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Page 1
Pharmacokinetic/pharmacodynamic relationship of eptazocine, a narcotic-antagonist analgesic, in rats.
Suzuki T, Shimizu R, Suganuma T, Nishino J, Tomono K, Hanano M, Watanabe J. Suzuki T, et al. Biol Pharm Bull. 2000 Dec;23(12):1504-10. doi: 10.1248/bpb.23.1504. Biol Pharm Bull. 2000. PMID: 11145186
The relationship between the pharmacokinetics and the pharmacodynamics of eptazocine, a narcotic-antagonist analgesic, was investigated in rats. ...Eptazocine produced a dose-dependent analgesic effect. It was demonstrated that eptazocine has a linear relatio …
The relationship between the pharmacokinetics and the pharmacodynamics of eptazocine, a narcotic-antagonist analgesic, was investigat …
[Pharmacological action of eptazocine (l-1,4-dimethyl-10-hydroxy-2,3,4,5,6,7-hexahydro-1,6-methano-1H-4-banzazonine). (II) Relationship between the analgesic action of eptazocine and brain 5-hydroxytryptamine (5-HT) (author's transl)].
Kameyama T, Nabeshima T, Yamaguchi K, Kamata K, Ukai M, Okuyama S, Sakakibara S. Kameyama T, et al. Nihon Yakurigaku Zasshi. 1981 Dec;78(6):613-27. Nihon Yakurigaku Zasshi. 1981. PMID: 6174403 Japanese.
In addition, eptazocine decreased the 5-HIAA level in the cortex and the 5-HT level in the hippocampus, but increased the 5-HT level in the spinal cord. ...On the other hand, MOR decreased the 5-HT level in the brain stem and striatum. These results suggest that the effect …
In addition, eptazocine decreased the 5-HIAA level in the cortex and the 5-HT level in the hippocampus, but increased the 5-HT level …
[Pharmacological action of eptazocine (l-1,4-dimethyl-10-hydroxy-2,3,4,5,6,7-hexahydro-1,6-methano-1H-4-benzazonine). (III) Central action of eptazocine (author's transl)].
Kameyama T, Nabeshima T, Yamaguchi K, Kamata K, Okuyama S, Tsuji H, Sakakibara S. Kameyama T, et al. Nihon Yakurigaku Zasshi. 1981 Dec;78(6):629-45. doi: 10.1254/fpj.78.629. Nihon Yakurigaku Zasshi. 1981. PMID: 7333566 Japanese.
Eptazocine produced sedation at low doses and Straub tail reaction in mice and ataxia in rats at high doses. ...Fighting behavior induced by electric shock and central stimulation effect of methamphetamine were inhibited by eptazocine in mice. Eptazocine show …
Eptazocine produced sedation at low doses and Straub tail reaction in mice and ataxia in rats at high doses. ...Fighting behavior ind …
[Pharmacological action of eptazocine (l-1,4-dimethyl-10-hydroxy-2,3,4,5,6,7-hexahydro-1,6-methano-1H-4-benzazonine). Effects of eptazocine on spontaneous movements].
Sakakibara S. Sakakibara S. Nihon Yakurigaku Zasshi. 1983 Jun;81(6):549-63. Nihon Yakurigaku Zasshi. 1983. PMID: 6618345 Japanese.
Eptazocine at 20, 40 and 80 mg/kg increased the spontaneous movements in a dose-dependent fashion. ...The effects of eptazocine may be mediated by opiate receptors and catecholaminergic neurons, but the potency of eptazocine to induce tolerance is less than p …
Eptazocine at 20, 40 and 80 mg/kg increased the spontaneous movements in a dose-dependent fashion. ...The effects of eptazocine …
[Pharmacological action of eptazocine (l-1,4-dimethyl-10-hydroxy-2,3,4,5,6,7-hexahydro-1,6-methano-1H-4-benz azonine). (V). A comparison of eptazocine, pentazocine and morphine with regard to ability of tolerance development after successive administration].
Nabeshima T, Yamada S, Kameyama T. Nabeshima T, et al. Nihon Yakurigaku Zasshi. 1986 Jun;87(6):619-27. doi: 10.1254/fpj.87.619. Nihon Yakurigaku Zasshi. 1986. PMID: 3744168 Japanese.
It was investigated whether tolerance to the pharmacological actions and cross-tolerance between eptazocine and pentazocine/morphine were developed by successive administration of eptazocine. ...On the tail flick method of rats, tolerance to the action of eptazoc …
It was investigated whether tolerance to the pharmacological actions and cross-tolerance between eptazocine and pentazocine/morphine …
A novel and practical asymmetric synthesis of eptazocine hydrobromide.
Li R, Liu Z, Chen L, Pan J, Lin K, Zhou W. Li R, et al. Beilstein J Org Chem. 2018 Sep 6;14:2340-2347. doi: 10.3762/bjoc.14.209. eCollection 2018. Beilstein J Org Chem. 2018. PMID: 30254698 Free PMC article.
In order to prepare eptazocine hydrobromide effectively, a novel, mild and practical asymmetric process was developed starting from 1-methyl-7-methoxy-2-tetralone under the catalysis of N-(p-trifluoromethylbenzyl)cinchonidinium bromide. ...
In order to prepare eptazocine hydrobromide effectively, a novel, mild and practical asymmetric process was developed starting from 1 …
[Pharmacological action of eptazocine (l-1,4-dimethyl-10-hydroxy-2,3,4,5,6,7-hexahydro-1,6-methano-1H-4-benzazonine). (I). Relationship between the analgesic action of eptazocine and brain catecholamine (author's transl)].
Kameyama T, Nabeshima T, Yamaguchi K, Ukai M, Okuyama S, Sakakibara S. Kameyama T, et al. Nihon Yakurigaku Zasshi. 1981 Dec;78(6):599-612. doi: 10.1254/fpj.78.599. Nihon Yakurigaku Zasshi. 1981. PMID: 7333565 Japanese.
Eptazocine increased the norepinephrine (NE)level in the brain stem, but decreased the dopamine (DA) level in the cortex. Eptazocine decreased the rates of DA turnover in the cortex and the brain stem and NE turnover in the spinal cord. ...
Eptazocine increased the norepinephrine (NE)level in the brain stem, but decreased the dopamine (DA) level in the cortex. Eptazoci …
[Pharmacological actions of eptazocine (l-1,4-dimethyl-10-hydroxy-2,3,4,5,6,7-hexahydro-1,6-methano-1,H-4-benzazonine). 4. Antagonistic action of naloxone on eptazocine analgesia].
Nabeshima T, Yamada S, Yamaguchi K, Matsuno K, Kameyama T, Sakakibara S, Matsumoto S. Nabeshima T, et al. Nihon Yakurigaku Zasshi. 1983 May;81(5):411-20. Nihon Yakurigaku Zasshi. 1983. PMID: 6629212 Japanese.
It was investigated whether the analgesic effects of eptazocine were antagonized by treatment with naloxone, one of the opiate antagonists, and whether morphine-induced effects were affected by eptazocine. ...Furthermore, the stimulating effect of morphine on sponta …
It was investigated whether the analgesic effects of eptazocine were antagonized by treatment with naloxone, one of the opiate antago …
[Protective effect of eptazocine, a novel analgesic, against cerebral hypoxia-anoxia in mice].
Tamura T, Taniguchi T, Aoki M, Waki I. Tamura T, et al. Nihon Yakurigaku Zasshi. 1990 Apr;95(4):167-75. doi: 10.1254/fpj.95.4_167. Nihon Yakurigaku Zasshi. 1990. PMID: 2370033 Japanese.
Cerebral protective effect of eptazocine, a mu-antagonist-kappa-agonist, was investigated using mice subjected to hypoxia-anoxia. ...The eptazocine effect was attenuated by either naloxone (5 mg/kg) or atropine (0.5 mg/kg), different from what was seen in the case o …
Cerebral protective effect of eptazocine, a mu-antagonist-kappa-agonist, was investigated using mice subjected to hypoxia-anoxia. ... …
Anesthetic management with eptazocine hydrobromide in patients receiving long-term antipsychotic medication.
Mizobe T, Oda Y, Natsuyama T, Miyazaki M. Mizobe T, et al. J Anesth. 1992 Jan;6(1):21-7. doi: 10.1007/s0054020060021. J Anesth. 1992. PMID: 15278579
Patients anesthetized with enflurane alone (enflurane group, n = 11), were compared with those anesthetized with enflurane and eptazocine hydrobromide 1 mg.kg(-1) (eptazocine group, n = 10). The mean daily dose of the antipsychotics, converted into the amount of chl …
Patients anesthetized with enflurane alone (enflurane group, n = 11), were compared with those anesthetized with enflurane and eptazocine …
33 results