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Page 1
Dehydroretronecine-induced rhabdomyosarcomas in rats.
Allen JR, Hsu IC, Carstens LA. Allen JR, et al. Cancer Res. 1975 Apr;35(4):997-1002. Cancer Res. 1975. PMID: 1116156
Rhabdomyosarcomas developed at the site of dehydroretronecine injection in 51.6% of the rats and in 3.3% of the monocrotaline-treated rats. ...These data indicate that either monocrotaline or its metabolite dehydroretronecine are capable of causing neoplastic transf …
Rhabdomyosarcomas developed at the site of dehydroretronecine injection in 51.6% of the rats and in 3.3% of the monocrotaline-treated …
Antimitotic activity of dehydroretronecine, a pyrrolizidine alkaloid metabolite, and some analogous compounds, in a rat liver parenchymal cell line.
Mattocks AR, Legg RF. Mattocks AR, et al. Chem Biol Interact. 1980 Jun;30(3):325-36. doi: 10.1016/0009-2797(80)90055-1. Chem Biol Interact. 1980. PMID: 7379211
The actions of 13 pyrrolic alcohols with similar chemical properties have been tested on cultured liver cells. Two, dehydroretronecine and dehydrosupinidine, were putative metabolites of hepatotoxic pyrrolizidine alkaloids; the remainder were synthetic. ...Eleven compounds …
The actions of 13 pyrrolic alcohols with similar chemical properties have been tested on cultured liver cells. Two, dehydroretronecine …
Pyrrolizidine alkaloid-induced DNA-protein cross-links.
Kim HY, Stermitz FR, Coulombe RA Jr. Kim HY, et al. Carcinogenesis. 1995 Nov;16(11):2691-7. doi: 10.1093/carcin/16.11.2691. Carcinogenesis. 1995. PMID: 7586188
Protein-associated DNA cross-links accounted for approximately 50% of the total cellular DNA cross-links at 300 microM. The simple necine pyrrole dehydroretronecine induced few DNA--protein cross-links and none were detected with indicine N-oxide. ...Our data indicated tha …
Protein-associated DNA cross-links accounted for approximately 50% of the total cellular DNA cross-links at 300 microM. The simple necine py …
Crosslinking of DNA by dehydroretronecine, a metabolite of pyrrolizidine alkaloids.
Reed RL, Ahern KG, Pearson GD, Buhler DR. Reed RL, et al. Carcinogenesis. 1988 Aug;9(8):1355-61. doi: 10.1093/carcin/9.8.1355. Carcinogenesis. 1988. PMID: 3402032
Dehydroretronecine (DHR), a major metabolite of the pyrrolizidine alkaloids, has been shown to bind and crosslink pBR322 plasmid DNA and M13 viral DNA, as monitored by electron microscopy and agarose gel electrophoresis. ...
Dehydroretronecine (DHR), a major metabolite of the pyrrolizidine alkaloids, has been shown to bind and crosslink pBR322 plasmid DNA …
Dehydroretronecine-induced skin tumors in mice.
Johnson WD, Robertson KA, Pounds JG, Allen JR. Johnson WD, et al. J Natl Cancer Inst. 1978 Jul;61(1):85-9. doi: 10.1093/jnci/61.1.85. J Natl Cancer Inst. 1978. PMID: 276619
Female Swiss mice susceptible to skin tumors received 6 sc injections and/or topical applications of dehydroretronecine, a metabolite of the pyrrolizidine alkaloid monocrotaline, and were observed for 15 months for tumor development. Of 92 animals examined, 63 had tumors a …
Female Swiss mice susceptible to skin tumors received 6 sc injections and/or topical applications of dehydroretronecine, a metabolite …
Primary and secondary pyrrolic metabolites of pyrrolizidine alkaloids form DNA adducts in human A549 cells.
He X, Xia Q, Wu Q, Tolleson WH, Lin G, Fu PP. He X, et al. Toxicol In Vitro. 2019 Feb;54:286-294. doi: 10.1016/j.tiv.2018.10.009. Epub 2018 Oct 24. Toxicol In Vitro. 2019. PMID: 30366057
Here we showed that the four characteristic DNA adducts were formed when human A549 brochoalveolar carcinoma cells were treated with three dehydro-PAs (dehydroriddelliine, dehydromonocrotaline, or dehydroretronecine) or with 7-GS-DHP or 7-cysteine-DHP. For comparison, two …
Here we showed that the four characteristic DNA adducts were formed when human A549 brochoalveolar carcinoma cells were treated with three d …
Covalent interaction of dehydroretronecine, a carcinogenic metabolite of the pyrrolizidine alkaloid monocrotaline, with cysteine and glutathione.
Robertson KA, Seymour JL, Hsia MT, Allen JR. Robertson KA, et al. Cancer Res. 1977 Sep;37(9):3141-4. Cancer Res. 1977. PMID: 884667
Dehydroretronecine was allowed to react with cysteine and glutathione in an in vitro system of phosphate buffer solutions. ...These data indicate that the reaction products are the sulfhydryl-linked 7-thiocysteine-dehydroretronecine and 7-thioglutathione-dehydror …
Dehydroretronecine was allowed to react with cysteine and glutathione in an in vitro system of phosphate buffer solutions. ...These d …
Neoplastic transformation in tissues of rats exposed to monocrotaline or dehydroretronecine.
Shumaker RC, Robertson KA, Hsu IC, Allen JR. Shumaker RC, et al. J Natl Cancer Inst. 1976 Apr;56(4):787-90. doi: 10.1093/jnci/56.4.787. J Natl Cancer Inst. 1976. PMID: 176409
Of 60 rats that received dehydroretronecine, 39 developed rhabdomyosarcomas at the injection site, and 5 of these neoplasms metastasized. ...The reason suggested for the variation in tissue response was that the metabolite dehydroretronecine is a proximate carcinoge …
Of 60 rats that received dehydroretronecine, 39 developed rhabdomyosarcomas at the injection site, and 5 of these neoplasms metastasi …
Binding of tritiated dehydroretronecine to macromolecules.
Hsu IC, Robertson KA, Shumaker RC, Allen JR. Hsu IC, et al. Res Commun Chem Pathol Pharmacol. 1975 May;11(1):99-106. Res Commun Chem Pathol Pharmacol. 1975. PMID: 239444
In vivo and in vitro experiments have shown that the pyrrolizidine alkaloid metabolite dehydroretronecine binds readily to macromolecules. In the in vivo experiment there was a preferential binding of dehydroretronecine to the gastric mucosa. ...These data suggest a …
In vivo and in vitro experiments have shown that the pyrrolizidine alkaloid metabolite dehydroretronecine binds readily to macromolec …
Alkylation of N2 in deoxyguanosine by dehydroretronecine, a carcinogenic metabolite of the pyrrolizidine alkaloid monocrotaline.
Robertson KA. Robertson KA. Cancer Res. 1982 Jan;42(1):8-14. Cancer Res. 1982. PMID: 6797726
Dehydroretronecine, an antimitotic and carcinogenic agent, reacted with deoxyguanosine at pH 7.4 in vitro to yield in nearly equal quantities two major adducts, which were isolated by thin-layer and high-pressure liquid chromatography. ...These results demonstrate that the …
Dehydroretronecine, an antimitotic and carcinogenic agent, reacted with deoxyguanosine at pH 7.4 in vitro to yield in nearly equal qu …
77 results