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Mahanimbine isolated from Murraya koenigii inhibits P-glycoprotein involved in lung cancer chemoresistance.
Mondal P, Natesh J, Abdul Salam AA, Meeran SM. Mondal P, et al. Bioorg Chem. 2022 Dec;129:106170. doi: 10.1016/j.bioorg.2022.106170. Epub 2022 Sep 22. Bioorg Chem. 2022. PMID: 36174443
The computational analysis revealed several key bioactives from curry leaves, specifically mahanimbine, exhibited a strong binding affinity with P-gp. Unfortunately, mahanimbine is available with few commercial sources at very high prices. ...Overall, mahanimbine …
The computational analysis revealed several key bioactives from curry leaves, specifically mahanimbine, exhibited a strong binding af …
Mahanimbine Improved Aging-Related Memory Deficits in Mice through Enhanced Cholinergic Transmission and Suppressed Oxidative Stress, Amyloid Levels, and Neuroinflammation.
Mani V, Mohd Azahan NS, Ramasamy K, Lim SM, Abdul Majeed AB. Mani V, et al. Brain Sci. 2021 Dec 23;12(1):12. doi: 10.3390/brainsci12010012. Brain Sci. 2021. PMID: 35053756 Free PMC article.
Murraya koenigii leaves contain mahanimbine, a carbazole alkaloid, reported with improving cholinergic neuronal transmission and reducing neuroinflammation in the CNS. ...Mahanimbine was administered (1 and 2 mg/kg, p.o.) daily to groups of aged mice for 30 days. .. …
Murraya koenigii leaves contain mahanimbine, a carbazole alkaloid, reported with improving cholinergic neuronal transmission and redu …
Mahanimbine Exerts Anticancer Effects on Human Pancreatic Cancer Cells by Triggering Cell Cycle Arrest, Apoptosis, and Modulation of AKT/Mammalian Target of Rapamycin (mTOR) and Signal Transducer and Activator of Transcription 3 (STAT3) Signalling Pathways.
Pei C, He Q, Liang S, Gong X. Pei C, et al. Med Sci Monit. 2018 Oct 1;24:6975-6983. doi: 10.12659/MSM.911013. Med Sci Monit. 2018. PMID: 30273298 Free PMC article.
Mahanimbine prompted apoptosis was also associated with decline in Bcl-2 and enhancement of the Bax expression. ...CONCLUSIONS We found that Mahanimbine inhibits the proliferation of pancreatic cancer cells and as such Mahanimbine may prove beneficial in the …
Mahanimbine prompted apoptosis was also associated with decline in Bcl-2 and enhancement of the Bax expression. ...CONCLUSIONS We fou …
Cytotoxicity of Mahanimbine from Curry Leaves in Human Breast Cancer Cells (MCF-7) via Mitochondrial Apoptosis and Anti-Angiogenesis.
Hobani YH. Hobani YH. Molecules. 2022 Feb 1;27(3):971. doi: 10.3390/molecules27030971. Molecules. 2022. PMID: 35164236 Free PMC article.
Mahanimbine (MN) is a carbazole alkaloid present in the leaves of Murraya koenigii, which is an integral part of medicinal and culinary practices in Asia. ...
Mahanimbine (MN) is a carbazole alkaloid present in the leaves of Murraya koenigii, which is an integral part of medicinal and culina …
Anticancer effects of Mahanimbine alkaloid on the human bladder cancer cells are due to the induction of G0/G1 cell cycle arrest, apoptosis and autophagy.
Xie H, Zhang T, Yang N, Li Z, Liu Y. Xie H, et al. J BUON. 2020 Mar-Apr;25(2):1166-1171. J BUON. 2020. PMID: 32521922 Free article.
Further, western blot assay was used to study the effects of Mahanimbine on apoptosis-related protein expressions including Bax and Bcl-2. ...The Mahanimbine-triggered autophagy was also linked with increase in the expression of LC3II and decrease in p62 expression. …
Further, western blot assay was used to study the effects of Mahanimbine on apoptosis-related protein expressions including Bax and B …
Effect of Mangiferin and Mahanimbine on Glucose Utilization in 3T3-L1 cells.
Kumar BD, Krishnakumar K, Jaganathan SK, Mandal M. Kumar BD, et al. Pharmacogn Mag. 2013 Jan;9(33):72-5. doi: 10.4103/0973-1296.108145. Pharmacogn Mag. 2013. PMID: 23661997 Free PMC article.
OBJECTIVE: To investigate the effects of mangiferin (xanthone glucoside) and mahanimbine (carbazole alkaloid) on glucose utilization in 3T3-L1 cells. ...RESULTS: Treatment of the 3T3-L1 cells with mangiferin and mahanimbine increased the glucose utilization in a dos …
OBJECTIVE: To investigate the effects of mangiferin (xanthone glucoside) and mahanimbine (carbazole alkaloid) on glucose utilization …
Effect of mahanimbine, an alkaloid from curry leaves, on high-fat diet-induced adiposity, insulin resistance, and inflammatory alterations.
Jagtap S, Khare P, Mangal P, Kondepudi KK, Bishnoi M, Bhutani KK. Jagtap S, et al. Biofactors. 2017 Mar;43(2):220-231. doi: 10.1002/biof.1333. Epub 2016 Sep 24. Biofactors. 2017. PMID: 27663177
Mahanimbine at 2 mg/kg (HFD + LD) and 4 mg/kg (HFD + HD) of body weight was administered daily along with HFD feeding for 12 weeks. ...Male and female mice showed different traits in development of HFD-induced metabolic disturbances; however, mahanimbine treatment e …
Mahanimbine at 2 mg/kg (HFD + LD) and 4 mg/kg (HFD + HD) of body weight was administered daily along with HFD feeding for 12 weeks. . …
Acetylcholinesterase inhibitory potential of a carbazole alkaloid, mahanimbine, from Murraya koenigii.
Kumar NS, Mukherjee PK, Bhadra S, Saha BP, Pal BC. Kumar NS, et al. Phytother Res. 2010 Apr;24(4):629-31. doi: 10.1002/ptr.3023. Phytother Res. 2010. PMID: 19943242
Inhibition of AChE was evaluated based on Ellman's method using 96-well microplate readers. Mahanimbine inhibited AChE activity in a dose-dependent manner with an IC(50) value of 0.03 +/- 0.09 mg/mL, while galantamine was used as a standard. The AChE inhibitory activity of …
Inhibition of AChE was evaluated based on Ellman's method using 96-well microplate readers. Mahanimbine inhibited AChE activity in a …
RP-HPLC-DAD for simultaneous estimation of mahanine and mahanimbine in Murraya koenigii.
Pandit S, Kumar M, Ponnusankar S, Pal BC, Mukherjee PK. Pandit S, et al. Biomed Chromatogr. 2011 Sep;25(9):959-62. doi: 10.1002/bmc.1561. Epub 2011 Mar 4. Biomed Chromatogr. 2011. PMID: 21381062
A rapid reverse-phase high-performance liquid chromatography (RP-HPLC) method has been developed for quantitative estimation of mahanine and mahanimbine, two major bioactive alkaloids in this plant. The amounts of mahanine and mahanimbine were detected as 9.56 1.04 …
A rapid reverse-phase high-performance liquid chromatography (RP-HPLC) method has been developed for quantitative estimation of mahanine and …
Synthesis of girinimbine and (plus or minus) mahanimbine.
Narasimhan NS, Paradkar MV, Gokhale AM. Narasimhan NS, et al. Tetrahedron Lett. 1970 Apr;(19):1665-8. doi: 10.1016/s0040-4039(01)98049-9. Tetrahedron Lett. 1970. PMID: 5430996 No abstract available.
32 results