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2001 2
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Page 1
Inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase.
Butler LM, Webb Y, Agus DB, Higgins B, Tolentino TR, Kutko MC, LaQuaglia MP, Drobnjak M, Cordon-Cardo C, Scher HI, Breslow R, Richon VM, Rifkind RA, Marks PA. Butler LM, et al. Clin Cancer Res. 2001 Apr;7(4):962-70. Clin Cancer Res. 2001. PMID: 11309347
CWR22 prostate cancer xenografts. Despite the potent growth-inhibitory effects of pyroxamide in this tumor model, serum prostate-specific antigen levels in control versus pyroxamide-treated mice were not significantly different. ...CONCLUSIONS: The findings suggest …
CWR22 prostate cancer xenografts. Despite the potent growth-inhibitory effects of pyroxamide in this tumor model, serum prostate-spec …
FRMD6 has tumor suppressor functions in prostate cancer.
Haldrup J, Strand SH, Cieza-Borrella C, Jakobsson ME, Riedel M, Norgaard M, Hedensted S, Dagnaes-Hansen F, Ulhoi BP, Eeles R, Borre M, Olsen JV, Thomsen M, Kote-Jarai Z, Sorensen KD. Haldrup J, et al. Oncogene. 2021 Jan;40(4):763-776. doi: 10.1038/s41388-020-01548-w. Epub 2020 Nov 28. Oncogene. 2021. PMID: 33249427
Connectivity Map analysis and drug repurposing experiments identified pyroxamide as a new potential therapy for FRMD6 deficient PC cells. ...
Connectivity Map analysis and drug repurposing experiments identified pyroxamide as a new potential therapy for FRMD6 deficient PC ce …
Histone deacetylase inhibitors and anticancer therapy.
Kouraklis G, Theocharis S. Kouraklis G, et al. Curr Med Chem Anticancer Agents. 2002 Jul;2(4):477-84. doi: 10.2174/1568011023353921. Curr Med Chem Anticancer Agents. 2002. PMID: 12678732 Review.
In the class of HDAC inhibitors, now included a short-chain fatty acids, such as 4-phenylbutyrate and valporic acid, hydroxamic acids, such as suberoylanilide hydroxamic acid (SAHA), pyroxamide, trichostatin A, oxamflatin and CHAPSs, cyclic tetrapeptides, such as trapoxin, …
In the class of HDAC inhibitors, now included a short-chain fatty acids, such as 4-phenylbutyrate and valporic acid, hydroxamic acids, such …
Histone deacetylase inhibitors: a novel target of anticancer therapy (review).
Kouraklis G, Theocharis S. Kouraklis G, et al. Oncol Rep. 2006 Feb;15(2):489-94. Oncol Rep. 2006. PMID: 16391874 Review.
The histone deacetylase inhibitors (HDIs) including the hydroxamic acids, such as suberoylanilide hydroxamic acid and pyroxamide, the benzamides MS-275 and CI-994 and the butyrate derivative 4-PBA are a new class of anti-neoplastic agents currently being evaluated in clini …
The histone deacetylase inhibitors (HDIs) including the hydroxamic acids, such as suberoylanilide hydroxamic acid and pyroxamide, the …
Histone deacetylase inhibitors induce growth suppression and cell death in human rhabdomyosarcoma in vitro.
Kutko MC, Glick RD, Butler LM, Coffey DC, Rifkind RA, Marks PA, Richon VM, LaQuaglia MP. Kutko MC, et al. Clin Cancer Res. 2003 Nov 15;9(15):5749-55. Clin Cancer Res. 2003. PMID: 14654560
Exposure of the RMS cells to SAHA and pyroxamide resulted in an accumulation of acetylated histones with increasing doses by Western blot analysis. ...CONCLUSIONS: SAHA and pyroxamide induce growth suppression and cell death in human RMS in vitro. ...
Exposure of the RMS cells to SAHA and pyroxamide resulted in an accumulation of acetylated histones with increasing doses by Western …
Colchicine inhibits the proliferation and promotes the apoptosis of papillary thyroid carcinoma cells likely due to the inhibitory effect on HDAC1.
Wang S, Cui Z, Zhu J, Zhou P, Cao X, Li X, Ma Y, He Q. Wang S, et al. Biochem Biophys Res Commun. 2023 Oct 30;679:129-138. doi: 10.1016/j.bbrc.2023.09.006. Epub 2023 Sep 8. Biochem Biophys Res Commun. 2023. PMID: 37690423
The cytotoxicity and inhibitory effect of colchicine on HDAC1 in PTC cells was stronger than that in normal thyroid cells. We then applied an HDAC1 inhibitor, pyroxamide, to verify that inhibition of HDAC1 inhibits proliferation and promotes apoptosis in PTC cells. ...
The cytotoxicity and inhibitory effect of colchicine on HDAC1 in PTC cells was stronger than that in normal thyroid cells. We then applied a …
HDAC1 in the Ovarian Granulosa Cells of Tan Sheep Improves Cumulus Cell Expansion and Oocyte Maturation Independently of the EGF-like Growth Factors.
Xu Y, Fan S, Liu Y, Shi J, Xie X, Wang X, Wang C, Liu X, Xia G. Xu Y, et al. Biology (Basel). 2022 Oct 6;11(10):1464. doi: 10.3390/biology11101464. Biology (Basel). 2022. PMID: 36290368 Free PMC article.
However, the level of HDAC1 was unaffected by luteinizing hormone (LH) induction in cultured granulosa cells. Meanwhile, the specific inhibition of HDAC1 using pyroxamide did not induce significant changes in the expression levels of EGF-like growth factors in vitro, where …
However, the level of HDAC1 was unaffected by luteinizing hormone (LH) induction in cultured granulosa cells. Meanwhile, the specific inhibi …
Causal network analysis of head and neck keloid tissue identifies potential master regulators.
Garcia-Rodriguez L, Jones L, Chen KM, Datta I, Divine G, Worsham MJ. Garcia-Rodriguez L, et al. Laryngoscope. 2016 Oct;126(10):E319-24. doi: 10.1002/lary.25958. Epub 2016 Mar 18. Laryngoscope. 2016. PMID: 26990118
RESULTS: Causal Network Analysis software identified four hierarchical networks that included four master regulators (pyroxamide, tributyrin, PRKG2, and PENK) and 19 intermediate regulators. ...
RESULTS: Causal Network Analysis software identified four hierarchical networks that included four master regulators (pyroxamide, tri …
New drugs in gynecologic cancer.
Daud A, Munster P, Munster P, Spriggs DR. Daud A, et al. Curr Treat Options Oncol. 2001 Apr;2(2):119-28. doi: 10.1007/s11864-001-0054-0. Curr Treat Options Oncol. 2001. PMID: 12057130 Review.