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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1926 4
1927 2
1928 2
1929 1
1930 4
1931 2
1932 1
1933 2
1934 5
1935 3
1936 4
1937 2
1939 1
1940 1
1942 2
1943 1
1944 1
1945 16
1946 37
1947 31
1948 49
1949 45
1950 52
1951 106
1952 124
1953 165
1954 163
1955 186
1956 205
1957 204
1958 232
1959 260
1960 244
1961 261
1962 359
1963 481
1964 655
1965 482
1966 551
1967 576
1968 641
1969 708
1970 743
1971 759
1972 876
1973 950
1974 971
1975 940
1976 954
1977 1050
1978 1125
1979 1158
1980 1174
1981 1156
1982 1209
1983 1173
1984 1216
1985 1234
1986 1260
1987 1173
1988 1147
1989 1185
1990 1199
1991 1106
1992 1081
1993 1103
1994 1035
1995 956
1996 1000
1997 992
1998 931
1999 895
2000 919
2001 917
2002 888
2003 963
2004 987
2005 1088
2006 1065
2007 1113
2008 1116
2009 1155
2010 1181
2011 1136
2012 1160
2013 1310
2014 1254
2015 1295
2016 1330
2017 1370
2018 1355
2019 1387
2020 1532
2021 1631
2022 1510
2023 1423
2024 436

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64,977 results

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Page 1
Levothyroxine for the Treatment of Subclinical Hypothyroidism and Cardiovascular Disease.
Sue LY, Leung AM. Sue LY, et al. Front Endocrinol (Lausanne). 2020 Oct 21;11:591588. doi: 10.3389/fendo.2020.591588. eCollection 2020. Front Endocrinol (Lausanne). 2020. PMID: 33193104 Free PMC article. Review.
In addition, evidence from multiple studies supports an association between subclinical hypothyroidism and cardiovascular disease. However, the use of levothyroxine in subclinical hypothyroidism to reduce cardiovascular disease risk is not clearly beneficial. Treatment wit …
In addition, evidence from multiple studies supports an association between subclinical hypothyroidism and cardiovascular disease. However, …
Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism: A Consensus Document.
Jonklaas J, Bianco AC, Cappola AR, Celi FS, Fliers E, Heuer H, McAninch EA, Moeller LC, Nygaard B, Sawka AM, Watt T, Dayan CM. Jonklaas J, et al. Thyroid. 2021 Feb;31(2):156-182. doi: 10.1089/thy.2020.0720. Thyroid. 2021. PMID: 33276704 Free PMC article. Review.
Background: Fourteen clinical trials have not shown a consistent benefit of combination therapy with levothyroxine (LT4) and liothyronine (LT3). Despite the publication of these trials, combination therapy is widely used and patients reporting benefit continue to generate …
Background: Fourteen clinical trials have not shown a consistent benefit of combination therapy with levothyroxine (LT4) and liothyro …
Levothyroxine Sodium Pentahydrate Tablets - Formulation Considerations.
Kaur N, Suryanarayanan R. Kaur N, et al. J Pharm Sci. 2021 Dec;110(12):3743-3756. doi: 10.1016/j.xphs.2021.08.006. Epub 2021 Aug 10. J Pharm Sci. 2021. PMID: 34384799 Review.
Even though levothyroxine sodium pentahydrate tablets have been in the market since 1955, there continue to be recalls due to sub potency. ...In drug products, depending on the formulation composition and storage conditions, the pentahydrate can dehydrate to highly reactiv …
Even though levothyroxine sodium pentahydrate tablets have been in the market since 1955, there continue to be recalls due to sub pot …
Role of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism.
Jonklaas J. Jonklaas J. Endocrinol Metab Clin North Am. 2022 Jun;51(2):243-263. doi: 10.1016/j.ecl.2021.12.003. Epub 2022 May 4. Endocrinol Metab Clin North Am. 2022. PMID: 35662440 Review.
Diverse causes potentially underlie decreased quality of life in biochemically euthyroid patients treated for hypothyroidism with levothyroxine. Once these contributing factors are addressed, if symptoms persist, there may be benefit to personalized use of combination ther …
Diverse causes potentially underlie decreased quality of life in biochemically euthyroid patients treated for hypothyroidism with levothy …
Levothyroxine Sodium - Thyroid Hormone Replacement Therapy for Hypothyroidism: A Review of Patent Literature.
Upadhyay U, Vora PA, Patel R, Prajapati B. Upadhyay U, et al. Recent Pat Biotechnol. 2023;17(3):245-256. doi: 10.2174/1872208317666221212124113. Recent Pat Biotechnol. 2023. PMID: 36515027 Review.
BACKGROUND: Levothyroxine Sodium is a thyroid hormone replacement therapy for Hypothyroidism. ...However, the formulation of Levothyroxine Sodium with better characteristics needs to be developed. ...
BACKGROUND: Levothyroxine Sodium is a thyroid hormone replacement therapy for Hypothyroidism. ...However, the formulation of Levot …
Hypothyroidism.
Chaker L, Bianco AC, Jonklaas J, Peeters RP. Chaker L, et al. Lancet. 2017 Sep 23;390(10101):1550-1562. doi: 10.1016/S0140-6736(17)30703-1. Epub 2017 Mar 20. Lancet. 2017. PMID: 28336049 Free PMC article. Review.
The standard treatment is thyroid hormone replacement therapy with levothyroxine. However, a substantial proportion of patients who reach biochemical treatment targets have persistent complaints. ...
The standard treatment is thyroid hormone replacement therapy with levothyroxine. However, a substantial proportion of patients who r …
Oral levothyroxine therapy postbariatric surgery: Biopharmaceutical aspects and clinical effects.
Azran C, Porat D, Fine-Shamir N, Hanhan N, Dahan A. Azran C, et al. Surg Obes Relat Dis. 2019 Feb;15(2):333-341. doi: 10.1016/j.soard.2019.01.001. Epub 2019 Jan 10. Surg Obes Relat Dis. 2019. PMID: 30704913 Review.
OBJECTIVE: The purpose of this work was to provide a mechanistic overview of levothyroxine absorption, and to thoroughly analyze the expected effects of bariatric surgery on oral levothyroxine therapy. ...RESULTS: Different mechanisms may support opposing trends as …
OBJECTIVE: The purpose of this work was to provide a mechanistic overview of levothyroxine absorption, and to thoroughly analyze the …
Liquid levothyroxine formulations in patients taking drugs interfering with L-T4 absorption.
Gatta E, Bambini F, Buoso C, Gava M, Maltese V, Anelli V, Delbarba A, Pirola I, Cappelli C. Gatta E, et al. Front Endocrinol (Lausanne). 2022 Dec 6;13:1080108. doi: 10.3389/fendo.2022.1080108. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 36561558 Free PMC article. Review.
The final reference list was defined based on the relevance of each paper to the scope of this review. RESULTS: The available data showed that novel levothyroxine formulations circumvent gastric pH impairment due to multiple interfering drugs such as proton pump inhibitors …
The final reference list was defined based on the relevance of each paper to the scope of this review. RESULTS: The available data showed th …
Editorial: Levothyroxine Therapy in Patients With Hypothyroidism.
Antonelli A, Wartofsky L, Miccoli P. Antonelli A, et al. Front Endocrinol (Lausanne). 2021 Jul 20;12:734895. doi: 10.3389/fendo.2021.734895. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 34354674 Free PMC article. No abstract available.
Triiodothyronine alongside levothyroxine in the management of hypothyroidism?
Gottwald-Hostalek U, Kahaly GJ. Gottwald-Hostalek U, et al. Curr Med Res Opin. 2021 Dec;37(12):2099-2106. doi: 10.1080/03007995.2021.1984219. Epub 2021 Oct 12. Curr Med Res Opin. 2021. PMID: 34553643 Review.
The current guideline-based management of hypothyroidism recommends monotherapy with levothyroxine (LT4), titrated to maintain the level of thyrotropin within a euthyroid reference range. ...
The current guideline-based management of hypothyroidism recommends monotherapy with levothyroxine (LT4), titrated to maintain the le …
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