Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2016 2
2017 1
2018 5
2019 11
2020 16
2021 13
2022 18
2023 25
2024 11

Text availability

Article attribute

Article type

Publication date

Search Results

81 results

Results by year

Filters applied: . Clear all
Page 1
18F-MK-6240 tau-PET in genetic frontotemporal dementia.
Levy JP, Bezgin G, Savard M, Pascoal TA, Finger E, Laforce R, Sonnen JA, Soucy JP, Gauthier S, Rosa-Neto P, Ducharme S. Levy JP, et al. Brain. 2022 Jun 3;145(5):1763-1772. doi: 10.1093/brain/awab392. Brain. 2022. PMID: 34664612 Free PMC article.
The objective of this study was to investigate the potential for the promising 18F-MK-6240 PET tracer to bind to tau in vivo in genetic frontotemporal dementia. ...These results highlight that a positive 18F-MK-6240 tau-PET does not necessarily imply a …
The objective of this study was to investigate the potential for the promising 18F-MK-6240 PET tracer to bind to tau in vivo i …
Longitudinal 18F-MK-6240 tau tangles accumulation follows Braak stages.
Pascoal TA, Benedet AL, Tudorascu DL, Therriault J, Mathotaarachchi S, Savard M, Lussier FZ, Tissot C, Chamoun M, Kang MS, Stevenson J, Massarweh G, Guiot MC, Soucy JP, Gauthier S, Rosa-Neto P. Pascoal TA, et al. Brain. 2021 Dec 16;144(11):3517-3528. doi: 10.1093/brain/awab248. Brain. 2021. PMID: 34515754 Free PMC article.
Here, we hypothesized the novel subnanomolar affinity tau tangles tracer 18F-MK-6240 can detect longitudinal tau accumulation in asymptomatic and symptomatic subjects. ...The highest magnitude of 18F-MK-6240 SUVR accumulation moved from the medial temp …
Here, we hypothesized the novel subnanomolar affinity tau tangles tracer 18F-MK-6240 can detect longitudinal tau accumulation …
Automated production of [(18)F]MK-6240 on CFN-MPS200.
Toyohara J, Nishino K, Sakai M, Tago T, Oda T. Toyohara J, et al. Appl Radiat Isot. 2021 Feb;168:109468. doi: 10.1016/j.apradiso.2020.109468. Epub 2020 Nov 24. Appl Radiat Isot. 2021. PMID: 33285465
Automated production of [(18)F]MK-6240 was implemented for the first time in the CFN-MPS200 module. ...Our established method can facilitate multi-center trials and widespread use of [(18)F]MK-6240....
Automated production of [(18)F]MK-6240 was implemented for the first time in the CFN-MPS200 module. ...Our established method …
18F-MK-6240 PET for early and late detection of neurofibrillary tangles.
Pascoal TA, Therriault J, Benedet AL, Savard M, Lussier FZ, Chamoun M, Tissot C, Qureshi MNI, Kang MS, Mathotaarachchi S, Stevenson J, Hopewell R, Massarweh G, Soucy JP, Gauthier S, Rosa-Neto P. Pascoal TA, et al. Brain. 2020 Sep 1;143(9):2818-2830. doi: 10.1093/brain/awaa180. Brain. 2020. PMID: 32671408
Here, we tested whether the novel high affinity tau tangles tracer 18F-MK-6240 can better identify individuals in the early stages of tau accumulation. To this end, we studied 301 individuals (30 cognitively unimpaired young, 138 cognitively unimpaired elderly, 67 w …
Here, we tested whether the novel high affinity tau tangles tracer 18F-MK-6240 can better identify individuals in the early st …
Tau PET imaging in neurodegenerative tauopathies-still a challenge.
Leuzy A, Chiotis K, Lemoine L, Gillberg PG, Almkvist O, Rodriguez-Vieitez E, Nordberg A. Leuzy A, et al. Mol Psychiatry. 2019 Aug;24(8):1112-1134. doi: 10.1038/s41380-018-0342-8. Epub 2019 Jan 11. Mol Psychiatry. 2019. PMID: 30635637 Free PMC article. Review.
., [(18)F]THK5317, [(18)F]THK5351, [(18)F]AV1451, and [(11)C]PBB3) and second-generation compounds [namely [(18)F]MK-6240, [(18)F]RO-948 (previously referred to as [(18)F]RO69558948), [(18)F]PI-2620, [(18)F]GTP1, [(18)F]PM-PBB3, and [(18)F]JNJ64349311 ([(18)F]JNJ311 …
., [(18)F]THK5317, [(18)F]THK5351, [(18)F]AV1451, and [(11)C]PBB3) and second-generation compounds [namely [(18)F]MK-6240, [(1 …
Cryo-EM structure of Alzheimer's disease tau filaments with PET ligand MK-6240.
Kunach P, Vaquer-Alicea J, Smith MS, Hopewell R, Monistrol J, Moquin L, Therriault J, Tissot C, Rahmouni N, Massarweh G, Soucy JP, Guiot MC, Shoichet BK, Rosa-Neto P, Diamond MI, Shahmoradian SH. Kunach P, et al. bioRxiv [Preprint]. 2023 Sep 22:2023.09.22.558671. doi: 10.1101/2023.09.22.558671. bioRxiv. 2023. PMID: 37790438 Free PMC article. Preprint.
Using autoradiography and cryo-EM, we identified AD brain tissue with elevated tau burden, purified filaments, and determined the structure of second-generation high avidity PET ligand MK-6240 at 2.31 A resolution, which bound at a 1:1 ratio within the cleft of tau …
Using autoradiography and cryo-EM, we identified AD brain tissue with elevated tau burden, purified filaments, and determined the structure …
Patterns of tau pathology identified with (18) F-MK-6240 PET imaging.
Kreisl WC, Lao PJ, Johnson A, Tomljanovic Z, Klein J, Polly K, Maas B, Laing KK, Chesebro AG, Igwe K, Razlighi QR, Honig LS, Yan X, Lee S, Mintz A, Luchsinger JA, Stern Y, Devanand DP, Brickman AM. Kreisl WC, et al. Alzheimers Dement. 2022 Feb;18(2):272-282. doi: 10.1002/alz.12384. Epub 2021 May 31. Alzheimers Dement. 2022. PMID: 34057284 Free PMC article.
INTRODUCTION: Positron emission tomography (PET) imaging for neurofibrillary tau allows investigation of the in vivo spatiotemporal progression of Alzheimer's disease (AD) pathology. We evaluated the suitability of (18) F-MK-6240 in a clinical sample and determined …
INTRODUCTION: Positron emission tomography (PET) imaging for neurofibrillary tau allows investigation of the in vivo spatiotemporal progress …
Microglial activation and tau propagate jointly across Braak stages.
Pascoal TA, Benedet AL, Ashton NJ, Kang MS, Therriault J, Chamoun M, Savard M, Lussier FZ, Tissot C, Karikari TK, Ottoy J, Mathotaarachchi S, Stevenson J, Massarweh G, Schöll M, de Leon MJ, Soucy JP, Edison P, Blennow K, Zetterberg H, Gauthier S, Rosa-Neto P. Pascoal TA, et al. Nat Med. 2021 Sep;27(9):1592-1599. doi: 10.1038/s41591-021-01456-w. Epub 2021 Aug 26. Nat Med. 2021. PMID: 34446931
We studied 130 individuals across the aging and AD clinical spectrum with positron emission tomography brain imaging for microglial activation ([(11)C]PBR28), amyloid-beta (Abeta) ([(18)F]AZD4694) and tau ([(18)F]MK-6240) pathologies. We further assessed microglial …
We studied 130 individuals across the aging and AD clinical spectrum with positron emission tomography brain imaging for microglial activati …
Direct Comparison of the Tau PET Tracers (18)F-Flortaucipir and (18)F-MK-6240 in Human Subjects.
Gogola A, Minhas DS, Villemagne VL, Cohen AD, Mountz JM, Pascoal TA, Laymon CM, Mason NS, Ikonomovic MD, Mathis CA, Snitz BE, Lopez OL, Klunk WE, Lopresti BJ. Gogola A, et al. J Nucl Med. 2022 Jan;63(1):108-116. doi: 10.2967/jnumed.120.254961. Epub 2021 Apr 16. J Nucl Med. 2022. PMID: 33863821 Free PMC article.
This study compared 2 frequently used tau PET tracers, (18)F-flortaucipir and (18)F-MK-6240, in the same subjects. Methods:(18)F-flortaucipir and (18)F-MK-6240 scans were collected within 2 mo in 15 elderly subjects varying in clinical diagnosis and co …
This study compared 2 frequently used tau PET tracers, (18)F-flortaucipir and (18)F-MK-6240, in the same subjects. Methods:(18 …
Association of Age at Menopause and Hormone Therapy Use With Tau and β-Amyloid Positron Emission Tomography.
Coughlan GT, Betthauser TJ, Boyle R, Koscik RL, Klinger HM, Chibnik LB, Jonaitis EM, Yau WW, Wenzel A, Christian BT, Gleason CE, Saelzler UG, Properzi MJ, Schultz AP, Hanseeuw BJ, Manson JE, Rentz DM, Johnson KA, Sperling R, Johnson SC, Buckley RF. Coughlan GT, et al. JAMA Neurol. 2023 May 1;80(5):462-473. doi: 10.1001/jamaneurol.2023.0455. JAMA Neurol. 2023. PMID: 37010830 Free PMC article.
DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study included participants enrolled in the Wisconsin Registry for Alzheimer Prevention. Cognitively unimpaired males and females with at least 1 18F-MK-6240 and 11C-Pittsburgh compound B PET scan were analyzed …
DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study included participants enrolled in the Wisconsin Registry for Alzheimer Prevent …
81 results