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Pharmacological characterization of a novel oestrogen antagonist, ZK 119010, in rats and mice.
Nishino Y, Schneider MR, Michna H, von Angerer E. Nishino Y, et al. J Endocrinol. 1991 Sep;130(3):409-14. doi: 10.1677/joe.0.1300409. J Endocrinol. 1991. PMID: 1834757
At the higher doses, however, ZK 119010 was strongly antioestrogenic, and ICI 164384 was less effective than ZK 119010 or tamoxifen. ZK 119010 at 10 mg/kg, like ICI 164384 at 30 mg/kg, caused an almost complete inhibition of the oestradio …
At the higher doses, however, ZK 119010 was strongly antioestrogenic, and ICI 164384 was less effective than ZK 1190 …
The rat endometrial adenocarcinoma cell line RUCA-I: a novel hormone-responsive in vivo/in vitro tumor model.
Vollmer G, Schneider MR. Vollmer G, et al. J Steroid Biochem Mol Biol. 1996 Apr;58(1):103-15. doi: 10.1016/0960-0760(96)00012-x. J Steroid Biochem Mol Biol. 1996. PMID: 8809192
In another series of experiments, treatment with the pure anti-estrogen ZK 119010 basically gave the same results as seen in ovariectomized animals, whereas tamoxifen treatment had no effect on metastasis of RUCA-I cells. ...Tamoxifen, like estradiol, stimulated com …
In another series of experiments, treatment with the pure anti-estrogen ZK 119010 basically gave the same results as seen in o …
Tamoxifen and ZK 119010 exert mixed agonistic and antagonistic effects on pS2 expression in MCF-7 cells.
Schütze N, Schneider MR, Knuppen R, Vollmer G. Schütze N, et al. Cancer Detect Prev. 1994;18(6):479-83. Cancer Detect Prev. 1994. PMID: 7867021
From these data we conclude that the antiestrogens tamoxifen and ZK 119010 possess both antagonistic and agonistic potencies in MCF-7 cells. However, the antiestrogenic potency of ZK 119010 seems to be higher than that of tamoxifen....
From these data we conclude that the antiestrogens tamoxifen and ZK 119010 possess both antagonistic and agonistic potencies i …
Screening of potential cancer-preventing chemicals for inhibition of induction of ornithine decarboxylase in epithelial cells from rat trachea.
White EL, Ross LJ, Schmid SM, Kelloff GJ, Steele VE, Hill DL. White EL, et al. Oncol Rep. 1998 May-Jun;5(3):717-22. doi: 10.3892/or.5.3.717. Oncol Rep. 1998. PMID: 9538183
At non-toxic concentrations, six test compounds had substantial activity (values for IC50 DFMO/IC50 compound >1): N-(2-carboxyphenyl)-all-trans-retinamide, ZK 119010 2-(4-hydroxyphenyl)-3-methyl-1-[6-(1-pyrrolidinyl)hexyl]-1H-indol-5- ol, curcumin, 18-a-olean-12- …
At non-toxic concentrations, six test compounds had substantial activity (values for IC50 DFMO/IC50 compound >1): N-(2-carboxyphenyl)-all …