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Table representation of search results timeline featuring number of search results per year.

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1987 4
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1989 12
1990 9
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1994 6
1995 1
1996 2
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Page 1
A review on leukotrienes and their receptors with reference to asthma.
Singh RK, Tandon R, Dastidar SG, Ray A. Singh RK, et al. J Asthma. 2013 Nov;50(9):922-31. doi: 10.3109/02770903.2013.823447. Epub 2013 Aug 16. J Asthma. 2013. PMID: 23859232 Review.
Most common among them are classical CysLT1 receptor antagonists such as montelukast, zafirlukast, pranlukast, pobilukast, iralukast, cinalukast and MK571. The pharmacological role of CysLT2 receptor, however, is less defined and there is no specific antagonist available s …
Most common among them are classical CysLT1 receptor antagonists such as montelukast, zafirlukast, pranlukast, pobilukast, iralukast, …
Cysteinyl-maresin 3 inhibits IL-13 induced airway hyperresponsiveness through alternative activation of the CysLT1 receptor.
Säfholm J, Abma W, Bankova LG, Boyce JA, Al-Ameri M, Orre AC, Wheelock CE, Dahlén SE, Adner M. Säfholm J, et al. Eur J Pharmacol. 2022 Nov 5;934:175257. doi: 10.1016/j.ejphar.2022.175257. Epub 2022 Sep 16. Eur J Pharmacol. 2022. PMID: 36116518 Free article.
In mouse trachea, this inhibitory effect of MCTR3 was blocked by three different CysLT(1) receptor antagonists (montelukast, zafirlukast and pobilukast) during IL-13 exposure. Likewise, MCTR3 failed to reduce the IL-13-induced 5-HT responsiveness in mice deficient of the C …
In mouse trachea, this inhibitory effect of MCTR3 was blocked by three different CysLT(1) receptor antagonists (montelukast, zafirlukast and …
Autocrine activity of cysteinyl leukotrienes in human vascular endothelial cells: Signaling through the CysLT₂ receptor.
Capra V, Carnini C, Accomazzo MR, Di Gennaro A, Fiumicelli M, Borroni E, Brivio I, Buccellati C, Mangano P, Carnevali S, Rovati G, Sala A. Capra V, et al. Prostaglandins Other Lipid Mediat. 2015 Jul;120:115-25. doi: 10.1016/j.prostaglandins.2015.03.007. Epub 2015 Apr 1. Prostaglandins Other Lipid Mediat. 2015. PMID: 25839425
We also demonstrate here that the CysLT1R antagonist zafirlukast, pranlukast, pobilukast and iralukast also possess CysLT2R antagonistic activity, which could help in reconsidering previous data on the role of cysteinyl-LTs in the cardiovascular system. ...
We also demonstrate here that the CysLT1R antagonist zafirlukast, pranlukast, pobilukast and iralukast also possess CysLT2R antagonis …
Pharmacology of leukotriene receptor antagonists.
Aharony D. Aharony D. Am J Respir Crit Care Med. 1998 Jun;157(6 Pt 2):S214-8; discussion S218-9, S247-8. Am J Respir Crit Care Med. 1998. PMID: 9647602 Review.
Preclinical pharmacological studies have demonstrated that cysLT, receptor antagonists, such as zafirlukast, montelukast, and pobilukast, are potent and selective antagonists of cysteinyl leukotriene (cysLT) activity. ...
Preclinical pharmacological studies have demonstrated that cysLT, receptor antagonists, such as zafirlukast, montelukast, and pobilukast …
Inhibition of 5-lipoxygenase diminishes neurally evoked tachykinergic contraction of guinea pig isolated airway.
McAlexander MA, Myers AC, Undem BJ. McAlexander MA, et al. J Pharmacol Exp Ther. 1998 May;285(2):602-7. J Pharmacol Exp Ther. 1998. PMID: 9580604
The effect of ZD 2138 on action potential-driven tachykinergic contractions was mimicked by pobilukast, pranlukast, montelukast and zafirlukast, four structurally unrelated antagonists of the cysteinyl leukotriene 1 receptor subtype. Pobilukast had no effect on the …
The effect of ZD 2138 on action potential-driven tachykinergic contractions was mimicked by pobilukast, pranlukast, montelukast and z …
Effects of LTD4 on human airway smooth muscle cell proliferation, matrix expression, and contraction In vitro: differential sensitivity to cysteinyl leukotriene receptor antagonists.
Panettieri RA, Tan EM, Ciocca V, Luttmann MA, Leonard TB, Hay DW. Panettieri RA, et al. Am J Respir Cell Mol Biol. 1998 Sep;19(3):453-61. doi: 10.1165/ajrcmb.19.3.2999. Am J Respir Cell Mol Biol. 1998. PMID: 9730873
The potentiating effect of LTD4 (1 microM) on EGF-induced DNA synthesis was abolished by pranlukast (1 microM) or pobilukast (30 microM), but unaffected by zafirlukast (1 microM). In contrast, pranlukast (pKB = 6.9), pobilukast (pKB = 7.0), and zafirlukast (pKB = 6. …
The potentiating effect of LTD4 (1 microM) on EGF-induced DNA synthesis was abolished by pranlukast (1 microM) or pobilukast (30 micr …
Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor.
Sarau HM, Ames RS, Chambers J, Ellis C, Elshourbagy N, Foley JJ, Schmidt DB, Muccitelli RM, Jenkins O, Murdock PR, Herrity NC, Halsey W, Sathe G, Muir AI, Nuthulaganti P, Dytko GM, Buckley PT, Wilson S, Bergsma DJ, Hay DW. Sarau HM, et al. Mol Pharmacol. 1999 Sep;56(3):657-63. doi: 10.1124/mol.56.3.657. Mol Pharmacol. 1999. PMID: 10462554
Evidence was provided that LTE(4) is a partial agonist at this receptor. [(3)H]LTD(4) binding and LTD(4)-induced calcium mobilization in HEK-293 cells expressing the CysLT receptor were potently inhibited by the structurally distinct CysLTR antagonists pranlukast, montelukast, za …
Evidence was provided that LTE(4) is a partial agonist at this receptor. [(3)H]LTD(4) binding and LTD(4)-induced calcium mobilization in HEK …
Leukotriene D4-induced activation of smooth-muscle cells from human bronchi is partly Ca2+-independent.
Accomazzo MR, Rovati GE, Viganò T, Hernandez A, Bonazzi A, Bolla M, Fumagalli F, Viappiani S, Galbiati E, Ravasi S, Albertoni C, Di Luca M, Caputi A, Zannini P, Chiesa G, Villa AM, Doglia SM, Folco G, Nicosia S. Accomazzo MR, et al. Am J Respir Crit Care Med. 2001 Jan;163(1):266-72. doi: 10.1164/ajrccm.163.1.9912019. Am J Respir Crit Care Med. 2001. PMID: 11208655 Free article.
This translocation was specifically inhibited by the LTD4 antagonist pobilukast. Phorbol-dibutyrate ester (PDBu) (a PKC activator) contracted HB strips to the same extent in the presence as in the absence of extra- and intracellular Ca2+. ...
This translocation was specifically inhibited by the LTD4 antagonist pobilukast. Phorbol-dibutyrate ester (PDBu) (a PKC activator) co …
Lipoxin, leukotriene, and PDGF receptors cross-talk to regulate mesangial cell proliferation.
McMahon B, Mitchell D, Shattock R, Martin F, Brady HR, Godson C. McMahon B, et al. FASEB J. 2002 Nov;16(13):1817-9. doi: 10.1096/fj.02-0416fje. Epub 2002 Sep 5. FASEB J. 2002. PMID: 12223454
LTD4-induced c-src activation was insensitive to pertussis toxin and the cysLT1 receptor antagonist Zafirlukast but was blocked by the nonselective antagonist Pobilukast. We show that LXA4 inhibits LTD4-stimulated activation of the PDGFRbeta and that LXA4 modulates PDGF-BB …
LTD4-induced c-src activation was insensitive to pertussis toxin and the cysLT1 receptor antagonist Zafirlukast but was blocked by the nonse …
89 results