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2004 2
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Amolimogene bepiplasmid, a DNA-based therapeutic encoding the E6 and E7 epitopes from HPV, for cervical and anal dysplasia.
Alvarez-Salas LM. Alvarez-Salas LM. Curr Opin Mol Ther. 2008 Dec;10(6):622-8. Curr Opin Mol Ther. 2008. PMID: 19051140
MGI Pharma Biologics is developing amolimogene bepiplasmid as a potential therapy for HPV-associated diseases, including cervical dysplasia. ...A phase II/III clinical trial was ongoing at the time of publication examining amolimogene bepiplasmid in th …
MGI Pharma Biologics is developing amolimogene bepiplasmid as a potential therapy for HPV-associated diseases, including cervi …
Medical treatment of cervical intraepithelial neoplasia II, III: an update review.
Kietpeerakool C, Srisomboon J. Kietpeerakool C, et al. Int J Clin Oncol. 2009 Feb;14(1):37-42. doi: 10.1007/s10147-008-0795-x. Epub 2009 Feb 20. Int J Clin Oncol. 2009. PMID: 19225922 Review.
Based on existing studies, cyclooxygenase (COX)-2 inhibitors; indole-3-carbinol; and novel immunotherapy agents, including ZYC101a, MVA E2, and HspE7, have been observed as possessing therapeutic activity without any major treatment-related complications. ...
Based on existing studies, cyclooxygenase (COX)-2 inhibitors; indole-3-carbinol; and novel immunotherapy agents, including ZYC101a, M …
ZYC101a for treatment of high-grade cervical intraepithelial neoplasia: a randomized controlled trial.
Garcia F, Petry KU, Muderspach L, Gold MA, Braly P, Crum CP, Magill M, Silverman M, Urban RG, Hedley ML, Beach KJ. Garcia F, et al. Obstet Gynecol. 2004 Feb;103(2):317-26. doi: 10.1097/01.AOG.0000110246.93627.17. Obstet Gynecol. 2004. PMID: 14754702 Clinical Trial.
In a prospectively defined population of women younger than 25 years (n = 43), resolution was significantly higher in the combined ZYC101a groups compared to placebo (70% versus 23%; P =.007). ZYC101a activity was not restricted to HPV-16-or HPV-18-positive lesions. …
In a prospectively defined population of women younger than 25 years (n = 43), resolution was significantly higher in the combined ZYC101 …
Immunization with a poly (lactide co-glycolide) encapsulated plasmid DNA expressing antigenic regions of HPV 16 and 18 results in an increase in the precursor frequency of T cells that respond to epitopes from HPV 16, 18, 6 and 11.
Matijevic M, Hedley ML, Urban RG, Chicz RM, Lajoie C, Luby TM. Matijevic M, et al. Cell Immunol. 2011;270(1):62-9. doi: 10.1016/j.cellimm.2011.04.005. Epub 2011 Apr 23. Cell Immunol. 2011. PMID: 21550027 Free PMC article. Clinical Trial.
Dynamics of human papillomavirus infection between biopsy and excision of cervical intraepithelial neoplasia: results from the ZYC101a protocol.
Crum CP, Beach KJ, Hedley ML, Yuan L, Lee KR, Wright TC, Urban RG. Crum CP, et al. J Infect Dis. 2004 Apr 15;189(8):1348-54. doi: 10.1086/382956. Epub 2004 Mar 30. J Infect Dis. 2004. PMID: 15073670 Clinical Trial.
METHODS: A total of 127 women with biopsy-confirmed CIN2/3 were enrolled in a phase 2 double-blinded, randomized, placebo-controlled clinical trial of ZYC101a. Colposcopic, cytologic, and HPV testing were performed over the course of 6 months, before a loop electrical surg …
METHODS: A total of 127 women with biopsy-confirmed CIN2/3 were enrolled in a phase 2 double-blinded, randomized, placebo-controlled clinica …