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160 results

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Page 1
Hextend attenuates hypercoagulability after severe liver injury in swine.
Todd SR, Malinoski D, Muller PJ, Schreiber MA. Todd SR, et al. J Trauma. 2005 Sep;59(3):589-93; discussion 593-4. J Trauma. 2005. PMID: 16361900
Animals required 119 +/- 78 mL/kg of fluid in the LR group and 40 +/- 21 mL/kg in the Hextend group (p = 0.01). After resuscitation, the secondary blood loss was 3.7 +/- 1.7 mL/kg in the LR group and 4.7 +/- 1.1 mL/kg in the Hextend group (p = 0.1). ...This was less …
Animals required 119 +/- 78 mL/kg of fluid in the LR group and 40 +/- 21 mL/kg in the Hextend group (p = 0.01). After resuscitation, …
Comparisons of lactated Ringer's and Hextend resuscitation on hemodynamics and coagulation following femur injury and severe hemorrhage in pigs.
Martini WZ, Dubick MA, Blackbourne LH. Martini WZ, et al. J Trauma Acute Care Surg. 2013 Mar;74(3):732-9; discussion 739-40. doi: 10.1097/TA.0b013e31827f156d. J Trauma Acute Care Surg. 2013. PMID: 23425729
METHODS: Pigs were randomized into control (n = 7 each), LR, and Hextend groups. Femur fracture was induced using the captive bolt stunner at midshaft of the pigs' left legs, followed by hemorrhage of 60% total blood volume and resuscitation with either Hextend (equ …
METHODS: Pigs were randomized into control (n = 7 each), LR, and Hextend groups. Femur fracture was induced using the captive bolt st …
What If I Don't Have Blood? Hextend is Superior to 3% Saline in an Experimental Model of Far Forward Resuscitation After Hemorrhage.
Jernigan PL, Hoehn RS, Cox D, Heyl J, Dorlac WC, Pritts TA. Jernigan PL, et al. Shock. 2016 Sep;46(3 Suppl 1):148-53. doi: 10.1097/SHK.0000000000000676. Shock. 2016. PMID: 27380529
CONCLUSIONS: HS performed inferiorly to Hextend as a volume expanding resuscitative fluid after hemorrhage. On the basis of our data, we would recommend the use of Hextend over 3% saline in far forward resuscitation after hemorrhage....
CONCLUSIONS: HS performed inferiorly to Hextend as a volume expanding resuscitative fluid after hemorrhage. On the basis of our data, …
Compatibility screening of hextend during simulated y-site administration with other drugs.
Trissel LA, Williams KY, Baker MB. Trissel LA, et al. Int J Pharm Compd. 2001 Jan-Feb;5(1):69-72. Int J Pharm Compd. 2001. PMID: 23981801
Hextend injection should not be administered simultaneously with those incompatible drugs. Other drugs previously reported to be incompatible with 6% hetastarch in 0.9% sodium chloride injection were not found to be incompatible with Hextend....
Hextend injection should not be administered simultaneously with those incompatible drugs. Other drugs previously reported to be inco …
Whole blood and Hextend: Bookends of modern tactical combat casualty care field resuscitation and starting point for multifunctional resuscitation fluid development.
Sheppard FR, Mitchell TA, Macko AR, Fryer DM, Schaub LJ, Ozuna KM, Glaser JJ. Sheppard FR, et al. J Trauma Acute Care Surg. 2018 Jul;85(1S Suppl 2):S33-S38. doi: 10.1097/TA.0000000000001772. J Trauma Acute Care Surg. 2018. PMID: 29261592
Animals were randomized to prehospital interventions of whole blood or Hextend at T = 0 minutes, and at T = 90 minutes definitive surgical interventions and balanced sanguineous damage control resuscitation could be implemented. ...RESULTS: No significant differences in su …
Animals were randomized to prehospital interventions of whole blood or Hextend at T = 0 minutes, and at T = 90 minutes definitive sur …
Effects of intraosseous and intravenous administration of Hextend on time of administration and hemodynamics in a Swine model.
Johnson D, Dial J, Ard J, Yourk T, Burke E, Paine C, Gegel B, Burgert J. Johnson D, et al. J Spec Oper Med. 2014 Spring;14(1):79-85. doi: 10.55460/83H7-PQIY. J Spec Oper Med. 2014. PMID: 24604442
PURPOSES: The purposes of this study were to compare the time of administration of Hextend and the hemodynamics of IV and IO routes in a Class II hemorrhage swine model. ...CONCLUSIONS: The IO route is an effective method of administering Hextend....
PURPOSES: The purposes of this study were to compare the time of administration of Hextend and the hemodynamics of IV and IO routes i …
Resuscitation with Hextend decreases endogenous circulating heparin activity and accelerates clot initiation after hemorrhage in the rabbit.
Nielsen VG. Nielsen VG. Anesth Analg. 2001 Nov;93(5):1106-10. doi: 10.1097/00000539-200111000-00007. Anesth Analg. 2001. PMID: 11682376
The reaction time significantly decreased by 34% after hemorrhage and resuscitation with Hextend, whereas no other significant changes in Thrombelastograph variables were noted. Antithrombin III activity was significantly less in the Albumin (83% +/- 8% of control, mean +/ …
The reaction time significantly decreased by 34% after hemorrhage and resuscitation with Hextend, whereas no other significant change …
Hydroxyethyl starch in balanced electrolyte solution (Hextend)--pharmacokinetic and pharmacodynamic profiles in healthy volunteers.
Wilkes NJ, Woolf RL, Powanda MC, Gan TJ, Machin SJ, Webb A, Mutch M, Bennett-Guerrero E, Mythen M. Wilkes NJ, et al. Anesth Analg. 2002 Mar;94(3):538-44; table of contents. doi: 10.1097/00000539-200203000-00011. Anesth Analg. 2002. PMID: 11867371
This open-label study was designed to investigate the pharmacokinetic and pharmacodynamic profiles of Hextend in 21 healthy volunteers. We infused Hextend 10 ml/kg IV over 20 min and determined serum concentrations of HES at selected intervals over a 7-day period. . …
This open-label study was designed to investigate the pharmacokinetic and pharmacodynamic profiles of Hextend in 21 healthy volunteer …
Intravenous Hydroxocobalamin Versus Hextend Versus Control for Class III Hemorrhage Resuscitation in a Prehospital Swine Model.
Bebarta VS, Garrett N, Boudreau S, Castaneda M. Bebarta VS, et al. Mil Med. 2018 Nov 5;183(11-12):e721-e729. doi: 10.1093/milmed/usy173. Mil Med. 2018. PMID: 30500921

BACKGROUND: Hydroxyethyl starch (Hextend) has been used for hemorrhagic shock resuscitation, however, hydroxyethyl starch may be associated with adverse outcomes. ...Prothrombin time was longer and platelet counts were lower in the Hextend group (p < 0.05). Moreo

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BACKGROUND: Hydroxyethyl starch (Hextend) has been used for hemorrhagic shock resuscitation, however, hydroxyethyl starch may be asso …
Hextend-perfluorocarbon cocktail inhibits mean arterial pressure response in a rabbit shock model.
Reynolds PS, Spiess BD. Reynolds PS, et al. J Surg Res. 2015 Dec;199(2):536-44. doi: 10.1016/j.jss.2015.04.063. Epub 2015 Apr 28. J Surg Res. 2015. PMID: 26001673
BACKGROUND: Hextend (HEX) is standard of care resuscitation fluid for combat-related traumatic hemorrhage. ...
BACKGROUND: Hextend (HEX) is standard of care resuscitation fluid for combat-related traumatic hemorrhage. ...
160 results