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1983 3
2024 1

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Elucidation of unusual biosynthesis and DnaN-targeting mode of action of potent anti-tuberculosis antibiotics Mycoplanecins.
Fu C, Liu Y, Walt C, Rasheed S, Bader CD, Lukat P, Neuber M, Haeckl FPJ, Blankenfeldt W, Kalinina OV, Müller R. Fu C, et al. Nat Commun. 2024 Jan 26;15(1):791. doi: 10.1038/s41467-024-44953-5. Nat Commun. 2024. PMID: 38278788 Free PMC article.
We show that mycoplanecins bind DnaN with nanomolar affinity and provide a co-crystal structure of mycoplanecin A-bound DnaN. Additionally, we reconstitute the biosyntheses of the unusual L-homoleucine, L-homonorleucine, and (2 S,4 R)-4-ethylproline building blocks …
We show that mycoplanecins bind DnaN with nanomolar affinity and provide a co-crystal structure of mycoplanecin A-bound DnaN. …
Mycoplanecins, novel antimycobacterial antibiotics from Actinoplanes awajinensis subsp. mycoplanecinus subsp. nov. II. Isolation, physico-chemical characterization and biological activities of mycoplanecin A.
Nakajima M, Torikata A, Ichikawa Y, Katayama T, Shiraishi A, Haneishi T, Arai M. Nakajima M, et al. J Antibiot (Tokyo). 1983 Aug;36(8):961-6. doi: 10.7164/antibiotics.36.961. J Antibiot (Tokyo). 1983. PMID: 6630066 Free article.
Mycoplanecin complex was extracted with organic solvents both from the culture filtrate and mycelium and purified by column chromatography on silica gel and Florisil. Mycoplanecin A, a major component, was separated by high performance liquid chromatography on Prep …
Mycoplanecin complex was extracted with organic solvents both from the culture filtrate and mycelium and purified by column chromatography o …
Mycoplanecins, novel antimycobacterial antibiotics from Actinoplanes awajinensis subsp. mycoplanecinus subsp. nov. III. Structural determination of mycoplanecin A.
Nakajima M, Torikata A, Tamaoki H, Haneishi T, Arai M, Kinoshita T, Kuwano H. Nakajima M, et al. J Antibiot (Tokyo). 1983 Aug;36(8):967-75. doi: 10.7164/antibiotics.36.967. J Antibiot (Tokyo). 1983. PMID: 6630067 Free article.
The structure of mycoplanecin A was determined by the analysis of chemical degradation products and by mass and 1H and 13C NMR spectrometries. Mycoplanecin A is a new cyclic peptide antibiotic composed of mol each of alpha-ketobutyric acid, glycine, L- …
The structure of mycoplanecin A was determined by the analysis of chemical degradation products and by mass and 1H and 13C NMR …