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Effects of pumaprazole (BY841), a novel reversible proton pump antagonist, and of omeprazole, on intragastric acidity before and after cure of Helicobacter pylori infection.
Martínek J, Blum AL, Stolte M, Hartmann M, Verdú EF, Lühmann R, Dorta G, Wiesel P. Martínek J, et al. Aliment Pharmacol Ther. 1999 Jan;13(1):27-34. doi: 10.1046/j.1365-2036.1999.00440.x. Aliment Pharmacol Ther. 1999. PMID: 9892876 Free article. Clinical Trial.
The 24-h pH values were higher before cure of the infection than after during both pumaprazole (6.0, 4.8-6.7 vs. 4.3, 2.6-5.7; P = 0.002) and omeprazole (5.8, 4.0-6.2 vs. 3.6, 2.8-5; P = 0.004). ...CONCLUSIONS: Both before and after cure of H. pylori infection, pumapraz
The 24-h pH values were higher before cure of the infection than after during both pumaprazole (6.0, 4.8-6.7 vs. 4.3, 2.6-5.7; P = 0. …
Animal pharmacology of reversible antagonism of the gastric acid pump, compared to standard antisecretory principles.
Kromer W, Postius S, Riedel R. Kromer W, et al. Pharmacology. 2000 May;60(4):179-87. doi: 10.1159/000028367. Pharmacology. 2000. PMID: 10828742
Regarding the less stringent parameter of inhibition of total acid output in the Heidenhain pouch dog, the modified Shay rat or the Ghosh-Schild rat, pumaprazole is, overall, slightly more efficacious than ranitidine. The M(1)-muscarinic antagonist pirenzepine is ineffecti …
Regarding the less stringent parameter of inhibition of total acid output in the Heidenhain pouch dog, the modified Shay rat or the Ghosh-Sc …