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Year Number of Results
1826 1
1829 2
1830 1
1847 1
1850 2
1851 2
1853 1
1866 1
1867 1
1869 1
1873 1
1875 1
1880 1
1882 1
1883 1
1885 1
1887 1
1889 5
1890 5
1891 5
1892 1
1893 2
1894 2
1895 3
1896 5
1897 6
1898 2
1899 1
1900 1
1901 1
1903 1
1904 1
1905 6
1906 3
1907 2
1908 1
1909 2
1910 3
1911 6
1912 2
1913 7
1914 1
1915 4
1916 3
1917 5
1918 3
1919 2
1920 1
1921 4
1923 3
1924 2
1925 1
1926 2
1927 1
1928 1
1929 3
1930 2
1933 5
1934 1
1935 2
1938 1
1939 4
1940 6
1942 1
1943 2
1944 5
1945 23
1946 24
1947 63
1948 73
1949 64
1950 91
1951 104
1952 92
1953 110
1954 145
1955 183
1956 159
1957 145
1958 134
1959 139
1960 130
1961 135
1962 150
1963 295
1964 405
1965 306
1966 297
1967 342
1968 427
1969 428
1970 502
1971 574
1972 695
1973 768
1974 709
1975 806
1976 800
1977 795
1978 843
1979 881
1980 967
1981 1026
1982 1193
1983 1199
1984 1243
1985 1269
1986 1241
1987 1128
1988 1135
1989 1189
1990 1221
1991 1228
1992 1220
1993 1265
1994 1261
1995 1282
1996 1309
1997 1302
1998 1315
1999 1202
2000 1393
2001 1360
2002 1303
2003 1465
2004 1490
2005 1657
2006 1675
2007 1627
2008 1723
2009 1705
2010 1749
2011 1827
2012 1900
2013 1942
2014 2121
2015 2057
2016 2087
2017 2154
2018 2238
2019 2482
2020 2833
2021 2845
2022 2735
2023 2462
2024 903

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78,088 results

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Page 1
Morphine metabolites.
Christrup LL. Christrup LL. Acta Anaesthesiol Scand. 1997 Jan;41(1 Pt 2):116-22. doi: 10.1111/j.1399-6576.1997.tb04625.x. Acta Anaesthesiol Scand. 1997. PMID: 9061094 Review.
Morphine is a member of the morphinan-framed alkaloids, which are present in the poppy plant. The drug is soluble in water, but its solubility in lipids is poor. In man, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) are the major metabolites o …
Morphine is a member of the morphinan-framed alkaloids, which are present in the poppy plant. The drug is soluble in water, but its s …
Hyperduric premedication.
ASQUITH E, THOMAS E. ASQUITH E, et al. Lancet. 1948 Dec 11;2(6537):930. doi: 10.1016/s0140-6736(48)91604-3. Lancet. 1948. PMID: 18101999 No abstract available.
Morphine-6-glucuronide: potency and safety compared with morphine.
van Dorp EL, Morariu A, Dahan A. van Dorp EL, et al. Expert Opin Pharmacother. 2008 Aug;9(11):1955-61. doi: 10.1517/14656566.9.11.1955. Expert Opin Pharmacother. 2008. PMID: 18627332 Review.
The search for opioid analgesics with a better side-effect profile than morphine has led to a morphine metabolites, morphine-6-glucuronide (M6G). ...M6G is an attractive alternative to morphine in the treatment of severe postoperative pain....
The search for opioid analgesics with a better side-effect profile than morphine has led to a morphine metabolites, morphin …
Morphine induces hyperalgesia without involvement of mu-opioid receptor or morphine-3-glucuronide.
Swartjes M, Mooren RA, Waxman AR, Arout C, van de Wetering K, den Hartigh J, Beijnen JH, Kest B, Dahan A. Swartjes M, et al. Mol Med. 2012 Dec 6;18(1):1320-6. doi: 10.2119/molmed.2012.00244. Mol Med. 2012. PMID: 23001479 Free PMC article.
Opioid-induced hyperalgesia (OIH) is a paradoxical increase in pain perception that may manifest during opioid treatment. For morphine, the metabolite morphine-3-glucuronide (M3G) is commonly believed to underlie this phenomenon. ...In these mice, the morphine …
Opioid-induced hyperalgesia (OIH) is a paradoxical increase in pain perception that may manifest during opioid treatment. For morphine …
A review of morphine and morphine-6-glucuronide's pharmacokinetic-pharmacodynamic relationships in experimental and clinical pain.
Sverrisdóttir E, Lund TM, Olesen AE, Drewes AM, Christrup LL, Kreilgaard M. Sverrisdóttir E, et al. Eur J Pharm Sci. 2015 Jul 10;74:45-62. doi: 10.1016/j.ejps.2015.03.020. Epub 2015 Apr 7. Eur J Pharm Sci. 2015. PMID: 25861720 Review.
Morphine is a widely used opioid for treatment of moderate to severe pain, but large interindividual variability in patient response and no clear guidance on how to optimise morphine dosage regimen complicates treatment strategy for clinicians. ...This review provid …
Morphine is a widely used opioid for treatment of moderate to severe pain, but large interindividual variability in patient response …
Morphine-6-glucuronide: morphine's successor for postoperative pain relief?
van Dorp EL, Romberg R, Sarton E, Bovill JG, Dahan A. van Dorp EL, et al. Anesth Analg. 2006 Jun;102(6):1789-97. doi: 10.1213/01.ane.0000217197.96784.c3. Anesth Analg. 2006. PMID: 16717327 Review.
In searching for an analgesic with fewer side effects than morphine, examination of morphine's active metabolite, morphine-6-glucuronide (M6G), suggests that M6G is possibly such a drug. ...Preliminary data indicate that M6G is associated less than …
In searching for an analgesic with fewer side effects than morphine, examination of morphine's active metabolite, mo …
Morphine-3-glucuronide causes antinociceptive cross-tolerance to morphine and increases spinal substance P expression.
Blomqvist KJ, Viisanen H, Ahlström FHG, Jokinen V, Sidorova YA, Suleymanova I, Rauhala PV, Kalso EA, Lilius TO. Blomqvist KJ, et al. Eur J Pharmacol. 2020 May 15;875:173021. doi: 10.1016/j.ejphar.2020.173021. Epub 2020 Feb 26. Eur J Pharmacol. 2020. PMID: 32112778 Free article.
Morphine-3-glucuronide (M3G), the main metabolite of morphine, has been implicated in the development of tolerance and of opioid-induced hyperalgesia, both limiting the analgesic use of morphine. ...Chronic M3G also induced antinociceptive cross-tolerance to …
Morphine-3-glucuronide (M3G), the main metabolite of morphine, has been implicated in the development of tolerance and of opio …
Considerations in morphine therapy.
Laizure SC. Laizure SC. Am J Hosp Pharm. 1994 Aug 15;51(16):2042-3. Am J Hosp Pharm. 1994. PMID: 7977426 Review. No abstract available.
Endogenous morphine and its metabolites in mammals: history, synthesis, localization and perspectives.
Laux-Biehlmann A, Mouheiche J, Vérièpe J, Goumon Y. Laux-Biehlmann A, et al. Neuroscience. 2013 Mar 13;233:95-117. doi: 10.1016/j.neuroscience.2012.12.013. Epub 2012 Dec 21. Neuroscience. 2013. PMID: 23266549 Review.
It is now accepted that endogenous morphine, structurally identical to vegetal morphine-alkaloid, is synthesized by mammalian cells from dopamine. Morphine binds mu opioid receptor and induces antinociceptive effects. ...
It is now accepted that endogenous morphine, structurally identical to vegetal morphine-alkaloid, is synthesized by mammalian …
Dissecting the innate immune recognition of morphine and its metabolites by TLR4/MD2: an in silico simulation study.
Zhang X, Li R, Xu H, Wu G, Wu S, Wang H, Wang Y, Wang X. Zhang X, et al. Phys Chem Chem Phys. 2023 Nov 8;25(43):29656-29663. doi: 10.1039/d3cp03715k. Phys Chem Chem Phys. 2023. PMID: 37882236
Additionally, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G), the major metabolites of morphine, possess similar chemical structures but exhibit distinct effects on TLR4 signaling. ...Herein, molecular dynamics simulations were performed to dis …
Additionally, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G), the major metabolites of morphine, possess …
78,088 results
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