and its management.
Bolton-Maggs PH
Haemophilia 2000 Jul;6 Suppl 1:100-9. doi: 10.1046/j.1365-2516.2000.00053.x. PMID: 10982275
The management of factor XI deficiency.
Bolton-Maggs PH
Haemophilia 1998 Jul;4(4):683-8. doi: 10.1046/j.1365-2516.1998.440683.x. PMID: 9873814

Prognosis

Overcoming ABCB1-mediated multidrug resistance by transcription factor BHLHE40.
Yin Y, Xin Y, Zhang F, An D, Fan H, Qin M, Xia J, Xi T, Xiong J
Neoplasia 2023 May;39:100891. Epub 2023 Mar 15 doi: 10.1016/j.neo.2023.100891. PMID: 36931039Free PMC Article
Knockdown of growth differentiation factor-15 inhibited nonsmall cell lung cancer through inactivating PTEN/PI3K/AKT signaling pathway.
Liu Y, Lei J, Ji X, Li C, Chen X, Wang J, Dong J, Zhang H, Li Y
Genes Genomics 2023 Apr;45(4):507-517. Epub 2022 Oct 28 doi: 10.1007/s13258-022-01328-8. PMID: 36306063
The Pathophysiology of The Antiphospholipid Syndrome: A Perspective From The Blood Coagulation System.
Arreola-Diaz R, Majluf-Cruz A, Sanchez-Torres LE, Hernandez-Juarez J
Clin Appl Thromb Hemost 2022 Jan-Dec;28:10760296221088576. doi: 10.1177/10760296221088576. PMID: 35317658Free PMC Article
Alterations of the Immunologic Co-Stimulator B7 and TNFR Families Correlate with Hepatocellular Carcinoma Prognosis and Metastasis by Inactivating STAT3.
Li YM, Liu ZY, Li ZC, Wang JC, Yu JM, Yang HJ, Chen ZN, Tang J
Int J Mol Sci 2019 Jan 3;20(1) doi: 10.3390/ijms20010156. PMID: 30609841Free PMC Article
Influence of C1-inhibitor on inflammation, edema and shock.
Dickneite G
Behring Inst Mitt 1993 Dec;(93):299-305. PMID: 8172580

Clinical prediction guides

FNDC5 prevents oxidative stress and neuronal apoptosis after traumatic brain injury through SIRT3-dependent regulation of mitochondrial quality control.
Ge Y, Wu X, Cai Y, Hu Q, Wang J, Zhang S, Zhao B, Cui W, Wu Y, Wang Q, Feng T, Liu H, Qu Y, Ge S
Cell Death Dis 2024 May 27;15(5):364. doi: 10.1038/s41419-024-06748-w. PMID: 38802337Free PMC Article
Liver-specific overexpression of Gab2 accelerates hepatocellular carcinoma progression by activating immunosuppression of myeloid-derived suppressor cells.
Chen S, Cheng J, Zhong Y, Liu R, Lu Z, Luo X
Oncogene 2022 Jun;41(24):3316-3327. Epub 2022 Apr 11 doi: 10.1038/s41388-022-02298-7. PMID: 35411035
CRL4-DCAF8L1 Regulates BRCA1 and BARD1 Protein Stability.
Liu F, Han Q, Zhang T, Chang F, Deng J, Huang X, Wang W, Xu Y, Li Q, Xu L, Zhang B, Li W, Li L, Su Y, Li Y, Shao G
Int J Biol Sci 2022;18(4):1434-1450. Epub 2022 Jan 24 doi: 10.7150/ijbs.57178. PMID: 35280675Free PMC Article
TBX3 functions as a tumor suppressor downstream of activated CTNNB1 mutants during hepatocarcinogenesis.
Liang B, Zhou Y, Qian M, Xu M, Wang J, Zhang Y, Song X, Wang H, Lin S, Ren C, Monga SP, Wang B, Evert M, Chen Y, Chen X, Huang Z, Calvisi DF, Chen X
J Hepatol 2021 Jul;75(1):120-131. Epub 2021 Feb 10 doi: 10.1016/j.jhep.2021.01.044. PMID: 33577921Free PMC Article
Inactivation of human plasma kallikrein and factor XIa by protein C inhibitor.
Meijers JC, Kanters DH, Vlooswijk RA, van Erp HE, Hessing M, Bouma BN
Biochemistry 1988 Jun 14;27(12):4231-7. doi: 10.1021/bi00412a005. PMID: 2844223

Recent systematic reviews

Factor V Leiden and inflammatory bowel disease: a systematic review and meta-analysis.
Liang J, Wu S, Feng B, Lei S, Luo G, Wang J, Li K, Li X, Xie H, Zhang D, Wang X, Wu K, Miao D, Fan D
J Gastroenterol 2011 Oct;46(10):1158-66. Epub 2011 Jul 30 doi: 10.1007/s00535-011-0441-7. PMID: 21805067
The use of desmopressin in congenital factor XI deficiency: a systematic review.
Franchini M, Manzato F, Salvagno GL, Montagnana M, Lippi G
Ann Hematol 2009 Oct;88(10):931-5. Epub 2009 Jul 17 doi: 10.1007/s00277-009-0792-9. PMID: 19609524

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