U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Necatoriasis

MedGen UID:
10277
•Concept ID:
C0027528
•
Disease or Syndrome
Synonym: Necatoriases
SNOMED CT: Necatoriasis (36667009); Necatorosis (36667009)
 
Monarch Initiative: MONDO:0005870

Definition

A disorder caused by an infection with hookworms of the genus Necator, which settle in the host''s small intestine, and cause abdominal pain, diarrhea, weight loss, and anemia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNecatoriasis

Professional guidelines

PubMed

Cytokine and chemokine responses in patients co-infected with Entamoeba histolytica/dispar, Necator americanus and Mansonella perstans and changes after anti-parasite treatment.
Soboslay PT, Hamm DM, Pfäfflin F, Fendt J, Banla M, Schulz-Key H
Microbes Infect 2006 Jan;8(1):238-47. Epub 2005 Sep 12 doi: 10.1016/j.micinf.2005.06.019. PMID: 16239120
Necatoriasis: treatment and developmental therapeutics.
Georgiev VS
Expert Opin Investig Drugs 2000 May;9(5):1065-78. doi: 10.1517/13543784.9.5.1065. PMID: 11060728
Parasitic infections. Treatment and developmental therapeutics. 1. Necatoriasis.
Georgiev VS
Curr Pharm Des 1999 Jul;5(7):545-54. PMID: 10438896

Recent clinical studies

Etiology

Safety and tolerability of experimental hookworm infection in humans with metabolic disease: study protocol for a phase 1b randomised controlled clinical trial.
Pierce D, Merone L, Lewis C, Rahman T, Croese J, Loukas A, McDonald M, Giacomin P, McDermott R
BMC Endocr Disord 2019 Dec 11;19(1):136. doi: 10.1186/s12902-019-0461-5. PMID: 31829172Free PMC Article
Molecular features of hookworm larvae (Necator spp.) raised by coproculture from Ugandan chimpanzees and Gabonese gorillas and humans.
Hasegawa H, Shigyo M, Yanai Y, McLennan MR, Fujita S, Makouloutou P, Tsuchida S, Ando C, Sato H, Huffman MA
Parasitol Int 2017 Apr;66(2):12-15. Epub 2016 Nov 10 doi: 10.1016/j.parint.2016.11.003. PMID: 27840196
A history of hookworm vaccine development.
Schneider B, Jariwala AR, Periago MV, Gazzinelli MF, Bose SN, Hotez PJ, Diemert DJ, Bethony JM
Hum Vaccin 2011 Nov;7(11):1234-44. Epub 2011 Nov 1 doi: 10.4161/hv.7.11.18443. PMID: 22064562Free PMC Article
The changing epidemiology of human hookworm infection in Australia.
Prociv P, Luke RA
Med J Aust 1995 Feb 6;162(3):150-4. doi: 10.5694/j.1326-5377.1995.tb138481.x. PMID: 7854229
A comparative trial of oxantel-pyrantel and mebendazole in multiple helminth infection in school children.
Dissanaike AS
Drugs 1978;15 Suppl 1:73-7. doi: 10.2165/00003495-197800151-00015. PMID: 350569

Diagnosis

Hookworm infection in central China: morphological and molecular diagnosis.
Xu FF, Niu YF, Chen WQ, Liu SS, Li JR, Jiang P, Wang ZQ, Cui J, Zhang X
Parasit Vectors 2021 Oct 14;14(1):537. doi: 10.1186/s13071-021-05035-3. PMID: 34649597Free PMC Article
Hookworm in the eye.
Tao Z, Wang Y, Yu S, Yin ZQ, Liu Y, Li S
Lancet Infect Dis 2018 May;18(5):582. doi: 10.1016/S1473-3099(18)30097-5. PMID: 29695368
Necatoriasis: treatment and developmental therapeutics.
Georgiev VS
Expert Opin Investig Drugs 2000 May;9(5):1065-78. doi: 10.1517/13543784.9.5.1065. PMID: 11060728
Parasitic infections. Treatment and developmental therapeutics. 1. Necatoriasis.
Georgiev VS
Curr Pharm Des 1999 Jul;5(7):545-54. PMID: 10438896
Ascariasis and hookworm.
Sarinas PS, Chitkara RK
Semin Respir Infect 1997 Jun;12(2):130-7. PMID: 9195678

Therapy

Hookworm vaccines.
Diemert DJ, Bethony JM, Hotez PJ
Clin Infect Dis 2008 Jan 15;46(2):282-8. doi: 10.1086/524070. PMID: 18171264
Necatoriasis: treatment and developmental therapeutics.
Georgiev VS
Expert Opin Investig Drugs 2000 May;9(5):1065-78. doi: 10.1517/13543784.9.5.1065. PMID: 11060728
Parasitic infections. Treatment and developmental therapeutics. 1. Necatoriasis.
Georgiev VS
Curr Pharm Des 1999 Jul;5(7):545-54. PMID: 10438896
Ascariasis and hookworm.
Sarinas PS, Chitkara RK
Semin Respir Infect 1997 Jun;12(2):130-7. PMID: 9195678
Hookworm infection.
Hotez PJ, Pritchard DI
Sci Am 1995 Jun;272(6):68-74. doi: 10.1038/scientificamerican0695-68. PMID: 7761817

Prognosis

Modulation of intestinal epithelial permeability by chronic small intestinal helminth infections.
Mules TC, Tang JS, Vacca F, Yumnam B, Schmidt A, Lavender B, Maclean K, Noble SL, Waugh C, van Ginkel R, Camberis M, Le Gros G, Inns S
Immunol Cell Biol 2024 May-Jun;102(5):396-406. Epub 2024 Apr 22 doi: 10.1111/imcb.12749. PMID: 38648862
New Insights Into the Kinetics and Variability of Egg Excretion in Controlled Human Hookworm Infections.
Hoogerwerf MA, Coffeng LE, Brienen EAT, Janse JJ, Langenberg MCC, Kruize YCM, Gootjes C, Manurung MD, Dekker M, Becker L, Erkens MAA, van der Beek MT, Ganesh MS, Feijt C, Winkel BMF, Westra IM, Meij P, Loukas A, Visser LG, de Vlas SJ, Yazdanbakhsh M, van Lieshout L, Roestenberg M
J Infect Dis 2019 Aug 9;220(6):1044-1048. doi: 10.1093/infdis/jiz218. PMID: 31077279
Improved insights into the transcriptomes of the human hookworm Necator americanus--fundamental and biotechnological implications.
Rabelo EM, Hall RS, Loukas A, Cooper L, Hu M, Ranganathan S, Gasser RB
Biotechnol Adv 2009 Mar-Apr;27(2):122-32. Epub 2008 Oct 18 doi: 10.1016/j.biotechadv.2008.10.002. PMID: 18977428
Early stage-specific immune responses in primary experimental human hookworm infection.
Geiger SM, Fujiwara RT, Santiago H, Corrêa-Oliveira R, Bethony JM
Microbes Infect 2008 Nov-Dec;10(14-15):1524-35. Epub 2008 Sep 23 doi: 10.1016/j.micinf.2008.09.003. PMID: 18848637
The innate allergenicity of helminth parasites.
Falcone FH, Loukas A, Quinnell RJ, Pritchard DI
Clin Rev Allergy Immunol 2004 Feb;26(1):61-72. doi: 10.1385/CRIAI:26:1:61. PMID: 14755076

Clinical prediction guides

Controlled human hookworm infection remodels plasmacytoid dendritic cells and regulatory T cells towards profiles seen in natural infections in endemic areas.
Manurung MD, Sonnet F, Hoogerwerf MA, Janse JJ, Kruize Y, Bes-Roeleveld L, König M, Loukas A, Dewals BG, Supali T, Jochems SP, Roestenberg M, Coppola M, Yazdanbakhsh M
Nat Commun 2024 Jul 16;15(1):5960. doi: 10.1038/s41467-024-50313-0. PMID: 39013877Free PMC Article
Modulation of intestinal epithelial permeability by chronic small intestinal helminth infections.
Mules TC, Tang JS, Vacca F, Yumnam B, Schmidt A, Lavender B, Maclean K, Noble SL, Waugh C, van Ginkel R, Camberis M, Le Gros G, Inns S
Immunol Cell Biol 2024 May-Jun;102(5):396-406. Epub 2024 Apr 22 doi: 10.1111/imcb.12749. PMID: 38648862
Old friends and friendly fire: Pregnancy, hookworm infection, and anemia among tropical horticulturalists.
Anderson AS, Trumble BC, Hové C, Kraft TS, Kaplan H, Gurven M, Blackwell AD
Am J Hum Biol 2020 Mar;32(2):e23337. Epub 2019 Oct 23 doi: 10.1002/ajhb.23337. PMID: 31642576Free PMC Article
Improved insights into the transcriptomes of the human hookworm Necator americanus--fundamental and biotechnological implications.
Rabelo EM, Hall RS, Loukas A, Cooper L, Hu M, Ranganathan S, Gasser RB
Biotechnol Adv 2009 Mar-Apr;27(2):122-32. Epub 2008 Oct 18 doi: 10.1016/j.biotechadv.2008.10.002. PMID: 18977428
Single dose mebendazole therapy for soil-transmitted nematodes.
Abadi K
Am J Trop Med Hyg 1985 Jan;34(1):129-33. doi: 10.4269/ajtmh.1985.34.129. PMID: 3970305

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...