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A novel long-acting human growth hormone fusion protein (VRS-317): enhanced in vivo potency and half-life.
Cleland JL, Geething NC, Moore JA, Rogers BC, Spink BJ, Wang CW, Alters SE, Stemmer WP, Schellenberger V. Cleland JL, et al. J Pharm Sci. 2012 Aug;101(8):2744-54. doi: 10.1002/jps.23229. Epub 2012 Jun 7. J Pharm Sci. 2012. PMID: 22678811 Free PMC article.
VRS-317 also did not cause lipoatrophy in pig and monkey studies. VRS-317 is currently being studied in GH-deficient patients to confirm the observations in these animal studies....
VRS-317 also did not cause lipoatrophy in pig and monkey studies. VRS-317 is currently being studied in GH-defic …
A long-acting human growth hormone with delayed clearance (VRS-317): results of a double-blind, placebo-controlled, single ascending dose study in growth hormone-deficient adults.
Yuen KC, Conway GS, Popovic V, Merriam GR, Bailey T, Hamrahian AH, Biller BM, Kipnes M, Moore JA, Humphriss E, Bright GM, Cleland JL. Yuen KC, et al. J Clin Endocrinol Metab. 2013 Jun;98(6):2595-603. doi: 10.1210/jc.2013-1437. Epub 2013 Apr 12. J Clin Endocrinol Metab. 2013. PMID: 23585663 Free PMC article. Clinical Trial.
MAIN OUTCOME MEASURES: Adverse events, laboratory safety assessments, and VRS-317 pharmacokinetics and pharmacodynamics (IGF-I and IGF binding protein-3) were analyzed. RESULTS: At 0.80 mg/kg, VRS-317 had a mean terminal elimination half-life of 131 ho …
MAIN OUTCOME MEASURES: Adverse events, laboratory safety assessments, and VRS-317 pharmacokinetics and pharmacodynamics (IGF-I …
A Randomized Safety and Efficacy Study of Somavaratan (VRS-317), a Long-Acting rhGH, in Pediatric Growth Hormone Deficiency.
Moore WV, Nguyen HJ, Kletter GB, Miller BS, Rogers D, Ng D, Moore JA, Humphriss E, Cleland JL, Bright GM. Moore WV, et al. J Clin Endocrinol Metab. 2016 Mar;101(3):1091-7. doi: 10.1210/jc.2015-3279. Epub 2015 Dec 16. J Clin Endocrinol Metab. 2016. PMID: 26672637 Free PMC article. Clinical Trial.
CONTEXT: Somavaratan (VRS-317) is a long-acting form of recombinant human GH under development for children and adults with GH deficiency (GHD). ...
CONTEXT: Somavaratan (VRS-317) is a long-acting form of recombinant human GH under development for children and adults with GH …
Comparison of the effect of photobiomodulation therapy and Ibuprofen on postoperative pain after endodontic treatment: randomized, controlled, clinical study.
Nunes EC, Herkrath FJ, Suzuki EH, Gualberto Júnior EC, Marques AAF, Sponchiado Júnior EC. Nunes EC, et al. Lasers Med Sci. 2020 Jun;35(4):971-978. doi: 10.1007/s10103-019-02929-8. Epub 2019 Dec 7. Lasers Med Sci. 2020. PMID: 31811497 Clinical Trial.

To measure the outcome, two pain scales were used: numerical rate scale (NRS) and verbal rate scale (VRS). Data were analyzed using the chi-square, Mann-Whitney, and Wilcoxon paired tests. Outcome was superior with photobiomodulation therapy at 6 h (p < 0.001), 12 h (p

…
To measure the outcome, two pain scales were used: numerical rate scale (NRS) and verbal rate scale (VRS). Data were analyzed using t …
Comparison of oral versus intravenous methadone on postoperative pain and opioid use after adult spinal deformity surgery: A retrospective, non-inferiority analysis.
Esfahani K, Tennant W, Tsang S, Naik BI, Dunn LK. Esfahani K, et al. PLoS One. 2023 Jul 21;18(7):e0288988. doi: 10.1371/journal.pone.0288988. eCollection 2023. PLoS One. 2023. PMID: 37478144 Free PMC article.
The primary outcome measured was postoperative opioid use in oral morphine equivalents (ME) and verbal response scale (VRS) pain scores up to postoperative day (POD) three. Secondary outcomes were time to first bowel movement and adverse effects (reintubation, myocardial i …
The primary outcome measured was postoperative opioid use in oral morphine equivalents (ME) and verbal response scale (VRS) pain scor …
The Risk, Need, and Responsivity Relevance of Working Alliance in a Sexual Offense Treatment Program: Its Intersection With Psychopathy, Diversity, and Treatment Change.
Olver ME, Stockdale KC, Riemer EK. Olver ME, et al. Sex Abuse. 2024 Jun;36(4):383-417. doi: 10.1177/10790632231172161. Epub 2023 Apr 24. Sex Abuse. 2024. PMID: 37093565 Free PMC article.
The current study examined the self-reported working alliance of men attending a high intensity sexual offense treatment program and its associations with psychopathy, sexual violence risk, treatment change, and recidivism, in a Canadian sample of 317 incarcerated men foll …
The current study examined the self-reported working alliance of men attending a high intensity sexual offense treatment program and its ass …
Assessment of feasibility and efficacy of Class IV laser therapy for postoperative pain relief in off-pump coronary artery bypass surgery patients: A pilot study.
Karlekar A, Bharati S, Saxena R, Mehta K. Karlekar A, et al. Ann Card Anaesth. 2015 Jul-Sep;18(3):317-22. doi: 10.4103/0971-9784.159800. Ann Card Anaesth. 2015. PMID: 26139735 Free PMC article.
VRS was used to assess pain severity and was recorded for statistical analysis using Friedman Test. ...Laser was re-applied in 40 patients whose VRS was 5 (mean [SD] - 6.38 [0.868]) at 24th h. After receiving the 2nd dose of laser the VRS scores fell signific …
VRS was used to assess pain severity and was recorded for statistical analysis using Friedman Test. ...Laser was re-applied in 40 pat …
A randomized controlled trial of intranasal fentanyl vs intravenous morphine for analgesia in the prehospital setting.
Rickard C, O'Meara P, McGrail M, Garner D, McLean A, Le Lievre P. Rickard C, et al. Am J Emerg Med. 2007 Oct;25(8):911-7. doi: 10.1016/j.ajem.2007.02.027. Am J Emerg Med. 2007. PMID: 17920976 Free article. Clinical Trial.
The end point was the difference in baseline/destination VRS. RESULTS: Groups were equivalent (P = not significant) for baseline VRS [mean (SD): INF 8.3 (1.7), IVM 8.1 (1.6)] and minutes to destination [mean (SD): INF 27.2 (15.5), IVM 30.6 (19.1)]. ...Higher baselin …
The end point was the difference in baseline/destination VRS. RESULTS: Groups were equivalent (P = not significant) for baseline V …
Effect of Homatropine eye drops on pain after photorefractive keratectomy: A pilot study.
Joshaghani M, Nazari H, Ghasemi Falavarjani K, Shokrollahi S, Jafar Ghaempanah M, Abri Aghdam K, Mirbolouk Jalali Z. Joshaghani M, et al. Saudi J Ophthalmol. 2013 Apr;27(2):83-5. doi: 10.1016/j.sjopt.2012.07.003. Epub 2012 Jul 31. Saudi J Ophthalmol. 2013. PMID: 24227967 Free PMC article.
The level of pain was evaluated using visual analogue scale (VAS), verbal rating scale (VRS) and pain rating index (PRI) at 0.5, 24 and 48 h after operation. RESULTS: The level of pain was statistically similar between the two eyes half an hour after operation, however, ho …
The level of pain was evaluated using visual analogue scale (VAS), verbal rating scale (VRS) and pain rating index (PRI) at 0.5, 24 a …
Needle-free delivery of lidocaine for reducing the pain associated with the fine-needle aspiration biopsy of thyroid nodules: time-saving and efficacious procedure.
Gursoy A, Ertugrul DT, Sahin M, Tutuncu NB, Demirer AN, Demirag NG. Gursoy A, et al. Thyroid. 2007 Apr;17(4):317-21. doi: 10.1089/thy.2006.0326. Thyroid. 2007. PMID: 17465861 Clinical Trial.
The patients rated pain associated with the procedure according to a 100-mm visual analog scale (VAS), an 11-point numeric rating scale (NRS), and a four-category verbal rating scale (VRS). MAIN OUTCOME MEASURE: The two groups studied were similar with respect to age, sex, …
The patients rated pain associated with the procedure according to a 100-mm visual analog scale (VAS), an 11-point numeric rating scale (NRS …