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Year Number of Results
1987 1
1988 4
1989 4
1990 5
1991 7
1992 12
1993 8
1994 15
1995 12
1996 11
1997 12
1998 9
1999 17
2000 14
2001 10
2002 16
2003 13
2004 8
2005 7
2006 9
2007 8
2008 12
2009 16
2010 14
2011 12
2012 14
2013 29
2014 21
2015 19
2016 21
2017 22
2018 29
2019 30
2020 40
2021 25
2022 32
2023 32
2024 9

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531 results

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Page 1
Fatty acid oxidation fuels glioblastoma radioresistance with CD47-mediated immune evasion.
Jiang N, Xie B, Xiao W, Fan M, Xu S, Duan Y, Hamsafar Y, Evans AC, Huang J, Zhou W, Lin X, Ye N, Wanggou S, Chen W, Jing D, Fragoso RC, Dugger BN, Wilson PF, Coleman MA, Xia S, Li X, Sun LQ, Monjazeb AM, Wang A, Murphy WJ, Kung HJ, Lam KS, Chen HW, Li JJ. Jiang N, et al. Nat Commun. 2022 Mar 21;13(1):1511. doi: 10.1038/s41467-022-29137-3. Nat Commun. 2022. PMID: 35314680 Free PMC article.
A glycolysis-to-FAO metabolic rewiring is associated with CD47 anti-phagocytosis in radioresistant GBM cells and regrown GBM after radiation in syngeneic mice. Inhibition of FAO by CPT1 inhibitor etomoxir or CRISPR-generated CPT1A(-/-), CPT2(-/-), ACAD9(-/-) cells demonstr …
A glycolysis-to-FAO metabolic rewiring is associated with CD47 anti-phagocytosis in radioresistant GBM cells and regrown GBM after radiation …
Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis.
Divakaruni AS, Hsieh WY, Minarrieta L, Duong TN, Kim KKO, Desousa BR, Andreyev AY, Bowman CE, Caradonna K, Dranka BP, Ferrick DA, Liesa M, Stiles L, Rogers GW, Braas D, Ciaraldi TP, Wolfgang MJ, Sparwasser T, Berod L, Bensinger SJ, Murphy AN. Divakaruni AS, et al. Cell Metab. 2018 Sep 4;28(3):490-503.e7. doi: 10.1016/j.cmet.2018.06.001. Epub 2018 Jun 28. Cell Metab. 2018. PMID: 30043752 Free PMC article.
Although excess etomoxir inhibits the adenine nucleotide translocase, oxidative phosphorylation is surprisingly dispensable for M(IL-4). Instead, the block in polarization was traced to depletion of intracellular free coenzyme A (CoA), likely resulting from conversion of t …
Although excess etomoxir inhibits the adenine nucleotide translocase, oxidative phosphorylation is surprisingly dispensable for M(IL- …
Targeting CPT1A-mediated fatty acid oxidation sensitizes nasopharyngeal carcinoma to radiation therapy.
Tan Z, Xiao L, Tang M, Bai F, Li J, Li L, Shi F, Li N, Li Y, Du Q, Lu J, Weng X, Yi W, Zhang H, Fan J, Zhou J, Gao Q, Onuchic JN, Bode AM, Luo X, Cao Y. Tan Z, et al. Theranostics. 2018 Mar 22;8(9):2329-2347. doi: 10.7150/thno.21451. eCollection 2018. Theranostics. 2018. PMID: 29721083 Free PMC article.
NPC tumor tissue microarray was used to investigate the prognostic role of CPT1A. Either RNA interference or pharmacological blockade by Etomoxir were used to inhibit CPT1A. Radiation resistance was evaluated by colony formation assay. ...Molecular markers of mitochondrial …
NPC tumor tissue microarray was used to investigate the prognostic role of CPT1A. Either RNA interference or pharmacological blockade by …
HNF4 Regulates Fatty Acid Oxidation and Is Required for Renewal of Intestinal Stem Cells in Mice.
Chen L, Vasoya RP, Toke NH, Parthasarathy A, Luo S, Chiles E, Flores J, Gao N, Bonder EM, Su X, Verzi MP. Chen L, et al. Gastroenterology. 2020 Mar;158(4):985-999.e9. doi: 10.1053/j.gastro.2019.11.031. Epub 2019 Nov 22. Gastroenterology. 2020. PMID: 31759926 Free PMC article.
RESULTS: Crypt cells rapidly absorbed labeled fatty acids, and messenger RNA levels of Lgr5(+) stem cell markers (Lgr5, Olfm4, Smoc2, Msi1, and Ascl2) were down-regulated in organoids incubated with etomoxir, an inhibitor of FAO, indicating that FAO was required for renewa …
RESULTS: Crypt cells rapidly absorbed labeled fatty acids, and messenger RNA levels of Lgr5(+) stem cell markers (Lgr5, Olfm4, Smoc2, Msi1, …
Etomoxir Actions on Regulatory and Memory T Cells Are Independent of Cpt1a-Mediated Fatty Acid Oxidation.
Raud B, Roy DG, Divakaruni AS, Tarasenko TN, Franke R, Ma EH, Samborska B, Hsieh WY, Wong AH, Stüve P, Arnold-Schrauf C, Guderian M, Lochner M, Rampertaap S, Romito K, Monsale J, Brönstrup M, Bensinger SJ, Murphy AN, McGuire PJ, Jones RG, Sparwasser T, Berod L. Raud B, et al. Cell Metab. 2018 Sep 4;28(3):504-515.e7. doi: 10.1016/j.cmet.2018.06.002. Epub 2018 Jun 28. Cell Metab. 2018. PMID: 30043753 Free PMC article.
Here we show that the ACC2/Cpt1a axis is largely dispensable for T(eff), T(mem), or T(reg) cell formation, and that the effects of etomoxir on T cell differentiation and function are independent of Cpt1a expression. Together our data argue that metabolic pathways other tha …
Here we show that the ACC2/Cpt1a axis is largely dispensable for T(eff), T(mem), or T(reg) cell formation, and that the effects of etomox …
miR-21-5p regulates mitochondrial respiration and lipid content in H9C2 cells.
Nasci VL, Chuppa S, Griswold L, Goodreau KA, Dash RK, Kriegel AJ. Nasci VL, et al. Am J Physiol Heart Circ Physiol. 2019 Mar 1;316(3):H710-H721. doi: 10.1152/ajpheart.00538.2017. Epub 2019 Jan 18. Am J Physiol Heart Circ Physiol. 2019. PMID: 30657727 Free PMC article.
Pre-miR-21-5p blocked additional increases in OCR in response to etomoxir and palmitic acid. Conversely, anti-miR-21-5p-transfected cells exhibited reduced OCR with both etomoxir and palmitic acid, and the glycolytic capacity was concomitantly reduced. ...
Pre-miR-21-5p blocked additional increases in OCR in response to etomoxir and palmitic acid. Conversely, anti-miR-21-5p-transfected c …
Delineating the early dissemination mechanisms of acral melanoma by integrating single-cell and spatial transcriptomic analyses.
Wei C, Sun W, Shen K, Zhong J, Liu W, Gao Z, Xu Y, Wang L, Hu T, Ren M, Li Y, Zhu Y, Zheng S, Zhu M, Luo R, Yang Y, Hou Y, Qi F, Zhou Y, Chen Y, Gu J. Wei C, et al. Nat Commun. 2023 Dec 8;14(1):8119. doi: 10.1038/s41467-023-43980-y. Nat Commun. 2023. PMID: 38065972 Free PMC article.
Furthermore, we demonstrate that LN metastasis requires a metabolic shift towards fatty acid oxidation (FAO) induced by MITF in MYC(+)MEL cells. Etomoxir, a clinically approved FAO inhibitor, can effectively suppress MITF-mediated LN metastasis. ...
Furthermore, we demonstrate that LN metastasis requires a metabolic shift towards fatty acid oxidation (FAO) induced by MITF in MYC(+)MEL ce …
Growth of Mycobacterium tuberculosis in vivo segregates with host macrophage metabolism and ontogeny.
Huang L, Nazarova EV, Tan S, Liu Y, Russell DG. Huang L, et al. J Exp Med. 2018 Apr 2;215(4):1135-1152. doi: 10.1084/jem.20172020. Epub 2018 Mar 2. J Exp Med. 2018. PMID: 29500179 Free PMC article.
Furthermore, in in vitro macrophage infections, 2-deoxyglucose treatment increased bacterial growth, whereas the fatty acid oxidation inhibitor etomoxir constrained bacterial growth. We hypothesize that different macrophage lineages respond divergently to Mtb infection, wi …
Furthermore, in in vitro macrophage infections, 2-deoxyglucose treatment increased bacterial growth, whereas the fatty acid oxidation inhibi …
NCoR1 controls immune tolerance in conventional dendritic cells by fine-tuning glycolysis and fatty acid oxidation.
Sen K, Pati R, Jha A, Mishra GP, Prusty S, Chaudhary S, Swetalika S, Podder S, Sen A, Swain M, Nanda RK, Raghav SK. Sen K, et al. Redox Biol. 2023 Feb;59:102575. doi: 10.1016/j.redox.2022.102575. Epub 2022 Dec 16. Redox Biol. 2023. PMID: 36565644 Free PMC article.
To confirm these observations, we used synthetic metabolic inhibitors and found that the combined inhibition of HIF-1alpha and CPT1a using KC7F2 and etomoxir, respectively, compromised the overall transcriptional signature of immunological tolerance including the regulator …
To confirm these observations, we used synthetic metabolic inhibitors and found that the combined inhibition of HIF-1alpha and CPT1a using K …
531 results