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Page 1
Experimental pneumonia due to Haemophilus influenzae: observations on pathogenesis and treatment.
Esposito AL, Pennington JE. Esposito AL, et al. J Infect Dis. 1984 May;149(5):728-34. doi: 10.1093/infdis/149.5.728. J Infect Dis. 1984. PMID: 6610002
Animals given ampicillin, cefamandole, chloramphenicol, erythromycin plus sulfisoxazole, or fludalanine plus pentizidone (MK 0641/MK 0642, an investigational combination drug) survived at a higher rate than did controls (P less than .001 at 72 hr for each antibiotic). ...S …
Animals given ampicillin, cefamandole, chloramphenicol, erythromycin plus sulfisoxazole, or fludalanine plus pentizidone (MK 0641/MK …
In vitro activity of fludalanine combined with pentizidone compared with those of other agents.
Wise R, Andrews JM. Wise R, et al. Antimicrob Agents Chemother. 1984 May;25(5):612-7. doi: 10.1128/AAC.25.5.612. Antimicrob Agents Chemother. 1984. PMID: 6610389 Free PMC article.
The in vitro activity of fludalanine ( MK641 ) combined with pentizidone ( MK642 ) so as to give a fludalanine /D-cycloserine ratio of 1:1 was compared with the activities of ampicillin, ticarcillin, cefuroxime, ceftazidime, and trimethoprim against 452 recent isola …
The in vitro activity of fludalanine ( MK641 ) combined with pentizidone ( MK642 ) so as to give a fludalanine /D-cycloserine …
Sequencing of chronic lymphocytic leukemia therapies.
Barrientos JC. Barrientos JC. Hematology Am Soc Hematol Educ Program. 2016 Dec 2;2016(1):128-136. doi: 10.1182/asheducation-2016.1.128. Hematology Am Soc Hematol Educ Program. 2016. PMID: 27913471 Free PMC article. Review.
Activity of the combination of fludalanine and cycloserine against mycobacteria in vitro.
Dickinson JM, Mitchison DA. Dickinson JM, et al. Tubercle. 1985 Jun;66(2):109-15. doi: 10.1016/0041-3879(85)90075-3. Tubercle. 1985. PMID: 4024268
The initial steps in the incorporation of alanine into the bacterial cell wall include the conversion of natural to D-alanine by a racemase followed by the coupling of 2 D-alanine molecules by a synthetase to yield a dipeptide. A combination of fludalanine (3-fluoro-2-deut …
The initial steps in the incorporation of alanine into the bacterial cell wall include the conversion of natural to D-alanine by a racemase …
Oxidative and defluorinative metabolism of fludalanine, 2-2H-3-fluoro-D-alanine.
Darland GK, Hajdu R, Kropp H, Kahan FM, Walker RW, Vandenheuvel WJ. Darland GK, et al. Drug Metab Dispos. 1986 Nov-Dec;14(6):668-73. Drug Metab Dispos. 1986. PMID: 2877824
The antibacterial agent fludalanine [2-2H-3-fluoro-D-alanine (DFA)] is a potent inhibitor of bacterial alanine racemase, an enzyme required for the generation of D-alanine, an essential component of the bacterial cell wall. ...
The antibacterial agent fludalanine [2-2H-3-fluoro-D-alanine (DFA)] is a potent inhibitor of bacterial alanine racemase, an enzyme re …
Determination of the antibiotic fludalanine in plasma and urine by high-performance liquid chromatography using a packed-bed, post-column reactor with o-phthalaldehyde and 2-mercaptoethanol.
Musson DG, Maglietto SM, Bayne WF. Musson DG, et al. J Chromatogr. 1985 Mar 22;338(2):357-67. doi: 10.1016/0378-4347(85)80106-7. J Chromatogr. 1985. PMID: 3998023
Fludalanine is a novel anti-bacterial agent active against gram-negative and gram-positive bacteria. ...The mobile phase contains sodium dodecyl sulfonate and methanol in a phosphate buffer. Fludalanine is derivatized post-column with o-phthalaldehyde via a packed-b …
Fludalanine is a novel anti-bacterial agent active against gram-negative and gram-positive bacteria. ...The mobile phase contains sod …
Simultaneous quantification of cycloserine and its prodrug acetylacetonylcycloserine in plasma and urine by high-performance liquid chromatography using ultraviolet absorbance and fluorescence after post-column derivatization.
Musson DG, Maglietto SM, Hwang SS, Gravellese D, Bayne WF. Musson DG, et al. J Chromatogr. 1987 Feb 20;414(1):121-9. doi: 10.1016/0378-4347(87)80030-0. J Chromatogr. 1987. PMID: 3571377
Its prodrug sodium (R)-4-[(1-methyl-3-oxo-1-butenyl)amino]-3-isoxazolidinone hemihydrate, developed for better aqueous stability and solubility, is combined with another broad-spectrum antibiotic, fludalanine. An ion-pair, reversed-phase high-performance liquid chromatogra …
Its prodrug sodium (R)-4-[(1-methyl-3-oxo-1-butenyl)amino]-3-isoxazolidinone hemihydrate, developed for better aqueous stability and solubil …
Unrelated cord blood transplantation in patients with idiopathic refractory severe aplastic anemia: a nationwide phase 2 study.
Peffault de Latour R, Chevret S, Jubert C, Sirvent A, Galambrun C, Ruggeri A, Gandemer V, Cornillon J, Rialland F, Dalle JH, Forcade E, Bruno B, Paillard C, Rorlich PS, Salmon A, Fürst S, Sicre de Fontbrune F, Rubio MT, Bay JO, Mohty M, Larghero J, Gluckman E, Socié G; Francophone Society of Bone Marrow Transplantation and Cellular Therapy. Peffault de Latour R, et al. Blood. 2018 Aug 16;132(7):750-754. doi: 10.1182/blood-2018-01-829630. Epub 2018 May 14. Blood. 2018. PMID: 29760162 Free article. Clinical Trial.