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Curdlan sulfate/O-linked quaternized chitosan nanoparticles acting as potential adjuvants promote multiple arms of immune responses.
Zhang S, Jiang H, Huang S, Li P, Wang F. Zhang S, et al. Carbohydr Polym. 2019 Jun 1;213:100-111. doi: 10.1016/j.carbpol.2019.02.093. Epub 2019 Feb 26. Carbohydr Polym. 2019. PMID: 30879649
We have proven that compared with antigens loaded on CS or O-HTCC alone in nasal vaccination, antigens loaded on the nanoparticles of curdlan sulfate/O-(2-hydroxyl) propyl-3-trimethyl ammonium chitosan chloride (CS/O-HTCC) can induce stronger systemic and mucosal im …
We have proven that compared with antigens loaded on CS or O-HTCC alone in nasal vaccination, antigens loaded on the nanoparticles of cur …
Curdlan sulfate-O-linked quaternized chitosan nanoparticles: potential adjuvants to improve the immunogenicity of exogenous antigens via intranasal vaccination.
Zhang S, Huang S, Lu L, Song X, Li P, Wang F. Zhang S, et al. Int J Nanomedicine. 2018 Apr 18;13:2377-2394. doi: 10.2147/IJN.S158536. eCollection 2018. Int J Nanomedicine. 2018. PMID: 29713168 Free PMC article.
METHODS: By using the advantages of polysaccharides, which can promote both T-helper 1 and 2 responses, curdlan sulfate (CS)-O-(2-hydroxyl)propyl-3-trimethyl ammonium chitosan chloride (O-HTCC) nanoparticles were prepared by interacting CS with O-HTCC, and the adjuv …
METHODS: By using the advantages of polysaccharides, which can promote both T-helper 1 and 2 responses, curdlan sulfate (CS)-O …
Preparation and in vitro immunomodulatory effect of curdlan sulfate.
Li P, Zhang X, Cheng Y, Li J, Xiao Y, Zhang Q, Zong A, Zhong C, Wang F. Li P, et al. Carbohydr Polym. 2014 Feb 15;102:852-61. doi: 10.1016/j.carbpol.2013.10.078. Epub 2013 Nov 2. Carbohydr Polym. 2014. PMID: 24507356
The surface plasmon resonance (SPR) analysis found that CS3 exhibited binding affinity against dectin-1. These results suggested that curdlan sulfate can possibly be developed as a new immunotherapy agent and anti-viral vaccine adjuvant....
The surface plasmon resonance (SPR) analysis found that CS3 exhibited binding affinity against dectin-1. These results suggested that cur …
Preparation and evaluation of the adjuvant effect of curdlan sulfate in improving the efficacy of dendritic cell-based vaccine for antitumor immunotherapy.
Jin Y, Mu Y, Zhang S, Li P, Wang F. Jin Y, et al. Int J Biol Macromol. 2020 Mar 1;146:273-284. doi: 10.1016/j.ijbiomac.2019.12.256. Epub 2020 Jan 2. Int J Biol Macromol. 2020. PMID: 31904453
However, tumor antigen alone has limited immunostimulatory effects, and so immunostimulants are needed to prepare mature DCs. In our previous study, curdlan sulfate (CS) showed potent adjuvant properties with the HBV vaccine; therefore, we attempted to use CS to mat …
However, tumor antigen alone has limited immunostimulatory effects, and so immunostimulants are needed to prepare mature DCs. In our previou …
Effect and mechanisms of curdlan sulfate on inhibiting HBV infection and acting as an HB vaccine adjuvant.
Li P, Tan H, Xu D, Yin F, Cheng Y, Zhang X, Liu Y, Wang F. Li P, et al. Carbohydr Polym. 2014 Sep 22;110:446-55. doi: 10.1016/j.carbpol.2014.04.025. Epub 2014 Apr 20. Carbohydr Polym. 2014. PMID: 24906778
In this study, the effect and mechanisms of curdlan sulfate (CS3) on hepatitis B virus (HBV) infection and promoting immune response of the mice immunized with recombinant hepatitis B surface protein (HBsAg) were investigated. ...
In this study, the effect and mechanisms of curdlan sulfate (CS3) on hepatitis B virus (HBV) infection and promoting immune re …
Sulfated polysaccharide, curdlan sulfate, efficiently prevents entry/fusion and restricts antibody-dependent enhancement of dengue virus infection in vitro: a possible candidate for clinical application.
Ichiyama K, Gopala Reddy SB, Zhang LF, Chin WX, Muschin T, Heinig L, Suzuki Y, Nanjundappa H, Yoshinaka Y, Ryo A, Nomura N, Ooi EE, Vasudevan SG, Yoshida T, Yamamoto N. Ichiyama K, et al. PLoS Negl Trop Dis. 2013 Apr 25;7(4):e2188. doi: 10.1371/journal.pntd.0002188. Print 2013. PLoS Negl Trop Dis. 2013. PMID: 23658845 Free PMC article.
Curdlan sulfate (CRDS), a sulfated 13-beta-D glucan, previously shown to be a potent HIV entry inhibitor, is characterized in this study as a potent inhibitor of the Dengue virus (DENV). ...
Curdlan sulfate (CRDS), a sulfated 13-beta-D glucan, previously shown to be a potent HIV entry inhibitor, is characterized in …
Preparation and characterization of curdlan-chitosan conjugate nanoparticles as mucosal adjuvants for intranasal influenza H1N1 subunit vaccine.
Jiang H, Zhang S, Chen Y, Wang F, Jiang W. Jiang H, et al. Int J Biol Macromol. 2024 Apr 1;266(Pt 2):131289. doi: 10.1016/j.ijbiomac.2024.131289. Online ahead of print. Int J Biol Macromol. 2024. PMID: 38570002
Our research has demonstrated that a polyelectrolyte complex, composed of curdlan sulfate/O-(2-hydroxyl) propyl-3-trimethyl ammonium chitosan chloride (CS/O-HTCC), effectively triggers both mucosal and systemic immune responses when administrated intranasal. ...
Our research has demonstrated that a polyelectrolyte complex, composed of curdlan sulfate/O-(2-hydroxyl) propyl-3-trimethyl am …
Construction and characterization of nanosized curdlan sulfate/chitosan polyelectrolyte complex toward drug release of zidovudine.
Yan JK, Wang YY, Qiu WY, Wu JY. Yan JK, et al. Carbohydr Polym. 2017 Oct 15;174:209-216. doi: 10.1016/j.carbpol.2017.06.082. Epub 2017 Jun 23. Carbohydr Polym. 2017. PMID: 28821060
In this study, as-synthesized curdlan sulfate (CRDS) with a flexible random coil chain was selected as a polyanion to construct nanosized polyelectrolyte complexes (PECs) with a polycation, chitosan (CS), via electrostatic interactions. ...
In this study, as-synthesized curdlan sulfate (CRDS) with a flexible random coil chain was selected as a polyanion to construc …
47 results