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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1954 1
1955 1
1971 1
1973 1
1974 2
1975 3
1976 7
1977 13
1978 13
1979 2
1980 7
1981 2
1982 3
1983 1
1984 4
1985 1
1986 1
1987 3
1989 3
1990 2
1991 2
1993 2
1994 4
1995 4
1996 16
1997 3
1998 10
1999 13
2000 23
2001 38
2002 58
2003 100
2004 104
2005 113
2006 180
2007 178
2008 206
2009 218
2010 308
2011 263
2012 243
2013 258
2014 247
2015 269
2016 224
2017 197
2018 193
2019 201
2020 140
2021 123
2022 35
2023 13
2024 4

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3,673 results

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Page 1
Effects of oxonic acid-induced hyperuricemia on mesenteric artery tone and cardiac load in experimental renal insufficiency.
Kurra V, Vehmas T, Eräranta A, Jokihaara J, Pirttiniemi P, Ruskoaho H, Tokola H, Niemelä O, Mustonen J, Pörsti I. Kurra V, et al. BMC Nephrol. 2015 Mar 27;16:35. doi: 10.1186/s12882-015-0033-5. BMC Nephrol. 2015. PMID: 25886588 Free PMC article.
Forty-four Sprague-Dawley rats were 5/6 nephrectomized (NX) or Sham-operated and fed 2.0% oxonic acid or control diet for 9 weeks. RESULTS: Oxonic acid feeding elevated plasma uric acid levels 2.4 and 3.6-fold in the NX and Sham groups, respecti …
Forty-four Sprague-Dawley rats were 5/6 nephrectomized (NX) or Sham-operated and fed 2.0% oxonic acid or control diet for 9 we …
Purine nucleotide catabolism in rat liver: labelling of uric acid and allantoin after treatment with oxonic acid and allopurinol.
Marinello E, Pizzichini M, Guerranti R, Cinci G, Arezzini L, Porcelli B, Terzuoli L. Marinello E, et al. Life Sci. 2001 Jan 26;68(10):1131-42. doi: 10.1016/s0024-3205(00)01015-8. Life Sci. 2001. PMID: 11228097
In our previous experiments on rat liver we found that 15' after intraperitoneal administration of 14C-formate the specific radioactivity of allantoin was always higher than that of uric acid. The present experiments have been carried out to interpret this unexpected resul …
In our previous experiments on rat liver we found that 15' after intraperitoneal administration of 14C-formate the specific radioactivity of …
Inhibition by oxonic acid of gastrointestinal toxicity of 5-fluorouracil without loss of its antitumor activity in rats.
Shirasaka T, Shimamoto Y, Fukushima M. Shirasaka T, et al. Cancer Res. 1993 Sep 1;53(17):4004-9. Cancer Res. 1993. PMID: 7689420
This selective inhibition of 5-FU phosphorylation in the GI tract was due to the much higher concentrations of oxonic acid in GI tissues than in other tissues and the blood. On p.o. administration with the 5-FU derivative, UFT, which is a combined form of 1 M tegafu …
This selective inhibition of 5-FU phosphorylation in the GI tract was due to the much higher concentrations of oxonic acid in …
Pharmacokinetics of S-1, an oral formulation of ftorafur, oxonic acid and 5-chloro-2,4-dihydroxypyridine (molar ratio 1:0.4:1) in patients with solid tumors.
Peters GJ, Noordhuis P, Van Kuilenburg AB, Schornagel JH, Gall H, Turner SL, Swart MS, Voorn D, Van Gennip AH, Wanders J, Holwerda U, Smid K, Giaccone G, Fumoleau P, Van Groeningen CJ. Peters GJ, et al. Cancer Chemother Pharmacol. 2003 Jul;52(1):1-12. doi: 10.1007/s00280-003-0617-9. Epub 2003 May 9. Cancer Chemother Pharmacol. 2003. PMID: 12739060 Clinical Trial.
S-1 is an oral formulation of ftorafur (FT), oxonic acid and 5-chloro-2,4-dihydroxypyridine (CDHP) at a molar ratio of 1:0.4:1. FT is a 5-fluorouracil (5-FU) prodrug, CDHP is a dihydropyrimidine dehydrogenase (DPD) inhibitor and oxonic acid is an inhib …
S-1 is an oral formulation of ftorafur (FT), oxonic acid and 5-chloro-2,4-dihydroxypyridine (CDHP) at a molar ratio of 1:0.4:1 …
[The optimization and assessment of the method for inducing hyperuricemia in rats].
Shi H, Liang XS, Huang LW, Luo ZG, Tan L. Shi H, et al. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2020 May;36(3):223-227. doi: 10.12047/j.cjap.5933.2020.049. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2020. PMID: 32981276 Chinese.
M1 group (gavage with 10 g/kg yeast extracts and 100 mg/kg adenine, twice per day, 300 mg/kg oxonic acid potassium by intraperitoneal injection, in the 7(th) day of model inducing), M2 group (gavage with 10 g/kg yeast extracts and 100 mg/kg adenine, twice per day, 3 …
M1 group (gavage with 10 g/kg yeast extracts and 100 mg/kg adenine, twice per day, 300 mg/kg oxonic acid potassium by intraper …
S-1 in the treatment of pancreatic cancer.
Sudo K, Nakamura K, Yamaguchi T. Sudo K, et al. World J Gastroenterol. 2014 Nov 7;20(41):15110-8. doi: 10.3748/wjg.v20.i41.15110. World J Gastroenterol. 2014. PMID: 25386059 Free PMC article. Review.
Urate-oxidase in liver of oxonic acid treated mice.
Otta ME, Bertini F. Otta ME, et al. Acta Physiol Lat Am. 1978;28(1):33-9. Acta Physiol Lat Am. 1978. PMID: 263154
Following a single intraperitoneal injection of oxonic acid, urate-oxidase inhibitor with optical and chromatographic properties of the injected drug was found in the supernatants of mouse liver homogenates. ...There was, instead, no increase of activity in 40 000 g …
Following a single intraperitoneal injection of oxonic acid, urate-oxidase inhibitor with optical and chromatographic properti …
3,673 results