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Leg edema

MedGen UID:
116006
•Concept ID:
C0235886
•
Finding; Pathologic Function

Professional guidelines

PubMed

The efficacy of physiotherapy for the prevention and treatment of prenatal symptoms: a systematic review.
Van Kampen M, Devoogdt N, De Groef A, Gielen A, Geraerts I
Int Urogynecol J 2015 Nov;26(11):1575-86. Epub 2015 Mar 31 doi: 10.1007/s00192-015-2684-y. PMID: 25822028
Leg edema assessment and management.
Simon EB
Medsurg Nurs 2014 Jan-Feb;23(1):44-53. PMID: 24707668
Edema: diagnosis and management.
Trayes KP, Studdiford JS, Pickle S, Tully AS
Am Fam Physician 2013 Jul 15;88(2):102-10. PMID: 23939641

Recent clinical studies

Etiology

Efficacy of micronized purified flavonoid fraction (Daflon®) on improving individual symptoms, signs and quality of life in patients with chronic venous disease: a systematic review and meta-analysis of randomized double-blind placebo-controlled trials.
Kakkos SK, Nicolaides AN
Int Angiol 2018 Apr;37(2):143-154. Epub 2018 Jan 31 doi: 10.23736/S0392-9590.18.03975-5. PMID: 29385792
Sleep Apnea and Idiopathic Leg Edema: A Case Control Study.
Shahmirzai R, Firouzifar M
Acta Med Iran 2017 Oct;55(10):612-615. PMID: 29228525
Sonographic signs of snakebite.
Vohra R, Rangan C, Bengiamin R
Clin Toxicol (Phila) 2014 Nov;52(9):948-51. Epub 2014 Sep 17 doi: 10.3109/15563650.2014.958613. PMID: 25229179
Interventions for leg edema and varicosities in pregnancy. What evidence?
Bamigboye AA, Hofmeyr GJ
Eur J Obstet Gynecol Reprod Biol 2006 Nov;129(1):3-8. Epub 2006 May 4 doi: 10.1016/j.ejogrb.2006.03.008. PMID: 16678328
Infective endocarditis developing as uremia.
Miyake M, Hatta K, Kameyama T, Himura Y, Gen H, Kobashi Y, Konishi T
Intern Med 2005 Jun;44(6):598-602. doi: 10.2169/internalmedicine.44.598. PMID: 16020887

Diagnosis

Efficacy of micronized purified flavonoid fraction (Daflon®) on improving individual symptoms, signs and quality of life in patients with chronic venous disease: a systematic review and meta-analysis of randomized double-blind placebo-controlled trials.
Kakkos SK, Nicolaides AN
Int Angiol 2018 Apr;37(2):143-154. Epub 2018 Jan 31 doi: 10.23736/S0392-9590.18.03975-5. PMID: 29385792
Leg edema assessment and management.
Simon EB
Medsurg Nurs 2014 Jan-Feb;23(1):44-53. PMID: 24707668
Edema: diagnosis and management.
Trayes KP, Studdiford JS, Pickle S, Tully AS
Am Fam Physician 2013 Jul 15;88(2):102-10. PMID: 23939641
Primary pulmonary hypertension.
Rashid A, Lehrman S, Romano P, Frishman W, Dobkin J, Reichel J
Heart Dis 2000 Nov-Dec;2(6):422-30. PMID: 11728293
The swollen leg.
Young JR
Am Fam Physician 1977 Jan;15(1):163-73. PMID: 188330

Therapy

Improvement of occupational leg edema and discomforts (RCT).
Hecko S, Lutze S, Arnold A, Haase H, Jünger M, Riebe H
Clin Hemorheol Microcirc 2022;82(2):125-139. doi: 10.3233/CH-211366. PMID: 35811511
Walking instead of standing.
Junge F, Konschake W, Haase H, Vollmer M, Jünger M
Vasa 2022 Mar;51(2):78-84. Epub 2022 Feb 10 doi: 10.1024/0301-1526/a000990. PMID: 35142231
Efficacy of micronized purified flavonoid fraction (Daflon®) on improving individual symptoms, signs and quality of life in patients with chronic venous disease: a systematic review and meta-analysis of randomized double-blind placebo-controlled trials.
Kakkos SK, Nicolaides AN
Int Angiol 2018 Apr;37(2):143-154. Epub 2018 Jan 31 doi: 10.23736/S0392-9590.18.03975-5. PMID: 29385792
Leg edema assessment and management.
Simon EB
Medsurg Nurs 2014 Jan-Feb;23(1):44-53. PMID: 24707668
Thiazolidinedione-induced edema.
Niemeyer NV, Janney LM
Pharmacotherapy 2002 Jul;22(7):924-9. doi: 10.1592/phco.22.11.924.33626. PMID: 12126225

Prognosis

Understanding lower leg volume measurements used in clinical studies focused on venous leg edema.
Rabe E, Carpentier P, Maggioli A
Int Angiol 2018 Dec;37(6):437-443. Epub 2018 Sep 24 doi: 10.23736/S0392-9590.18.04057-9. PMID: 30256052
Tegafur-uracil-induced rapid development of advanced hepatic fibrosis.
Honda S, Sawada K, Hasebe T, Nakajima S, Fujiya M, Okumura T
World J Gastroenterol 2017 Aug 21;23(31):5823-5828. doi: 10.3748/wjg.v23.i31.5823. PMID: 28883709Free PMC Article
Leg fluid accumulation during prolonged sitting.
Vena D, Rubianto J, Popovic M, Yadollahi A
Annu Int Conf IEEE Eng Med Biol Soc 2016 Aug;2016:4284-4287. doi: 10.1109/EMBC.2016.7591674. PMID: 28269228
Infective endocarditis developing as uremia.
Miyake M, Hatta K, Kameyama T, Himura Y, Gen H, Kobashi Y, Konishi T
Intern Med 2005 Jun;44(6):598-602. doi: 10.2169/internalmedicine.44.598. PMID: 16020887
Primary pulmonary hypertension.
Rashid A, Lehrman S, Romano P, Frishman W, Dobkin J, Reichel J
Heart Dis 2000 Nov-Dec;2(6):422-30. PMID: 11728293

Clinical prediction guides

Detection and quantitation of venous leg edema with the edema ruler and ultrasound.
Calzon ME, Blebea J, Pittman C
Phlebology 2024 Sep;39(8):557-563. Epub 2024 May 30 doi: 10.1177/02683555241258283. PMID: 38817097
Understanding lower leg volume measurements used in clinical studies focused on venous leg edema.
Rabe E, Carpentier P, Maggioli A
Int Angiol 2018 Dec;37(6):437-443. Epub 2018 Sep 24 doi: 10.23736/S0392-9590.18.04057-9. PMID: 30256052
Tegafur-uracil-induced rapid development of advanced hepatic fibrosis.
Honda S, Sawada K, Hasebe T, Nakajima S, Fujiya M, Okumura T
World J Gastroenterol 2017 Aug 21;23(31):5823-5828. doi: 10.3748/wjg.v23.i31.5823. PMID: 28883709Free PMC Article
Diurnal and twenty-four hour patterning of human diseases: cardiac, vascular, and respiratory diseases, conditions, and syndromes.
Smolensky MH, Portaluppi F, Manfredini R, Hermida RC, Tiseo R, Sackett-Lundeen LL, Haus EL
Sleep Med Rev 2015 Jun;21:3-11. Epub 2014 Jul 18 doi: 10.1016/j.smrv.2014.07.001. PMID: 25129838
Sonographic signs of snakebite.
Vohra R, Rangan C, Bengiamin R
Clin Toxicol (Phila) 2014 Nov;52(9):948-51. Epub 2014 Sep 17 doi: 10.3109/15563650.2014.958613. PMID: 25229179

Recent systematic reviews

Prognostic factors for VTE and bleeding in hospitalized medical patients: a systematic review and meta-analysis.
Darzi AJ, Karam SG, Charide R, Etxeandia-Ikobaltzeta I, Cushman M, Gould MK, Mbuagbaw L, Spencer FA, Spyropoulos AC, Streiff MB, Woller S, Zakai NA, Germini F, Rigoni M, Agarwal A, Morsi RZ, Iorio A, Akl EA, Schünemann HJ
Blood 2020 May 14;135(20):1788-1810. doi: 10.1182/blood.2019003603. PMID: 32092132Free PMC Article
Efficacy of micronized purified flavonoid fraction (Daflon®) on improving individual symptoms, signs and quality of life in patients with chronic venous disease: a systematic review and meta-analysis of randomized double-blind placebo-controlled trials.
Kakkos SK, Nicolaides AN
Int Angiol 2018 Apr;37(2):143-154. Epub 2018 Jan 31 doi: 10.23736/S0392-9590.18.03975-5. PMID: 29385792
Efficacy of Ruscus extract, HMC and vitamin C, constituents of Cyclo 3 fort®, on improving individual venous symptoms and edema: a systematic review and meta-analysis of randomized double-blind placebo-controlled trials.
Kakkos SK, Allaert FA
Int Angiol 2017 Apr;36(2):93-106. doi: 10.23736/S0392-9590.17.03815-9. PMID: 28225220
Exercise training improves physical fitness in patients with pulmonary arterial hypertension: a systematic review and meta-analysis of controlled trials.
Buys R, Avila A, Cornelissen VA
BMC Pulm Med 2015 Apr 22;15:40. doi: 10.1186/s12890-015-0031-1. PMID: 25896259Free PMC Article
The efficacy of physiotherapy for the prevention and treatment of prenatal symptoms: a systematic review.
Van Kampen M, Devoogdt N, De Groef A, Gielen A, Geraerts I
Int Urogynecol J 2015 Nov;26(11):1575-86. Epub 2015 Mar 31 doi: 10.1007/s00192-015-2684-y. PMID: 25822028

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