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1972 1
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1978 2
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2014 1
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Page 1
Analgesic and other effects of nalmexone in man.
Forrest WH Jr, Shroff PF, Mahler DL. Forrest WH Jr, et al. Clin Pharmacol Ther. 1972 Jul-Aug;13(4):520-5. doi: 10.1002/cpt1972134520. Clin Pharmacol Ther. 1972. PMID: 4557582 Clinical Trial. No abstract available.
Further evaluation of the discriminative effects of morphine in the rat.
Shannon HE, Holtzman SG. Shannon HE, et al. J Pharmacol Exp Ther. 1977 Apr;201(1):55-66. J Pharmacol Exp Ther. 1977. PMID: 15104
Of the narcotic antagonist analgesics tested, butorphanol and nalmexone produced discriminative effects equivalent to those of the morphine training dose whereas nalorphine, levallorphan, oxilorphan, nalbuphine and ketocyclazocine did not. ...
Of the narcotic antagonist analgesics tested, butorphanol and nalmexone produced discriminative effects equivalent to those of the mo …
Quantum chemical studies of N-substituent variation in the oxymorphone series of opiate narcotics.
Loew GH, Berkowitz DS. Loew GH, et al. J Med Chem. 1978 Jan;21(1):101-6. doi: 10.1021/jm00199a018. J Med Chem. 1978. PMID: 73588
Quantum chemical calculations were performed on six N-derivatives of oxymorphone including N-methyl- (oxymorphone), N-allyl- (naloxone), N-dimethylallyl- (nalmexone), N-methylcyclopropyl- (naltrexone), N-methylcyclobutyl-(nalbuphone), and N-phenethylnoroxymorphone using th …
Quantum chemical calculations were performed on six N-derivatives of oxymorphone including N-methyl- (oxymorphone), N-allyl- (naloxone), N-d …
Opioids and efflux transporters. Part 4: influence of N-substitution on P-glycoprotein substrate activity of noroxymorphone analogues.
Metcalf MD, Rosicky AD, Hassan HE, Eddington ND, Coop A, Cunningham CW, Mercer SL. Metcalf MD, et al. Bioorg Med Chem Lett. 2014 Aug 1;24(15):3592-5. doi: 10.1016/j.bmcl.2014.05.033. Epub 2014 May 22. Bioorg Med Chem Lett. 2014. PMID: 24915880 Free PMC article.
Here, we present SAR describing P-gp recognition of a short series of N-modified 4,5-epoxymorphinans. Oxymorphone, naloxone, naltrexone, and nalmexone all failed to demonstrate P-gp substrate activity, indicating these opioid scaffolds contain structural features that prec …
Here, we present SAR describing P-gp recognition of a short series of N-modified 4,5-epoxymorphinans. Oxymorphone, naloxone, naltrexone, and …
Morphine-like stimulus effects in the monkey: opioids with antagonist properties.
Schaefer GJ, Holtzman SG. Schaefer GJ, et al. Pharmacol Biochem Behav. 1981 Feb;14(2):241-5. doi: 10.1016/0091-3057(81)90250-1. Pharmacol Biochem Behav. 1981. PMID: 6451874
Tests of stimulus generalization were conducted with compounds that were previously shown in the rat to produce discriminative stimulus effects that are: (a) morphine-like (profadol, WY-16,225, pentazocine, butorphanol, nalmexone); (b) cyclazocine-like (cyclazocine, ketocy …
Tests of stimulus generalization were conducted with compounds that were previously shown in the rat to produce discriminative stimulus effe …
Discriminative effects of cyclazocine in the squirrel monkey.
Schaefer GJ, Holtzman SG. Schaefer GJ, et al. J Pharmacol Exp Ther. 1978 May;205(2):291-301. J Pharmacol Exp Ther. 1978. PMID: 417173
The monkeys showed partial generalization to other drugs with activity as narcotic agonists, antagonists or both (e.g., morphine, naloxone, pentazocine, nalbuphine, nalmexone and nalorphine), but little or no generalization to the nonopioid psychoactive drugs, d-amphetamin …
The monkeys showed partial generalization to other drugs with activity as narcotic agonists, antagonists or both (e.g., morphine, naloxone, …