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Year Number of Results
1989 2
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1993 5
1994 1
1995 4
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Page 1
Bidisomide (SC-40230), a new antiarrhythmic agent: initial study of tolerability and pharmacokinetics.
Page RL, Wharton JM, Wilkinson WE, Friedman IM, Claypool WD, Karim A, Kowalski KG, McDonald SJ, Gardiner P, Pritchett EL. Page RL, et al. Clin Pharmacol Ther. 1992 Apr;51(4):371-8. doi: 10.1038/clpt.1992.36. Clin Pharmacol Ther. 1992. PMID: 1563207 Clinical Trial.
Forty-nine healthy male volunteers received the test article for bidisomide (SC-40230) in a double-blind, placebo-controlled, dose-ranging study. ...Bioavailability was studied in 12 male volunteers, with each receiving 2.0 mg/kg of bidisomide, both orally and intra …
Forty-nine healthy male volunteers received the test article for bidisomide (SC-40230) in a double-blind, placebo-controlled, dose-ra …
Reduced systemic availability of an antiarrhythmic drug, bidisomide, with meal co-administration: relationship with region-dependent intestinal absorption.
Pao LH, Zhou SY, Cook C, Kararli T, Kirchhoff C, Truelove J, Karim A, Fleisher D. Pao LH, et al. Pharm Res. 1998 Feb;15(2):221-7. doi: 10.1023/a:1011958400362. Pharm Res. 1998. PMID: 9523307 Free article. Clinical Trial.
Non-viscous liquid meals decreased Cmax but not AUC, while viscous homogenized solid meals decreased both Cmax and AUC for bidisomide with oral drug-meal co-administration. Oral non-caloric hydroxypropyl methylcellulose meals decreased bidisomide to the same extent …
Non-viscous liquid meals decreased Cmax but not AUC, while viscous homogenized solid meals decreased both Cmax and AUC for bidisomide …
Comparison of bidisomide, flecainide and dofetilide on action potential duration in isolated canine atria: effect of isoproterenol.
Martin CL, Palomo MA, Mcmahon EG. Martin CL, et al. J Pharmacol Exp Ther. 1996 Jul;278(1):154-62. J Pharmacol Exp Ther. 1996. PMID: 8764346
Bidisomide was inactive in a functional beta-adrenergic antagonism assay, thus ruling out beta-adrenergic blockade as a potential mechanism. ...These data suggest that bidisomide would be effective in the presence of elevated sympathetic tone and on the agents studi …
Bidisomide was inactive in a functional beta-adrenergic antagonism assay, thus ruling out beta-adrenergic blockade as a potential mec …
Metabolism of a novel antiarrhythmic agent, bidisomide, in man: use of high resolution mass spectrometry to distinguish desisopropyl bidisomide from desacetyl bidisomide.
Cook CS, Ames GB, Hribar JD, Liu NW, Sweeney DL, Schoenhard GL, Karim A. Cook CS, et al. Xenobiotica. 1995 Sep;25(9):981-91. doi: 10.3109/00498259509046669. Xenobiotica. 1995. PMID: 8553691
The mass spectra of bidisomide metabolites indicate that the two major metabolic pathways of bidisomide were hydroxylation of the piperidine ring and N-dealkylation. ...The N-dealkylated metabolite on the side chain containing the piperidine ring was cyclized to res …
The mass spectra of bidisomide metabolites indicate that the two major metabolic pathways of bidisomide were hydroxylation of …
Treatment of atrial fibrillation and paroxysmal supraventricular tachycardia with bidisomide. The Atrial Fibrillation Investigation with Bidisomide (AFIB) Investigators.
[No authors listed] [No authors listed] Circulation. 1997 Oct 21;96(8):2625-32. doi: 10.1161/01.cir.96.8.2625. Circulation. 1997. PMID: 9355903 Clinical Trial.
BACKGROUND: Atrial fibrillation and paroxysmal supraventricular tachycardia are common disorders of the heart rhythm for which antiarrhythmic drug therapy is commonly prescribed. The Atrial Fibrillation Investigation with Bidisomide (AFIB) study was a randomized, placebo-c …
BACKGROUND: Atrial fibrillation and paroxysmal supraventricular tachycardia are common disorders of the heart rhythm for which antiarrhythmi …
Absorption and disposition of a new antiarrhythmic agent bidisomide in man.
Cook CS, Ames GB, Smith ME, Kowalski KG, Karim A. Cook CS, et al. Pharm Res. 1993 Nov;10(11):1675-82. doi: 10.1023/a:1018945324876. Pharm Res. 1993. PMID: 8290484
The percentages of the dose recovered as bidisomide in urine and feces were 19 +/- 1 and 29 +/- 4 for the iv dose and 9.1 +/- 0.9 and 48 +/- 5 for the oral dose. Bidisomide did not exhibit substantial enantioselective pharmacokinetics in plasma regardless of the rou …
The percentages of the dose recovered as bidisomide in urine and feces were 19 +/- 1 and 29 +/- 4 for the iv dose and 9.1 +/- 0.9 and …
Electrophysiologic effects of an antiarrhythmic agent, bidisomide, on sodium current in isolated rat ventricular myocytes: comparison with mexiletine and disopyramide.
Homma N, Tsujimoto G, Hashimoto K. Homma N, et al. Jpn J Pharmacol. 2001 May;86(1):23-31. doi: 10.1254/jjp.86.23. Jpn J Pharmacol. 2001. PMID: 11430469 Free article.
Bidisomide blocked I(Na) with a Ki of 214 microM at a holding potential of -140 mV. ...Our results indicate that bidisomide binds to rat cardiac sodium channels and that the dissociation kinetics of bidisomide from the inactivated sodium channel is slower tha …
Bidisomide blocked I(Na) with a Ki of 214 microM at a holding potential of -140 mV. ...Our results indicate that bidisomide bi …
Rapid infusions of bidisomide or disopyramide in conscious dogs: effect of myocardial infarction on acute tolerability.
Schmidt JJ, Frederick LG, Garthwaite SM. Schmidt JJ, et al. J Cardiovasc Pharmacol. 1992 Aug;20(2):236-50. doi: 10.1097/00005344-199208000-00009. J Cardiovasc Pharmacol. 1992. PMID: 1381015
The acute tolerability of rapid infusions of bidisomide or disopyramide was evaluated in normal conscious dogs and in conscious dogs 48 h after the creation of myocardial infarctions (MIs). ...Both drugs prolonged the ECG lead II P duration, PR interval (bidisomide …
The acute tolerability of rapid infusions of bidisomide or disopyramide was evaluated in normal conscious dogs and in conscious dogs …
Effects of bidisomide (SC-40230), a new class I antiarrhythmic agent, on ventricular arrhythmias induced by coronary artery occlusion and reperfusion in anesthetized rats; comparison with mexiletine and disopyramide.
Komori S, Sano S, Li BH, Matsumura K, Naitoh A, Mochizuki S, Ishihara T, Watanabe A, Umetani K, Ijiri H, et al. Komori S, et al. Heart Vessels. 1995;10(1):7-11. doi: 10.1007/BF01745072. Heart Vessels. 1995. PMID: 7537263
The effects of bidisomide were compared with those of mexiletine (MXT) and disopyramide (DSP), established class I antiarrhythmic drugs. ...Our results suggest that bidisomide may effectively reduce the severity of life-threatening ventricular arrhythmias that occur …
The effects of bidisomide were compared with those of mexiletine (MXT) and disopyramide (DSP), established class I antiarrhythmic dru …
Effect of diet and gavage on the dose- and dose-mode-dependent absorption and metabolism of bidisomide in rat.
Cook CS, Lonien M, Hribar J. Cook CS, et al. Xenobiotica. 2000 May;30(5):523-33. doi: 10.1080/004982500237523. Xenobiotica. 2000. PMID: 10875685
1. The metabolism of bidisomide was investigated to examine how dose and mode of drug administration (i.e. diet admixture versus oral solution) affect the absorption and metabolism of bidisomide in the toxicity studies. 2. After dietary admixture, bidisomide …
1. The metabolism of bidisomide was investigated to examine how dose and mode of drug administration (i.e. diet admixture versus oral …
22 results