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The natural sesquiterpene lactones arglabin, grosheimin, agracin, parthenolide, and estafiatin inhibit T cell receptor (TCR) activation.
Schepetkin IA, Kirpotina LN, Mitchell PT, Kishkentaeva АS, Shaimerdenova ZR, Atazhanova GA, Adekenov SM, Quinn MT. Schepetkin IA, et al. Phytochemistry. 2018 Feb;146:36-46. doi: 10.1016/j.phytochem.2017.11.010. Epub 2017 Dec 22. Phytochemistry. 2018. PMID: 29216473 Free PMC article.
To identify natural compounds that could inhibit inflammatory T cell responses, we screened 13 sesquiterpene lactones, including achillin, arglabin, argolide, argracin, 3beta-hydroxyarhalin, artesin, artemisinin, estafiatin, grosheimin, grossmisin, leucomisine, parthenolid …
To identify natural compounds that could inhibit inflammatory T cell responses, we screened 13 sesquiterpene lactones, including achillin, a …
Diastereoselective Allylation in the Divergent Total Syntheses of Guaianolides (+)-Ligustrin and (+)-Grosheimin and the Formal Synthesis of (-)-Eupalinilide E.
Fernandes RA, Ramakrishna GV. Fernandes RA, et al. J Org Chem. 2024 Jan 19;89(2):815-824. doi: 10.1021/acs.joc.2c02094. Epub 2022 Oct 24. J Org Chem. 2024. PMID: 36279194
An efficient diastereoselective allylation of aldehydes with functionalized allyl bromolactone paved an excellent path toward the protecting-group-free divergent total synthesis of various guaianolides (+)-ligustrin, (+)-8-epi-ligustrin, and (+)-grosheimin and the formal s …
An efficient diastereoselective allylation of aldehydes with functionalized allyl bromolactone paved an excellent path toward the protecting …
Effects of Sesquiterpene Lactones on Primary Cilia Formation (Ciliogenesis).
Murillo-Pineda M, Coto-Cid JM, Romero M, Zorrilla JG, Chinchilla N, Medina-Calzada Z, Varela RM, Juárez-Soto Á, Macías FA, Reales E. Murillo-Pineda M, et al. Toxins (Basel). 2023 Oct 27;15(11):632. doi: 10.3390/toxins15110632. Toxins (Basel). 2023. PMID: 37999495 Free PMC article.
However, the impact of SLs on primary cilia remains unknown. This study evaluated the effects of selected SLs (grosheimin, costunolide, and three cyclocostunolides) on primary cilia biogenesis and stability in human retinal pigment epithelial (RPE) cells. ...All SLs disrup …
However, the impact of SLs on primary cilia remains unknown. This study evaluated the effects of selected SLs (grosheimin, costunolid …
Receptor Polymorphism and Genomic Structure Interact to Shape Bitter Taste Perception.
Roudnitzky N, Behrens M, Engel A, Kohl S, Thalmann S, Hübner S, Lossow K, Wooding SP, Meyerhof W. Roudnitzky N, et al. PLoS Genet. 2015 Sep 25;11(9):e1005530. doi: 10.1371/journal.pgen.1005530. eCollection 2015. PLoS Genet. 2015. PMID: 26406243 Free PMC article.
Therefore, to investigate more complex associations, we examined taste responses to six structurally diverse compounds (absinthin, amarogentin, cascarillin, grosheimin, quassin, and quinine) in a sample of the Caucasian population. ...When sensitive alleles for bitter comp …
Therefore, to investigate more complex associations, we examined taste responses to six structurally diverse compounds (absinthin, amarogent …
Encapsulation of Cynara Cardunculus Guaiane-type Lactones in Fully Organic Nanotubes Enhances Their Phytotoxic Properties.
Mejías FJR, Fernández IP, Rial C, Varela RM, Molinillo JMG, Calvino JJ, Trasobares S, Macías FA. Mejías FJR, et al. J Agric Food Chem. 2022 Mar 30;70(12):3644-3653. doi: 10.1021/acs.jafc.1c07806. Epub 2022 Mar 15. J Agric Food Chem. 2022. PMID: 35289164 Free PMC article.
In addition, biological studies were performed with aguerin B (1), cynaropicrin (2), and grosheimin (3) on the inhibition of germination, roots, and shoots in weeds (Phalaris arundinacea L., Lolium perenne L., and Portulaca oleracea L.). ...
In addition, biological studies were performed with aguerin B (1), cynaropicrin (2), and grosheimin (3) on the inhibition of germinat …
Study on the metabolism of natural sesquiterpene lactones in human liver microsomes using LC-Q-TOF-MS/MS.
Grafakou ME, Barda C, Skaltsa H, Heilmann J. Grafakou ME, et al. Nat Prod Res. 2023 Jun 24:1-9. doi: 10.1080/14786419.2023.2226301. Online ahead of print. Nat Prod Res. 2023. PMID: 37354443
Sesquiterpene lactones are naturally occurring, highly active -specialised metabolites, which are biosynthesized by important medicinal plants, fulfilling many functions. The in vitro metabolism of parthenolide (1), grosheimin (2), carbetolide C (3), 8alpha-O-(3,4-dihydrox …
Sesquiterpene lactones are naturally occurring, highly active -specialised metabolites, which are biosynthesized by important medicinal plan …
Byproducts of Globe Artichoke and Cauliflower Production as a New Source of Bioactive Compounds in the Green Economy Perspective: An NMR Study.
Ingallina C, Di Matteo G, Spano M, Acciaro E, Campiglia E, Mannina L, Sobolev AP. Ingallina C, et al. Molecules. 2023 Jan 31;28(3):1363. doi: 10.3390/molecules28031363. Molecules. 2023. PMID: 36771031 Free PMC article.
In particular, globe artichoke byproducts are a source of health-beneficial compounds including chiro-inositol (up to 10.1 mg/g), scyllo-inositol (up to 1.8 mg/g), sesquiterpene lactones (cynaropicrin, grosheimin, dehydrocynaropicrin, up to 45.5 mg/g in total), inulins, an …
In particular, globe artichoke byproducts are a source of health-beneficial compounds including chiro-inositol (up to 10.1 mg/g), scyllo-ino …
Bioguided isolation of potential antitumor agents from the aerial parts of cultivated cardoon (Cynara cardunculus var. altilis).
Hamza RA, Mostafa I, Mohamed YS, Dora GA, Ateya AM, Abdelaal M, Fantoukh OI, Alqahtani A, Attia RA. Hamza RA, et al. Saudi Pharm J. 2023 Jan;31(1):125-134. doi: 10.1016/j.jsps.2022.11.011. Epub 2022 Nov 21. Saudi Pharm J. 2023. PMID: 36685304 Free PMC article.
Bioguided chromatographic separation of the ethanol extract of C. cardunculus led to the isolation of seven secondary metabolites including two sesquiterpene lactones as the principal active components of the methylene chloride soluble fraction, grosheimin (IC(50) = 7.49 g …
Bioguided chromatographic separation of the ethanol extract of C. cardunculus led to the isolation of seven secondary metabolites including …
19 results