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Page 1
NFX1-123: A potential therapeutic target in cervical cancer.
Chintala S, Dankoski MA, Anbarasu A, Ramaiah S, Miryala SK, Katzenellenbogen RA. Chintala S, et al. J Med Virol. 2023 Jun;95(6):e28856. doi: 10.1002/jmv.28856. J Med Virol. 2023. PMID: 37288708
The top four compounds were used to treat HPV- and HPV+ cervical cancer cell lines, three of which (Ropitoin, R428 and Ketoconazole) reduced NFX1-123 protein levels, inhibited cellular growth, survival, and migration, and enhanced the cytotoxicity of Cisplatin. ...
The top four compounds were used to treat HPV- and HPV+ cervical cancer cell lines, three of which (Ropitoin, R428 and Ketoconazole) …
Effects of the novel antiarrhythmic compound TR 2985 (ropitoin) on action potentials of different mammalian cardiac tissues.
Elizalde A, Sanchéz-Chapula J. Elizalde A, et al. Naunyn Schmiedebergs Arch Pharmacol. 1988 Mar;337(3):316-22. doi: 10.1007/BF00168845. Naunyn Schmiedebergs Arch Pharmacol. 1988. PMID: 3393234
Ropitoin (TR 2985) is a novel antiarrhythmic drug. In the present work we have found that the main effect of the compound on the normal action potential of different cardiac tissues, guinea-pig atrial and ventricular muscle (1-3 mumol/l), and dog Purkinje fib
Ropitoin (TR 2985) is a novel antiarrhythmic drug. In the present work we have found that the main effect of the compou
Electrophysiologic interactions between mexiletine-quinidine and mexiletine-ropitoin in guinea pig papillary muscle.
Valenzuela C, Sanchez-Chapula J. Valenzuela C, et al. J Cardiovasc Pharmacol. 1989 Nov;14(5):783-9. doi: 10.1097/00005344-198911000-00016. J Cardiovasc Pharmacol. 1989. PMID: 2481194
The effects of quinidine alone, ropitoin alone, and in combination with mexiletine at the sodium channel level were studied in isolated guinea pig papillary muscles using a sucrose gap technique. ...The combination of mexiletine and quinidine decreased use-dependent Vmax b …
The effects of quinidine alone, ropitoin alone, and in combination with mexiletine at the sodium channel level were studied in isolat …
Antiarrhythmic vs. antifibrillatory activity of the basic diphenylhydantoin derivative 3-[3-(4-phenyl-1-piperidyl)propyl]-5-(4-methoxyphenyl)-5-phenylhydantoin hydrochloride.
Lynch J, Montgomery D, Ventura A, Wilber D, Lucchesi BR. Lynch J, et al. Arzneimittelforschung. 1986 Mar;36(3):475-81. Arzneimittelforschung. 1986. PMID: 3707667
In conscious dogs, 48 h after myocardial infarction, TR 2985 significantly reduced the frequency of spontaneous ventricular arrhythmias. However, in anesthetized dogs, TR 2985 produced only a slight and insignificant increase in the ventricular fibrill …
In conscious dogs, 48 h after myocardial infarction, TR 2985 significantly reduced the frequency of spontaneous ventricular ar …