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Did you mean gardening (46,426 results)?
Gardenin A improves cognitive and motor function in A53T-alpha-syn mice.
Hack W, Gladen-Kolarsky N, Chatterjee S, Liang Q, Maitra U, Ciesla L, Gray NE. Hack W, et al. bioRxiv [Preprint]. 2023 Nov 1:2023.10.27.564401. doi: 10.1101/2023.10.27.564401. bioRxiv. 2023. PMID: 37961574 Free PMC article. Updated. Preprint.
These effects may be related to activation of the NRF2-regulated antioxidant response and downregulation of NFkB-dependent inflammatory response by Gardenin A in treated animals. The study also showed excellent brain bioavailability of Gardenin A and modifications o …
These effects may be related to activation of the NRF2-regulated antioxidant response and downregulation of NFkB-dependent inflammatory resp …
Evaluation of the neuropharmacological effects of Gardenin A in mice.
Alonso-Castro AJ, Gasca-Martínez D, Cortez-Mendoza LV, Alba-Betancourt C, Ruiz-Padilla AJ, Zapata-Morales JR. Alonso-Castro AJ, et al. Drug Dev Res. 2020 Aug;81(5):600-608. doi: 10.1002/ddr.21659. Epub 2020 Mar 17. Drug Dev Res. 2020. PMID: 32181517
This work describes the neuropharmacological (sedative, anxiolytic, antidepressant, and anticonvulsant) actions of Gardenin A (GA) (0.1-25 mg/kg p.o.), a flavonoid found in medicinal plants. ...
This work describes the neuropharmacological (sedative, anxiolytic, antidepressant, and anticonvulsant) actions of Gardenin A (GA) (0 …
Gardenin A treatment attenuates inflammatory markers, synuclein pathology and deficits in tyrosine hydroxylase expression and improves cognitive and motor function in A53T-alpha-syn mice.
Hack W, Gladen-Kolarsky N, Chatterjee S, Liang Q, Maitra U, Ciesla L, Gray NE. Hack W, et al. Biomed Pharmacother. 2024 Apr;173:116370. doi: 10.1016/j.biopha.2024.116370. Epub 2024 Mar 8. Biomed Pharmacother. 2024. PMID: 38458012 Free PMC article.
Oxidative stress and neuroinflammation are widespread in the Parkinson's disease (PD) brain and contribute to the synaptic degradation and dopaminergic cell loss that result in cognitive impairment and motor dysfunction. The polymethoxyflavone Gardenin A (GA) has been show …
Oxidative stress and neuroinflammation are widespread in the Parkinson's disease (PD) brain and contribute to the synaptic degradation and d …
Gardenin B-induced cell death in human leukemia cells involves multiple caspases but is independent of the generation of reactive oxygen species.
Cabrera J, Saavedra E, Del Rosario H, Perdomo J, Loro JF, Cifuente DA, Tonn CE, García C, Quintana J, Estévez F. Cabrera J, et al. Chem Biol Interact. 2016 Aug 25;256:220-7. doi: 10.1016/j.cbi.2016.07.016. Epub 2016 Jul 14. Chem Biol Interact. 2016. PMID: 27423764
Comparative studies with the best-studied bioflavonoid quercetin indicate that gardenin B is a more cytotoxic and more apoptotic inducer than quercetin. ...In conclusion, apoptosis induced by gardenin B is associated with activation of both the extrinsic and the int …
Comparative studies with the best-studied bioflavonoid quercetin indicate that gardenin B is a more cytotoxic and more apoptotic indu …
Identification of metabolites of gardenin A in rats by combination of high-performance liquid chromatography with linear ion trap-Orbitrap mass spectrometer based on multiple data processing techniques.
Zhang J, Wang F, Cai W, Zhang Q, Liu Y, Li Y, Liu R, Cao G. Zhang J, et al. Biomed Chromatogr. 2015 Mar;29(3):379-87. doi: 10.1002/bmc.3287. Epub 2014 Jul 9. Biomed Chromatogr. 2015. PMID: 25041995
Gardenin A is one of the less abundant hydroxylated polymethoxyflavonoids (OH-PMFs) in nature, and has many potential significant health benefits. ...Overall, this study gives us a first insight into the in vivo metabolism of gardenin A. The study also provides a pr …
Gardenin A is one of the less abundant hydroxylated polymethoxyflavonoids (OH-PMFs) in nature, and has many potential significant hea …
Neurotrophic action of 5-hydroxylated polymethoxyflavones: 5-demethylnobiletin and gardenin A stimulate neuritogenesis in PC12 cells.
Chiu SP, Wu MJ, Chen PY, Ho YR, Tai MH, Ho CT, Yen JH. Chiu SP, et al. J Agric Food Chem. 2013 Oct 2;61(39):9453-63. doi: 10.1021/jf4024678. Epub 2013 Sep 23. J Agric Food Chem. 2013. PMID: 24003765
The aim of this study is to investigate the neurotrophic effects of 5-demethylnobiletin, a hydroxylated PMF found in citrus plants, and gardenin A, a synthetic PMF analogue, on neurite outgrowth and neuronal differentiation in PC12 cells. ...Furthermore, our results showed …
The aim of this study is to investigate the neurotrophic effects of 5-demethylnobiletin, a hydroxylated PMF found in citrus plants, and g …
Antihyperlipidemic and hepatoprotective effects of Gardenin A in cellular and high fat diet fed rodent models.
Toppo E, Darvin SS, Esakkimuthu S, Stalin A, Balakrishna K, Sivasankaran K, Pandikumar P, Ignacimuthu S, Al-Dhabi NA. Toppo E, et al. Chem Biol Interact. 2017 May 1;269:9-17. doi: 10.1016/j.cbi.2017.03.013. Epub 2017 Mar 25. Chem Biol Interact. 2017. PMID: 28351695
This study was aimed to evaluate the antihyperlipidemic and anti-NAFLD effects of Gardenin A (Gar-A) from G. resinifera gum using in vitro and in vivo models. ...
This study was aimed to evaluate the antihyperlipidemic and anti-NAFLD effects of Gardenin A (Gar-A) from G. resinifera gum using in …
Gene expression profile induced by oral administration of baicalin and gardenin after focal brain ischemia in rats.
Zhang ZJ, Wang Z, Zhang XY, Ying K, Liu JX, Wang YY. Zhang ZJ, et al. Acta Pharmacol Sin. 2005 Mar;26(3):307-14. doi: 10.1111/j.1745-7254.2005.00051.x. Acta Pharmacol Sin. 2005. PMID: 15715926
AIM: To investigate differential gene expression and the pharmacological mechanism of baicalin and gardenin in focal cerebral ischemia in rats with high-density cDNA microarray. ...The differential genes were 211, 177, and 70 (upregulated or downregulated) in the model gro …
AIM: To investigate differential gene expression and the pharmacological mechanism of baicalin and gardenin in focal cerebral ischemi …
Characterization of bioactive constituents from the gum resin of Gardenia lucida and its pharmacological potential.
Maurya P, Singh S, Gupta MM, Luqman S. Maurya P, et al. Biomed Pharmacother. 2017 Jan;85:444-456. doi: 10.1016/j.biopha.2016.11.049. Epub 2016 Nov 26. Biomed Pharmacother. 2017. PMID: 27899258
Xanthomicrol (8) found as potent DPPH scavenger (85.861.3%) along with strong ferric plummeting ability (53.602.0 FSE) and reducing potential (1.070.01) as compared to ascorbic acid. Gardenin B (5) strongly inhibit biochemical production of nitric oxide (IC(50) 10.590.4mug …
Xanthomicrol (8) found as potent DPPH scavenger (85.861.3%) along with strong ferric plummeting ability (53.602.0 FSE) and reducing potentia …
Major flavonoids from Psiadia punctulata produce vasodilation via activation of endothelial dependent NO signaling.
Abdallah HM, Hassan NA, El-Halawany AM, Mohamed GA, Safo MK, El-Bassossy HM. Abdallah HM, et al. J Adv Res. 2020 Jan 3;24:273-279. doi: 10.1016/j.jare.2020.01.002. eCollection 2020 Jul. J Adv Res. 2020. PMID: 32382447 Free PMC article.
The bioactive chloroform fraction yielded five methoxylated flavonoids: umuhengerin (1), gardenin A (2), gardenin B (3), luteolin-3',4' -dimethyl ether (4), and 5,3'-dihydroxy-6,7,4',5'-tetramethoxyflavone (5). ...
The bioactive chloroform fraction yielded five methoxylated flavonoids: umuhengerin (1), gardenin A (2), gardenin B (3), luteo …
39 results